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23761“…At present, there are only a few existing dementia-specific research guidelines (Committee for Medicinal Products for Human Use in Clinical investigation of medicines for the treatment Alzheimer’s disease (Internet). https://www.ema.europa.eu/en/clinical-investigation-medicines-treatment-alzheimers-disease; Food and Drug Administration, Early Alzheimer’s Disease: Developing Drugs for Treatment Guidance for Industry [Internet]. http://www.fda.gov/regulatory-information/search-fda-guidance-documents/alzheimers-disease-developing-drugs-treatment-guidance-industy), necessitating a more systematic and comprehensive approach to this topic to help researchers and stakeholders address dementia-specific ethical issues in research. …”
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23762por Heinrich, Maria, Müller, Anika, Cvijan, Andela, Mörgeli, Rudolf, Kruppa, Jochen, Winterer, Georg, Slooter, Arjen J. C., Spies, Claudia D.“…METHODS: This investigation was part of the European BioCog project (http://www.biocog.eu), a prospective multicenter observational study in older adult surgical patients (ClinicalTrials.gov identifier: NCT02265263, 15 October 2014). …”
Publicado 2021
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23763por Barabássy, Ágota, Sebe, Barbara, Acsai, Károly, Laszlovszky, István, Szatmári, Balázs, Earley, Willie R, Németh, György“…Cariprazine is a potent dopamine D(3)/D(2) receptor partial agonist that is approved for the treatment of adults with schizophrenia (EU, US) and acute manic/mixed and depressive episodes associated with bipolar I disorder (US). …”
Publicado 2021
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23764por Méroc, Estelle, Fröberg, Janeri, Almasi, Timea, Winje, Brita Askeland, Orrico-Sánchez, Alejandro, Steens, Anneke, McDonald, Scott A., Bollaerts, Kaatje, Knol, Mirjam J.“…CONCLUSION: This study provides an exhaustive overview of the available data sources and data gaps for the estimation of BoD of five (P) VPD in ageing adults in the EU/EAA, which is useful to guide pathogen-specific BoD studies and contribute to calculation of (P)VPDs BoD. …”
Publicado 2021
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23765“…METHODS: In the present work, a case study was performed on Bisphenol AF (BPAF) to explore the application of the EU criteria and EFSA/ECHA guidance document for the ED assessment of a non-pesticide chemical regulated under REACH. …”
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23766por Giannuzzi, Viviana, Felisi, Mariagrazia, Bonifazi, Donato, Devlieger, Hugo, Papanikolaou, George, Ragab, Lamis, Fattoum, Slaheddine, Tempesta, Bianca, Reggiardo, Giorgio, Ceci, Adriana“…The upcoming application of Regulation (EU) 536/2014 is expected to harmonise practices in Europe and possibly outside. …”
Publicado 2021
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23767por Desmecht, Daniel, Gerbier, Guillaume, Gortázar Schmidt, Christian, Grigaliuniene, Vilija, Helyes, Georgina, Kantere, Maria, Korytarova, Daniela, Linden, Annick, Miteva, Aleksandra, Neghirla, Ioana, Olsevskis, Edvins, Ostojic, Sasa, Petit, Tom, Staubach, Christoph, Thulke, Hans‐Hermann, Viltrop, Arvo, Richard, Wallo, Wozniakowski, Grzegorz, Cortiñas, José Abrahantes, Broglia, Alessandro, Dhollander, Sofie, Lima, Eliana, Papanikolaou, Alexandra, Van der Stede, Yves, Ståhl, Karl“…An update on the African swine fever (ASF) situation in the 10 affected Member States (MS) in the EU and in two neighbouring countries from the 1 September 2019 until the 31 August 2020 is provided. …”
Publicado 2021
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23768por Sturesson, Linda, Palmgren, Per J., Öhlander, Magnus, Nilsson, Gunnar H., Stenfors, Terese“…The aim of this study was to explore aspects that influence MPs’, with a medical degree from outside EU/EEA, choice of employment and medical specialty in Sweden, and to explore and understand a potential over-representation in general practice (family medicine), a specialty suffering from staff shortages in Sweden. …”
Publicado 2021
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23769por Bertelsen, Natasha, Landi, Isotta, Bethlehem, Richard A. I., Seidlitz, Jakob, Busuoli, Elena Maria, Mandelli, Veronica, Satta, Eleonora, Trakoshis, Stavros, Auyeung, Bonnie, Kundu, Prantik, Loth, Eva, Dumas, Guillaume, Baumeister, Sarah, Beckmann, Christian F., Bölte, Sven, Bourgeron, Thomas, Charman, Tony, Durston, Sarah, Ecker, Christine, Holt, Rosemary J., Johnson, Mark H., Jones, Emily J. H., Mason, Luke, Meyer-Lindenberg, Andreas, Moessnang, Carolin, Oldehinkel, Marianne, Persico, Antonio M., Tillmann, Julian, Williams, Steve C. R., Spooren, Will, Murphy, Declan G. M., Buitelaar, Jan K., Baron-Cohen, Simon, Lai, Meng-Chuan, Lombardo, Michael V.“…Applying this model to resting state fMRI data from the EU-AIMS LEAP dataset (n = 509), we find that while the phenotypic subtypes share many commonalities in terms of intrinsic functional connectivity, they also show replicable differences within some networks compared to a typically-developing group (TD). …”
