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29121por Yamamizu, Kohei, Iwasaki, Mio, Takakubo, Hitomi, Sakamoto, Takumi, Ikuno, Takeshi, Miyoshi, Mami, Kondo, Takayuki, Nakao, Yoichi, Nakagawa, Masato, Inoue, Haruhisa, Yamashita, Jun K.“…Neuron-derived Dll1, which activates Notch signaling in ECs, was essential for the BEC specification. We performed in vitro BBB permeability tests and assessed ten clinical drugs by nanoLC-MS/MS, finding a good correlation with the BBB permeability reported in previous cases. …”
Publicado 2017
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29122por Ogasawara, Satoshi, Kaneko, Mika K., Yamada, Shinji, Honma, Ryusuke, Nakamura, Takuro, Saidoh, Noriko, Yanaka, Miyuki, Yoshida, Kanae, Fujii, Yuki, Kato, Yukinari“…PODXL is also expressed in many normal cells such as renal podocytes and endothelial cells (ECs). However, high-sensitive and high-specific anti-PODXL monoclonal antibodies (mAbs) have not been established. …”
Publicado 2017
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29123por Park, Do Young, Lee, Junyeop, Kim, Jaeryung, Kim, Kangsan, Hong, Seonpyo, Han, Sangyeul, Kubota, Yoshiaki, Augustin, Hellmut G., Ding, Lei, Kim, Jin Woo, Kim, Hail, He, Yulong, Adams, Ralf H., Koh, Gou Young“…Although selective pericyte loss in stable adult retinal vessels surprisingly does not cause BRB disintegration, it sensitizes retinal vascular endothelial cells (ECs) to VEGF-A, leading to upregulation of angiopoietin-2 (Ang2) in ECs through FOXO1 activation and triggering a positive feedback that resembles the pathogenesis of DR. …”
Publicado 2017
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29124por Sanada, Fumihiro, Taniyama, Yoshiaki, Muratsu, Jun, Otsu, Rei, Shimizu, Hideo, Rakugi, Hiromi, Morishita, Ryuichi“…This mechanism mediates interleukin-6/gp130-induced premature senescence in human fibroblasts, irradiation-induced premature senescence in human endothelial cells (ECs), and replicative senescence in human ECs independent of insulin-like growth factor I (IGF-I) and IGF-II. …”
Publicado 2018
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29125por Kuch, Alicja, Goc, Anna, Belkiewicz, Katarzyna, Filipello, Virginia, Ronkiewicz, Patrycja, Gołębiewska, Agnieszka, Wróbel, Izabela, Kiedrowska, Marlena, Waśko, Izabela, Hryniewicz, Waleria, Lomonaco, Sara, Skoczyńska, Anna“…We identified clonal complexes (CCs) and epidemic clones (ECs) previously involved in outbreaks worldwide, with the most prevalent CCs/ECs being: CC6/ECII (32.6%), CC1/ECI (17.2%), CC8/ECV (6.1%) and CC2/ECIV (5.5%). …”
Publicado 2018
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29126por Mao, Sifeng, Zhang, Qiang, Li, Haifang, Zhang, Wanling, Huang, Qiushi, Khan, Mashooq, Lin, Jin-Ming“…Here, we present a microfluidic method for adhesion strength analysis of single CTCs on a base layer of endothelial cells (ECs) to clarify cell-to-cell adhesion at single cell resolution. …”
Publicado 2018
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29127por Mandić, Ana D., Woting, Anni, Jaenicke, Tina, Sander, Anika, Sabrowski, Wiebke, Rolle-Kampcyk, Ulrike, von Bergen, Martin, Blaut, Michael“…Peripheral serotonin (5-hydroxytryptamine: 5-HT) synthesized in the intestine by enterochromaffin cells (ECs), plays an important role in the regulation of peristaltic of the gut, epithelial secretion and promotes the development and maintenance of the enteric neurons. …”
Publicado 2019
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29128por Tafur, Lucas, Sadian, Yashar, Hanske, Jonas, Wetzel, Rene, Weis, Felix, Müller, Christoph W“…Strikingly, most of the nucleotide-bound ECs lack the A49-A34.5 heterodimer and adopt a Pol II-like conformation, in which the A12.2 C-terminal domain is bound in a previously unobserved position at the A135 surface. …”
Publicado 2019
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29129por Zi, Ye, Yi-An, Yao, Bing, Ji, Yan, Lai, Jing, Tong, Chun-Yu, Guan, Fan, Ping, Hao, Lin, Jia-Ni, Tang, Han-Jin, Hou, Fei, Chen, Xue-Bo, Liu“…Here we demonstrate that oxidatively modified low density lipoprotein (ox-LDL)-treated endothelial cells (ECs) exhibited increased TREM-1-mediated pyroptosis and decreased Sirt6-induced autophagy. …”
