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37701por Novák, Jakub, Fabrik, Ivo, Linhartová, Irena, Link, Marek, Černý, Ondřej, Stulík, Jiří, Šebo, Peter“…The adenylate cyclase toxin (CyaA) of the whooping cough agent Bordetella pertussis subverts immune functions of host myeloid cells expressing the α(M)β(2) integrin (CD11b/CD18, CR3 or Mac-1). CyaA delivers into cytosol of cells an extremely catalytically active adenylyl cyclase enzyme, which disrupts the innate and adaptive immune functions of phagocytes through unregulated production of the key signaling molecule cAMP. …”
Publicado 2017
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37702por Rasmy, Amr H. M., Harhash, Tarek A., Ghali, Rami M. S., El Maghraby, Eman M. F., El Rouby, Dalia H.“…Buccal surfaces were prepared by the Er,Cr:YSGG laser (Waterlase iPlus) 2780 nm, using the gold handpiece with MZ10 Tip in non-contact and the “H” mode, following parameters of cavity preparation – power 6 W, frequency 50 Hz, 90% water and 70% air, then shifting to surface treatment laser parameters – power 4.5 W, frequency 50 Hz, 80% water and 50% air. …”
Publicado 2017
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37703“…After a single cycle of induction chemotherapy complete remission (CR) was seen in 26 (41.9%) and non-remission (NR) in 17 (27.4%), while 19 patients (30.6%) died during the first admission for induction. …”
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37704por Binesh, Nader, Huda, Amir, Thomas, M. Albert, Wyckoff, Nathaniel, Bugbee, Mary, Han, Steven, Rasgon, Natalie, Davanzo, Pablo, Sayre, James, Guze, Barry, Martin, Paul, Fawzy, Fawzy“…Absolute concentrations and ratios with respect to creatine (Cr) of several metabolites were computed from MR spectra. …”
Publicado 2006
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37705“…Software R 3.2.3 and STATA 13.0 were used to conduct the Bayesian NMA, calculating odds ratios (ORs) and hazard ratios (HRs) with 95% credible interval (CrI) to evaluate different treatments.Almost all treatments were superior to best supportive care (BSC) and FU in terms of 1-OS, 2-OS and 1-PFS. …”
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37706por Huang, Yuan-Mao, Zheng, Yi, Li, Jing-Gang, Wang, Xue-Chun, Wang, Ze-Chuan, Chen, Wan-Ling, Pan, Li-Li, Li, Yang, Luo, Dong-Feng, Wang, Shao-Yuan“…Higher expression of FAMLF-1 was related to a higher complete remission (CR) rate, but shorter relapse free survival (RFS) in AML. …”
Publicado 2017
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37707por Vincenti, Flavio, Fervenza, Fernando C., Campbell, Kirk N., Diaz, Montserrat, Gesualdo, Loreto, Nelson, Peter, Praga, Manuel, Radhakrishnan, Jai, Sellin, Lorenz, Singh, Ajay, Thornley-Brown, Denyse, Veronese, Francisco Veríssimo, Accomando, Beverly, Engstrand, Sara, Ledbetter, Steven, Lin, Julie, Neylan, John, Tumlin, James“…The primary efficacy endpoint was the percentage of patients achieving partial (50% reduction) or complete (< 300 mg/g Cr) remission of proteinuria. RESULTS: Of 36 enrolled patients, 10, 14, and 12 patients received placebo, fresolimumab 1 mg/kg, and fresolimumab 4 mg/kg, respectively. …”
Publicado 2017
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37708por Suzuki-Sawano, Ema, Ueno, Kohei, Naganos, Shintaro, Sawano, Yoshihiro, Horiuchi, Junjiro, Saitoe, Minoru“…This association induces feeding behavior, a conditioned response (CR), upon subsequent exposure to the CS. In this study, we developed a model of this behavior in isolated Drosophila brains. …”
Publicado 2017
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37709por Rahman, Salimur, Faroque Ahmed, Mohammad, Jamshed Alam, Mohammad, Ranjan Debnath, chitta, Izazul Hoque, Mohammad, Mahbub Hussain, Muhammad, Shamsul Kabir, AKM, Fazal Karim, Mohammad, Ahmed Khondokar, Faiz, Mamun-Al-Mahtab, Ahmed Khondokar, Golam Masud, Mohammad, uddin Mollick, Mohammad Kutub, Lutful Moben, Ahmed, Mohammad Noor-E-Alam, Sheikh, Kumar Podder, Provat, Kumar Raha, Aloke, Abdur Rahim, Mohammad, Harun or Rashid, Mohammad, Zaki, KMJ, Mohammad Fazle Akbar, Sheikh“…How to cite this article: Rahman S, Ahmed MF, Alam MJ, Debnath CR, Hoque MI, Hussain MM, Shamsul Kabir AKM, Karim MF, Khondokar FA, Mahtab MA, Masud MG, Mollick MKU, Moben AL, Noor-E-Alam SM, Podder PK, Raha AK, Rahim MA, Rashid MHO, Zaki KMJ, Akbar SMF. …”
Publicado 2014
