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23301por Buhl, Roland, Dreher, Michael, Korn, Stephanie, Taube, Christian, Stock, Christian, Zehendner, Christoph M, Kondla, Anke, Vogelmeier, Claus F“…TRIAL REGISTRATION: The European Union electronic Register of Post-authorisation Studies (EU PAS Register): EUPAS29784; the Federal Institute for Drugs and Medical Devices (BfArM): NIS Study No 7305; Clinicaltrials.gov: NCT03954132.…”
Publicado 2020
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23302por Abendschön, Nora, Senf, Steffanie, Deffner, Pauline, Miller, Regina, Grott, Andrea, Werner, Julia, Saller, Anna M., Reiser, Judith, Weiß, Christine, Zablotski, Yury, Fischer, Johannes, Bergmann, Shana, Erhard, Michael H., Baumgartner, Christine, Ritzmann, Mathias, Zöls, Susanne“…SIMPLE SUMMARY: More than 80 million male piglets are castrated every year within the first week of life mostly without pain relief in the EU. Castration is performed to prevent boar taint, to minimize aggressive and sexual behavior associated with intact males and to gain a constant quality of meat. …”
Publicado 2020
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23303por Herrington, William G., Staplin, Natalie, Wanner, Christoph, Green, Jennifer B., Hauske, Sibylle J., Emberson, Jonathan R., Preiss, David, Judge, Parminder, Mayne, Kaitlin J., Ng, Sarah Y.A., Sammons, Emily, Zhu, Doreen, Hill, Michael, Stevens, Will, Wallendszus, Karl, Brenner, Susanne, Cheung, Alfred K., Liu, Zhi-Hong, Li, Jing, Hooi, Lai Seong, Liu, Wen, Kadowaki, Takashi, Nangaku, Masaomi, Levin, Adeera, Cherney, David, Maggioni, Aldo P., Pontremoli, Roberto, Deo, Rajat, Goto, Shinya, Rossello, Xavier, Tuttle, Katherine R., Steubl, Dominik, Petrini, Michaela, Massey, Dan, Eilbracht, Jens, Brueckmann, Martina, Landray, Martin J., Baigent, Colin, Haynes, Richard“…(Funding:Boehringer Ingelheim, Eli Lilly and others; Clinicaltrials.gov:NCT03594110, EuDRACT: 2017-002971-24).…”
Publicado 2023
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23304“…Science and regulation are in continuous exchange on the development of AIT products that correspond to the current state of clinical research and regulation in the EU and enable early causal treatment of widespread allergies.…”
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23305“…Application of analgesics in frame of the animal welfare act (European directive 2010/63/EU) is more and more becoming a matter of debate. …”
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23306por Jackson, Isaac M., Lee, So Jeong, Sowa, Alexandra R., Rodnick, Melissa E., Bruton, Laura, Clark, Mara, Preshlock, Sean, Rothley, Jill, Rogers, Virginia E., Botti, Leslie E., Henderson, Bradford D., Hockley, Brian G., Torres, Jovany, Raffel, David M., Brooks, Allen F., Frey, Kirk A., Kilbourn, Michael R., Koeppe, Robert A., Shao, Xia, Scott, Peter J. H.“…BACKGROUND: In the US, EU and elsewhere, basic clinical research studies with positron emission tomography (PET) radiotracers that are generally recognized as safe and effective (GRASE) can often be conducted under institutional approval. …”
Publicado 2020
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23307por Al-Jallad, Tamara, Kassouha, Morshed, Salhab, Mohamad, Alomar, Anouar, AL-Masalma, Mouhamad, Abdelaziz, Fahim“…The IBV isolates showed sequence similarity between the Syrian isolates that vary from 96.20 to 100%, and those being closer to the Variant-2 strain IS/1494/06 (EU780077.2) with 97.5 to 99.4% similarities. However, less nucleotide identity was found with sequences belonging to the used vaccine strains such as H120, Mass5, and 4/91. …”
Publicado 2020
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23308“…TRIAL REGISTRATION: Registration number 2010–023311-34 at the EU Clinical Trials Register, registration date 2010-12-21.…”
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23309por Čečrle, Michal, Černý, Dalibor, Sedláčková, Eva, Míková, Barbora, Dudková, Vlasta, Drncová, Eva, Pokusová, Michala, Skalský, Ivo, Tamášová, Jana, Halačová, Milada“…This trial may help to open up a wider range of postoperative healing issues. TRIAL REGISTRATION: EU Clinical Trials Register, EUDRA CT No: 2016-002606-39. …”
Publicado 2020
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23310por Russo, Giulia, Sgroi, Giuseppe, Parasiliti Palumbo, Giuseppe Alessandro, Pennisi, Marzio, Juarez, Miguel A., Cardona, Pere-Joan, Motta, Santo, Walker, Kenneth B., Fichera, Epifanio, Viceconti, Marco, Pappalardo, Francesco“…Over the years, Mycobacterium tuberculosis has developed a form of resistance to first-line tuberculosis treatments, specifically to isoniazid, leading to multi-drug-resistant tuberculosis. In this context, the EU and Indian DBT funded project STriTuVaD—In Silico Trial for Tuberculosis Vaccine Development—is supporting the identification of new interventional strategies against tuberculosis thanks to the use of Universal Immune System Simulator (UISS), a computational framework capable of predicting the immunity induced by specific drugs such as therapeutic vaccines and antibiotics. …”
