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  1. 39681
    “…We identify 46 high-confident significantly mutated genes, 8 of which mutate in 14.9% of patients: LYST, DAPK1, CR2, KIF16B, NPIPB15, SYTL2, ZNF91, and KIAA0586. …”
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    Comprehensive profiling of 1015 patients’ exomes reveals genomic-clinical associations in colorectal cancer
  2. 39682
    “…Importantly, genetic lineage tracing of nestin(+) and Cx3cr1(+) cells in vivo showed that the repopulation of microglia was derived from residual microglia after SCI. …”
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    Single-cell transcriptome analysis reveals the immune heterogeneity and the repopulation of microglia by Hif1α in mice after spinal cord injury
  3. 39683
    “…In this study, we generated an inducible Pabpn1(flox/flox) mouse model using crRNA-tracrRNA:Cas9 complexes targeting upstream and downstream genomic regions, respectively, in combination with a long single-stranded DNA (ssDNA) template. …”
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    CRISPR-Cas9 mediated generation of a conditional poly(A) binding protein nuclear 1 (Pabpn1) mouse model reveals an essential role for hematopoietic stem cells
  4. 39684
    “…SLC7A11 was negatively correlated with the expression of chemokines and chemokine receptors, such as CCL17, CCL19, CCL22, CCL23, CXCL14, CCR10, CX3CR1, and CXCR3, in COAD. Conclusion: SLC7A11 may play a role in induced ferroptosis and regulating tumor immunity, which can be considered as potential therapeutic targets in COAD.…”
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    SLC7A11, a Potential Therapeutic Target Through Induced Ferroptosis in Colon Adenocarcinoma
  5. 39685
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    D-Dimer Values and Venous Thromboembolism in Patients With COVID-19 in Japan　― From the CLOT-COVID Study ―
  6. 39686
    “…The concentration of Pb, Cr, Zn, Mn, Cu, Cd, Sn, and Hg was higher in the water samples collected from the polluted site compared to the non-polluted site of the Red sea. …”
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    Ecogenotoxicological studies for an early toxicity screening and monitoring in Epinephalus chlorostigma and Scamberomorus commerson
  7. 39687
    “…Serum CLCF1 was measured using an enzyme-linked immunosorbent assay (ELISA), and serum creatinine (Cr) was tested to evaluate kidney function. RESULTS: By comparing the IRI database and the DGF database, we identified 107 differentially expressed genes, including 79 upregulated and 28 downregulated genes. …”
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    CLCF1 is up-regulated in renal ischemia reperfusion injury and may associate with FOXO3
  8. 39688
    “…Cd, Cu and Pb showed higher bioaccumulation in the pre-monsoon samples whereas As, Cr and Zn exhibited higher bioaccumulation during the post monsoon period. …”
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    A study on the impact of water quality on the murrel fish Channa striata and Channa punctata from three major Southern Tamilnadu rivers, India
  9. 39689
    por Ying, Zhitao, Song, Yuqin, Zhu, Jun
    Publicado 2022
    “…The pooled best overall response (BOR) was 74.0% (95%CI: 67–79%), with a best complete response (BCR) of 48% (95%CI: 42–54%) and a 3-months CR rate (CRR) of 41% (95%CI: 35–47%). The subgroup analyses by costimulatory domain suggested statistically significant differences in BOR and BCR, whereas not in the 12-months OS rate and 3-months CRR. …”
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    Effectiveness and Safety of Anti-CD19 Chimeric Antigen Receptor-T Cell Immunotherapy in Patients With Relapsed/Refractory Large B-Cell Lymphoma: A Systematic Review and Meta-Analysis
  10. 39690
    “…In addition, exogenous MeJa application enhanced the accumulation of macro (N, P, K, Mg, and Ca) and micronutrients (Mn, Zn, Fe, and Cr) in both cultivars under Cd stress, while reduced the Cd contents in different plant parts. …”
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    Exogenous Methyl Jasmonate Application Improved Physio-Biochemical Attributes, Yield, Quality, and Cadmium Tolerance in Fragrant Rice
  11. 39691
    “…Here, we review the molecular mechanisms of HPHE interactions with TMs (Fe, Co, Ni, Cd, Cr, and Pt) as well as their implications in renal physiology, pathophysiology and toxicology. …”
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    Renal hypoxia–HIF–PHD–EPO signaling in transition metal nephrotoxicity: friend or foe?
  12. 39692
    “…A total of 9 patients (47.4%) achieved pathological complete remission (pCR). No recurrence was found, but metastasis occurred in 2 patients (10.5%) in the preliminary follow-up. …”
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    Neoadjuvant radiotherapy for soft tissue sarcoma in China: a preliminary result
  13. 39693
    “…A high fraction of Al, Be, Cr, Li, Mo, Sb, Tl, and V remained in the residue. …”
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    Investigation of metal mobility in gold and silver mine tailings by single-step and sequential extractions
  14. 39694
    “…Pearson correlation analysis showed that traffic emissions were the main source of heavy metals. The Cr(VI) concentrations were 1.53 and 1.92 ng/m(3) for urban and suburban sites, respectively, exceeding the national ambient air quality standards limit of 0.025 ng/m(3). …”
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    Characteristics of PM(2.5) in an Industrial City of Northern China: Mass Concentrations, Chemical Composition, Source Apportionment, and Health Risk Assessment
  15. 39695
    “…Besides, the serum levels of low-density lipoprotein (LDL), high-density lipoprotein (HDL), cholesterol (CHO), triglyceride (TG), blood glucose (BG), creatinine (Cr), urea nitrogen (BUN), uric acid (UA) were determined. …”
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    Serum Intestinal Metabolites are Raised in Patients with Psoriasis and Metabolic Syndrome
  16. 39696
    “…Pathological complete response (pCR) was documented in 68 cases (46%) and 32 patients (21.6%) had microscopic residual disease. …”
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    Neoadjuvant Chemoradiotherapy With Simultaneous Integrated Boost in Locally Advanced Cervical Cancer: Long Term Results of a Single-Center Experience
  17. 39697
    “…We show that Cas13d-mediated coronavirus inhibition is dependent on the crRNA cellular spatial colocalization with Cas13d and target viral RNA. …”
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    Broad-spectrum CRISPR-mediated inhibition of SARS-CoV-2 variants and endemic coronaviruses in vitro
  18. 39698
    “…REFERENCE: • Shah SM, Carey IM, Harris T, DeWilde S, Victor CR, Cook DG. The effect of unexpected bereavement on mortality in older couples. …”
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    Study of Psychopathology in family members of patients who died due to Covid-19 – A door-to-door survey
  19. 39699
    “…Better treatment response with CR + PR was associated with a longer duration of OS, PFS1, and PFS2. …”
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    Evaluating the Efficacy of EGFR-TKIs Combined With Radiotherapy in Advanced Lung Adenocarcinoma Patients With EGFR Mutation: A Retrospective Study
  20. 39700
    “…After a median follow-up of 35.3 months, the ORR was 83.7%, with 77.9% achieving complete response (CR); the median duration of response was not reached. …”
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    Zanubrutinib in relapsed/refractory mantle cell lymphoma: long-term efficacy and safety results from a phase 2 study
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