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37710por Tu, Mengjun, Lin, Li, Cheng, Yilu, He, Xiubin, Sun, Huihui, Xie, Haihua, Fu, Junhao, Liu, Changbao, Li, Jin, Chen, Ding, Xi, Haitao, Xue, Dongyu, Liu, Qi, Zhao, Junzhao, Gao, Caixia, Song, Zongming, Qu, Jia, Gu, Feng“…AsCpf1 and LbCpf1 require a single crRNA and recognize a 5′-TTTN-3′ protospacer adjacent motif (PAM) at the 5′ end of the protospacer for genome editing. …”
Publicado 2017
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37711“…However, the number of cells expressing distinct calcium-binding proteins, namely parvalbumin (PV), calbindin (CB) or calretinin (CR) varied significantly among the three glomerulus types. …”
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37712“…We prospectively followed 1281 normotensive individuals from Watari town (34.3% men; mean age, 58.0±12.3 years old) whose UAE was <30 mg g(−1)· Cr. Hypertension was diagnosed as a systolic blood pressure (BP)⩾140 mm Hg and/or a diastolic BP⩾90 mm Hg, or antihypertensive medication use. …”
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37713“…Objective: This paper aims to determine of the type, source, chemical form, fate and transport, and accurate risk assessment of 17 metal(loid) contaminants including As, Cd, Cu, Ni, Pb, Zn, Cr, Ag, B, Bi, Co, Mo, Sb, Ti, V, W and Sn in the soils collected from an abandoned tungsten mining area, and to guide the implementing of appropriate remediation strategies. …”
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37714por Hawkins, Angela K, Garza, Elyssa R, Dietz, Valerie A, Hernandez, Oscar J, Hawkins, W Daryl, Burrell, A Millie, Pepper, Alan E“…Serpentine outcrops are derived from ultramafic rock and have extremely low levels of essential plant nutrients (e.g., N, P, K, and Ca), as well as toxic levels of heavy metals (e.g., Ni, Cr, and Co) and low moisture availability. These outcrops provide habitat to a number of endemic plant species, including the annual mustard Caulanthus amplexicaulis var. barbarae (Cab) (Brassicaceae). …”
Publicado 2017
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37715por Bao, Siqin, Tang, Walfred WC, Wu, Baojiang, Kim, Shinseog, Li, Jingyun, Li, Lin, Kobayashi, Toshihiro, Lee, Caroline, Chen, Yanglin, Wei, Mengyi, Li, Shudong, Dietmann, Sabine, Tang, Fuchou, Li, Xihe, Surani, M AzimEnlace del recurso
Publicado 2018
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37718por Zhu, Hanyu, Han, Qiuxia, Zhang, Dong, Wang, Yong, Gao, Jing, Geng, Wenjia, Yang, Xiaoli, Chen, Xiangmei“…RESULTS: Thirteen indicators including Anti-phospholipase A2 receptor (anti-PLA2R) (P = 0.000), Total protein (TP) (P = 0.000), Albumin (ALB) (P = 0.000), Direct bilirubin (DB) (P = 0.002), Creatinine (Cr) (P = 0.000), Total cholesterol (CH) (P = 0.000), Lactate dehydrogenase (LDH) (P = 0.007), High density lipoprotein cholesterol (HDL) (P = 0.000), Low density lipoprotein cholesterol (LDL) (P = 0.000), Thrombin time (TT) (P = 0.000), Plasma fibrinogen (FIB) (P = 0.000), Immunoglobulin A (IgA) (P = 0.008) and Complement 3 (C3) (P = 0.019) were significantly correlated with MCD. …”
Publicado 2018
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37719por Piasecka, Barbara, Duffy, Darragh, Urrutia, Alejandra, Quach, Hélène, Patin, Etienne, Posseme, Céline, Bergstedt, Jacob, Charbit, Bruno, Rouilly, Vincent, MacPherson, Cameron R., Hasan, Milena, Albaud, Benoit, Gentien, David, Fellay, Jacques, Albert, Matthew L., Quintana-Murci, Lluis“…Importantly, we identified numerous genetic variants that manifested their regulatory effects exclusively on immune stimulation, including a Candida albicans-specific master regulator at the CR1 locus. These response eQTLs were enriched in disease-associated variants, particularly for autoimmune and inflammatory disorders, indicating that differences in disease risk may result from regulatory variants exerting their effects only in the presence of immune stress. …”
Publicado 2018
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37720“…As a cell culture-based manufacturing process would be more suitable to fulfill large-scale production needs of an antiviral and enables full process control in closed systems, we investigated options to produce DI244 in the avian cell line AGE1.CR.pIX in chemically defined suspension culture. …”
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