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30141por Tang, Decai, Zhang, Shuo, Shi, Xiaoxia, Wu, Jiafei, Yin, Gang, Tan, Xiying, Liu, Fuyan, Wu, Xingdong, Du, Xiangyu“…Tumor vessels of HepG2 tumor-bearing mice treated with the combination were sparse with uniform growth, morphology rules, and complete vascular walls, which had fewer branches and sprouts. ECs of tumor vessels were arranged regularly and were tightly connected, tending toward normalization. …”
Publicado 2019
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30142por Allegra, Mario, Restivo, Ignazio, Fucarino, Alberto, Pitruzzella, Alessandro, Vasto, Sonya, Livrea, Maria Antonia, Tesoriere, Luisa, Attanzio, Alessandro“…Interestingly, HNE induces significant increase of erythrocytes adhesion to endothelial cells (ECs) that are in turn dysfunctionated as evident by overexpression of ICAM-1. …”
Publicado 2020
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30143por Gomes, Samara Tatielle Monteiro, da Silva Graça Amoras, Ednelza, Gomes, Érica Ribeiro, Queiroz, Maria Alice Freitas, Júnior, Edivaldo Costa Sousa, de Vasconcelos Massafra, Janaína Mota, da Silva Lemos, Poliana, Júnior, João Lídio Vianez, Ishak, Ricardo, Vallinoto, Antonio Carlos Rosário“…The sample included 30 treatment-naive patients classified into three groups based on infection duration (> 6 years), CD4(+)TC count and viral load: (i) 2 elite controllers (ECs), (ii) 7 viremia controllers (VCs) and (iii) 21 nonviremia controllers (NVCs). …”
Publicado 2020
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30144por Qiu, Xinyu, Liu, Jin, Zheng, Chenxi, Su, Yuting, Bao, Lili, Zhu, Bin, Liu, Siying, Wang, Lulu, Wang, Xiao, Wang, Yirong, Zhao, Wanmin, Zhou, Jun, Deng, Zhihong, Liu, Shiyu, Jin, Yan“…Mechanistically, we revealed that the recipient endothelial cells (ECs) were targeted and the exosomes promoted their functions to enhance angiogenesis via regulating AKT/eNOS pathway. …”
Publicado 2020
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30145por Dickens, Alex M., Borgan, Faith, Laurikainen, Heikki, Lamichhane, Santosh, Marques, Tiago, Rönkkö, Tuukka, Veronese, Mattia, Lindeman, Tuomas, Hyötyläinen, Tuulia, Howes, Oliver, Hietala, Jarmo, Orešič, Matej“…It is known that obesity-associated metabolic disorders are promoted by activation of specific cannabinoid targets (endocannabinoid system (ECS)). Our recent data suggest that there is a change in the circulating lipidome at the onset of first episode psychosis (FEP). …”
Publicado 2020
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30146por Castellan, Raphael F.P., Vitiello, Milena, Vidmar, Martina, Johnstone, Steven, Iacobazzi, Dominga, Mellis, David, Cathcart, Benjamin, Thomson, Adrian, Ruhrberg, Christiana, Caputo, Massimo, Newby, David E., Gray, Gillian A., Baker, Andrew H., Caporali, Andrea, Meloni, Marco“…Moreover, ANLN expression inversely correlated with miR-96 expression and age in cardiac ECs of cardiovascular patients. In vivo, ANLN(+) vessels were enriched in the peri-infarct area of miR-96/miR-183–KO mice. …”
Publicado 2020
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30147“…We discovered that the EP was significantly reduced while ABR thresholds were significantly elevated in cisplatin-treated mice; cisplatin induced ultrastructural changes in marginal cells (MCs), endothelial cells (ECs), pericytes, etc. We found that cisplatin insulted auditory function not only by reducing the expression of zonula occludens protein-1 (ZO-1) in MCs of the SV but also by decreasing the expression of connexin 26 (Cx26) and connexin 43 (Cx43) in MCs and basal cells (BCs). …”
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30148por Kesidou, Despoina, da Costa Martins, Paula A., de Windt, Leon J., Brittan, Mairi, Beqqali, Abdelaziz, Baker, Andrew Howard“…Several studies have demonstrated the ability of EVs to stimulate angiogenesis by transferring microRNA (miRNA, miR) molecules to endothelial cells (ECs). In this review, we describe the process of neovascularisation and current developments in modulating neovascularisation in the heart using miRNAs and EV-bound miRNAs. …”
Publicado 2020
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30149por Sareło, Przemysław, Duda, Maciej, Gąsior-Głogowska, Marlena, Wysokińska, Edyta, Kałas, Wojciech, Podbielska, Halina, Wawrzyńska, Magdalena, Kopaczyńska, Marta“…These include the strategy of biofunctionalization of the stent surface with antibodies that facilitate adhesion of endothelial cells (ECs) or endothelial progenitor cells (EPCs). Rapid re-endothelialization of the surface minimizes the risk of possible complications. …”
Publicado 2020
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30150por Zhang, Dongliang, Shao, Jialiang, Zhuang, Jingming, Zhou, Shukui, Yin, Shuo, Wu, Fuyue, Hou, Jiangang, Wang, Xiang“…Compared with 4-degree storage, programmed cryopreservation preserved the ECS structural integrity, enhanced the mechanical properties, decreased HLA-I expression, and increased cell viability and survival. …”
