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  1. 56481
    “…BACKGROUND: Direct measures of HIV incidence are needed to assess the population-level impact of prevention programs but are scarcely available in the subnational epidemic hotspots of sub-Saharan Africa. We created a sentinel HIV incidence cohort within a community-based program that provided home-based HIV testing to all residents of Namibia’s Zambezi region, where approximately 24% of the adult population was estimated to be living with HIV. …”
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    Rates and Correlates of HIV Incidence in Namibia’s Zambezi Region From 2014 to 2016: Sentinel, Community-Based Cohort Study
  2. 56482
    “…The Registry includes sites that collect outcomes of pregnancies in women and their babies in rural areas in 6 countries in South Asia, sub-Saharan Africa and Central America. The Registry is population based and tracks women from early in pregnancy to day 42 post-partum. …”
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    Development of the Global Network for Women’s and Children’s Health Research’s socioeconomic status index for use in the network’s sites in low and lower middle-income countries
  3. 56483
    “…America, 29 (26%) Europe, 14 (13%) S. Africa, and 3 (3%) Latin America. Majority of participants were male (87, 79%), white (74, 65%), with median age 35 years. …”
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    LB-8. Summary of COVID-Related Impact on Cabotegravir and Rilpivirine Long-Acting (CAB+RPV LA) Dosing Across the Six Ongoing Global Phase IIb and IIIb Clinical Trials
  4. 56484
    “…Most of maternal deaths globally occur in sub-Saharan Africa, with most of these deaths linked to lack of access to antenatal care and skilled assistance during delivery. …”
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    Determinants of antenatal care and skilled birth attendance services utilization among childbearing women in Guinea: evidence from the 2018 Guinea Demographic and Health Survey data
  5. 56485
    “…TRIAL REGISTRATION: The trial was registered on the 17th October 2014 with the Pan African Clinical Trial Registry in South Africa with number (PACTR201410000859336) and 32-month follow-up as an amendment to the trial.…”
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    Effects on childhood infections of promoting safe and hygienic complementary-food handling practices through a community-based programme: A cluster randomised controlled trial in a rural area of The Gambia
  6. 56486
    “…RESULTS: Between September 2016 and June 2018, 707 children weighing ≥14 kg were enrolled; including 311 ART-naïve children and 396 children starting second-line. 47% of children were enrolled in Uganda, 21% Zimbabwe, 20% South Africa, 9% Thailand, 4% Europe. 362 (51%) participants were male; median age [range] at enrolment was 12.2 years [2.9–18.0]. 82 (12%) children weighed 14 to < 20 kg, 135 (19%) 20 to < 25 kg, 206 (29%) 25 to < 35 kg, 284 (40%) ≥35 kg. 128 (18%) had WHO stage 3 and 60 (8%) WHO stage 4 disease. …”
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    ODYSSEY clinical trial design: a randomised global study to evaluate the efficacy and safety of dolutegravir-based antiretroviral therapy in HIV-positive children, with nested pharmacokinetic sub-studies to evaluate pragmatic WHO-weight-band based dolutegravir dosing
  7. 56487
    “…METHODS: Adult volunteers aged 18–59 years were recruited at five geographically distinct communities in South Africa. Whole blood was sampled for RISK11 by quantitative RT-PCR assay from eligible volunteers without HIV, recent previous tuberculosis (ie, <3 years before screening), or comorbidities at screening. …”
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    Biomarker-guided tuberculosis preventive therapy (CORTIS): a randomised controlled trial
  8. 56488
    “…Understanding the interplay of these determinants in the context of lymphopenia and COVID-19 complications in patients in Africa may help with risk stratification and appropriate deployment of targeted treatment regimens with repurposed drugs to improve prognosis. …”
