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2261Docking-guided rational engineering of a macrolide glycosyltransferase glycodiversifies epothilone Bpor Zhang, Peng, Zhang, Lijuan, Jiang, Xukai, Diao, Xiao-tong, Li, Shuang, Li, Dan-dan, Zhang, Zheng, Fang, Junqiang, Tang, Ya-jie, Wu, Da-lei, Wu, Changsheng, Li, Yue-zhong“…Glycosyltransferases typically display acceptor substrate flexibility but more stringent donor specificity. BsGT-1 is a highly effective glycosyltransferase to glycosylate macrolides, including epothilones, promising antitumor compounds. …”
Publicado 2022
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2262por Miyata, Kohei, Ikoma, Yoko, Murata, Koshi, Kusumoto-Yoshida, Ikue, Kobayashi, Kenta, Kuwaki, Tomoyuki, Ootsuka, Youichirou“…A low dose of METH induced hyperthermia and tachycardia responses in ORX;vGT2-KO mice, which were significant compared to ORX-KO and WT mice. …”
Publicado 2022
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2263por Sugimoto, Koichi, Zager, Jordan J, Aubin, Brian St, Lange, Bernd Markus, Howe, Gregg A“…The most conspicuous structure on leaves of cultivated tomato (Solanum lycopersicum) is the type-VI GT (tVI-GT), which accumulates both flavonoids and volatile terpenoids. …”
Publicado 2021
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2264por Ranjkesh, Bahram, Haddadi, Yasser, Krogsgaard, Christian-Aalund, Schurmann, Andreas, Bahrami, Golnosh“…RESULTS: The fracture resistance of teeth with single FRC (Rebilda Post) and bundled FRC (Rebilda Post GT) were 787 ± 156 and 850 ± 166 Newton, respectively. …”
Publicado 2022
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2265por Feng, Yi, Zhang, Hanxi, Xie, Xiaoxue, Chen, Yu, Yang, Geng, Wei, Xiaodan, Li, Ningxi, Li, Mengyue, Li, Tingting, Qin, Xiang, Li, Shun, You, Fengming, Wu, Chunhui, Yang, Hong, Liu, Yiyao“…Moreover, the GSH depletion in tumor tissues induced by L-Arg/MB@MP biodegradation can cooperate with GT to amplify the therapeutic effect of PDT. These results demonstrate that this “nanobomb” provides new ideas for clinical translation to treat tumor patients in terms of synergistic PDT-GT nanotherapy in hypoxic-solid tumors.…”
Publicado 2022
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2266por Rau, Monika, Buggisch, Peter, Mauss, Stefan, Boeker, Klaus H. W., Klinker, Hartwig, Müller, Tobias, Stoehr, Albrecht, Schattenberg, Jörn M., Geier, Andreas“…RESULTS: At the time of study inclusion 12.3% (n = 962) of HCV patients presented with steatosis (+S) (higher rate in GT-3). Diabetes mellitus was more frequent in GT-1 patients. …”
Publicado 2022
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2267por Dupas, Thomas, Persello, Antoine, Blangy-Letheule, Angélique, Denis, Manon, Erraud, Angélique, Aillerie, Virginie, Leroux, Aurélia A., Rivière, Matthieu, Lebreton, Jacques, Tessier, Arnaud, Rozec, Bertrand, Lauzier, Benjamin“…One hour after, rats were assigned to no therapy or fluidotherapy (NaCl 0.9%, 10 mL.kg(−1)) ± NButGT (10 mg·kg(−1)) to stimulate O-GlcNAc levels. …”
Publicado 2022
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2268por Samadbeik, Mahnaz, Garavand, Ali, Aslani, Nasim, Ebrahimzadeh, Farzad, Fatehi, Farhad“…INTRODUCTION: Google Trends (GT) is an important free tool for online search behavior analysis, which provides access to Internet search patterns in Google. …”
Publicado 2022
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2269por Barootchi, Shayan, Tavelli, Lorenzo, Di Gianfilippo, Riccardo, Shedden, Kerby, Oh, Tae‐Ju, Rasperini, Giulio, Neiva, Rodrigo, Giannobile, William V., Wang, Hom‐Lay“…AIC‐driven model selection and regression analyses demonstrated that 6‐month keratinized tissue width (KTW) and gingival thickness (GT) influenced the trajectory of the gingival margin similarly in a concave manner; however, GT was the driving determinant that predicted significantly less relapse in the treatments, with stability of the treated gingival margin obtained beyond values of 1.46 mm. …”
Publicado 2022
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2270por Yao, Yu, Gu, Jiajun, Luo, Yanjiao, Wang, Yuanyue, Pang, Yongzhen, Shen, Guoan, Guo, Baolin“…The optimal temperature, pH, k(m) and V(max) were determined for the recombinant EpGT60 protein. In addition, expression of recombinant EpGT60 in E. coli cell culture led to successful production of baohuoside II when fed 8-prenylkaempferol. …”
Publicado 2022