Publicado 2021
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23770“…WIDER IMPLICATIONS OF THE FINDINGS: This study highlights the need for consistent EU regulations and guidelines that allow genetic matching of gamete donors to their recipients, preventing the need to reject donors who are known carriers. …”
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23771por van Schalkwyk, May C. I., Barlow, Pepita, Siles-Brügge, Gabriel, Jarman, Holly, Hervey, Tamara, McKee, Martin“…The UK’s departure from the EU provides a rare opportunity to examine a context where trade governance arrangements are being created anew, and to explore the consequences of governance choices and structures for health and social justice. …”
Publicado 2021
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23772por Farrell, Emma, Bustillo, Marta, le Roux, Carel W., Nadglowski, Joe, Hollmann, Eva, McGillicuddy, Deirdre“…DISCUSSION: The findings from this synthesis will be used to inform the EU Innovative Medicines Initiative (IMI)-funded SOPHIA (Stratification of Obesity Phenotypes to Optimize Future Obesity Therapy) study. …”
Publicado 2021
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23773“…However, they present significant weaknesses and faults. For years, the EU has been prioritizing programs for the prevention of damage caused by large carnivores, rather than compensation programs, introducing compulsory compensation for the purposes of decision EC (2019) 772 of 29/01/19. …”
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23774por van de Wiel, Willemine, Castillo-Laborde, Carla, Francisco Urzúa, I., Fish, Michelle, Scholte, Willem F.“…BACKGROUND: Ever since the implementation of the EU-Turkey deal, most refugees that enter Greece via sea are confined to the island on which they arrive until their asylum claims are adjudicated, where they generally reside in camps. …”
Publicado 2021
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23775por Jackson, Graham H., Davies, Faith E., Pawlyn, Charlotte, Cairns, David A., Striha, Alina, Collett, Corinne, Waterhouse, Anna, Jones, John R., Kishore, Bhuvan, Garg, Mamta, Williams, Cathy D., Karunanithi, Kamaraj, Lindsay, Jindriska, Allotey, David, Shafeek, Salim, Jenner, Matthew W., Cook, Gordon, Russell, Nigel H., Kaiser, Martin F., Drayson, Mark T., Owen, Roger G., Gregory, Walter M., Morgan, Gareth J.“…The trial was registered with the EU Clinical Trials Register (EudraCT 2009-010956-93) and ISRCTN49407852.…”
Publicado 2021
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23776por Chi, Susan, Hsieh, Antony, Foley, Megan, Shi, Hongliang, Swamy, Preethi, Rodstrom, Jill, Rudoltz, Marc“…Avapritinib is approved for the treatment of adults with unresectable/metastatic gastrointestinal stromal tumors (GIST) harboring PDGFRA exon 18 mutations (including D842V) in the USA based on an overall response rate ³84% with 59% response durations >6 months, and in the EU for adults with unresectable/metastatic GIST harboring a PDGFRA D842V mutation. …”
Publicado 2021
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23777por De Francesco, Silvia, Galluzzi, Samantha, Vanacore, Nicola, Festari, Cristina, Rossini, Paolo Maria, Cappa, Stefano F., Frisoni, Giovanni B., Redolfi, Alberto“…The aim of this study was to set norms, established from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) population, for hippocampal volume measured with FS v.6.0 and AA tools in the neuGRID platform (www.neugrid2.eu) and demonstrate their applicability for the Italian population. …”
Publicado 2021
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23778por Reetz, Jana, Richter, Gesine, Borzikowsky, Christoph, Glinicke, Christine, Darabaneanu, Stephanie, Buyx, Alena“…BACKGROUND: The EU’s 2006 Paediatric Regulation aims to support authorisation of medicine for children, thus effectively increasing paediatric research. …”
Publicado 2021
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23779“…Genomes exhibit highly various recombination profiles along chromosomes associated with several chromatin states. However, eu-heterochromatin boundaries are not available nor easily provided for non-model organisms, especially for newly sequenced ones. …”
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23780Threshold-dependent iodine imaging and spectral separation in a whole-body photon-counting CT systempor Sawall, S., Klein, L., Wehrse, E., Rotkopf, L. T., Amato, C., Maier, J., Schlemmer, H.-P., Ziener, C. H., Heinze, S., Kachelrieß, M.“…The system comprises a PC detector with two energy bins (20 keV, T) and (T, eU) with threshold T and tube voltage U. Measurements using the PCCT are performed at all available tube voltages (80 to 140 kV) and threshold settings (50–90 keV). …”
Publicado 2021
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