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  1. 37281
    por Moore, K., Moore, M.
    Publicado 1979
    “…Evidence that the effector function of TIL was mediated in part by natural killer (NK) cells was derived from concurrent experiments using human myeloid cells (K562) as targets in an 18h 51Cr-release assay. In this system the level of NK activity was critically dependent on the numbers of tumour cells in the TIL population; contamination in excess of 2% gave rise to dose-dependent inhibition of NK function. …”
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    Systemic and in-situ natural killer activity in tumour-bearing rats.
  2. 37282
    “…Each treatment cycle consisted of a 2 day pulse phase, with 9 x 10(6) IU m-2 of rIL-2 being given subcutaneously every 12 h, followed by a 6 week maintenance phase during which rIL-2 1.8 x 10(6) IU m-2 was administered subcutaneously every 12 h on days 1-5 and rIFN-alpha 2b 5 x 10(6) IU m-2 once a day on days 1, 3 and 5. Objective responses (CR+PR) occurred in 9/50 (18%) patients, six of whom (12%) achieved a complete response. …”
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    Subcutaneous administration of interleukin 2 and interferon-alpha-2b in advanced renal cell carcinoma: a confirmatory study.
  3. 37283
    “…Five patients obtained a complete response (CR) and 27 a partial response (PR); the response rate (RR) was 44.4% (95% confidence interval 32.7-56.6%). …”
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    A late phase II study of RP56976 (docetaxel) in patients with advanced or recurrent breast cancer.
  4. 37284
    Publicado 1991
    “…In RPMI supplemented with 100 microM Br-, phorbol myristate acetate- activated EOs, but not polymorphonuclear leukocytes, caused 1.8-3.6 times as much 51Cr release from four types of endothelial cell monolayers as in RPMI alone. …”
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    Bromide-dependent toxicity of eosinophil peroxidase for endothelium and isolated working rat hearts: a model for eosinophilic endocarditis
  5. 37285
    Publicado 1994
    “…Cyclin D1 mRNA and protein is specifically downregulated in cells expressing SV40 large T antigen, adenovirus E1A, and papillomavirus E7/E6 oncogene products and this effect requires intact RB-binding, CR2 domain of E1A. Exceptionally low expression of cyclin D1 is also seen in genetically RB-deficient cell lines, in which ectopically expressed wild-type pRB results in specific induction of this G1 cyclin. …”
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    DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1
  6. 37286
    por Holm, Göran, Perlmann, Peter
    Publicado 1967
    “…Cell damage was quantitated by measuring the release of isotope from target cells labeled with chromate-(51)Cr. The cytotoxicity of the lymphocytes was dependent on the concentration of PHA in the incubation medium. …”
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    CYTOTOXIC POTENTIAL OF STIMULATED HUMAN LYMPHOCYTES
  7. 37287
    “…One complete response (CR) (soft tissue sarcoma) and two partial responses (PRs) were documented. …”
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    Phase I study on docetaxel and ifosfamide in patients with advanced solid tumours.
