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  1. 41941
    “…These actions were mediated via decreasing hippocampal neurodegeneration and neural demyelination through upregulating neural myelination factors (myelin%, Olig2, Opalin expression), neurotropic growth factors (BDNF, FGF-2), synaptic factors (synaptophysin), and fractalkine receptor expression (Cx3cr1). Halting neurodegeneration in DOX-induced chemobrain was achieved through epigenetic induction of key factors in Wnt/β-catenin and hedgehog signaling pathways mediated primarily by the most abundant secreted exosomal miRNAs (miR-21-5p, miR-125b-5p, miR-199a-3p, miR-24-3p, let-7a-5p). …”
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    Bone marrow mesenchymal stem cells and their derived exosomes resolve doxorubicin-induced chemobrain: critical role of their miRNA cargo
  2. 41942
    “…LC did not correlate with any TDR, but tumor response (partial response [PR] or complete response [CR]) correlated with all TDR in univariate analysis (e.g., TDR(60min,98%): hazard ration [HR] = 0.974, confidence interval [CI] = 0.952–0.996, p = 0.019). …”
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    Tumor-dose-rate variations during robotic radiosurgery of oligo and multiple brain metastases
  3. 41943
    “…Primary endpoint is the complete response (CR) rate determined 12 months after start of induction therapy. …”
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    A phase II study of the PI3K inhibitor copanlisib in combination with the anti-CD20 monoclonal antibody rituximab for patients with marginal zone lymphoma: treatment rationale and protocol design of the COUP-1 trial
  4. 41944
    “…Tests revealed serum Ca 13.1mg/dL (8-10.5mg/dL), PTH 1750pg/mL (11-90 pg/mL), and serum Cr 3.34mg/dL (0.5-1.3mg/dL). Imaging identified tumor in the right 6(th) rib (3.6cm lytic lesion), and soft tissue lesions in the left thyroid bed (3 masses, the largest 1.6cm) and the suprasternal notch (1.1cm). …”
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    Use Of Temozolomide In Parathyroid Carcinoma With Negative Mgmt Promoter Methylation
  5. 41945
    por Arabi, Yaseen M., Gordon, Anthony C., Derde, Lennie P. G., Nichol, Alistair D., Murthy, Srinivas, Beidh, Farah Al, Annane, Djillali, Swaidan, Lolowa Al, Beane, Abi, Beasley, Richard, Berry, Lindsay R., Bhimani, Zahra, Bonten, Marc J. M., Bradbury, Charlotte A., Brunkhorst, Frank M., Buxton, Meredith, Buzgau, Adrian, Cheng, Allen, De Jong, Menno, Detry, Michelle A., Duffy, Eamon J., Estcourt, Lise J., Fitzgerald, Mark, Fowler, Rob, Girard, Timothy D., Goligher, Ewan C., Goossens, Herman, Haniffa, Rashan, Higgins, Alisa M., Hills, Thomas E., Horvat, Christopher M., Huang, David T., King, Andrew J., Lamontagne, Francois, Lawler, Patrick R., Lewis, Roger, Linstrum, Kelsey, Litton, Edward, Lorenzi, Elizabeth, Malakouti, Salim, McAuley, Daniel F., McGlothlin, Anna, Mcguinness, Shay, McVerry, Bryan J., Montgomery, Stephanie K., Morpeth, Susan C., Mouncey, Paul R., Orr, Katrina, Parke, Rachael, Parker, Jane C., Patanwala, Asad E., Rowan, Kathryn M., Santos, Marlene S., Saunders, Christina T., Seymour, Christopher W., Shankar-Hari, Manu, Tong, Steven Y. C., Turgeon, Alexis F., Turner, Anne M., Van de Veerdonk, Frank Leo, Zarychanski, Ryan, Green, Cameron, Berry, Scott, Marshall, John C., McArthur, Colin, Angus, Derek C., Webb, Steven A.
