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38221
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38222por Boos, Christopher J., Thiri-Toon, Lin, Steadman, Christopher D., Khambekar, Sujata, Jordan, Andrew, Carpenter, John PaulEnlace del recurso
Publicado 2021
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38223por Bartsch, Rupert, Singer, Christian F., Pfeiler, Georg, Hubalek, Michael, Stoeger, Herbert, Pichler, Angelika, Petru, Edgar, Bjelic-Radisic, Vesna, Greil, Richard, Rudas, Margaretha, Muy-Kheng, Tea Maria, Wette, Viktor, Petzer, Andreas L., Sevelda, Paul, Egle, Daniel, Dubsky, Peter C., Filipits, Martin, Fitzal, Florian, Exner, Ruth, Jakesz, Raimund, Balic, Marija, Tinchon, Christoph, Bago-Horvath, Zsuzsanna, Frantal, Sophie, Gnant, Michael“…RESULTS: No significant differences in terms of RCB 0/I (40.1% vs. 37.2%; P = 0.61) or pathologic complete response (pCR) rates (24.3% vs. 25%, P = 0.89) were observed between conventional or reverse chemotherapy sequence. …”
Publicado 2021
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38224por Caruso, Giuseppe, Benatti, Cristina, Musso, Nicolò, Fresta, Claudia G., Fidilio, Annamaria, Spampinato, Giorgia, Brunello, Nicoletta, Bucolo, Claudio, Drago, Filippo, Lunte, Susan M., Peterson, Blake R., Tascedda, Fabio, Caraci, Filippo“…This protective activity of carnosine was not mediated by modulation of the canonical inflammatory pathway but instead can be explained by the well-known antioxidant and free-radical scavenging activities of carnosine, enhanced macrophage phagocytic activity, and the rescue of fractalkine receptor CX3CR1. These new findings obtained with macrophages challenged with Aβ1-42 oligomers, along with the well-known multimodal mechanism of action of carnosine in vitro and in vivo, substantiate the therapeutic potential of this dipeptide in the context of AD pathology.…”
Publicado 2021
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38225“…Permanent ligation of the left anterior descending (LAD) artery was conducted in 10 wild-type mice and 10 each of three knockout models: CX3CR(−/−), CCR2(−/−), and MCP-1(−/−). At 7 days and 30 days after permanent ligation, cardiac MRI was performed with a 7 T-Bruker horizontal scanner for in vivo detection of elastin with an elastin/tropoelastin-specific contrast agent (ESMA). …”
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38226por Hsiao, Cheng-Chih, Sankowski, Roman, Prinz, Marco, Smolders, Joost, Huitinga, Inge, Hamann, Jörg“…We identified 17 rhodopsin and adhesion family GPCRs robustly expressed in microglia from human brains, including the homeostasis-associated genes CX3CR1, GPR34, GPR183, P2RY12, P2RY13, and ADGRG1. …”
Publicado 2021
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38227“…A single isolate had the aac(6′)‐Ib‐cr PMQR gene. The qnr and qepA determinants were not detected. …”
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38228por Lillemoe, Tamera J., Rendi, Mara, Tsai, Michaela L., Knaack, Monica, Yarosh, Rina, Grimm, Erin, Susnik, Barbara, Krueger, Janet, Olet, Susan, Swenson, Karen K.“…RESULTS: 64/151 (42.4%) patients with HER2+ disease had pathologic complete response (pCR). Tumors with suboptimal response (RCB-II and RCB-III) were more likely to demonstrate less than 100% HER2 IHC 3+ staining (p < 0.0001), lower HER2 FISH copies (p < 0.0001), and lower HER2/CEP17 ratios (p = 0.0015) compared to RCB-I and RCB-II responses. …”
Publicado 2021
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38229por Meng, Chunyan, Wang, Peng, Hao, Zhuolu, Gao, Zhenjie, Li, Qiang, Gao, Hongxia, Liu, Yingli, Li, Qingzhao, Wang, Qian, Feng, Fumin“…This research aims to determine the levels of Cr, Ni, Cu, Zn, As, Cd, Hg and Pb in four medicinal plant species (Aster tataricus L.f., Salvia miltiorrhiza Bge, Radix Aucklandiae, Scutellaria baicalensis Georgi) and their native soil. …”
Publicado 2021
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38230por Peng, Yin-yin, Xiong, Yi-ying, Zhang, Li-xia, Wang, Jing, Zhang, Hong-bin, Xiao, Qing, Guo, Shu-liang“…Furthermore, 35.3% (48) of the patients were reported to have relapsed, but 2 of those relapsed only locally and achieved complete remission (CR) again with additional irradiation, chemotherapy, and donor lymphocyte infusions for one and rapid tapering and discontinuation of cyclosporine for the other, earning more than one year of extra survival. …”