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    Improving the Understanding of the Immunopathogenesis of Lymphopenia as a Correlate of SARS-CoV-2 Infection Risk and Disease Progression in African Patients: Protocol for a Cross-sectional Study
  9. 56489
    “…The trials were carried out between 2006 and 2015 in sub‐Saharan Africa (Benin, Mali, Mozambique, Tanzania, Kenya, Democratic Republic of the Congo, Burkina Faso, and The Gambia). …”
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    Paediatric formulations of artemisinin‐based combination therapies for treating uncomplicated malaria in children
  10. 56490
    “…Studies originated from 16 countries including in North America, Europe, Australia, east Africa, and Asia. Pooling unadjusted estimates, recent homelessness or unstable housing was associated with an increased risk of acquiring HIV (crude relative risk [cRR] 1·55 [95% CI 1·23–1·95; p=0·0002]; I(2)= 62·7%; n=17) and HCV (1·65 [1·44–1·90; p<0·0001]; I(2)= 44·8%; n=28]) among PWID compared with those who were not homeless or were stably housed. …”
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    Homelessness, unstable housing, and risk of HIV and hepatitis C virus acquisition among people who inject drugs: a systematic review and meta-analysis
  11. 56491
    “…BACKGROUND: Undiagnosed HIV infection remains substantial in key population subgroups including adolescents, older adults, and men, driving ongoing transmission in sub-Saharan Africa. We evaluated the impact, safety, and costs of community-led delivery of HIV self-testing (HIVST), aiming to increase HIV testing in underserved subgroups and stimulate demand for antiretroviral therapy (ART). …”
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    Effect of community-led delivery of HIV self-testing on HIV testing and antiretroviral therapy initiation in Malawi: A cluster-randomised trial
  12. 56492
    “…The efficacy and safety of a single-dose combination of artefenomel (800 mg) plus ferroquine (400/600/900/1200 mg doses) for the treatment of uncomplicated P. falciparum malaria were evaluated in Africa (focusing on children ≤ 5 years) and Asia. …”
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    A randomized, double-blind, phase 2b study to investigate the efficacy, safety, tolerability and pharmacokinetics of a single-dose regimen of ferroquine with artefenomel in adults and children with uncomplicated Plasmodium falciparum malaria
  13. 56493
    por Tardif, Jean-Claude, Bouabdallaoui, Nadia, L'Allier, Philippe L, Gaudet, Daniel, Shah, Binita, Pillinger, Michael H, Lopez-Sendon, Jose, da Luz, Protasio, Verret, Lucie, Audet, Sylvia, Dupuis, Jocelyn, Denault, André, Pelletier, Martin, Tessier, Philippe A, Samson, Sarah, Fortin, Denis, Tardif, Jean-Daniel, Busseuil, David, Goulet, Elisabeth, Lacoste, Chantal, Dubois, Anick, Joshi, Avni Y, Waters, David D, Hsue, Priscilla, Lepor, Norman E, Lesage, Frédéric, Sainturet, Nicolas, Roy-Clavel, Eve, Bassevitch, Zohar, Orfanos, Andreas, Stamatescu, Gabriela, Grégoire, Jean C, Busque, Lambert, Lavallée, Christian, Hétu, Pierre-Olivier, Paquette, Jean-Sébastien, Deftereos, Spyridon G, Levesque, Sylvie, Cossette, Mariève, Nozza, Anna, Chabot-Blanchet, Malorie, Dubé, Marie-Pierre, Guertin, Marie-Claude, Boivin, Guy
    Publicado 2021
    “…The study was done in Brazil, Canada, Greece, South Africa, Spain, and the USA, and was led by the Montreal Heart Institute. …”
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    Colchicine for community-treated patients with COVID-19 (COLCORONA): a phase 3, randomised, double-blinded, adaptive, placebo-controlled, multicentre trial
  14. 56494
    “…FUNDING: Unitaid, through the Self-Testing Africa Initiative.…”
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    Partner-delivered HIV self-test kits with and without financial incentives in antenatal care and index patients with HIV in Malawi: a three-arm, cluster-randomised controlled trial
  15. 56495
