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54681por Gray, Glenda E, Bekker, Linda-Gail, Laher, Fatima, Malahleha, Mookho, Allen, Mary, Moodie, Zoe, Grunenberg, Nicole, Huang, Yunda, Grove, Doug, Prigmore, Brittany, Kee, Jia J., Benkeser, David, Hural, John, Innes, Craig, Lazarus, Erica, Meintjes, Graeme, Naicker, Nivashnee, Kalonji, Dishiki, Nchabeleng, Maphoshane, Sebe, Modulakgotla, Singh, Nishanta, Kotze, Philip, Kassim, Sheetal, Dubula, Thozama, Naicker, Vimla, Brumskine, William, Ncayiya, Cleon N, Ward, Amy M, Garrett, Nigel, Kistnasami, Girisha, Gaffoor, Zakir, Selepe, Pearl, Makhoba, Philisiwe B, Mathebula, Matsontso P, Mda, Pamela, Adonis, Tania, Mapetla, Katlego S, Modibedi, Bontle, Philip, Tricia, Kobane, Gladys, Bentley, Carter, Ramirez, Shelly, Takuva, Simbarashe, Jones, Megan, Sikhosana, Mpho, Atujuna, Millicent, Andrasik, Michele, Hejazi, Nima S., Puren, Adrian, Wiesner, Lubbe, Phogat, Sanjay, Diaz Granados, Carlos, Koutsoukos, Marguerite, Van Der Meeren, Olivier, Barnett, Susan W., Kanesa-thasan, Niranjan, Kublin, James G., McElrath, M. Juliana, Gilbert, Peter B., Janes, Holly, Corey, Lawrence“…An analogous regimen using HIV-1 subtype C virus demonstrated potent humoral and cellular responses in a Phase 1/2a trial and triggered a Phase 2b/3 double-blinded trial to assess the safety and efficacy of this regimen in South Africa. METHODS: We enrolled and randomized 5,404 healthy, HIV-uninfected 18-35-year olds at 14 sites to vaccine (2,704 participants) or placebo (2,700 participants) between 26 October 2016 and 21 June 2019. …”
Publicado 2021
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54682por Sivakumaran, Dhanasekaran, Ritz, Christian, Gjøen, John Espen, Vaz, Mario, Selvam, Sumithra, Ottenhoff, Tom H. M., Doherty, Timothy Mark, Jenum, Synne, Grewal, Harleen M. S.“…Subsequently, we evaluated the performance of the 11-gene signature in two external validation data sets viz, an independent cohort at the Glenfield Hospital, University Hospitals of Leicester NHS Trust, Leicester, UK (GSE107994 data set), and the Catalysis treatment response cohort (GSE89403 data set) from South Africa. The 11-gene signature validated and distinguished PTB from healthy and asymptomatic M. tuberculosis infected household controls in the GSE107994 data set, with an AUC of 0.95 (95% CI: 0.91–0.98) and 0.94 (95% CI: 0.89–0.98). …”
Publicado 2021
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54683por Yitagesu, Erdachew, Jackson, Wendi, Kebede, Nigatu, Smith, Woutrina, Fentie, Tsegaw“…Relatively few studies have focused on understanding BVDV seroprevalence, virus detection, genotyping and its distribution in Africa. Most BVDV research in Ethiopia has involved serologic surveys in adult cattle, rather than the identification of PI calves, despite their role in viral shedding and recurring infections. …”
Publicado 2021
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54684por Vogel, Cassandra, Chunga, Timothy L., Sun, Xiaoxuan, Poveda, Katja, Steffan-Dewenter, Ingolf“…Though landscape effects on ecosystem service providers have been studied in large-scale agriculture in temperate regions, there is a lack of representation of tropical smallholder agriculture within this field of study, especially in sub-Sahara Africa. Legume crops can provide important food security and soil improvement benefits to vulnerable agriculturalists. …”
Publicado 2021
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54685por Pinto, Daniel O., Al Sharif, Sarah, Mensah, Gifty, Cowen, Maria, Khatkar, Pooja, Erickson, James, Branscome, Heather, Lattanze, Thomas, DeMarino, Catherine, Alem, Farhang, Magni, Ruben, Zhou, Weidong, Alais, Sandrine, Dutartre, Hélène, El-Hage, Nazira, Mahieux, Renaud, Liotta, Lance A., Kashanchi, Fatah“…HTLV-1 has currently infected up to 10 million globally with highly endemic areas in Japan, Africa, the Caribbean and South America. We have previously shown that Extracellular Vesicles (EVs) enhance HTLV-1 transmission by promoting cell–cell contact. …”
