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  1. 5581
    “…Stratified analysis showed that an increased NIHL risk was found in the subjects who exposed to noise >16 years with rs2802292 GG/GT and rs10457180 AG/GG genotype with an OR of 1.62 and 1.66 respectively. …”
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    Association of genetic variations in FOXO3 gene with susceptibility to noise induced hearing loss in a Chinese population
  2. 5582
    “…DNA from HNC patients were isolated from whole blood and genotypes were determined by sequencing method. Patients with TT or GT genotype demonstrated higher risk of manifestation of grade 3 OM in 5th week of RTH (p=0.041; OR=9.240; 95% CI: 1.101–77.581) compared to GG carriers. …”
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    Polymorphism of Promoter Region of TNFRSF1A Gene (−610 T > G) as a Novel Predictive Factor for Radiotherapy Induced Oral Mucositis in HNC Patients
  3. 5583
    “…Treatment with metformin resulted in G1 arrest, induction of apoptosis, reduction of invasion and decreased hTERT expression. In the K18-gT(121)(+/-); p53(fl/) (fl); Brca1(fl/fl) (KpB) mouse model, metformin inhibited tumor growth in both lean and obese mice. …”
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    Increased efficacy of metformin corresponds to differential metabolic effects in the ovarian tumors from obese versus lean mice
  4. 5584
    “…Using humanized mice, complete protection was observed after genotype 1a and 4a HCV challenge, while only partial protection was achieved using gt1b and 6a isolates. Epitope mapping revealed that mAb 2A5 binding is conformation-dependent and identified the E2-region spanning amino acids 434 to 446 (epitope II) as the predominant contact domain. …”
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    A novel neutralizing human monoclonal antibody broadly abrogates hepatitis C virus infection in vitro and in vivo
  5. 5585
    “…We found that patients who carried the GT or TT genotypes had significantly shorter median survival times (MSTs) compared to patients with the GG genotype (14.6 vs.21.4 months). …”
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    A sequence polymorphism on 8q24 is associated with survival in hepatocellular carcinoma patients who received radiation therapy
  6. 5586
    “…METHODS: We investigated the association between objectively measured PA (Actigraph GT3x accelerometers) and multiple dimensions of the built environment, using a cross-sectional multilevel linear regression analysis. …”
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    Investigating associations between the built environment and physical activity among older people in 20 UK towns
  7. 5587
    “…We provide the first approximation of near-global RG water volume equivalent and this is 62.02 ± 12.40 Gt. Excluding the Antarctic and Subantarctic, Greenland Periphery, and regions lacking data, we estimate a near-global RG to glacier water volume equivalent ratio of 1:618. …”
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    Mountain rock glaciers contain globally significant water stores
  8. 5588
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    Efficacy of combining ING4 and TRAIL genes in cancer-targeting gene virotherapy strategy: first evidence in preclinical hepatocellular carcinoma
  9. 5589
    “…RESULTS: Genotype frequencies of GG, GT and TT in IL21 gene (rs3093390) were found to be 27.6%, 48.3%, 24.1% and 25.2%, 55,5%, 19,3% respectively in HCV infected patients and control group. …”
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    Interleukin-21 rs2055979 and Interleukin-21 receptor rs3093390 genetic variants and hepatitis C virus chronic infection
  10. 5590
    “…They wore an accelerometer (ActiGraph GT3X+) for one week to record free-living PA, yielding measures of sedentariness and various intensities of PA (i.e., light, moderate, and vigorous). …”
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    Moderate intensity physical activity associates with CSF biomarkers in a cohort at risk for Alzheimer's disease
  11. 5591
    “…CC: adjusted odds ratio (AOR) = 1.58, 95% confidence interval (CI) = 1.82–2.10, P = 0.002] and the rs6725189 T allele was also associated with a significantly elevated CAS risk (GT vs. GG: AOR = 1.82, 95% CI = 1.14–2.92, P = 0.013). …”
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    Association between apolipoprotein B genetic polymorphism and the risk of calcific aortic stenosis in Chinese subjects, in Xinjiang, China
  12. 5592
    “…Data from physical activity and HRV were obtained for 3–4 days using tri-axial accelerometers (Actigraph GT3X+) and a heart rate monitor (Actiheart). HRV indices were determined during sitting, standing and moving both at work and leisure. …”
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    Different autonomic responses to occupational and leisure time physical activities among blue-collar workers
  13. 5593
    “…An increased mass discharge (53 ± 14 Gt yr(−1)) was found in the East Indian Ocean sector since 2008 due to unexpected widespread glacial acceleration in Wilkes Land, East Antarctica, while the other five oceanic sectors did not exhibit significant changes. …”
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    Recent high-resolution Antarctic ice velocity maps reveal increased mass loss in Wilkes Land, East Antarctica
  14. 5594
    “…A ‘gene therapy-compatible’ Gene Transport Unit (gtGTU, FIT Biotech), a plasmid backbone that co-encodes viral elements, failed to improve in vivo reporter and mAb expression compared to a conventional plasmid. …”
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    Prolonged in vivo expression and anti-tumor response of DNA-based anti-HER2 antibodies
  15. 5595
    “…METHODS: Participants (n = 108) wore an ActiGraph GT9X Link on their non-dominant wrist for 7 days. …”
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    Calibration of the global physical activity questionnaire to Accelerometry measured physical activity and sedentary behavior
  16. 5596
    “…In the prp18 mutant, splicing of a U2-type intron with non-canonical AT-AC splice sites in GFP pre-mRNA is reduced while splicing of a canonical GT-AG intron is enhanced, resulting in decreased levels of translatable GFP mRNA and GFP protein. …”
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    A Genetic Screen Identifies PRP18a, a Putative Second Step Splicing Factor Important for Alternative Splicing and a Normal Phenotype in Arabidopsis thaliana
  17. 5597
    “…METHODS: Forty four participants (12–13 years old; 61% girls) completed the YPAQ following 7 days wearing the Actigraph GT3X+. Mean moderate-to-vigorous physical activity (MVPA) per day was derived from YPAQ and accelerometer and validity was assessed using Spearman's correlation; Bland-Altman plots examined absolute agreement between methods. …”
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    The validity of the Youth Physical Activity Questionnaire in 12–13-year-old Scottish adolescents
  18. 5598
    “…Circular F-actin arrangements in platelets from a patient with type II Glanzmann thrombasthenia (GT) were consistent with the residual activity of a small number of α(IIb)β(3) integrins. …”
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    Morphometric analysis of spread platelets identifies integrin α(IIb)β(3)-specific contractile phenotype
  19. 5599
    “…RESULTS: The MIC of fidaxomicin displayed by three mutants CRG20291-TA, CRG20291-TG and CRG20291-GT was substantially increased (>32, 8 and 2 mg/L, respectively) relative to that of the parent strain (0.25 mg/L). …”
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    Characterization of the impact of rpoB mutations on the in vitro and in vivo competitive fitness of Clostridium difficile and susceptibility to fidaxomicin
  20. 5600
    “…Step counts and time in VPA were assessed using ActiGraph wGT3X-BT triaxial accelerometers that were worn during the entirety of a 7-hour school day for one school week. …”
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    Development of Step-Count Cut Points for School-Day Vigorous Physical Activity
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