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22441por Navas, Tony, Pfister, Thomas D., Colantonio, Simona, Aziz, Amina, Dieckman, Lynda, Saul, Richard G., Kaczmarczyk, Jan, Borgel, Suzanne, Alcoser, Sergio Y., Hollingshead, Melinda G., Lee, Young H., Bottaro, Donald P., Hiltke, Tara, Whiteley, Gordon, Takebe, Naoko, Kinders, Robert J., Parchment, Ralph E., Tomaszewski, Joseph E., Doroshow, James H.“…Similarly, our new anti-CD133 antibody enabled detection and quantitation of drug-induced reductions in CD133-positive tumor cells following treatment of SUM149PT triple-negative breast cancer xenograft models with the CSC/focal adhesion kinase (FAK) inhibitor VS-6063. …”
Publicado 2018
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22442por Freitag, Nils, Weber, Pia Deborah, Sanders, Tanja Christiane, Schulz, Holger, Bloch, Wilhelm, Schumann, Moritz“…CASE PRESENTATION: A female patient (51 years; 49.1 kg; 1.65 m; tumor stage: pT3, pN2a (5/29), pM1a (HEP), L0, V0, R0) performed 8 sessions of HIIT (5 × 3 minutes at 90% of W(max), separated by 2 minutes at 45% W(max)) with an increased inspired oxygen fraction of 30%. …”
Publicado 2018
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22443por Pinazza, Marica, Ghisi, Margherita, Minuzzo, Sonia, Agnusdei, Valentina, Fossati, Gianluca, Ciminale, Vincenzo, Pezzè, Laura, Ciribilli, Yari, Pilotto, Giorgia, Venturoli, Carolina, Amadori, Alberto, Indraccolo, Stefano“…Moreover, TSA markedly reduced the levels of Notch target genes, including pTα, CR2, and DTX-1, and induced apoptosis of T-ALL cells. …”
Publicado 2018
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22444por Vieira Neto, Eduardo, Laranjeira, Francisco, Quelhas, Dulce, Ribeiro, Isaura, Seabra, Alexandre, Mineiro, Nicole, d. M. Carvalho, Lilian, Lacerda, Lúcia, G. Ribeiro, Márcia“…The most frequent pathogenic variants were: p.V388M (12.7%), p.R261Q (11.8%), IVS10‐11G>A (10.3%), IVS2+5G>C (6.4%), p.S349P (6.4%), p.R252W (5.4%), p.I65T (4.4%), p.T323del (4.4%), and p.P281L (3.4%). One novel variant was detected: c.934G>T (p.G312C) [rs763115697]. …”
Publicado 2018
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22445“…Multivariate Cox analysis revealed that diabetes mellitus, LNI status, pT, pathologic GS, extraprostatic invasion, margin positivity and obesity with BMI ≥ 27.5 kg/m(2) were significantly associated with BCR-free survival after RP. …”
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22446por Magbanua, Mark Jesus M., Rugo, Hope S., Hauranieh, Louai, Roy, Ritu, Scott, Janet H., Lee, Jen Chieh, Hsiao, Feng, Sosa, Eduardo V., van’t Veer, Laura, Esserman, Laura J., Park, John W.“…Genome-wide copy number profiles of DTC pools (n = 45) appeared less aberrant than the corresponding primary tumors (PT, n = 16). PIK3CA mutations were detected in 26% of DTC pools (n = 53), none of them were shared with matched PTs. …”
Publicado 2018
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22447por Zhang, Qian, Wang, Ya-Li, Gao, Die, Cai, Liang, Yang, Yi-Yao, Hu, Yuan-Jia, Yang, Feng-Qing, Chen, Hua, Xia, Zhi-Ning“…ST showed haemostatic activity for promoting the platelet aggregation induced by collagen and trap-6, and reducing APTT and PT significantly with a concentration of 171.7 μM in vitro. …”
Publicado 2018
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22448por Xie, Huilin, Zhang, Erge, Hong, Nanchao, Fu, Qihua, Li, Fen, Chen, Sun, Yu, Yu, Sun, Kun“…RESULTS: The probably damaging variants p.R608W, p.T249I, and p.R616Q of TBX2 and p.A192T, p.M65L, and p.A562V of TBX3 were identified in CTD patients, but none in controls. …”
