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  1. 41521
    “…The bla(TEM) gene was identified in all 9 MDR isolates. bla(SHV), bla(AQU-1), bla(MOX), bla(CepH), bla(CphA) and aac(6′)-Ib-cr were detected in 4 isolates, 2 isolates, 1 isolate, 3 isolates, 8 isolates, and 3 isolates, respectively. …”
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    Online Artículo Texto
    Taxonomy, virulence determinants and antimicrobial susceptibility of Aeromonas spp. isolated from bacteremia in southeastern China
  2. 41522
    por Janssen, Jeroen, Löwenberg, Bob, Manz, Markus, Bargetzi, Mario, Biemond, Bart, Borne, Peter von dem, Breems, Dimitri, Brouwer, Rolf, Chalandon, Yves, Deeren, Dries, Efthymiou, Anna, Gjertsen, Bjørn-Tore, Graux, Carlos, Gregor, Michael, Heim, Dominik, Hess, Urs, Hoogendoorn, Mels, Jaspers, Aurelie, Jie, Asiong, Jongen-Lavrencic, Mojca, Klein, Saskia, van der Klift, Marjolein, Kuball, Jürgen, van Lammeren-Venema, Danielle, Legdeur, Marie-Cecile, van de Loosdrecht, Arjan, Maertens, Johan, Kooy, Marinus van Marwijk, Moors, Ine, Nijziel, Marten, van Obbergh, Florence, Oosterveld, Margriet, Pabst, Thomas, van der Poel, Marjolein, Sinnige, Harm, Spertini, Olivier, Terpstra, Wim, Tick, Lidwine, van der Velden, Walter, Vekemans, Marie-Christiane, Vellenga, Edo, de Weerdt, Okke, Westerweel, Peter, Stüssi, Georg, van Norden, Yvette, Ossenkoppele, Gert
    Publicado 2021
    “…In the second cycle, patients received cytarabine 1000 mg/m(2) twice daily on days 1-6 with or without tosedostat. CR/CRi rates in the 2 arms were not significantly different (69% (95% C.I. 60–77%) vs 64% (55–73%), respectively). …”
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    Inferior Outcome of Addition of the Aminopeptidase Inhibitor Tosedostat to Standard Intensive Treatment for Elderly Patients with AML and High Risk MDS
  3. 41523
    “…ABSTRACT: Measurable residual disease (MRD) is increasingly employed as a biomarker of quality of complete remission (CR) in intensively treated acute myeloid leukemia (AML) patients. …”
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    Use of Measurable Residual Disease to Evolve Transplant Policy in Acute Myeloid Leukemia: A 20-Year Monocentric Observation
  4. 41524
    “…Additionally, we identified a group of crAssphages, including lineages that were previously thought only to be found in the human gut. …”
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    Online Artículo Texto
    Hybrid assembly of an agricultural slurry virome reveals a diverse and stable community with the potential to alter the metabolism and virulence of veterinary pathogens
  5. 41525
    “…FLT3-ITD was associated with inferior post-consolidation complete remission (CR) (p = 0.02) and 5-year overall survival (OS) of 79.7%, compared to 94.4% for FLT3-WT (wild-type) (p = 0.02). …”
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    Online Artículo Texto
    FLT3-ITD Allelic Burden and Acute Promyelocytic Leukemia Risk Stratification
  6. 41526
    “…Clinically significant difference for QLQ-C30/CR38 score after chemotherapy was reported between patients who received open conventional surgeries and those patients who received fast-track laparoscopy (59.63 ± 2.26 score/patient vs. 71.67 ± 5.19 score/patient). …”
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    Retrospective analysis of safety and efficacy of enhanced recovery pathways in stage II–III colorectal cancer patients submitted to surgery and adjuvant therapy
  7. 41527
    “…Some reports have observed neoadjuvant chemotherapy (NAC) to have poor pathological complete response (pCR) rates in TNBC with PIK3CA mutation. This study aimed to explore the mechanism of how mutant PIK3CA alters chemotherapeutic susceptibility in TNBC. …”
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    Online Artículo Texto
    PIK3CA mutation confers resistance to chemotherapy in triple-negative breast cancer by inhibiting apoptosis and activating the PI3K/AKT/mTOR signaling pathway
  8. 41528
    “…The disease control rate (DCR) with TVB-2640 monotherapy was 42%; no patient treated with monotherapy had a complete or partial response (CR or PR). In combination with paclitaxel, the PR rate was 11% and the DCR was 70%. …”
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    First-in-human study of the safety, pharmacokinetics, and pharmacodynamics of first-in-class fatty acid synthase inhibitor TVB-2640 alone and with a taxane in advanced tumors
  9. 41529
    “…Upon generating saliency maps that visualize the areas each model views as significant for prediction, models trained on less compressed (CR <  = 5 K) images had maps encapsulating a radiologist’s label, while models trained on images with higher amounts of compression had maps that missed the ground truth completely. …”
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    Impact of image compression on deep learning-based mammogram classification
  10. 41530
    “…KEY POINTS: • A multimodality approach, integrating independent genomic and radiomic information, is promising to improve prediction of γpCR in patients with esophageal cancer. • HER2 and CD44 are potential biological tumor markers in the initial work-up of patients with esophageal cancer. • Prediction models combining (18)F-FDG PET radiomic features with HER2 and CD44 may be useful in the decision to omit surgery after neoadjuvant chemoradiotherapy in patients with esophageal cancer. …”
