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  1. 23301
    “…TRIAL REGISTRATION: The European Union electronic Register of Post-authorisation Studies (EU PAS Register): EUPAS29784; the Federal Institute for Drugs and Medical Devices (BfArM): NIS Study No 7305; Clinicaltrials.gov: NCT03954132.…”
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    A Non-Interventional Study of Tiotropium/Olodaterol versus Any Triple Combination Therapy for Chronic Obstructive Pulmonary Disease: The EVELUT(®) Study Protocol
  2. 23302
    “…SIMPLE SUMMARY: More than 80 million male piglets are castrated every year within the first week of life mostly without pain relief in the EU. Castration is performed to prevent boar taint, to minimize aggressive and sexual behavior associated with intact males and to gain a constant quality of meat. …”
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    Local Anesthesia in Piglets Undergoing Castration—A Comparative Study to Investigate the Analgesic Effects of Four Local Anesthetics Based on Defensive Behavior and Side Effects
  3. 23303
    “…(Funding:Boehringer Ingelheim, Eli Lilly and others; Clinicaltrials.gov:NCT03594110, EuDRACT: 2017-002971-24).…”
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    Empagliflozin in Patients with Chronic Kidney Disease
  4. 23304
    “…Science and regulation are in continuous exchange on the development of AIT products that correspond to the current state of clinical research and regulation in the EU and enable early causal treatment of widespread allergies.…”
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    Immuntherapien von Allergien: Aktueller Stand
  5. 23305
    “…Application of analgesics in frame of the animal welfare act (European directive 2010/63/EU) is more and more becoming a matter of debate. …”
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    Opioid-Induced Immunomodulation: Consequences for the Experimental Coxsackievirus B3-Induced Myocarditis Model
  6. 23306
    “…BACKGROUND: In the US, EU and elsewhere, basic clinical research studies with positron emission tomography (PET) radiotracers that are generally recognized as safe and effective (GRASE) can often be conducted under institutional approval. …”
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    Use of 55 PET radiotracers under approval of a Radioactive Drug Research Committee (RDRC)
  7. 23307
    “…The IBV isolates showed sequence similarity between the Syrian isolates that vary from 96.20 to 100%, and those being closer to the Variant-2 strain IS/1494/06 (EU780077.2) with 97.5 to 99.4% similarities. However, less nucleotide identity was found with sequences belonging to the used vaccine strains such as H120, Mass5, and 4/91. …”
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    Molecular characterization of isolated infectious bronchitis viruses from affected vaccinated broiler flocks in Syria
  8. 23308
    “…TRIAL REGISTRATION: Registration number 2010–023311-34 at the EU Clinical Trials Register, registration date 2010-12-21.…”
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    Pharmacodynamic and pharmacokinetic behavior of landiolol during dobutamine challenge in healthy adults
  9. 23309
    “…This trial may help to open up a wider range of postoperative healing issues. TRIAL REGISTRATION: EU Clinical Trials Register, EUDRA CT No: 2016-002606-39. …”
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    Vitamin D for prevention of sternotomy healing complications: REINFORCE-D trial
  10. 23310
    “…Over the years, Mycobacterium tuberculosis has developed a form of resistance to first-line tuberculosis treatments, specifically to isoniazid, leading to multi-drug-resistant tuberculosis. In this context, the EU and Indian DBT funded project STriTuVaD—In Silico Trial for Tuberculosis Vaccine Development—is supporting the identification of new interventional strategies against tuberculosis thanks to the use of Universal Immune System Simulator (UISS), a computational framework capable of predicting the immunity induced by specific drugs such as therapeutic vaccines and antibiotics. …”
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    Moving forward through the in silico modeling of tuberculosis: a further step with UISS-TB
  11. 23311
    “…Council Directive 2005/94/EC requires EU Member States (MSs) to carry out surveillance in poultry and wild birds and notify the results to the responsible authority. …”
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    Annual Report on surveillance for Avian Influenza in poultry and wild birds in Member States of the European Union in 2019
  12. 23312
