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41141por Bestvina, Christine M, Le, Xiuning, Veillon, Remi, Anderson, Ian, Patel, Jyoti, Demedts, Ingel, Garassino, Marina, Mazières, Julien, Morise, Masahiro, Smit, Egbert, Eggleton, S Peter, O’Brate, Aurora, Otto, Gordon, Bruns, Rolf, Schumacher, Karl Maria, Paik, Paul“…For patients with NTL only (n=8), one had PD, and seven achieved intracranial disease control with three patients achieving CR of the enhancing NTL. CONCLUSIONS: Tepotinib demonstrated intracranial activity in patients with METex14 skipping NSCLC with BM. …”
Publicado 2021
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41142por Müller, Julian, Lichtblau, Mona, Saxer, Stéphanie, Calendo, Luigi-Riccardo, Carta, Arcangelo F., Schneider, Simon R., Berlier, Charlotte, Furian, Michael, Bloch, Konrad E., Schwarz, Esther I., Ulrich, Silvia“…Blood gases at rest and end-exercise, dyspnea by Borg CR10 score at end-exercise; continuous SpO(2), minute ventilation (V'E), carbon dioxide output (V'CO(2)), and cerebral and quadricep muscle tissue oxygenation (CTO and QMTO) were measured. …”
Publicado 2021
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41143por Ruff, Christer, Artzner, Christoph, Syha, Roland, Grosse, Ulrich, Hoffmann, Rüdiger, Bitzer, Michael, Partovi, Sasan, Horger, Marius, Nikolaou, Konstantin, Grözinger, Gerd“…The absence of RTP significantly improved lesion-based mid-term response rates regarding complete response (CR, 30/34 (88%) vs 2/16 (12.5%), p = .0002*), lesion-based complete response rate was 75% (21/28) for DE ≥ 50% vs. 50% (11/22) for DE < 50% (p = .08) and 82% (27/33) for ED ≥ 2 vs. 29% for ED < 2 (5/17), p = .005*). …”
Publicado 2021
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41144por Yang, Xia, Weng, Xin, Yang, Yajie, Zhang, Meng, Xiu, Yingjie, Peng, Wenfeng, Liao, Xuhui, Xu, Meiquan, Sun, Yanhua, Liu, Xia“…Furthermore, the ratio of complete response (CR) was greatly declined, and the ratio of breast cancer related events were significantly elevated in the high-risk group. …”
Publicado 2021
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41145“…Change from baseline in OMEDD at 2 weeks after treatment was −15.11 (95% CI: −34.73, 4.50), at 1 month after treatment was −10.87 (95% CI: −26.32, 4.58), and at 3 months after treatment was −5.53 (95% CI: −20.44, 9.38). The overall CR rate was 0.36 (95% CI: 0.24–0.48), PR rate was 0.47 (95% CI: 0.36–0.58), and NR rate was 0.23 (95% CI: 0.13–0.34). …”
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41146“…Unfortunately, in the current state of therapies, a complete response (CR) to the therapy is still limited despite a more commonly achieved partial response (PR) and stable disease (SD) in patients. …”
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41147por Takigawa, Kosuke, Hata, Nobuhiro, Michiwaki, Yuhei, Hiwatashi, Akio, Yonezawa, Hajime, Kuga, Daisuke, Hatae, Ryusuke, Sangatsuda, Yuhei, Fujioka, Yutaka, Funakoshi, Yusuke, Otsuji, Ryosuke, Sako, Aki, Togao, Osamu, Yoshiura, Takashi, Yoshimoto, Koji, Mizoguchi, Masahiro“…The results were categorized into improved (complete response [CR] or partial response [PR]) or non-improved (stable disease [SD] or progressive disease [PD]) groups; outcomes were compared using Kaplan–Meier analysis. …”
Publicado 2021
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41148por Mustafa, Erman, Bivas, Biswas, Pongwut, Danchaivijitr, Lingwu, Chen, Wong, Yoke Fui, Hashem, Tarek, Lim, Chun Sen, Karabulut, Bulent, Chung, Hsiao-Jen, Chikatapu, Chandra, Ingles, Sara, Slimane, Khemaies, Kanesvaran, Ravindran“…The best response per RECIST 1.1 was CR/PR in 24%, stable disease in 44%, and PD in 31%. …”
Publicado 2021
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41149por Raghavan, Kadalraja, Dedeepiya, Vidyasagar Devaprasad, Suryaprakash, Vaddi, Rao, Kosagi-Sharaf, Ikewaki, Nobunao, Sonoda, Tohru, Levy, Gary A., Iwasaki, Masaru, Senthilkumar, Rajappa, Preethy, Senthilkumar, Abraham, Samuel JK“…The same trend was observed with ESR. LCR and LeCR increased while NLR decreased significantly in Gr. 3. …”
Publicado 2022
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41150por Sun, Heng, Sui, Bowen, Li, Yu, Yan, Jun, Cao, Mingming, Zhang, Lijia, Liu, Songjiang“…CONCLUSION: (1) The longevity of patients with non-small-cell lung cancer was substantially connected with the presence of immature B cells, activated B cells, MDSC, effector memory CD4 T cells, eosinophils, and regulatory T cells. (2) Immune-related genes such as CX3CR1, CXCR4, CXCR5, and CCR7, which are associated with the survival of NSCLC, affect the prognosis of NSCLC patients by regulating the immune process.…”
Publicado 2021