Publicado 2021
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54686por Omondi, Brian R., Muthui, Michelle K., Muasya, William I., Orindi, Benedict, Mwakubambanya, Ramadhan S., Bousema, Teun, Drakeley, Chris, Marsh, Kevin, Bejon, Philip, Kapulu, Melissa C.“…BACKGROUND: Malaria caused by Plasmodium falciparum remains a serious global public health challenge especially in Africa. Interventions that aim to reduce malaria transmission by targeting the gametocyte reservoir are key to malaria elimination and/or eradication. …”
Publicado 2021
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54687“…BACKGROUND: Along with a nutritional transition in Sub-Saharan Africa, the prevalence of non-communicable diseases is increasing rapidly. …”
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54688por Oosthuizen, Jaco, Kotze, Maritha J., Van Der Merwe, Nicole, Myburgh, Ettienne J., Bester, Phillip, van der Merwe, Nerina C.“…Breast cancer patients historically benefitted from population-based genetic research performed in South Africa, which led to the development of founder-based BRCA1/2 diagnostic tests. …”
Publicado 2021
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54689por Sternberg, Eleanore D, Cook, Jackie, Alou, Ludovic P Ahoua, Assi, Serge Brice, Koffi, Alphonsine A, Doudou, Dimi T, Aoura, Carine J, Wolie, Rosine Z, Oumbouke, Welbeck A, Worrall, Eve, Kleinschmidt, Immo, N'Guessan, Raphael, Thomas, Matthew B“…Cost-effectiveness simulations suggested that screening plus Eave Tubes has a 74·0% chance of representing a cost-effective intervention, compared with existing healthcare activities in Côte d'Ivoire, and is similarly cost-effective to other core vector control interventions across sub-Saharan Africa. No serious adverse events associated with the intervention were reported during follow-up. …”
Publicado 2021
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54690por Afolabi, Muhammed O., Ale, Boni M., Dabira, Edgard D., Agbla, Schadrac C., Bustinduy, Amaya L., Ndiaye, Jean Louis A., Greenwood, Brian“…The 28 studies enrolled 22, 114 children in 13 countries across sub-Saharan Africa, Southeast Asia and South America. Overall, the pooled estimates showed a prevalence of Plasmodium-helminth co-infections of 17.7% (95% CI 12.7–23.2%). …”
Publicado 2021
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54691por Gowda, Manje, Makumbi, Dan, Das, Biswanath, Nyaga, Christine, Kosgei, Titus, Crossa, Jose, Beyene, Yoseph, Montesinos-López, Osval A., Olsen, Michael S., Prasanna, Boddupalli M.“…Benth., commonly known as the purple witchweed or giant witchweed, is a serious problem for maize-dependent smallholder farmers in sub-Saharan Africa. Breeding for Striga resistance in maize is complicated due to limited genetic variation, complexity of resistance and challenges with phenotyping. …”
Publicado 2021
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54692por Galosi, Livio, Attili, Anna Rita, Perrucci, Stefania, Origgi, Francesco C., Tambella, Adolfo Maria, Rossi, Giacomo, Cuteri, Vincenzo, Napoleoni, Maira, Mandolini, Nicholas Aconiti, Perugini, Gianni, Loehr, Victor J. T.“…The speckled dwarf tortoise (Chersobius [Homopus] signatus) is a threatened species that is mostly restricted to the Succulent Karoo biome in South Africa, and little information on pathogens of this species is available yet. …”
Publicado 2021
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54693por Serunjogi, Robert, Barlow-Mosha, Linda, Mumpe-Mwanja, Daniel, Williamson, Dhelia, Valencia, Diana, Tinker, Sarah C., Adler, Michelle R., Namale-Matovu, Joyce, Kalibbala, Dennis, Nankunda, Jolly, Nabunya, Evelyn, Birabwa-Male, Doreen, Byamugisha, Josaphat, Musoke, Philippa“…BACKGROUND: Uganda has one of the highest adolescent pregnancy rates in sub-Saharan Africa. We compared the risk of adverse birth outcomes between adolescents (age 12–19 years) and mothers (age 20–34 years) in four urban hospitals. …”
