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    “…Material and Methods. A total sample of 1198 consecutive TMD patients was selected. After a neurological examination, a diagnosis of headache, according to the latest edition of the International Classification of Headache Disorders, was performed in 625 subjects. …”
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    “…This analysis identifies an unusually severe continuous dry period from around 1198 to 1196 (±3) bc, potentially indicating a tipping point, and signals the type of episode that can overwhelm contemporary risk-buffering practices.…”
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    “…Appendectomies were divided into daytime and nighttime operations. RESULTS: A total of 1198 patients underwent appendectomy, of which 65% were operated during daytime and 35% during nighttime. …”
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    “…A recent study reported the newest generation inhibitor resistant mutation L1198F led to the resensitization to crizotinib, which is the first Food and Drug Administration (FDA) approved drug for the treatment of ALK-positive NSCLC. …”
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    “…IC(50) = 20 nM for wild-type), whereas L1198F mutant is more responsive (IC(50) = 0.4 nM). …”
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    “…RESULTS: We identified a heterozygous missense mutation (c.3593 C>T, Pro1198Leu) in ABCC8. The mutated residue (P1198) is located within a putative binding site of sulfonylureas, such as tolbutamide or gliclazide. …”
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    “…ALK-L1198F is activated by the FAM150 (AUG) ligands and its ligand-dependant activity is similar to the wild type full length ALK receptor. …”
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    “…A male infant patient developed diabetic ketoacidosis at 2 months‐of‐age due to the heterozygous ABCC8 gene mutation (p.Pro1198Leu). After genetic diagnosis, insulin therapy was successfully transitioned to oral sulfonylurea therapy. …”
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