Publicado 2021
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38231por Ye, Zai-Sheng, Zheng, Miao, Liu, Qin-Ying, Zeng, Yi, Wei, Sheng-Hong, Wang, Yi, Lin, Zhi-Tao, Shu, Chen, Zheng, Qiu-Hong, Chen, Lu-Chuan“…RESULTS: An eleven-AS-signature prognostic model (CD44|14986|ES, PPHLN1|21214|AT, RASSF4|11351|ES, KIAA1147|82046|AP, PPP2R5D|76200|ES, LOH12CR1|20507|ES, CDKN3|27569|AP, UBA52|48486|AD, CADPS|65499|AT, SRSF7| 53276|RI, and WEE1|14328|AP) was constructed and significantly related to STAD overall survival, immune cells, and cancer-related pathways. …”
Publicado 2021
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38232por Kawada, Yu, Kitada, Shuichi, Hachiya, Kenta, Kato, Marina, Nakasuka, Kosuke, Kikuchi, Shohei, Seo, Yoshihiro, Ohte, NobuyukiEnlace del recurso
Publicado 2021
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38233“…Detection of HCR assemblies is accomplished by first adsorbing to the desthiobiotin-modified optical fiber, followed by fluorescence emission induced by an evanescent field. Three Cas13a crRNAs targeting the genes of S, N and Orf1ab of SARS-CoV-2 are programmed to specifically target SARS-CoV-2 or broadly detect related coronavirus strains, such as MERS-CoV and SARS-CoV. …”
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38234por Napoli, Niccolò, Kauffmann, Emanuele F., Vistoli, Fabio, Amorese, Gabriella, Boggi, Ugo“…In conclusion, when proficiency is achieved, RPD may be superior to OPD with respect to CR-POPF and oncologic outcomes. Achievement of proficiency requires commitment, dedication, and truly high volumes.…”
Publicado 2021
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38235por Hoefer, Richard A., Obiora, Chukwuemeka, Azab, Basem, Harden, Elizabeth A., Kessler, John F.“…The patient experienced a 30-month disease free survival and was subsequently found to have oligometastases to the brain. DISCUSSION: CR and HIPEC have not been reported to be efficacious in patients with pancreatic carcinomatosis. …”
Publicado 2021
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38236por Zhang, Bo, Luo, Diyin, Li, Yu, Perčulija, Vanja, Chen, Jing, Lin, Jinying, Ye, Yangmiao, Ouyang, Songying“…Formation of the 19-bp crRNA-target DNA strand heteroduplex in the R-loop complexes triggers a conformational rearrangement and unleashes the DNase activity. …”
Publicado 2021
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38237por Vaz, Ana Rita, Vizinha, Daniela, Morais, Hermes, Colaço, Ana Rita, Loch-Neckel, Gecioni, Barbosa, Marta, Brites, Dora“…Secretome from such modulated MNs, when added to SC organotypic cultures from mSOD1 mice in the early symptomatic stage, also coun-teracted the pathology associated to GFAP decrease, PSD-95 and CX3CL1-CX3CR1 signaling im-pairment, neuro-immune homeostatic imbalance, and enhanced miR-124 expression levels. …”
Publicado 2021
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38238por Aires, Vanessa, Coulon-Bainier, Claire, Pavlovic, Anto, Ebeling, Martin, Schmucki, Roland, Schweitzer, Christophe, Kueng, Erich, Gutbier, Simon, Harde, Eva“…To assess the impact of CD22 blockage on microglia morphology and dynamics, we have established a protocol to image microglia process motility in acutely prepared brain slices from CX3CR1-GFP reporter mice. We observed a significant reduction of microglial ramification and surveillance capacity in brain slices from aged versus adult mice. …”
Publicado 2021
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38239por Cavalheiro, Ana Helena, Silva Cardoso, José, Rocha, Afonso, Moreira, Emília, Azevedo, Luís Filipe“…CONCLUSION: TR showed to be superior than UC without CR on functional capacity improvement in HF patients. …”
Publicado 2021
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38240por Aratani, Sae, Matsunobu, Takeshi, Shimizu, Akira, Okubo, Kimihiro, Kashiwagi, Tetsuya, Sakai, Yukinao“…The initial urine protein was 0.7 g/gCr, which was not different between the two groups. …”
Publicado 2021
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