    Publicado 2021
    “…The three interventions reduced hospital survival compared with control (OR [95% CrI]: 0.65 [0.45, 0.95], 0.56 [0.30, 0.89], and 0.36 [0.17, 0.73]), yielding high probabilities of harm (98.5% and 99.4% and 99.8%, respectively). …”
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    Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial
  6. 41946
    “…The median OS was not reached in patients with a CR or PR, while patients who did not respond have a median OS of 4.9 months (p < 0.0001). …”
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    Survival among patients with relapsed/refractory diffuse large B cell lymphoma treated with single-agent selinexor in the SADAL study
  7. 41947
    “…The primary outcomes were European Organisation for Research and Treatment of Cancer QLQ-C30 and CR38 quality of life scores 3 years after surgery, which were compared with linear generalised estimating equations, after adjustment for baseline values, a time effect, and an interaction effect between time and treatment. …”
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    Quality of life after sphincter preservation surgery or abdominoperineal resection for low rectal cancer (ASPIRE): A long-term prospective, multicentre, cohort study
  8. 41948
    “…After the treatment, 31 patients had complete response (CR group). The remaining 26 patients had partial response (NCR group). …”
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    The Role of Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Predicting Treatment Response for Cervical Cancer Treated with Concurrent Chemoradiotherapy
  9. 41949
    “…The objective response rate (ORR) was 38.8% (95% CI, 11.9-65.67%), disease control rate (DCR) was 69.30% (95% CI, 51.6-87.0%), complete response (CR) was 2.20% (95% CI, 0.8-3.7%), partial response (PR) was 34.70% (95% CI, 7.8-61.5%), and stable disease (SD) was 20.90% (95% CI, 9.1-32.6%). …”
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    The benefits and risks of pembrolizumab in combination with chemotherapy as first-line therapy in small-cell lung cancer: a single-arm meta-analysis of noncomparative clinical studies and randomized control trials
  10. 41950
    “…According to Response Evaluation Criteria in Solid Tumors criteria (RECIST), the patient showed a complete response (CR) after treatment with regorafenib and sintilimab immunotherapy. …”
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    Long-term survival of a patient with microsatellite-stable refractory colorectal cancer with regorafenib and PD-1 inhibitor sintilimab: a case report and review of literature
  11. 41951
    “…Univariate logistic regression analysis revealed significant differences in group, gender, PTA, ALT, AST, CR, and LDL-C between groups with and without seroconversion. …”
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    Effects of dyslipidemia on E antigen seroconversion of patients with chronic hepatitis B treated by nucleoside (acid) analogs
  12. 41952
    “…SKv2E carried 13 resistance genes (bla(KPC-2), bla(TEM-1A), bla(LEN17), aadA16, arr-3, qnrB4, oqxA/B, dfrA27, sul1, tetD, fosA, qacEΔ1) and SKp2F carried 23 (bla(KPC-2), bla(CTX-M-3), bla(TEM-1B), bla(CTX-M-65), bla(SHV-27), aac(6ʹ)-IIa, rmtB, arr-3, aph(3ʹ)-Ia, aadA16, qnrS1, aac(6ʹ)-Ib-cr, qnrB91, oqxA/B, mph(A), tet(A), fosA, dfrA27, and two copies of qacEΔ1-sul1). …”
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    Co-occurrence of Klebsiella variicola and Klebsiella pneumoniae Both Carrying bla(KPC) from a Respiratory Intensive Care Unit Patient
  13. 41953
    “…The overall response rate was 32.0% (24/75), and the rate of durable disease control for at least 6 months was 30.7% (23/75, one (iCR, immune complete response) or 20 iPR (immune partial response), or 2iSD (immune stable disease). …”
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    Tumor response as defined by iRECIST in gastrointestinal malignancies treated with PD-1 and PD-L1 inhibitors and correlation with survival
  14. 41954