Publicado 2019
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29130por van Engeland, Nicole C. A., Suarez Rodriguez, Freddy, Rivero-Müller, Adolfo, Ristori, Tommaso, Duran, Camille L., Stassen, Oscar M. J. A., Antfolk, Daniel, Driessen, Rob C. H., Ruohonen, Saku, Ruohonen, Suvi T., Nuutinen, Salla, Savontaus, Eriika, Loerakker, Sandra, Bayless, Kayla J., Sjöqvist, Marika, Bouten, Carlijn V. C., Eriksson, John E., Sahlgren, Cecilia M.“…Signaling between endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) through the Notch pathway regulates arterial remodeling in response to changes in blood flow. …”
Publicado 2019
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29131por Kwan Cheung, Keith A., Peiris, Hassendrini, Wallace, Geoffrey, Holland, Olivia J., Mitchell, Murray D.“…We review the research that demonstrates how the ECS can contribute to neuroinflammation, and could therefore be modulated by cannabinoids to potentially reduce the incidence and severity of seizures. …”
Publicado 2019
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29132por Wisniewski, Laura, French, Vanessa, Lockwood, Nicola, Valdivia, Leonardo E., Frankel, Paul“…Mechanistically, we show that P130Cas mediates Bmp2b-induced ectopic angiogenic sprouting of ECs in the developing embryo and provide pharmacological evidence for a role of Src family kinases in CVP development.…”
Publicado 2020
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29133“…Very little is known about PA-expressed genes and signaling pathways that mediate contact and communication with endothelial cells (ECs) to regulate BBB physiology. This is due, in part, to lack of suitable models to distinguish PAs from other astrocyte sub-populations in the brain. …”
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29134“…Every day, thousands of patients receive erythrocyte concentrates (ECs). They are indispensable for modern medicine, despite their limited resource. …”
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29135“…The structure and function of endothelial cells (ECs), vascular smooth muscle cells (VSMCs), fibroblasts, and macrophages are disrupted during the aging process, causing vascular cell senescence as well as vascular dysfunction. …”
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29136“…The plasma glycoprotein von Willebrand factor (VWF) is exclusively synthesized in endothelial cells (ECs) and megakaryocytes, the precursor cells of platelets. …”
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29137por Mattei, Vincenzo, Martellucci, Stefano, Pulcini, Fanny, Santilli, Francesca, Sorice, Maurizio, Delle Monache, Simona“…It is also known that co-cultures of perivascular and endothelial cells (ECs) can form a vascular network in vitro and also in vivo. …”
Publicado 2021
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29138“…However, little is known about the impact of the endocannabinoid system (ECS) regulation over glial cells, even less in pathological conditions such as epilepsy. …”
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29139“…Since the identification of the components of the endogenous cannabinoid system (ECS) in the 1990s, research into the potential of cannabinoids as medicine has exploded, including in anti-cancer research. …”
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29140por Luck, Robert, Karakatsani, Andromachi, Shah, Bhavin, Schermann, Geza, Adler, Heike, Kupke, Janina, Tisch, Nathalie, Jeong, Hyun-Woo, Kerstin Back, Michaela, Hetsch, Florian, D’Errico, Anna, Palma, Michele De, Wiedtke, Ellen, Grimm, Dirk, Acker-Palmer, Amparo, von Engelhardt, Jakob, Adams, Ralf H., Augustin, Hellmut G., de Almodóvar, Carmen Ruiz“…Altogether, our data propose Ang/Tie2 signaling as a mediator of intercellular communication between neural cells, ECs, and PCs, required for proper PC dendritic morphogenesis and function.…”
Publicado 2021
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