Publicado 2021
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30151por Beins, Eva C., Beiert, Thomas, Jenniches, Imke, Hansen, Jan N., Leidmaa, Este, Schrickel, Jan W., Zimmer, Andreas“…The endocannabinoid system (ECS) regulates neuronal and endocrine stress responses via the cannabinoid receptor 1 (CB1). …”
Publicado 2021
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30152por Zhao, Yang, Ting, Ka Ka, Coleman, Paul, Qi, Yanfei, Chen, Jinbiao, Vadas, Mathew, Gamble, Jennifer“…Such recruitment involves interactions between the leucocytes and the endothelial cells (ECs) of the vessel and occurs through a series of steps including leucocyte capture, their rolling, adhesion, and intraluminal crawling, and finally leucocyte transendothelial migration across the endothelium. …”
Publicado 2021
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30153por Yang, Ting, Jiang, Yi-Xin, Wu, Ye, Lu, Dong, Huang, Rui, Wang, Long-Ling, Wang, Shi-Qi, Guan, Ying-Yun, Zhang, Hong, Luan, Xin“…In addition, Western blot analysis was used to reveal that RBF inhibited the phosphorylation of VEGFR2 and its downstream protein kinases FAK and Src in endothelial cells (ECs). Molecular docking simulations showed that RBF affected the phosphorylation of VEGFR2 by competitively binding to the ATP-bound VEGFR2 kinase domain, thus preventing ATP from providing phosphate groups. …”
Publicado 2021
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30154por Angyal, Ágnes, Pénzes, Zsófia, Alimohammadi, Shahrzad, Horváth, Dorottya, Takács, Lili, Vereb, György, Zsebik, Barbara, Bíró, Tamás, Tóth, Kinga Fanni, Lisztes, Erika, Tóth, Balázs István, Oláh, Attila, Szöllősi, Attila Gábor“…Therefore, we determined whether human corneal epithelial cells (HCECs) express members of the endocannabinoid system (ECS), and examined how the endocannabinoid anandamide (AEA, N-arachidonoyl ethanolamine) influences the Toll-like receptor 3 (TLR3) agonism- or UVB irradiation-induced inflammatory response of these cells. …”
Publicado 2021
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30155A Personalized Glomerulus Chip Engineered from Stem Cell-Derived Epithelium and Vascular Endotheliumpor Roye, Yasmin, Bhattacharya, Rohan, Mou, Xingrui, Zhou, Yuhao, Burt, Morgan A., Musah, Samira“…In this study, we engineered a personalized glomerulus chip system reconstituted from human induced pluripotent stem (iPS) cell-derived vascular endothelial cells (ECs) and podocytes from a single patient. Our stem cell-derived kidney glomerulus chip successfully mimics the structure and some essential functions of the glomerular filtration barrier. …”
Publicado 2021
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30156por Maffioletti, Elisabetta, Carvalho Silva, Rosana, Bortolomasi, Marco, Baune, Bernhard T., Gennarelli, Massimo, Minelli, Alessandra“…We propose an overview of the molecular studies on ECT, concerning its course and outcome prediction, including also animal studies on electroconvulsive seizures (ECS), an experimental analogue of ECT. Most of these investigations underlie biological systems related to major depressive disorder (MDD), such as the neurotrophic and inflammatory/immune ones, indicating effects of ECT on these processes. …”
Publicado 2021
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30157“…The endocannabinoid system (ECS) may largely modulate these circuits, presenting a promising pharmaceutical avenue for treating addictions. …”
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30158por He, Yijun, Wang, Wenhao, Lin, Shaozhang, Yang, Yixi, Song, Lizhi, Jing, Yihan, Chen, Lihao, He, Zaopeng, Li, Wei, Xiong, Ao, Yeung, Kelvin W.K., Zhao, Qi, Jiang, Yuan, Li, Zijie, Pei, Guoxian, Zhang, Zhi-Yong“…Human umbilical vein endothelial cell-derived decellularized extracellular matrix (HdECM), which contains a collection of angiocrine biomolecules, has recently been demonstrated to mediate endothelial cells(ECs) – osteoprogenitors(OPs) crosstalk. We employed the HdECM to create a PCL (polycaprolactone)/fibrin/HdECM (PFE) hybrid scaffold. …”
Publicado 2021
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30159por Małecka, Arleta, Konkolewska, Agnieszka, Hanć, Anetta, Ciszewska, Liliana, Staszak, Aleksandra Maria, Jarmuszkiewicz, Wieslawa, Ratajczak, Ewelina“…We have shown that in the first 24 h of stress condiction, activation of glutamylcysteine-γ synthetase (yECS) and glutathione reductase (GR1) enzymes related to the detoxification of heavy metals is important for B. juncea plants. …”
Publicado 2021
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30160por Wu, Ting, Jiang, Danli, Zou, Meijuan, Sun, Wei, Wu, Di, Cui, Jing, Huntress, Ian, Peng, Xinxia, Li, Gang“…Downregulation of either PABPC1 or FOXC2 in human endothelial cells (ECs) can induce the p16(INK)(4)(a)-dependent cellular senescence. …”
Publicado 2021
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