  8. 37288
    “…Injury to target fibroblasts was measured by release of radioactive (51)Cr from previously labeled fibroblasts or by direct count of viable fibroblasts after incubation with sensitized lymphocytes. …”
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    GLUCOCORTICOIDS AND CELLULAR IMMUNITY IN VITRO : FACILITATION OF THE SENSITIZATION PHASE AND INHIBITION OF THE EFFECTOR PHASE OF A LYMPHOCYTE ANTI-FIBROBLAST REACTION
  9. 37289
    Publicado 1982
    “…The homing efficiency of 51Cr-labeled helper cells into the spleen of nude recipients was determined. …”
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    Regulatory idiotypes. T helper cells recognize a shared VH idiotope on phosphorylcholine-specific antibodies
  10. 37290
    Publicado 1987
    “…The in vivo half-life of 51Cr-labeled mouse FFI-RBCs injected into syngeneic mice was reduced to 7 d, as compared to a half-life of 20 d for the controls. …”
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    Advanced glycosylation endproducts on erythrocyte cell surface induce receptor-mediated phagocytosis by macrophages. A model for turnover of aging cells
  11. 37291
    Publicado 1993
    “…Zymosan uptake by LC from both strains of mice was inhibited in the presence of mannan or beta-glucan, although to different extents, but not by antibodies specific for CR3 (CD11b/CD18). These data indicate that zymosan uptake by LC can be mediated by a mannose/beta-glucan receptor(s) that is differentially expressed in the two strains of mice and that is downregulated during maturation of LC in culture.…”
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    Phagocytosis of antigens by Langerhans cells in vitro
  12. 37292
    Publicado 1995
    “…However, we identified the leukocyte integrins LFA-1 and CR3 as components of the uPA-R complex as indicated by coisolation of these molecules, as well as by cocapping and comodulation of uPA-R and leukocyte integrins on the monocyte surface. …”
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    Urokinase plasminogen activator receptor, beta 2-integrins, and Src- kinases within a single receptor complex of human monocytes
  13. 37293
    Publicado 1995
    “…However, to detect lysis in a standard 51Cr release assay of the LCL against which these CTL were raised, superinfection with recombinant vaccinia expressing the appropriate EBV protein or incubation with the peptide epitope was necessary. …”
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    Class I major histocompatibility complex-restricted cytotoxic T lymphocytes specific for Epstein-Barr virus (EBV)-transformed B lymphoblastoid cell lines against which they were raised
  14. 37294
    Publicado 1996
    “…CD8+ CTL lines from H-2b mice were generated against a variant peptide, pE4R, (arginine for glutamic acid at the TCR contact position 4). In short-term 51Cr-release assays, these CTL lysed H-2Kb targets that were pulsed with picomolar levels of pE4R but did not lyse target cells coated with the self peptide at micromolar levels. …”
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    Selective activation of Fas/Fas ligand-mediated cytotoxicity by a self peptide
  15. 37295
    “…Thus, CS and DTH were inhibited by administration of a C-blocker, soluble recombinant C receptor-1 (sCR1), when given 30 min before, but not 3 h after local antigen challenge. …”
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    Required Early Complement Activation in Contact Sensitivity with Generation of Local C5-dependent Chemotactic Activity, and Late T Cell Interferon γ: A Possible Initiating Role of B Cells
  16. 37296
    “…PD098059 also interfered with NK lysis of tumor cells in a 5-h (51)Cr-release assay, but had no ability to block NK cell proliferation. …”
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    Control of Lytic Function by Mitogen-activated Protein Kinase/Extracellular Regulatory Kinase 2 (ERK2) in a Human Natural Killer Cell Line: Identification of Perforin and Granzyme B Mobilization by Functional ERK2
  17. 37297
    “…CD19 and CD21 (CR2) are co-receptors found on B-cells and various B-cell lymphomas, including non-Hodgkin lymphoma. …”
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    High CD21 expression inhibits internalization of anti-CD19 antibodies and cytotoxicity of an anti-CD19-drug conjugate
  18. 37298
    “…The effective vascular volume perfused in 1 min by H33342 was compared with the volume perfused in 30 min with 51Cr labelled erythrocytes. Similar volumes were estimated with the two techniques in a murine carcinoma and in a sarcoma. …”
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    Validation of the fluorescent dye Hoechst 33342 as a vascular space marker in tumours.
  19. 37299
    “…For the 28 patients who received the RD, the median treatment course was 6.5 cycles (2–14), RR of 50% (1 CR and 13 PR: 95% CI 31–69%), with a median progression-free survival of 196 days. …”
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    Phase I/II study of oxaliplatin with oral S-1 as first-line therapy for patients with metastatic colorectal cancer
  20. 37300
    “…The final RH map is composed of 22 framework markers extending over a 245.6 cR distance. A corresponding genetic map was developed, whose length is 103 cM in the East Lansing reference population. …”
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    Addition of the microchromosome GGA25 to the chicken genome sequence assembly through radiation hybrid and genetic mapping
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