“…Based on physical chemical analysis and free energies estimates, we can shed some light on the involved molecular recognition processes, their clinical aspects, the implications for drug developments, and suggest structural modifications on the CR3022 antibody that would improve its binding affinities for SARS-CoV-2 and contribute to address the ongoing international health crisis.…”
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“…CONCLUSION: Chronic occupational SHS exposure among non-smokers deteriorates CR exercise performance. Its impact on chronic disease development should be further explored. …”
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“…Supported by the grant projects MH CR AZV 17-32957A and MEYS NPU4NUDZ: LO1611.…”
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“…The contribution of Zn was followed by those of Pb, Cr, Cu and Mn, while those of Ni, Cd, and Co were quite low (<2.2%).…”
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“…Consistent with the T(RM) cell phenotype, CD8(+) TILs minimally expressed CX3CR1 but expressed CXCR3 at higher levels than circulating CD8(+) T cells. …”
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“…We predicted that nine additional species will become threatened due to climate change in the future; one species will be classified as critically endangered (CR), two as endangered (EN), and six as vulnerable (VU). …”
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“…To resolve these issues we directly observed microglia behaviors with two-photon microscopy in ex vivo spinal cord slices from CX3CR1-GFP mice complemented with confocal analyses of CD68 protein. …”
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“…Finally, PCR results demonstrated that, compared with the sham group, the proinflammatory and prooxidative genes, such as IL-1β, IL-6, TNF-α, iNOS, and CX3CR1, were upregulated in the prefrontal cortices of OVX rats after CUS stimulation, whereas the anti-inflammatory factor Arg1 and microglial cell negative regulatory factor CD200 were downregulated. …”
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“…The nanoparticles exerted lower toxicity in Crandell-Rees feline kidney (CrFK) cells and enhanced antiviral activities with a selective index (SI) value three times higher than that of curcumin. …”
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“…METHODS: Depletion of microglia was achieved in C57BL/6 mice by chronic oral administration of PLX5622, a specific antagonist of colony stimulating factor-1 receptor, and in rats by a knock-in model in which the diphtheria toxin receptor was expressed under the control of the endogenous fractalkine receptor (CX3CR1) promoter sequence. After successful microglia depletion, mice and rats were injected with a sickness-inducing dose of lipopolysaccharide according to a 2 (depletion vs. control) × 2 (LPS vs. saline) factorial design. …”
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“…Rev Bras Orthop. 2013; 48(5): 421-6. 2. Kim CW, Lee CR. Effects of femoral lateral bowing on coronal alignment and component position after total knee arthroplasty: a comparison of conventional and navigation-assisted surgery. …”
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“…Two of the three Cobalt-Chrome-Molybdenum (CoCrMo) structure geometries (grids, offset lines) also showed a significant reduction in abrasion compared to the reference group, with a maximum wear reduction of 55.5%. …”
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“…Similarly, significant (p<0.05) liver bioaccumulation occurred for Zinc (Zn), chromium (Cr), iron (Fe), and copper (Cu) compared to their levels in muscle. …”
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“…Although, chronic infection accompanied with granulomatous allergic reaction from Cobalt (Co),Chromium (Cr) debris after metal-on-metal (MoM) THA implantation can cause severe osteolysis, with subsequent loosening and migration of the implants. …”
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“…PIOS score was strongly associated with best overall responses (BOR), with those patients having benefit/good response (stable disease (SD) or partial (PR) or complete response (CR), achieving a higher score compared to patients who developed progressive disease (PD) (p < 0.001). …”
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“…As compared to previous reports, complete remission and survival was slightly better in our cohort, with 73% complete remission (CR) and 73% survival despite a high relapse rate (43%). …”
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“…The in vitro investigation determined that 76.2% of six selected pathogens considered “biofilm formers” actually formed biofilms and were also highly resistant to tetracycline, doxycycline, nalidixic acid, ampicillin, and chloramphenicol and remained sensitive to metals (Cr, Co, Ni, Cu, Zn) at varying concentrations. We also found bacterial flagellar movement and chemotaxis, regulation and cell signaling, and oxidative stress to be significantly associated with the pathophysiology of CM. …”
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“…CONCLUSIONS: The proposed method answers to a fundamental open question: “How many undetected cases are going around?”. CR methods provide a straightforward solution to shed light on undetected cases, incorporating heterogeneity that may arise in the probability of being detected.…”
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“…The methodology and results of experimental studies are also presented in detail, with the aim of determining the influence of the application of the hybrid method of cooling and lubrication of the machining zone on the course and results of the internal cylindrical grinding process of 100Cr6 steel in comparison with other methods of cooling and lubrication, as well as compared with dry grinding. …”
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“…Mineral carbonation also reduces the leachability of pollutants such as: Zn, Cu, Pb, Ni, As, Hg, Cd, Cr, Cl, and SO(4)(2-). The pH is also reduced from about 12 to about 9. …”
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