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41151“…METHODS: We compared the diagnostic performance of NASBA, PCR and cryptococcal antigen (CrAg) test (colloidal gold method) in clinical samples from 25 cryptococcosis patients (including 8 cryptococcal meningoencephalitis and 17 pulmonary cryptococcosis) who were categorized as proven cases (n = 10) and probable cases (n = 15) according to the revised EORTC/MSG definitions. 10 patients with non-Cryptococcus infection and 30 healthy individuals were categorized as control group. …”
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41152por Chen, Zihao, Wang, Maoli, De Wilde, Rudy Leon, Feng, Ruifa, Su, Mingqiang, Torres-de la Roche, Luz Angela, Shi, Wenjie“…However, only about 10% of TNBC patients could achieve the complete response (CR) to ICB because of the low response rate and potential adverse reactions to ICB. …”
Publicado 2021
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41153por Liu, Xiaoyu, Shi, Hua, Shen, Jing, Li, Yang, Yan, Wei, Sun, Ying, Liao, Aijun, Tan, Yehui, Yang, Wei, Wang, Huihan“…After the first D-CTAG cycle, the overall response rate (ORR) was 84.2% (16/19), including 13 (73.7%) complete remissions (CRs) and three (15.8%) partial remissions. This CR rate surpassed that of the D-CAG treatment (p < 0.05). …”
Publicado 2021
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41154por Gwark, Sungchan, Noh, Woo Chul, Ahn, Sei Hyun, Lee, Eun Sook, Jung, Yongsik, Kim, Lee Su, Han, Wonshik, Nam, Seok Jin, Gong, Gyungyub, Kim, Seon-Ok, Kim, Hee Jeong“…The axillary pathologic complete response (pCR) rate was significantly higher in the NCT group (13.8% vs. 4.8%, P=.045) than in the NET group. …”
Publicado 2021
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41155por Zhou, Keshu, Zou, Dehui, Zhou, Jianfeng, Hu, Jianda, Yang, Haiyan, Zhang, Huilai, Ji, Jie, Xu, Wei, Jin, Jie, Lv, Fangfang, Feng, Ru, Gao, Sujun, Zhou, Daobin, Tam, Constantine S., Simpson, David, Wang, Michael, Phillips, Tycel J., Opat, Stephen, Huang, Zhiyue, Lu, Huafei, Song, Yuqin, Song, Yongping“…Overall response rate (ORR) and complete response (CR) rate were 84.8% and 62.5%, and median duration of response, progression-free survival (PFS) and overall survival (OS) were 24.9, 25.8 and 38.2 months, respectively. …”
Publicado 2021
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41156por Jin, Yuan‐zhang, Zhao, Bin, Lu, Xiang‐dong, Zhao, Yi‐bo, Zhao, Xiao‐feng, Wang, Xiao‐nan, Zhou, Run‐tian, Qi, De‐tai, Wang, Wen‐xuan“…The CCI did not change much from the 6‐month follow‐up to the last follow‐up. and the cage rate (CR) was 100% at the 6‐month and last follow‐ups. …”
Publicado 2021
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41157“…The contents of major (Na, Mg, Al, Si, P, S, K and Ca), trace (Li, Be, B, Ti, V, Cr, Mn, Co, Ni, Cu, Zn, Ga, As, Se, Rb, Sr, Mo, Ag, Cd, Sn, Sb, Cs, Ba, Hg, Tl, Pb, Bi, Th and U) and rare earth (Sc, Y, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, and Lu) elements varied greatly, which was probably associated with the peculiarities of the functional state and mineral nutrition of phytoplankton in the autumn period. …”
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41158por Pereira, Daniela S. M., Pereira, Ana Mónica, Castanho, Teresa Costa, Silva, Gabriela A., Falcão, Filipe, Costa, Patrício, Pêgo, José Miguel“…The internal consistency of the RTT was assessed through Cronbach’s alpha, Composite reliability (CR) and Average Variance Extracted (AVE) for the total scale and each of the four subscales. …”
Publicado 2021
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41159por Stringhini, Silvia, Zaballa, María-Eugenia, Pullen, Nick, Perez-Saez, Javier, de Mestral, Carlos, Loizeau, Andrea Jutta, Lamour, Julien, Pennacchio, Francesco, Wisniak, Ania, Dumont, Roxane, Baysson, Hélène, Richard, Viviane, Lorthe, Elsa, Semaani, Claire, Balavoine, Jean-François, Pittet, Didier, Vuilleumier, Nicolas, Chappuis, François, Kherad, Omar, Azman, Andrew S., Posfay-Barbe, Klara, Kaiser, Laurent, Guessous, Idris“…The total seroprevalence was 66.1% (95% credible interval (CrI): 64.1–68.0). We estimated that 29.9% (95% Crl: 28.0–31.9) of the population developed antibodies after infection; the rest having developed antibodies via vaccination. …”
Publicado 2021
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41160por Fukada, Ippei, Ito, Yoshinori, Kondo, Naoto, Ohtani, Shoichiro, Hattori, Masaya, Tokunaga, Eriko, Matsunami, Nobuki, Mashino, Kohjiro, Kosaka, Taijiro, Tanabe, Masahiko, Yotsumoto, Daisuke, Yamanouchi, Kosho, Sawaki, Masataka, Kashiwaba, Masahiro, Kawabata, Hidetaka, Kuroi, Katsumasa, Morita, Satoshi, Ohno, Shinji, Toi, Masakazu, Masuda, Norikazu“…Thirty percent (8/26) of patients had PD in the E phase, 6 of whom had achieved cCR/PR in the AT phase. Reported grade ≥ 3 AEs related to E were neutropenia (42%), white blood cell count decrease (27%), febrile neutropenia (7.6%), weight gain (3.8%), and weight loss (3.8%). …”
Publicado 2021
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