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2271por Gauci, Marc-Olivier, Jacquot, Adrien, Boux de Casson, François, Deransart, Pierric, Letissier, Hoël, Berhouet, Julien“…The transverse axis was generated either from the identified landmarks (Glenoid-Trigonum line (GT-line), Best-Fit Line Fossa (BFLF)) or by an automatic software (Y-axis). …”
Publicado 2022
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2272por Sarki, Mahesh, Ming, Chang, Aceti, Monica, Fink, Günther, Aissaoui, Souria, Bürki, Nicole, Graffeo, Rossella, Heinimann, Karl, Caiata Zufferey, Maria, Monnerat, Christian, Rabaglio, Manuela, Zürrer-Härdi, Ursina, Chappuis, Pierre O., Katapodi, Maria C.“…We compared the characteristics of relatives from HBOC or LS families who did not have genetic testing (GT (−) group) with those who had genetic testing (GT (+) group), regardless of the outcome. …”
Publicado 2022
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2273por Hultman, Cathrine, Tjernström, Nikita, Vadlin, Sofia, Rehn, Mattias, Nilsson, Kent W., Roman, Erika, Åslund, Cecilia“…The rat gambling task (rGT) is a pre-clinical version using palatable reinforcers as wins and timeouts mimicking losses. …”
Publicado 2022
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2274por Willis, Jordan R., Berndsen, Zachary T., Ma, Krystal M., Steichen, Jon M., Schiffner, Torben, Landais, Elise, Liguori, Alessia, Kalyuzhniy, Oleksandr, Allen, Joel D., Baboo, Sabyasachi, Omorodion, Oluwarotimi, Diedrich, Jolene K., Hu, Xiaozhen, Georgeson, Erik, Phelps, Nicole, Eskandarzadeh, Saman, Groschel, Bettina, Kubitz, Michael, Adachi, Yumiko, Mullin, Tina-Marie, Alavi, Nushin B., Falcone, Samantha, Himansu, Sunny, Carfi, Andrea, Wilson, Ian A., Yates, John R., Paulson, James C., Crispin, Max, Ward, Andrew B., Schief, William R.“…We then engineered ApexGT Env trimers that bound inferred germlines for PCT64 and PG9 and had higher affinities for bnAbs, determined cryo-EM structures of ApexGT trimers complexed with inferred-germline and bnAb forms of PCT64 and PG9, and developed an mRNA-encoded cell-surface ApexGT trimer. …”
Publicado 2022
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2275por Campos, Letícia Bomfim, de Almeida, Nathália Alves Araújo, de Santana, Catarina Góis, Barbosa, Evorah Nascimento Pereira, Horta, Marco Aurelio Pereira, Amendola Pires, Márcia, Brandão Mello, Carlos Eduardo, de Paula, Vanessa Salete, de Barros, José Júnior França“…We evaluated the R70Q/H and L/C91M substitutions, clinical and epidemiological profiles, and risk factors of Brazilian patients chronically infected with HCV subgenotypes 1a and 1b (HCV-GT1a and HCV-GT1b) unresponsive to IFN and/or RBV therapy. …”
Publicado 2023
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2276por Lee, Ji‐Young, Hong, Hyein, Lee, Jae‐Eun, Hong, Yi‐Jee, Hwang, Hye Won, Jin, Hyeon‐Su, Shim, Hyunkyou, Hong, Yong‐deog, Park, Won‐Seok, Chung, Jin‐Oh, Lee, Dong‐Woo“…NanoLC‐MS/MS analysis and thin‐layer chromatography allowed the identification of peptide sequences and the composition of glycan moieties in the GTRs. Remarkably, GT peptide fractions produced by Lactiplantibacillus plantarum APsulloc 331261, a strain isolated from GT, showed a potent‐binding activity for P2RY6, a GPCR involved in intestinal homeostasis. …”
Publicado 2022
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2277por Kwak, Myung Ji, Kim, Wha Young, Jung, Seung-Hyun, Chung, Yeun-Jun, Kim, Jeong-Hoon“…A rodent version of the gambling task (rGT) has been developed to measure decision-making by adopting the same principle of Iowa Gambling Task in humans. …”
Publicado 2022
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2278por Rubbia, A“…\nNeglecting any systematic error, LBNO in its first phase, has the power to reach\na CPV discovery level $> 5\sigma$'s C.L., the actual significance depending on how far from\nzero and $\pi$ the true value\nof $\delta_{CP}$ is.…”
Publicado 2013
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2279por Li, Xiang, Li, Yijie, Wei, Ailin, Wang, Zeping, Huang, Hairong, Huang, Quyan, Yang, Litao, Gao, Yijing, Zhu, Guanghu, Liu, Qihuai, Li, Yangrui, Wei, Shaolong, Wei, Debin“…RESULTS: The stain test showed that GT42 had more lignin and vascular bundles in the stem than GF98-296. …”
Publicado 2023
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2280por Alicino, Cristiano, Bragazzi, Nicola Luigi, Faccio, Valeria, Amicizia, Daniela, Panatto, Donatella, Gasparini, Roberto, Icardi, Giancarlo, Orsi, Andrea“…METHODS: Google Trends (GT) was used to explore Internet activity related to Ebola. …”
Publicado 2015
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