Publicado 2018
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22449por Zhang, Xin, Zhao, Yuechao, Wang, Changjun, Ju, Hongge, Liu, Wenjie, Zhang, Xiaohui, Miao, Shiying, Wang, Linfang, Sun, Qiang, Song, Wei“…RESULTS: RHBDD1 was highly up-regulated in breast cancer tissue compared with that in normal tissue and associated with pathological tumor (pT) stage, pathological tumor-node-metastasis (pTNM) stage and estrogen receptor (ER) expression. …”
Publicado 2018
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22450por Zhang, Xinping, Zhang, Fangfang, Wang, Dexiang, Fan, Junxi, Hu, Youning, Kang, Haibin, Chang, Mingjie, Pang, Yue, Yang, Yang, Feng, Yang“…Ten vegetation cover types comprising broadleaved mixed natural forest (BM), cultivated land (CL), economic forest (EF), grassland (GL), Platycladus orientalis natural forest (PON), Platycladus orientalis plantation (POP), Pinus tabuliformis plantation (PT), Quercus wutaishanica natural forest (QW), Robinia pseudoacacia plantation (RP), and Shrubwood (SW) were associated with significant differences in TN, OM, AN, AP, and AK, across the three soil layers. …”
Publicado 2018
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22451por Nutting, Christopher M., Morden, James P., Beasley, Matthew, Bhide, Shreerang, Cook, Audrey, De Winton, Emma, Emson, Marie, Evans, Mererid, Fresco, Lydia, Gollins, Simon, Gujral, Dorothy, Harrington, Kevin, Joseph, Mano, Lemon, Catherine, Luxon, Linda, van den Blink, Qurrat, Mendes, Ruheena, Miah, Aisha, Newbold, Kate, Prestwich, Robin, Robinson, Martin, Sanghera, Paul, Simpson, Joanna, Sivaramalingam, Muthiah, Srihari, Narayanan Nair, Sydenham, Mark, Wells, Emma, Witts, Stephanie, Hall, Emma“…COSTAR, a phase III trial, investigated the role of cochlear-sparing IMRT (CS-IMRT) in reducing hearing loss. METHODS: Patients (pT1-4 N0-3 M0) were randomly assigned (1:1) to 3-dimensional conformal radiotherapy (3DCRT) or CS-IMRT by minimisation, balancing for centre and radiation dose of 60Gy or 65Gy in 30 daily fractions. …”
Publicado 2018
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22452por Chen, Ting, Xu, Weize, Wu, Dingwen, Han, Jiamin, Zhu, Ling, Tong, Fan, Yang, Rulai, Zhao, Zhengyan, Jiang, Pingping, Shu, Qiang“…These included two synonymous and five pathogenic nonsynonymous variants (p.S36*, p.T186I, p.L255W, p.F302V and p.R413H). The most common variant among all patients was p.R243Q, followed by p.R241C, p.Y204C, p.R111* and c.442-1G > A. …”
Publicado 2018
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22453por Del Bene, Gabriella, Calabrò, Fabio, Giannarelli, Diana, Plimack, Elizabeth R., Harshman, Lauren C., Yu, Evan Y., Crabb, Simon J., Pal, Sumanta Kumar, Alva, Ajjai S., Powles, Thomas, De Giorgi, Ugo, Agarwal, Neeraj, Bamias, Aristotelis, Ladoire, Sylvain, Necchi, Andrea, Vaishampayan, Ulka N., Niegisch, Günter, Bellmunt, Joaquim, Baniel, Jack, Galsky, Matthew D., Sternberg, Cora N.“…Methods: Data from patients with muscle invasive bladder cancer (>pT2) collected from 2005 to 2012 within the RISC data base (Retrospective International Study of Cancers of the Urothelial Tract) were evaluated. …”
Publicado 2018
