“…To better understand anti-malaria protective immune responses, we examined the cellular mechanisms that govern protective immunity in a murine Plasmodium yoelii 17X NL (PyNL) re-infection model. Initially, we confirmed that immune B cells generated during a primary PyNL infection were largely responsible for protection from a second PyNL infection. …”
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“…This study assessed sex differences in the effects of oral probiotic, antibiotics, and synbiotic treatments in the App(NL-G-F) mouse model of AD. The fecal microbiome demonstrated significant correlations between bacterial genera in App(NL-G-F) mice and Aβ plaque load, gliosis, and memory performance. …”
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“…Methods: CPX transungual permeation after applying CPX-HPCH NL once or twice a day on bovine hoof membranes pre-covered with a breathable cosmetic nail polish was compared to that obtained applying CPX-HPCH NL directly on the membrane. …”
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“…We compared the proportion with virologic suppression and CD4(+)T-cell count over time between the following groups of children with PHIV: adopted and born outside NL, non-adopted born in NL, and non-adopted born outside NL, using generalized estimating equations and linear mixed effects models, respectively. …”
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“…However, the replicative capability of NL-4/5S6/7SvifS in human cells was severely impaired. …”
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“…Considering non-local primordial non-Gaussianity (NLPNG), we find that current methods will yield constraints of order <math altimg="si1.svg"><mi>σ</mi><mo stretchy="false">(</mo><msubsup><mrow><mi>f</mi></mrow><mrow><mi mathvariant="normal">NL</mi></mrow><mrow><mi mathvariant="normal">eq</mi></mrow></msubsup><mo stretchy="false">)</mo><mo>≈</mo><mn>23</mn></math>, <math altimg="si2.svg"><mi>σ</mi><mo stretchy="false">(</mo><msubsup><mrow><mi>f</mi></mrow><mrow><mi mathvariant="normal">NL</mi></mrow><mrow><mi mathvariant="normal">orth</mi></mrow></msubsup><mo stretchy="false">)</mo><mo>≈</mo><mn>12</mn></math> in a joint power-spectrum and bispectrum analysis, varying both nuisance parameters and cosmology, including a conservative range of scales. …”
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“…The results show that supplementation with 6% NL + 15% PEG in the concentrate had a higher (p < 0.05) feed intake gDM/d, % BW, g/kgBW(0.75), nutrient intake, nutrient digestion, weight change, and ADG than did the goats that were fed with 0% NL + 0% PEG, 0% NL + 15% PEG, and 6% NL + 0% PEG in concentrate, respectively. …”
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“…Ammonia, with the use of IBU in the NL, obtained values higher than in the RL (p = 0.007), and with the use of PLA, the NL was higher than the RL (p = 0.038, η2p = 0.570). …”
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“…The cytotoxic and hemolytic activities of NL-Cur(+Dox) were evaluated. The anti-biofilm and anti-metabolic effects of NL-Cur(+Dox) -mediated antimicrobial photodynamic therapy (aPDT) were examined. …”
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“…Patient IgG levels were higher than controls for HKU1, NL63, and OC43, with HKU1 and NL63 both showing highly significant patient-to-control differences (HKU1, P ≤ .002; NL63, P ≤ .00001). …”
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“…To identify immune molecules that may be associated with the BCG-induced protection, gene expression was evaluated by RT-PCR in i) naïve controls, ii) BCG-vaccinated mice, iii) PyNL infected mice and iv) BCG vaccinated/PyNL infected mice at 0, 1, 5, and 9 days after the P. yoelii infection. …”
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“…CONCLUSION: The NL% was a prognostic factor in our study population. …”
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“…RESULTS: nNO values were significantly lower in children with PCD (median 25.66 nL/min) than in children with asthma (186.26 ± 58.95 nL/ min), BO (143.47 ± 49.71 nL/min) and non‐PCD/non‐CF bronchiectasis (173.13 ± 63.80 nL/min), but not in children with CF (90.90 ± 43.20 nL/min). …”
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“…To explore the potential mechanisms for LC degeneration, we also examined the occurrence of tau pathology in LC neurons, the association of reactive gliosis with LC neurons, and impaired trophic support in the brains of App(NL-G-F/NL-G-F) mice. RESULTS: We observed a significant reduction in the density of noradrenergic axons from the LC in aged App(NL-G-F/NL-G-F) mice without neuron loss or tau pathology, which was not limited to areas near Aβ plaques. …”
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“…Blocking GAT3/4 associated tonic inhibition recorded in CA1 and DG principal cells resulted in an increased membrane input resistance, enhanced firing frequency and synaptic excitation in both wild-type and APP ( NL-F/NL-F ) mice. These effects exacerbated synaptic hyperactivity reported previously in the APP ( NL-F/NL-F ) mice model. …”
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“…METHODS: A cross-section of NL mother-child pairs was included in a time allocation substudy [intervention (NL-I) n = 74 and control (NL-C) n = 69]. …”
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“…Importantly, the PLA–NL composite films constantly outperformed their PLA–L counterparts, due to the finer dispersion of NL in the PLA matrix, as verified by the TEM micrographs. …”
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“…We therefore studied how genetic knockout of NL3 alters responses to chronic morphine in male mice. …”
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“…However, triple cKO of NL1-NL3 or single cKO of NL1 impaired NMDAR-mediated excitatory postsynaptic currents (NMDAR EPSCs), and abolished NMDAR-dependent LTP. …”
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“…NL-CLU was prepared by a conjugation reaction between the carboxylated surface of NL and the primary amines of the CLU protein. …”
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