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36981por Yao, Cheng, Yan, Mengjie, Li, Kehang, Gao, Weihao, Li, Xihai, Zhang, Jiaxin, Liu, Hong, Zhong, Yaohua“…Under the ER stress induced by high concentrations of DTT, knockout of hrd1, hrd3 and der1 resulted in severely impaired growth, and the mutants Δhrd1 and Δhrd3 exhibited high sensitivity to the cell wall-disturbing agents, CFW and CR. In addition, the absence of either hrd3 or der1 led to the decreased heat tolerance of this fungus. …”
Publicado 2023
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36982por Pérez-Iglesias, Juan Manuel, Bach, Nadia Carla, Colombetti, Patricia Laura, Acuña, Pablo, Colman-Lerner, Jorge Esteban, González, Silvia Patricia, Brodeur, Julie Celine, Almeida, Cesar Américo“…The combination of physicochemical parameters, metals, and pesticide levels allowed typification and differentiation of the sites. Some metal (Cr, Mn, Pb, and Zn) and pesticide (α-BHC, chlorpyrifos, permethrin and cypermethrin, and endosulfan α) levels recorded exceeded the recommended Argentinian legislation values. …”
Publicado 2023
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36983por Besis, Athanasios, Romano, Maria Pia, Serafeim, Eleni, Avgenikou, Anna, Kouras, Athanasios, Lionetto, Maria Giulia, Guascito, Maria Rachele, De Bartolomeo, Anna Rita, Giordano, Maria Elena, Mangone, Annarosa, Contini, Daniele, Samara, Constantini“…Chemical analysis of the water-soluble PM fraction included water-soluble organic carbon (WSOC), humic-like substances (HULIS), and trace elements (V, Cr, Mn, Fe, Ni, Cu, Zn, As, Cd and Pb). The bulk (sum of all size fractions) concentrations of HULIS were 2.5 ± 0.5 and 1.2 ± 0.3 μg m(−3), for the cold and warm sampling periods, respectively with highest values in the <0.49 μm particle size fraction. …”
Publicado 2023
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36984por Parker, Megan, Sawant, Hannah Brady, Flannery, Thuvia, Tarrant, Rachel, Shardha, Jenna, Bannister, Rebecca, Ross, Denise, Halpin, Stephen, Greenwood, Darren C., Sivan, Manoj“…This prospective study investigated the effect of a 6‐week structured World Health Organization (WHO) Borg CR‐10 5‐phase pacing protocol on PESE episodes and quality of life in a cohort of individuals with long‐standing PCS (average duration of symptoms was 17 months). …”
Publicado 2022
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36985por Natarajan, Aravind, Fremin, Brayon J., Schmidtke, Danica T., Wolfe, Marlene K., Zlitni, Soumaya, Graham, Katherine E., Brooks, Erin F., Severyn, Christopher J., Sakamoto, Kathleen M., Lacayo, Norman J., Kuersten, Scott, Koble, Jeff, Caves, Glorianna, Kaplan, Inna, Singh, Upinder, Jagannathan, Prasanna, Rezvani, Andrew R., Bhatt, Ami S., Boehm, Alexandria B.“…We applied the assays to detect fecal contamination in urban stormwater samples and found that the ToBRFV markers matched cross-assembly phage (crAssphage), an established viral MST marker, in prevalence across samples. …”
Publicado 2023
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36986por Li, Zhang, Zimmerman, Kurt A., Cherakara, Sreelakshmi, Chumley, Phillip H., Collawn, James F., Wang, Jun, Haycraft, Courtney J., Song, Cheng J., Chacana, Teresa, Andersen, Reagan S., Croyle, Mandy J., Aloria, Ernald J., Hombal, Raksha P., Thomas, Isis N., Chweih, Hanan, Simanyi, Kristin L., George, James F., Parant, John M., Mrug, Michal, Yoder, Bradley K.“…We observed that CD206(+) resident macrophages were minimal in a normal adult kidney but accumulated in cystic areas in adult-induced Pkd2 mutants. Using Cx3cr1 null mice, we reduced macrophage number, including CD206(+) macrophages, and showed that this significantly reduced cyst severity in adult-induced Pkd2 mutant kidneys. …”
Publicado 2023
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36987por Wang, Xiaoyu, Liu, Dan, Chen, Erling, Wang, Li, Zhao, Na, Zhou, Li, Tong, Juan, Xue, Lei, Zhang, Lei, Geng, Liangquan, Tang, Baolin, Liu, Huilan, Liu, Xin, Zheng, Changcheng“…METHODS: One hundred and eighty-three AML patients with complete remission (CR) were evaluated. RESULTS AND DISCUSSION: The 3-year relapse rate was 33.4% in the HDAC group and 50.5% in the SDMSC group (p=0.066). …”
Publicado 2023
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36988por Avila-George, Himer, De-la-Torre, Miguel, Sánchez-Garcés, Jorge, Coaquira Quispe, Joel Jerson, Prieto, Jose Manuel, Castro, Wilson“…Then, one thousand images were obtained from each class in RGB space and transformed into four different color spaces (L*a*b*, HSV, YCbCr, and Gray). Three convolutional neural networks (AlexNet, MobileNetv2, and DenseNet-201) were trained using the five color spaces, and the evaluation results were expressed in terms of accuracy and F-score. …”