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22454por Ryan, É. J., Creavin, B., Khaw, Y. L., Kelly, M. E., Mohan, H. M., Geraghty, R., Ryan, E. J., Kennelly, R., Hanly, A., Martin, S. T., Fennelly, D., McDermott, R., Gibbons, D., O'Connell, P. R, Sheahan, K., Winter, D. C.“…Budding (hazard ratio (HR) 2·79, 95 per cent c.i. 1·60 to 4·87; P < 0·001), pT status (HR 3·59, 1·29 to 10·01; P = 0·015) and adjuvant chemotherapy (HR 2·07, 1·15 to 3·74; P = 0·016) were independently associated with worse disease‐free survival. …”
Publicado 2018
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22455por Evensen, Kari Anne I., Robinson, Hilde Stendal, Meisingset, Ingebrigt, Woodhouse, Astrid, Thielemann, Marit, Bjorbækmo, Wenche S., Myhre, Gard, Hansen, Anne E., Vasseljen, Ottar, Vøllestad, Nina K.“…The patients are recruited to three different cohorts depending on age and whether they are referred to a private practitioner or a municipally employed PT. All data are recorded electronically, transferred and stored securely. …”
Publicado 2018
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22456por Ekun, Oloruntoba Ayodele, Ogidi, Nkeiruka Ogochukwu, Lawal, Rukayat Adetutu, Ogunmuyiwa, Olumuyiwa Adeniran, Umewune, Mirian Chiamaka, Adefolaju, Florence Oreitan, Oshundun, Mary Foluke, Oremosu, Ayoola Islamiyat“…MDA (7.16±5.00 vs. 2.91±2.66, p<0.001), cTnI (0.46±0.31 vs. 0.13±0.14 p<0.001), PT (19.36±4.06 vs. 13.45±1.97 p<0.001), APTT (45.53±2.92 vs. 37.49±4.99; p<0.001) were higher in preeclampsia. …”
Publicado 2018
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22457por Alzahrani, Azzah, Othman, Nada, Bin-Ali, Tahani, Elfaraidi, Huda, Al Mussaed, Eman, Alabbas, Fahad, Sedick, Qanita, Albatniji, Fatma, Alshahrani, Ziyad, Asiri, Mohammed, Alsuhaibani, Omar, Elyamany, Ghaleb“…We reviewed and collected the details of the clinical history, previous surgery, trauma, family history, detail of anti-thrombotic medication and coagulation tests performed (prothrombin time (PT), the activated partial prothrombin time (APTT), and international normalized ratio (INR)) at the time of admission. …”
Publicado 2019
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22458“…She subsequently underwent a distal femur resection. Final staging was pT2bN0M0. She underwent adjuvant radiation therapy, but was found to have developed metastatic disease. …”
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22459por Ben Hamou, Adrien, Espiard, Stéphanie, Do Cao, Christine, Ladsous, Miriam, Loyer, Camille, Moerman, Alexandre, Boury, Samuel, Kyheng, Maéva, Dhaenens, Claire-Marie, Tiffreau, Vincent, Pigny, Pascal, Lebuffe, Gilles, Caiazzo, Robert, Aubert, Sébastien, Vantyghem, Marie Christine“…Sixteen of the 115 patients had a thyroidectomy, after 22 fine-needle aspiration cytology guided by thyroid imaging reporting and data system (TIRADS) classification. Six micro- (1/6 pT3) and 3 macro-papillary thyroid carcinoma (PTCs) (2/3 intermediate risk) were diagnosed (7.9% of 115). …”
Publicado 2019
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22460por Lehmann, F., Rau, J., Malcolm, B., Sander, M., von Heymann, C., Moormann, T., Geyer, T., Balzer, F., Wernecke, K. D., Kaufner, L.“…Random assignment to intra- and postoperative haemostatic management following either an algorithm based on conventional coagulation assays (conventional group: platelet count, aPTT, PT, fibrinogen) or based on point-of-care (PoC-group) monitoring, i.e. activated rotational thromboelastometry (ROTEM®) combined with multiple aggregometry (Multiplate®). …”
Publicado 2019
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