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29421por Reinhard, Nathalie R., Van Der Niet, Sanne, Chertkova, Anna, Postma, Marten, Hordijk, Peter L., Gadella Jr., Theodorus W.J., Goedhart, Joachim“…By performing single cell FRET measurements with Rho GTPase biosensors in primary human ECs, we monitored GEF efficiency towards Cdc42 and Rac1. …”
Publicado 2019
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29422por Galeano-Otero, Isabel, Del Toro, Raquel, Khatib, Abdel-Majid, Rosado, Juan Antonio, Ordóñez-Fernández, Antonio, Smani, Tarik“…Angiogenesis is a multistep process that controls endothelial cells (ECs) functioning to form new blood vessels from preexisting vascular beds. …”
Publicado 2021
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29423“…Rapid ECS shrinkage has been observed following epileptiform activity and can inherently concentrate ions and neurotransmitters including glutamate. …”
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29424por Galán-Ganga, M., Rodríguez-Cueto, C., Merchán-Rubira, J., Hernández, F., Ávila, J., Posada-Ayala, M., Lanciego, J. L., Luengo, E., Lopez, M. G., Rábano, A., Fernández-Ruiz, J., Lastres-Becker, I.“…Therefore, new pharmacological targets are being sought, such as elements of the endocannabinoid system (ECS). We analysed the occurrence of changes in the ECS in tauopathies and their implication in the pathogenesis. …”
Publicado 2021
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29425“…The latter, along with the virus itself, the increased levels of angiotensin II and hypoxia, drive the major cellular changes promoting thrombosis, which include: (1) aberrant expression of tissue factor by activated alveolar epithelial cells, monocytes-macrophages and neutrophils, and production of other prothrombotic factors by activated endothelial cells (ECs) and platelets; (2) reduced expression of physiological anticoagulants by dysfunctional ECs, and (3) suppression of fibrinolysis by the endothelial overproduction of plasminogen activator inhibitor-1 and, likely, by heightened thrombin-mediated activation of thrombin-activatable fibrinolysis inhibitor. …”
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29426por Pethő, Dávid, Gáll, Tamás, Hendrik, Zoltán, Nagy, Annamária, Beke, Lívia, Gergely, Attila Péter, Méhes, Gábor, Tóth, Csaba, Gram, Magnus, Åkerström, Bo, Balla, György, Balla, József“…To reveal a possible inducer of A1M expression in ruptured lesions, we exposed aortic endothelial cells (ECs), SMCs and macrophages to heme, Oxy- and FerrylHb. …”
Publicado 2021
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29427“…The endocannabinoid system (ECS) appears to be a very important, highly expressed, and active system of control in the central nervous system (CNS). …”
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29428“…Hypoxic injury to cerebrovascular endothelial cells (ECs) after stroke leads to blood-brain barrier (BBB) dysfunction, which is commonly associated with disruptions of endothelial tight junctions (TJs) and increased permeability. …”
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29429por Li, Chen C., Zhang, Guangyu, Du, Junjie, Liu, Di, Li, Zongcheng, Ni, Yanli, Zhou, Jie, Li, Yunqiao, Hou, Siyuan, Zheng, Xiaona, Lan, Yu, Liu, Bing, He, Aibin“…Although definitive hematopoietic stem cells (HSCs) are known to emerge via endothelial-to-hematopoietic transition (EHT), how the multi-layered epigenome is sequentially unfolded in a small portion of endothelial cells (ECs) transitioning into the hematopoietic fate remains elusive. …”
Publicado 2022
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29430por Dawson, Ashley, Li, Yanming, Li, Yang, Ren, Pingping, Vasquez, Hernan G., Zhang, Chen, Rebello, Kimberly R., Ageedi, Waleed, Azares, Alon R., Mattar, Aladdein Burchett, Sheppard, Mary Burchett, Lu, Hong S., Coselli, Joseph S., Cassis, Lisa A., Daugherty, Alan, Shen, Ying H., LeMaire, Scott A.“…However, TGF-β receptor genes (predominantly TGFBR2) and SMAD genes were downregulated in SMCs, fibroblasts, and ECs in MFS, indicating impairment in TGF-β signaling. …”