Publicado 2023
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36989por Wang, Junkai, Huang, Xiuqin, Chen, Siping, Chen, Jiahao, Liang, Zhengyi, Chen, Biao, Yang, Xin, Zhou, Guohui, Zhang, Tong“…When the RT-RAA products were recognized by crRNA and formed a complex with LbCas12a, the ssDNA labeled with a quenched green fluorescent molecule will be cleaved by LbCas12a, and then a significant green fluorescence signal will appear. …”
Publicado 2023
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36990“…The risk scores were significantly lower in patients who responded to immunotherapy (complete response/partial response – CR/PR) than in patients who did not respond to immunotherapy (stable disease/progressive disease – SD/PD). …”
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36991por Bogaert, Patrick, Diélie, Gwenaël, Briffault, Axel, de Saint-Hubert, Benoit, Verbanck, Michel A.“…The concentrations of Cd, Cr, Cu, Ni, Pb and Zn have been measured in the finest fraction ([Formula: see text] μm) using ICP-OES. …”
Publicado 2023
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36992“…Magnetic resonance spectroscopy revealed increased choline (Cho) and decreased creatine (Cr) and N-acetyl aspartate (Naa) in the tumor. INTERVENTIONS: The patient underwent tumor resection and postoperative chemoradiotherapy and immunotherapy. …”
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36993por Ibrahim, Mona Abdel-Halim, Eltayeb, Nada, Ibrahim, Mirna Michel, Nassar, Ahmed, Daruish, Maged, El-Zimaity, Maha, El-Lithy, Mahmoud, Mostafa, Ahmed, El-Afifi, Amal, Abdelbary, Haitham, El-Sayed, Mahira Hamdy“…All patients with complete response (CR) enter a maintenance and follow-up schedule. …”
Publicado 2023
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36994“…METHODS: Skin color was quantified using the RGB (Red, Green, Blue), HSV (Hue Saturation Value), CIELab, and YCbCr color spaces in the acquired Korean skin images, which were classified through clustering. …”
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36995“…The patient successfully completed RP after another dose of zimberelimab, and achieved a pathological complete response (pCR). LESSONS: Our case represents a successful attempt at personalized treatment and provides preliminary evidence for the clinical use of downstaging therapy of androgen deprivation therapy, chemotherapy, and add-on zimberelimab for very-high-risk clinically localized PCa.…”
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36996por Zhang, Heyu, He, Yan, Wu, Xiaomin, Huang, Peixiang, Qin, Wenkang, Wang, Fan, Ye, Juxiang, Huang, Xirui, Liao, Yanfang, Chen, Hang, Guo, Limei, Shi, Xueying, Luo, Lin“…Following PathNarratives, we recruited 8 pathologist annotators to build a colorectal pathological dataset, CR-PathNarratives, containing 174 whole-slide images (WSIs). …”
Publicado 2023
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36997“…Concentrations of seventeen elements (Na, Ca, Sc, Cr, Fe, Co, Zn, Rb, Zr, Ba, La, Hf, Ce, Eu, Yb, Sm, and Th) were determined in all analyzed glass samples by INAA at major, minor, and trace concentration levels, indicating its capability for potential applications to forensic studies. …”
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36998por Zhang, Chenlu, Liu, Wenshuai, Wang, Binliang, Zhu, Na, Guo, Xi, Wang, Zhiming, Zhuang, Rongyuan, You, Yang, Zhang, Yong, Tong, Hanxing, Lu, Weiqi, Zhou, Yuhong“…Examination of the surgical specimens showed a pathological complete response (pCR). Until the latest follow-up (April 2022), no recurrence was observed, and disease-free survival has exceeded 14 months. …”
Publicado 2023
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36999por Chayangsu, Chawalit, Khorana, Jiraporn, Charoentum, Chaiyut, Sriuranpong, Virote, Patumanond, Jayanton, Tantraworasin, Apichat“…There were 117 responders (CR or PR) and 90 non-responders (SD or PD). The clinical prediction score was developed by six clinical parameters including gender, age, smoking status, ECOG, pre-treatment albumin, and histologic subtype. …”
Publicado 2023
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37000“…In addition, the health risk assessment results indicated that the priority control pollutants of non-carcinogenic risk and carcinogenic risk were Zn and Cr, respectively. The high-risk area was mainly located in the middle of the study area. …”
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