    por Godman, Brian, Haque, Mainul, Leong, Trudy, Allocati, Eleonora, Kumar, Santosh, Islam, Salequl, Charan, Jaykaran, Akter, Farhana, Kurdi, Amanj, Vassalo, Carlos, Bakar, Muhammed Abu, Rahim, Sagir Abdur, Sultana, Nusrat, Deeba, Farzana, Khan, M. A. Halim, Alam, A. B. M. Muksudul, Jahan, Iffat, Kamal, Zubair Mahmood, Hasin, Humaira, Munzur-E-Murshid, Nahar, Shamsun, Haque, Monami, Dutta, Siddhartha, Abhayanand, Jha Pallavi, Kaur, Rimple Jeet, Rwegerera, Godfrey Mutashambara, do Nascimento, Renata Cristina Rezende Macedo, Dias Godói, Isabella Piassi, Irfan, Mohammed, Amu, Adefolarin A., Matowa, Patrick, Acolatse, Joseph, Incoom, Robert, Sefah, Israel Abebrese, Acharya, Jitendra, Opanga, Sylvia, Njeri, Lisper Wangeci, Kimonge, David, Kwon, Hye-Young, Bae, SeungJin, Khuan, Karen Koh Pek, Abubakar, Abdullahi Rabiu, Sani, Ibrahim Haruna, Khan, Tanveer Ahmed, Hussain, Shahzad, Saleem, Zikria, Malande, Oliver Ombeva, Piloya-Were, Thereza, Gambogi, Rosana, Hernandez Ortiz, Carla, Alutuli, Luke, Kalungia, Aubrey Chichonyi, Hoxha, Iris, Marković-Peković, Vanda, Tubic, Biljana, Petrova, Guenka, Tachkov, Konstantin, Laius, Ott, Harsanyi, András, Inotai, András, Jakupi, Arianit, Henkuzens, Svens, Garuoliene, Kristina, Gulbinovič, Jolanta, Wladysiuk, Magdalene, Rutkowski, Jakub, Mardare, Ileana, Fürst, Jurij, McTaggart, Stuart, MacBride-Stewart, Sean, Pontes, Caridad, Zara, Corinne, Tagoe, Eunice Twumwaa, Banzi, Rita, Wale, Janney, Jakovljevic, Mihajlo
    Publicado 2021
    “…However, concerns with costs and value limited their use across Africa, Brazil and Pakistan. There was though limited use of biosimilar insulin glargine 100 IU/ml compared with other recent biosimilars especially among European countries and Korea. …”
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    The Current Situation Regarding Long-Acting Insulin Analogues Including Biosimilars Among African, Asian, European, and South American Countries; Findings and Implications for the Future
  16. 56496
    “…BACKGROUND: The World Health Organization (WHO) declared the West Africa Ebola epidemic as a Public Health Emergency of International Concern in August 2014. …”
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    Factors associated with length of stay and treatment outcome of Ebola patients treated at an Ebola treatment center in Sierra Leone during the peak period of the West African Ebola outbreak 2013–2016
  17. 56497
    “…METHODS: In this prospective, open-label, phase 2, randomised controlled trial, patients with pulmonary tuberculosis were recruited at three clinical sites in South Africa. Eligible patients were aged 18–65 years, HIV-1-negative, and had rifampicin-susceptible Mycobacterium tuberculosis, a sputum Xpert cycle threshold of less than 20, and moderately advanced or far advanced disease on chest radiography. …”
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    Adjunctive host-directed therapies for pulmonary tuberculosis: a prospective, open-label, phase 2, randomised controlled trial
  18. 56498
    “…There is a fair amount of evidence from South Asia (n = 73) and Sub‐Saharan Africa (n = 51). There is a significant gap with respect to study quality, especially with respect to impact evaluation. …”
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    Evidence and gap map of studies assessing the effectiveness of interventions for people with disabilities in low‐and middle‐income countries
  19. 56499
    “…All studies were conducted in sub‐Saharan Africa. The ages of included infants and children in the evaluations were as follows: at birth (n = 6), ≤ 12 months (n = 3), ≤ 18 months (n = 5), and ≤ 24 months (n = 1). …”
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    Point‐of‐care tests detecting HIV nucleic acids for diagnosis of HIV‐1 or HIV‐2 infection in infants and children aged 18 months or less
  20. 56500
    “…BACKGROUND: In Sierra Leone (SL), a low-income country in West Africa, dental care is very limited, largely private, and with services focused in the capital Freetown. …”
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    Needs-led human resource planning for Sierra Leone in support of oral health
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