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    Addition of HER2 and CD44 to (18)F-FDG PET–based clinico-radiomic models enhances prediction of neoadjuvant chemoradiotherapy response in esophageal cancer
  11. 41531
    “…Four established AKI definitions were used: an increase in serum creatinine (sCR) ≥ 1.5 fold, ≥ 0.3 mg/dl, and ≥ 0.5 mg/dl and a decrease in eGFR > 25% from baseline (AKIN 1, AKIN 2, CIN, and RIFLE definition groups, respectively). …”
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    Definition of acute kidney injury impacts prevalence and prognosis in ACS patients undergoing coronary angiography
  12. 41532
    “…Internal consistency of items was assessed using Cronbach alpha (α), composite reliability (CR) and average variance extracted (AVE) to evaluate both discriminant and convergent validity of constructs. …”
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    Online Artículo Texto
    Healthcare providers’ acceptance of telemedicine and preference of modalities during COVID-19 pandemics in a low-resource setting: An extended UTAUT model
  13. 41533
    “…The presence of different beta-lactamase genes (bla(CTX-M), bla(SHV), bla(TEM), bla(KPC), bla(NDM,) bla(VIM,) bla(OXA-48,) bla(CMY-2), bla(DHA-1,) bla(FOX,) bla(MOX,) and bla(ACC)) was analyzed by PCR/sequencing in ESBL-producer isolates, as well as the presence of other resistance genes (aac(6’)-Ib-cr, tetA/B, dfrA, qnrA/B/S, sul1/2/3) or integron-related genes (int1/2/3). …”
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    Multidrug-resistant Klebsiella pneumoniae harboring extended spectrum β-lactamase encoding genes isolated from human septicemias
  14. 41534
    “…CONCLUSION: We concluded that NAC was superior to NACRT in terms of the sphincter preservation rate, and non-inferior to NACRT in terms of pCR, N down-staging, R0 resection, local relapse, and distant metastasis. …”
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    Meta-analysis of neoadjuvant chemotherapy versus neoadjuvant chemoradiotherapy for locally advanced rectal cancer
  15. 41535
    “…A total of 8 patients received surgical resection after the combined systemic therapies and 3 patients achieved pathological CR. No recurrence or metastasis was observed in 6 patients. …”
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    Immune checkpoint inhibitor plus tyrosine kinase inhibitor for unresectable hepatocellular carcinoma in the real world
  16. 41536
    por Go, Se-Il, Park, Mi Jung, Lee, Gyeong-Won
    Publicado 2021
    “…Only one of 24 patients (4.2%) with LD in the low-CXI group achieved a complete response (CR), whereas 30 of 83 patients (36.1%) with LD in the high-CXI group achieved CRs (p = 0.004). …”
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    Clinical significance of the cachexia index in patients with small cell lung cancer
  17. 41537
    “…METHODS: We retrospectively analyzed outcomes of adult patients with ALL in CR1 that had received HCT with PTCy as GVHD prophylaxis from HLA-matched sibling (MSD) (n = 78), matched unrelated (MUD) (n = 94) and haploidentical family (Haplo) (n = 297) donors registered in the EBMT database between 2010 and 2018. …”
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    Post-transplant cyclophosphamide containing regimens after matched sibling, matched unrelated and haploidentical donor transplants in patients with acute lymphoblastic leukemia in first complete remission, a comparative study of the ALWP of the EBMT
  18. 41538
    “…For patients with measurable disease, best responses per COG criteria were CR (n=3), PR (n=7), SD (n=3) and PD (n=1). With median follow-up of 29 months (range 8–78), two-year PFS and OS for the cohort were 74.7% and 81.1%, respectively. …”
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    HGG-37. UPFRONT TARGETED THERAPY FOR THE TREATMENT OF BRAFV600E-MUTANT PEDIATRIC HIGH-GRADE GLIOMA – A MULTI-INSTITUTIONAL EXPERIENCE
  19. 41539
    por O'Toole, Ronan F.
    Publicado 2021
    “…SOURCES: Using PubMed, the literature was searched using terms including: ‘COVID-19’; ‘SARS-CoV-2’; ‘bacterial infection’; ‘healthcare-associated infection’; ‘antibiotic resistance’; ‘antimicrobial resistance’; ‘multi-drug resistance’; ‘Streptococcus’; ‘Staphylococcus’; ‘Pseudomonas’; ‘Escherichia’; ‘Klebsiella’; ‘Enterococcus’; ‘Acinetobacter’; ‘Haemophilus’; ‘MRSA’; ‘VRE’; ‘ESBL’; ‘NDM-CRE’; ‘CR-Ab’; ‘VRSA’; ‘MDR’. CONTENT: There is a growing number of reports of bacterial infections acquired by patients with severe COVID-19 after hospital admission. …”
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    The interface between COVID-19 and bacterial healthcare-associated infections
  20. 41540
    “…Among patients who had a CR at 3 months, the PFS and OS rates at 12 months were 66.7% and 100%, respectively. …”
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    A Prospective Investigation of Bispecific CD19/22 CAR T Cell Therapy in Patients With Relapsed or Refractory B Cell Non-Hodgkin Lymphoma
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