Publicado 2020
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23311por Baldinelli, Francesca, Papanikolaou, Aleksandra, Stoicescu, Anca, Van der Stede, Yves, Aznar, Inma“…Council Directive 2005/94/EC requires EU Member States (MSs) to carry out surveillance in poultry and wild birds and notify the results to the responsible authority. …”
Publicado 2020
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23312por Nava, Chiara, Modiano Hedenmalm, Astrid, Borys, Franciszek, Hooft, Lotty, Bruschettini, Matteo, Jenniskens, Kevin“…Only two of the studies showed an MARD lower than 10%, with none of the five CGM devices studied satisfying the European Union (EU) ISO 15197 requirements. Pooled sensitivity and specificity of CGM devices for hypoglycaemia were 0.39 and 0.99, whereas for hyperglycaemia were 0.87 and 0.99, respectively. …”
Publicado 2020
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23313por Devereux, Graham, Wrolstad, Danielle, Bourke, Stephen J., Daines, Cori L., Doe, Simon, Dougherty, Ryan, Franco, Rose, Innes, Alastair, Kopp, Benjamin T., Lascano, Jorge, Layish, Daniel, MacGregor, Gordon, Murray, Lorna, Peckham, Daniel, Lucidi, Vincenzina, Lovie, Emma, Robertson, Jennifer, Fraser-Pitt, Douglas J., O'Neil, Deborah A.“…Eighty nine participants in fifteen US and EU centres were randomized, 78 completed the 14-day treatment period. …”
Publicado 2020
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23314por Maina, G., Rosso, G., Carezana, C., Mehanović, E., Risso, F., Villari, V., Gariglio, L., Cardano, M.“…BACKGROUND: Despite the EU recommendations on mental health, involuntary admission has been under researched in Italy for a long time and the overall picture of involuntary admission still appears fragmentary. …”
Publicado 2021
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23315por Gautam, Vaishali, S, Dileepan, Rustagi, Neeti, Mittal, Ankit, Patel, Mehul, Shafi, Shazia, Thirunavukkarasu, Prasanna, Raghav, Pankaja“…Telephonic interviews of participants were conducted to determine their health literacy using HLS-EU-Q47 questionnaire, adherence to COVID-19 preventive behaviour as per World Health Organization recommendations, and compliance to prescribed pharmacological and physical activity recommendations for chronic disease. …”
Publicado 2021
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23316por Mleczek, Mirosław, Gąsecka, Monika, Budka, Anna, Siwulski, Marek, Mleczek, Patrycja, Magdziak, Zuzanna, Budzyńska, Sylwia, Niedzielski, Przemysław“…Only 27 of the elements (Ag, Al, Ba, Ca, Cd, Cu, Fe, In, K, La, Mg, Mn, Na, Nd, Ni, P, Pb, Pr, Pt, Rh, Sr, Ti, Tm, V, Y, Zn, and Zr) were detected in all mushroom species, while others (As, Au, B, Be, Bi, Ce, Co, Cr, Dy, Er, Eu, Ga, Gd, Ge, Hf, Ho, Ir, Li, Lu, Mo, Os, Pb, Rb, Re, Ru, Sb, Sc, Se, Sm, Tb, Te, Th, Tl, Tm, U, and Yb) were below the limit of detection in the fruit bodies of at least one species. …”
Publicado 2020
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23317“…Immunogenicity and safety data were summarized across one Phase II and four Phase III randomized, active-comparator-controlled clinical trials (Protocol 004 in Canada [Control: PENTACEL™]; Protocols 005 and 006 in the US [Control: PENTACEL™]; and Protocols 007 and 008 in the EU [Control: INFANRIX™ hexa]) and one Phase III clinical trial in the UK (PRI01C); no formal statistical comparisons were performed. …”
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23318“…BACKGROUND: Although the tearing of tissues during castration is forbidden in the EU, it is still routinely applied in many countries. …”
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23319por Toma, Maddalena, Felisi, Mariagrazia, Bonifazi, Donato, Bonifazi, Fedele, Giannuzzi, Viviana, Reggiardo, Giorgio, de Wildt, Saskia, Ceci, Adriana“…However, the reasons for the limited development of paediatric medicines in Europe, should be further discussed, taking advantage of recent initiatives in the regulatory field, such as the Action Plan on Paediatrics, and the open consultation on EU Pharmaceutical Strategy.…”
Publicado 2021
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23320por Kopilaš, Vanja, Hasratian, Anni M., Martinelli, Lucia, Ivkić, Goran, Brajković, Lovorka, Gajović, Srećko“…The online survey was applied during the ascending phase of the pandemic in March 2020 in two neighboring EU countries: Italy and Croatia. The study subjects involved four groups, two directly affected by epidemiological measures and two serving as controls—(1) participants from Italy who were in lockdown (Italy group), (2) participants from Croatia who were not in lockdown but who were in direct contact with an infected person and underwent epidemiological measures (CRO-contact group), (3) participants from Croatia who were in an analogous situation but not near the same infected person (CRO-no contact group), and (4) participants from Croatia who were not aware of any infected person (CRO-unrelated group). …”
Publicado 2021
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