    “…CINV symptoms assessed included “no significant nausea” (NSN), “significant nausea” (SN), “no vomiting” (NoV), “vomiting” (V), and complete response (CR). RESULTS: Across all AC cycles, the mean scores for the FLIE nausea domain for patients who experienced NSN versus SN were 10.92 versus 53.92, respectively (p < .0001), with lower scores indicating better QoL; the mean scores for the FLIE vomiting domain for patients who experienced NoV versus V were 1.44 versus 19.11, respectively (p < .0001), with similar results across subsequent cycles. …”
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    Quality of Life Associated with Nausea and Vomiting from Anthracycline‐Based Chemotherapy: A Pooled Data Analysis from Three Prospective Trials
  15. 41955
    “…Backwards stepwise selection using the Akaike information criterion (AIC) identified the following four variables as independent risk factors for progression, which were all used in the nomogram: age ≥ 65 years [odds ratio (OR) 7.004; 95% confidence interval (CI) 1.783–27.505; p = 0.005], Ln (sPLA2R-Ab) (OR 2.150; 95% CI 1.293–3.577; p = 0.003), Ln (proteinuria) (OR 5.939; 95% CI 1.055–33.436; p = 0.043) and Ln (Uα1m/Cr) (OR 2.808; 95% CI 1.035–7.619; p = 0.043). The discriminative ability and calibration of the nomogram revealed good predictive ability, as indicated by a C-index of 0.888 (95% CI 0.814–0.940) and a bootstrap-corrected C-index of 0.869; calibration curves were also well fitted. …”
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    Nomogram to predict the progression of patients with primary membranous nephropathy and nephrotic syndrome
  16. 41956
    “…Per RECIST V.1.1, patients with NSCLC receiving Isa+Cemi achieved no CR or PR, and 13 (65%) achieved SD. In post-therapy biopsies obtained from patients with mCRPC or NSCLC, Isa+Cemi treatment resulted in a reduction in median CD38+ tumor-infiltrating immune cells from 40% to 3%, with no consistent modulation of PD-L1 on tumor cells or T regulatory cells in the TME. …”
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    Targeting CD38 and PD-1 with isatuximab plus cemiplimab in patients with advanced solid malignancies: results from a phase I/II open-label, multicenter study
  17. 41957
    “…In the order of Cavovarus, AAFD, and Control, the mean HMA- CR values were -20.43mm, 14.02mm, and 0.03mm, respectively; HMA-WBCT values were -6.34mm, 15.75 mm, and 3.19 mm; FAO values were -11.17%, 7.42%, and 2.63%; TNCA were -16.8 degrees, 22.11, and 6.45; The MFS values were -17%, 42%, and 22%; CCS values were -21% (IQR=-35%,-0.17%), -7% (IQR=-11%, 0) and 0 (IQR=-4%, 5%); The Kite's angles were 22.19 degrees, 34.27 degrees, and 28.06 degrees; The arch height index values were 0.25, 0.71, and 0.44. …”
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    Peritalar Subluxation: A Key Finding for Both Cavovarus and Flatfoot Deformities
  18. 41958
    “…His proteinuria and albuminuria concentrations were 7.1 and 4.5 g/g⋅Cr, respectively. Three-dimensional contrast-enhanced computed tomography (CT) showed double IVC and narrowing of the LRV after interflow of the left IVC. …”
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    Disruption of the glomerular basement membrane associated with nutcracker syndrome and double inferior vena cava in Noonan syndrome: a case report
  19. 41959
    “…The Cas13 system utilizes base complementarity between a crRNA/sgRNA (crispr RNA or single guide RNA) and a target RNA transcript, to preferentially bind to only the target transcript. …”
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    CASowary: CRISPR-Cas13 guide RNA predictor for transcript depletion
  20. 41960
    “…ID was defined as ferritin <100 μg/L or as transferrin saturation (TSAT) < 20% if ferritin was 100‐ < 300 μg/L or if CrP > 5 mg/L. Anaemia was defined as Hb < 12 g/dL (women) and <13 g/dL (men). …”
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    Iron deficiency is related to low functional outcome in patients at early rehabilitation after acute stroke
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