Publicado 2021
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54694por Packer, Corinne, Halabi, Sam F., Hollmeyer, Helge, Mithani, Salima S., Wilson, Lindsay, Ruckert, Arne, Labonté, Ronald, Fidler, David P., Gostin, Lawrence O., Wilson, Kumanan“…METHODS: In collaboration with WHO officials, we administered a voluntary online survey to all 196 States Parties to the IHR (2005) in Africa, Asia, Europe, and South and North America, from October to November 2019. …”
Publicado 2021
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54695por Finda, Marceline F., Okumu, Fredros O., Minja, Elihaika, Njalambaha, Rukiyah, Mponzi, Winfrida, Tarimo, Brian B., Chaki, Prosper, Lezaun, Javier, Kelly, Ann H., Christofides, Nicola“…BACKGROUND: Different forms of mosquito modifications are being considered as potential high-impact and low-cost tools for future malaria control in Africa. Although still under evaluation, the eventual success of these technologies will require high-level public acceptance. …”
Publicado 2021
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54696por Kagaruki, Gibson B, Mahande, Michael J, Kimaro, Godfather D, Ngadaya, Esther S, Mayige T, Mary, Selemani, Majige, Jaacks, Lindsay M, Jaffar, Shabbar, Mfinanaga, Sayoki G, Bonfoh, Bassirou“…BACKGROUND: Regular street food consumers (RSFCs) in Africa are at an increased risk of unhealthy eating practices, which have been associated with intermediate risk factors of cardio-metabolic diseases. …”
Publicado 2021
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54697por Anyayo, Lucas, Ashaba, Scholastic, Kaggwa, Mark Mohan, Maling, Samuel, Nakimuli-Mpungu, Etheldreda“…BACKGROUND: Bipolar disorder is a psychiatric disorder that alters mood and affects over 55 million people globally with an estimated lifetime prevalence of approximately 0.8–1.1%. In Africa, the lifetime prevalence of the bipolar spectrum disorders is slightly lower at 0.1–0.6%. …”
Publicado 2021
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54698por Schlum, Katrina A., Lamour, Kurt, de Bortoli, Caroline Placidi, Banerjee, Rahul, Meagher, Robert, Pereira, Eliseu, Murua, Maria Gabriela, Sword, Gregory A., Tessnow, Ashley E., Viteri Dillon, Diego, Linares Ramirez, Angela M., Akutse, Komivi S., Schmidt-Jeffris, Rebecca, Huang, Fangneng, Reisig, Dominic, Emrich, Scott J., Jurat-Fuentes, Juan Luis“…We found members from the Eastern Hemisphere interspersed within both continental USA overwintering subpopulations, suggesting multiple individuals were likely introduced to Africa. CONCLUSIONS: Our research is the largest diverse collection of United States S. frugiperda whole genome sequences characterized to date, covering eight continental states and a USA territory (Puerto Rico). …”
Publicado 2021
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54699“…The corresponding estimates were 67.6% [95% CI: 65.5%–69.7%; n = 91 trials; I(2) = 90.5%; 24,218 patients] in studies conducted in the Indian sub-continent and 74.1% [95% CI: 68.4%–79.1%; n = 24 trials; I(2) = 94.4%; 6,716 patients] in studies from Eastern Africa. The proportion of male participants was 57.9% [95% CI: 54.2%–61.5%] in studies enrolling children aged <15 years, 78.2% [95% CI: 66.0%–86.9%] in studies that enrolled adults (≥15 years), and 68.1% [95% CI: 65.9%–70.0%] in studies that enrolled patients of all ages. …”
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54700“…BACKGROUND: Mosquito larval source management (LSM) is a key outdoor malaria vector control strategy in rural communities in sub-Saharan Africa. Knowledge of this strategy is important for optimal design and implementation of effective malaria control interventions in this region. …”
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