    “…Only two of the studies showed an MARD lower than 10%, with none of the five CGM devices studied satisfying the European Union (EU) ISO 15197 requirements. Pooled sensitivity and specificity of CGM devices for hypoglycaemia were 0.39 and 0.99, whereas for hyperglycaemia were 0.87 and 0.99, respectively. …”
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    Accuracy of continuous glucose monitoring in preterm infants: a systematic review and meta-analysis
  13. 23313
    “…Eighty nine participants in fifteen US and EU centres were randomized, 78 completed the 14-day treatment period. …”
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    Oral cysteamine as an adjunct treatment in cystic fibrosis pulmonary exacerbations: An exploratory randomized clinical trial
  14. 23314
    “…BACKGROUND: Despite the EU recommendations on mental health, involuntary admission has been under researched in Italy for a long time and the overall picture of involuntary admission still appears fragmentary. …”
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    Factors associated with involuntary admissions: a register-based cross-sectional multicenter study
  15. 23315
    “…Telephonic interviews of participants were conducted to determine their health literacy using HLS-EU-Q47 questionnaire, adherence to COVID-19 preventive behaviour as per World Health Organization recommendations, and compliance to prescribed pharmacological and physical activity recommendations for chronic disease. …”
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    Health literacy, preventive COVID 19 behaviour and adherence to chronic disease treatment during lockdown among patients registered at primary health facility in urban Jodhpur, Rajasthan
  16. 23316
    “…Only 27 of the elements (Ag, Al, Ba, Ca, Cd, Cu, Fe, In, K, La, Mg, Mn, Na, Nd, Ni, P, Pb, Pr, Pt, Rh, Sr, Ti, Tm, V, Y, Zn, and Zr) were detected in all mushroom species, while others (As, Au, B, Be, Bi, Ce, Co, Cr, Dy, Er, Eu, Ga, Gd, Ge, Hf, Ho, Ir, Li, Lu, Mo, Os, Pb, Rb, Re, Ru, Sb, Sc, Se, Sm, Tb, Te, Th, Tl, Tm, U, and Yb) were below the limit of detection in the fruit bodies of at least one species. …”
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    Mineral composition of elements in wood-growing mushroom species collected from of two regions of Poland
  17. 23317
    “…Immunogenicity and safety data were summarized across one Phase II and four Phase III randomized, active-comparator-controlled clinical trials (Protocol 004 in Canada [Control: PENTACEL™]; Protocols 005 and 006 in the US [Control: PENTACEL™]; and Protocols 007 and 008 in the EU [Control: INFANRIX™ hexa]) and one Phase III clinical trial in the UK (PRI01C); no formal statistical comparisons were performed. …”
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    Safety and immunogenicity of a fully-liquid DTaP-IPV-Hib-HepB vaccine (Vaxelis™) in premature infants
  18. 23318
    “…BACKGROUND: Although the tearing of tissues during castration is forbidden in the EU, it is still routinely applied in many countries. …”
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    Impact of tearing spermatic cords during castration in live and dead piglets and consequences on welfare
  19. 23319
    “…However, the reasons for the limited development of paediatric medicines in Europe, should be further discussed, taking advantage of recent initiatives in the regulatory field, such as the Action Plan on Paediatrics, and the open consultation on EU Pharmaceutical Strategy.…”
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    Paediatric Medicines in Europe: The Paediatric Regulation—Is It Time for Reform?
  20. 23320
    “…The online survey was applied during the ascending phase of the pandemic in March 2020 in two neighboring EU countries: Italy and Croatia. The study subjects involved four groups, two directly affected by epidemiological measures and two serving as controls—(1) participants from Italy who were in lockdown (Italy group), (2) participants from Croatia who were not in lockdown but who were in direct contact with an infected person and underwent epidemiological measures (CRO-contact group), (3) participants from Croatia who were in an analogous situation but not near the same infected person (CRO-no contact group), and (4) participants from Croatia who were not aware of any infected person (CRO-unrelated group). …”
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    Self-Perceived Mental Health Status, Digital Activity, and Physical Distancing in the Context of Lockdown Versus Not-in-Lockdown Measures in Italy and Croatia: Cross-Sectional Study in the Early Ascending Phase of the COVID-19 Pandemic in March 2020
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