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23201por Manova, Manoela, Savova, Alexandra, Vasileva, Maria, Terezova, Silvia, Kamusheva, Maria, Grekova, Daniela, Petkova, Valentina, Petrova, Guenka“…The aim of this study was to conduct comparative price analysis of biological products for rheumatoid arthritis therapy among seventeen EU countries. The point of view is that of the Bulgarian pricing and reimbursement system and the chosen countries are those from external reference basket for prices comparison at manufacturing level. …”
Publicado 2018
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23202por Paillot, Romain, Garrett, Dion, Lopez-Alvarez, Maria R., Birand, Ihlan, Montesso, Fernando, Horspool, Linda“…In this study, the impact of the immunity gap in ponies was limited after primary vaccination with this whole inactivated, ISCOMatrix adjuvanted EI and tetanus vaccine (Equilis Prequenza-Te) when infected several months after V2 with a recent FC2 strain, which is representative of EIV circulating in the EU.…”
Publicado 2018
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23203por Bessonova, Leona, Volkova, Nataliya, Higgins, Mark, Bengtsson, Leif, Tian, Simon, Simard, Christopher, Konstan, Michael W, Sawicki, Gregory S, Sewall, Ase, Nyangoma, Stephen, Elbert, Alexander, Marshall, Bruce C, Bilton, Diana“…CONCLUSIONS: While general limitations of observational research apply, analyses revealed favourable results for clinically important outcomes among ivacaftor-treated patients, adding to the growing body of literature supporting disease modification by CFTR modulation with ivacaftor. EU PAS REGISTRATION NUMBER: EUPAS4270…”
Publicado 2018
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23204Identification of a novel broadly HIV-1-neutralizing antibody from a CRF01_AE-infected Chinese donorpor Ju, Bin, Li, Dan, Ren, Li, Hou, Jiali, Hao, Yanling, Liang, Hua, Wang, Shuo, Zhu, Jiang, Wei, Min, Shao, Yiming“…In this study, we used antigen-specific single B-cell sorting and monoclonal antibody expression to isolate monoclonal antibodies from a CRF01_AE-infected Chinese donor (GX2016EU04), a broad neutralizer based on neutralizing activity against a cross-clade virus panel. …”
Publicado 2018
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23205por Hollinger, Alexa, Wittebole, Xavier, François, Bruno, Pickkers, Peter, Antonelli, Massimo, Gayat, Etienne, Chousterman, Benjamin Glenn, Lascarrou, Jean-Baptiste, Dugernier, Thierry, Di Somma, Salvatore, Struck, Joachim, Bergmann, Andreas, Beishuizen, Albertus, Constantin, Jean-Michel, Damoisel, Charles, Deye, Nicolas, Gaudry, Stéphane, Huberlant, Vincent, Marx, Gernot, Mercier, Emanuelle, Oueslati, Haikel, Hartmann, Oliver, Sonneville, Romain, Laterre, Pierre-François, Mebazaa, Alexandre, Legrand, Matthieu“…METHODS: The Kid-SSS study was a substudy of Adrenomedullin and Outcome in Severe Sepsis and Septic Shock (AdrenOSS) (NCT02393781), a prospective, observational, multinational study including 583 patients admitted to the intensive care unit with sepsis or septic shock and a validation cohort of 525 patients from the French and euRopean Outcome reGistry in Intensive Care Units (FROG-ICU) study. …”
Publicado 2018
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23206por Kasper, Stefan, Kisro, Jens, Fuchs, Martin, Müller, Christian, Schulz-Abelius, Armin, Karthaus, Meinolf, Rafiyan, Mohammad-Reza, Stein, Alexander“…FTD/TPI was approved in the European Union (EU) in April 2016 and launched on the German market in August 15, 2016. …”
Publicado 2018
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23207por Unger, Martin, Morelli, Andrea, Singer, Mervyn, Radermacher, Peter, Rehberg, Sebastian, Trimmel, Helmut, Joannidis, Michael, Heinz, Gottfried, Cerny, Vladimír, Dostál, Pavel, Siebers, Christian, Guarracino, Fabio, Pratesi, Francesca, Biancofiore, Gianni, Girardis, Massimo, Kadlecova, Pavla, Bouvet, Olivier, Zörer, Michael, Grohmann-Izay, Barbara, Krejcy, Kurt, Klade, Christoph, Krumpl, Günther“…This study will investigate whether HR control using landiolol is safe, feasible, and effective, and further enhance the understanding of beta blockade in patients with septic shock. TRIAL REGISTRATION: EU Clinical Trials Register; EudraCT, 2017-002138-22. …”
Publicado 2018
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23208por Leonardo Alves, Teresa, Poplavska, Elita, Mezinska, Signe, Salmane-Kulikovska, Ieva, Andersone, Liga, Mantel-Teeuwisse, Aukje K., Mintzes, Barbara“…Disease awareness campaigns were assessed using a previously developed instrument based on the WHO Ethical Criteria for Medicinal Drug promotion and European standards (EU law and pharmaceutical industry self-regulatory guidelines). …”
Publicado 2018
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23209por Valade, Aude, Luyssaert, Sebastiaan, Vallet, Patrick, Njakou Djomo, Sylvestre, Jesus Van Der Kellen, Ingride, Bellassen, Valentin“…RESULTS: All three intensification strategies produced 11.6–12.4 million tonnes of oil equivalent per year of wood-based energy by 2026, which corresponds to the target assigned to French wood-energy to meet the EU 2020 renewable energy target. Sustaining this level past 2026 will be challenging, let alone further increasing it. …”