Publicado 2021
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29431“…It also inhibits ox-LDL-induced cholesterol accumulation in endothelial cells (ECs), improves U937 monocytes adhesion, and decreases the representation of NADPH oxidase (NOX-4) and generation of reactive oxygen species (ROS) in endothelial cells (ECs). …”
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29432por Dave, Jui M., Chakraborty, Raja, Ntokou, Aglaia, Saito, Junichi, Saddouk, Fatima Z., Feng, Zhonghui, Misra, Ashish, Tellides, George, Riemer, Robert K., Urban, Zsolt, Kinnear, Caroline, Ellis, James, Mital, Seema, Mecham, Robert, Martin, Kathleen A., Greif, Daniel M.“…Eln(–/–) mice expressed higher levels of NOTCH ligand JAGGED1 (JAG1) in aortic SMCs and endothelial cells (ECs). Finally, Jag1 deletion in SMCs, but not ECs, mitigated the hypermuscular and stenotic phenotype in the aorta of Eln(–/–) mice. …”
Publicado 2022
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29433por Guerrero, Julien, Dasen, Boris, Frismantiene, Agne, Pigeot, Sebastien, Ismail, Tarek, Schaefer, Dirk J, Philippova, Maria, Resink, Therese J, Martin, Ivan, Scherberich, Arnaud“…The osteogenic potential of T-cad-depleted SVF cells was fully rescued by co-culture with ECs from a human umbilical vein (HUVECs), constitutively expressing T-cad. …”
Publicado 2022
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29434“…Persistence (P), bioaccumulation (B), mobility (M) and toxicity (T) of detected ECs were assessed based on in silico strategy for PBT assessment and recently developed REACH PMT/vPvM guidelines. …”
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29435“…Studies confirmed that β-amyloid (Aβ) deposition induced high BBB permeability by disrupting tight junction (TJ) proteins formed from endothelial cells (ECs). Here, we found TARBP2, SNHG7 and NFATC3 in expressions were increased and miR-17-5p expression was decreased in Aβ(1-42)-incubated ECs. …”
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29436“…BACKGROUND AND OBJECTIVES: Endothelial progenitor cells (EPCs) and endothelial cells (ECs) have been applied in the clinic to treat pulmonary arterial hypertension (PAH), a disease characterized by disordered pulmonary vasculature. …”
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29437por Zhou, Qiao, Zhang, Xin, Tong, Xia, Tang, Chuang, Chen, Xin, Peng, Ling, Xia, Xiangen, Zhang, Lanlan“…We next established a single-cell network elucidating the cellular and molecular characteristics of endothelial cells (ECs) across many lesions and identified key genes linked with EndMT in premalignant lesions and cancer lesions. …”
Publicado 2022
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29438por Palakeel, Jaimee J, Ali, Mazin, Chaduvula, Phani, Chhabra, Sanika, Lamsal Lamichhane, Smriti, Ramesh, Vaiishnavi, Opara, Collins O, Khan, Farhana Yaqoob, Kabiraj, Gargi, Kauser, Humaira, Mostafa, Jihan A“…However, these studies have not successfully isolated HIV virions, HIV-DNA, protein 24 antigen (p24), or HIV-RNA from the pulmonary endothelial cells (ECs). It provides an insight into an ongoing inflammatory process that could be attributed to viral proteins. …”
Publicado 2022
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29439por Yang, Mu, Li, Shujin, Huang, Li, Zhao, Rulian, Dai, Erkuan, Jiang, Xiaoyan, He, Yunqi, Lu, Jinglin, Peng, Li, Liu, Wenjing, Zhang, Zhaotian, Jiang, Dan, Zhang, Yi, Jiang, Zhilin, Yang, Yeming, Zhao, Peiquan, Zhu, Xianjun, Ding, Xiaoyan, Yang, Zhenglin“…We performed inducible deletion of Ctnnd1 in the postnatal mouse endothelial cells (ECs) and observed typical phenotypes of FEVR with reactive gliosis. …”
Publicado 2022
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29440por Chiacchio, Manuela Flavia, Tagliamonte, Silvia, Visconti, Attilio, Ferracane, Rosalia, Mustafa, Arwa, Vitaglione, Paola“…WHC and OHC ranged between 2–7 g H(2)O-Oil/g, with fibrous filaments showing the highest values. ECs were not found, whereas NAEs were abundant in seed oil (2408.7 ± 11.1 ng/g). …”
Publicado 2022
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