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  1. 23981
    “…TRIAL REGISTRATION: https://eudract.ema.europa.eu (EudraCT- Nr. 2011–003238-15); October 24th, 2012.…”
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    Combatting pain after orthopedic/trauma surgery- perioperative oral extended-release tapentadol vs. extended-release oxycodone/naloxone
  2. 23982
    “…Furthermore it may provide understanding of efficacy and tolerability of chemotherapy in older cancer patients and thus offer a better chance for tailored treatment strategies in these patients. TRIAL REGISTRATION: EU Clinical Trial Register, EudraCT no. 2014–000394-39. …”
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    Randomized study comparing full dose monotherapy (S-1 followed by irinotecan) and reduced dose combination therapy (S-1/oxaliplatin followed by S-1/irinotecan) as initial therapy for older patients with metastatic colorectal cancer: NORDIC 9
  3. 23983
    “…METHODS: A diagnostic gene expression signature (BRCA1ness) was developed using a centroid model with 128 triple-negative breast cancer samples from the EU FP7 RATHER project. This BRCA1ness signature was then tested in HER2-negative patients (n = 116) from the I-SPY 2 TRIAL who received an oral PARP inhibitor veliparib in combination with carboplatin (V-C), or standard chemotherapy alone. …”
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    The BRCA1ness signature is associated significantly with response to PARP inhibitor treatment versus control in the I-SPY 2 randomized neoadjuvant setting
  4. 23984
    “…Clinical Trial Registration URL: https://eudract.ema.europa.eu. Unique identifier: 2011-000887-92…”
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    Dose escalation study of intravenous and intra-arterial N-acetylcysteine for the prevention of oto- and nephrotoxicity of cisplatin with a contrast-induced nephropathy model in patients with renal insufficiency
  5. 23985
    “…This interval time was based on EU regulations and the goal set by the government of Japan. …”
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    Relationship between menstruation status and work conditions in Japan
  6. 23986
    “…However, it was found that EU and CIMMYT germplasm has high breeding potential to improve yield performance in Central and Southern regions. …”
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    GWAS for plant growth stages and yield components in spring wheat (Triticum aestivum L.) harvested in three regions of Kazakhstan
  7. 23987
    “…Other knowledge and tools developed in the project will be made available via the project website (www.bluehealth2020.eu). Project results will ultimately provide key inputs to planning and policy relating to blue space, further stimulating the integration of environmental and health considerations into decision-making, such that blue infrastructure is developed across Europe with both public health and the environment in mind.…”
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    BlueHealth: a study programme protocol for mapping and quantifying the potential benefits to public health and well-being from Europe’s blue spaces
  8. 23988
    “…ABSTRACT: Urgent development of alternative on-farm killing methods for poultry is required following the number restrictions placed on the use of traditional manual cervical dislocation by European Legislation (EU 1099/2009). Alternatives must be proven to be humane and, crucially, practical in commercial settings with multiple users. …”
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    On Farm Evaluation of a Novel Mechanical Cervical Dislocation Device for Poultry
  9. 23989
    “…The lipid produced by M. buryatense was estimated to have a cetane number of 75, which is 50% higher than biofuel standards requested by US and EU. CONCLUSIONS: Cell growth and lipid production were significantly influenced by culture conditions for both 5GB1 and AP18. …”
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    Enhanced biological fixation of methane for microbial lipid production by recombinant Methylomicrobium buryatense
  10. 23990
    “…BACKGROUND: Titanium dioxide (TiO(2)) particles are commonly used as a food additive (E171 in the EU) for its whitening and opacifying properties. …”
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    Food-grade TiO(2) is trapped by intestinal mucus in vitro but does not impair mucin O-glycosylation and short-chain fatty acid synthesis in vivo: implications for gut barrier protection
  11. 23991
    “…Not prospectively registered. http://www.encepp.eu/encepp/viewResource.htm?id=16229 ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13223-018-0262-9) contains supplementary material, which is available to authorized users.…”
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    An observational cohort study of the use of five-grass-pollen extract sublingual immunotherapy during the 2015 pollen season in France
  12. 23992
    “…The preparations were found to be sterile and have a pyrogen level <0.50 EU/mL. Cell binding was retained by the (211)At-BC8-B10. (211)At-BC8-B10 in ascorbic acid solution demonstrated a radiochemical stability of >95% for up to 21 h at room temperature. …”
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    cGMP production of astatine-211-labeled anti-CD45 antibodies for use in allogeneic hematopoietic cell transplantation for treatment of advanced hematopoietic malignancies
  13. 23993
    “…SUBJECTS/METHODS: Data were drawn from the EU Childhood Obesity Project (CHOP). PA and SB were measured with the SenseWear Armband 2 at the ages of 6 (T1), 8 (T2) and 11 (T3) years. …”
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    Longitudinal analysis of physical activity, sedentary behaviour and anthropometric measures from ages 6 to 11 years
  14. 23994
    “…INTRODUCTION: Healthcare workers account for 10% of the EU’s total workforce, with a significant proportion of those employed in hospitals. …”
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    Musculoskeletal injuries and absenteeism among healthcare professionals—ICD-10 characterization
  15. 23995
    “…Bayesian networks were estimated for the complete (23,865 EU-citizens with complete data) sample and for sex- and four age-specific subgroups. …”
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    Factors influencing sedentary behaviour: A system based analysis using Bayesian networks within DEDIPAC
  16. 23996
    “…TRIAL REGISTRATION: Clinicaltrials.gov: NCT02306720, December 2014; ENCePP.eu: EUPAS13526, May 2016 (retrospectively registered).…”
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    Diagnostic delay is common among patients with hypophosphatasia: initial findings from a longitudinal, prospective, global registry
  17. 23997
    “…Pregabalin is endorsed as first-line therapy for these indications by several US and EU medical professional societies. However, restriction policies such as prior authorization (PA) and step therapy (ST) often favor less costly generic pain medications over pregabalin. …”
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    A systematic review of the effectiveness of policies restricting access to pregabalin
  18. 23998
    “…RESULTS: In this paper, we analysed an extensive collection of full genome gene-expression data (RNA-seq) and DNA methylation data of genomic CpG islands (using Illumina methylation arrays) generated from a sample of tumor and normal gut epithelial tissues of 300 patients with colorectal cancer (at different stages of the disease) (data generated in the EU-supported SysCol project). Identification of potential epigenetic biomarkers of DNA methylation was performed using the fully automatic multi-omics analysis web service “My Genome Enhancer” (MGE) (my-genome-enhancer.com). …”
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    Walking pathways with positive feedback loops reveal DNA methylation biomarkers of colorectal cancer
  19. 23999
    “…Translational research is performed to discover biomarkers related to the mode of action of the combination. TRIAL REGISTRATION: EU Clinical Trials Register: EudraCT 2016-001569-97, registered on 19-6-2017. …”
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    PRIMMO study protocol: a phase II study combining PD-1 blockade, radiation and immunomodulation to tackle cervical and uterine cancer
  20. 24000
    “…The clinical importance of these findings needs further investigation. TRIAL REGISTRATION: (EU Clinical trials register number: 2015–002585-23, registered on 5th November 2015)…”
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    Effect of 3% saline and furosemide on biomarkers of kidney injury and renal tubular function and GFR in healthy subjects – a randomized controlled trial
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