Publicado 2018
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23210por Guillot, Laetitia, Delage, Ludovic, Viari, Alain, Vandenbrouck, Yves, Com, Emmanuelle, Ritter, Andrés, Lavigne, Régis, Marie, Dominique, Peterlongo, Pierre, Potin, Philippe, Pineau, Charles“…This workflow is also accessible through the Galaxy framework and for use by non-computer scientists at https://galaxy.protim.eu. Data are available via ProteomeXchange under identifier PXD010618. …”
Publicado 2019
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23211“…However, rates remain higher than in other EU countries and further effort is required to reduce the number of deaths further, particularly among adolescent males.…”
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23212por Brzezinski, Michal“…The data come from longitudinal 2011 European Union Statistics on Income and Living Conditions (EU-SILC) database. Increases in low SRH incidence over time are decomposed into the contributions of changes in the distribution of covariates and changes in returns to the covariates. …”
Publicado 2019
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23213por Becker, Monika, Bühn, Stefanie, Breuing, Jessica, Firanek, Catherine A., Hess, Simone, Nariai, Hisanori, Marshall, Mark R., Sloand, James A., Yao, Qiang, Goossen, Käthe, Pieper, Dawid“…We will conduct systematic searches in MEDLINE, EMBASE, CENTRAL, Ichushi-Web, Chinese and Japanese databases, and in clinical trials registries (ClinicalTrials.gov, International Clinical Trials Registry Platform Search Portal (ICTRP), EU Clinical Trials Register, Japan Registries Network (JPRN), China’s Clinical Trial Registry (ChiCTR)). …”
Publicado 2019
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23214“…Further innovation and evaluation will be required to improve recruitment to clinical trials. TRIAL REGISTRATION: EU Clinical Trials Register. EudraCT Number: 2011–001883-23. …”
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23215por Burchert, Sebastian, Alkneme, Mohammed Salem, Bird, Martha, Carswell, Kenneth, Cuijpers, Pim, Hansen, Pernille, Heim, Eva, Harper Shehadeh, Melissa, Sijbrandij, Marit, van't Hof, Edith, Knaevelsrud, Christine“…Given the great need for improving the responsiveness and accessibility of health systems in host countries, the EU-funded STRENGTHS consortium studies the adaptation, implementation and scaling-up of SbS for Syrian refugees in Germany, Sweden and Egypt. …”
Publicado 2019
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23216por Lattanzio, Veronica M. T., von Holst, Christoph, Lippolis, Vincenzo, De Girolamo, Annalisa, Logrieco, Antonio F., Mol, Hans G. J., Pascale, Michelangelo“…Specific guidelines for validation and verification of mycotoxin screening methods are set in the Commission Regulation (EU) No 2014/519. This regulation establishes that the “aim of the validation is to demonstrate the fitness-for-purpose of the screening method” and focuses the entire validation procedure on determining specific cut-off values ensuring a maximum rate of false negative results of 5%. …”
Publicado 2019
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23217por Smith, Christine, Sun, Mingxu, Kenney, Laurence, Howard, David, Luckie, Helen, Waring, Karen, Taylor, Paul, Merson, Earl, Finn, Stacey, Cotterill, Sarah“…Objective: This paper reports on a three center clinical investigation with the primary aim of demonstrating compliance of the new FES system with relevant essential requirements of the EU Medical Device Directive, namely to evaluate whether use of the FES-UPP enables PwS to perform a wider range of functional activities, and/or perform the same activities in an improved way. …”
Publicado 2019
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23218por Heuser, Christian, Diekmann, Annika, Kowalski, Christoph, Enders, Anna, Conrad, Rupert, Pfaff, Holger, Ansmann, Lena, Ernstmann, Nicole“…After descriptive analysis, t-tests were conducted, correlations for independent variables were run, and logistic multilevel regression analysis was applied to estimate the association between patient participation in MTCs at T1 and HL (HLS-EU-Q16 [1]), sociodemographic and disease-related characteristics (n = 863 patients) and the variation between breast cancer centers (n = 43 centers). …”
Publicado 2019
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23219“…BACKGROUND: In 2011 there was a strengthening of European Union (EU) legislation on the licencing of herbal products which, in the UK, resulted in the introduction of the Traditional Herbal Registration (THR) scheme. …”
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23220por Marx, Gernot, Meybohm, Patrick, Schuerholz, Tobias, Lotz, Gösta, Ledinko, Mandy, Schindler, Achim W., Rossaint, Rolf, Zacharowski, Kai“…TRIAL REGISTRATION: ClinicalTrials.gov (NCT01515397) and clinicaltrialsregister.eu, EudraCT number 2010-018524-58.…”
Publicado 2019
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