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21“…MEIS2 (Meis homeobox 2) encodes a homeobox protein in the three amino acid loop extension (TALE) family of highly conserved homeodomain-containing transcription regulators important for development. …”
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22por Agoston, Zsuzsa, Li, Naixin, Haslinger, Anja, Wizenmann, Andrea, Schulte, Dorothea“…Using in ovo electroporation of the mesencephalic vesicle of chick embryos we show that (i) Pax3 and Pax7 mutually regulate each other's expression in the mesencephalic vesicle, (ii) Meis2 acts downstream of Pax3/7 and requires balanced expression levels of both proteins, and (iii) Meis2 physically interacts with Pax3 and Pax7. …”
Publicado 2012
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23por Laursen, Kristian B., Mongan, Nigel P., Zhuang, Yong, Ng, Mary M., Benoit, Yannick D., Gudas, Lorraine J.“…Functional depletion of the essential PRC2 protein Suz12 by short hairpin RNA (shRNA) technology enhanced the RA-associated transcription of Nr2F1, Nr2F2, Meis1, Sox9 and BMP2, but had no effect on the Hoxa5, Hoxa1, Cyp26a1, Cyp26b1 and RARβ(2) transcript levels in wild-type embryonic stem cells. …”
Publicado 2013
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24“…This study compared the co-expression of Foxp2, Meis2, Pax6, and Sp8 transcription factors with Calretinin, Calbindin, or Th in human and mouse OB interneurons. …”
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25“…Early studies in chick embryos suggested that RA as well as Meis1 and Meis2 (Meis1/2) are required for subsequent proximodistal patterning of both forelimbs and hindlimbs, with RA diffusing from the trunk, functioning to activate Meis1/2 specifically in the proximal limb bud mesoderm. …”
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26por Regal, Joshua A., Guerra García, María E., Jain, Vaibhav, Chandramohan, Vidyalakshmi, Ashley, David M., Gregory, Simon G., Thompson, Eric M., López, Giselle Y., Reitman, Zachary J.“…Gene regulatory network interrogation in these neuroectoderm-like cells revealed control of transcriptional programming by TCF7L2/MEIS1-PAX6 and SOX2, similar to that found during neuroectodermal/neural development. …”
Publicado 2023
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27“…Moreover, muscle enhancers are modulated through coordinated binding of transcription factors, including c-Jun, Jdp2, Meis, and Runx1, which are recruited to muscle enhancers in a MyoD1-dependent manner. …”
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28por Abruzzese, Maria Pia, Bilotta, Maria Teresa, Fionda, Cinzia, Zingoni, Alessandra, Soriani, Alessandra, Petrucci, Maria Teresa, Ricciardi, Maria Rosaria, Molfetta, Rosa, Paolini, Rossella, Santoni, Angela, Cippitelli, Marco“…The transcription factor Myeloid Ecotropic Insertion Site 2 (MEIS2) has been identified as a cellular substrate of the E3-ubiquitin ligase complex CRL4-cereblon ((CRL4)CRBN) in crystal structure and by biochemical screen. …”
Publicado 2019
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29“…Our molecular evolutionary analyses reveal recurrent positive selection at two mei-MCM genes. Our transgenic assays show that sequence divergence among mei-218 alleles from D. melanogaster, D. pseudoobscura, and D. virilis has functional consequences for crossing over. …”
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30por Zhang, Jie, Zhao, Kai, Hou, Dan, Cai, Junhuo, Zhang, Qixiang, Cheng, Tangren, Pan, Huitang, Yang, Weiru“…In this study, we performed whole-genome re-sequencing of two mei cultivars with contrasting tree architecture. 75.87 million 100 bp pair-end reads were generated, with 92 % coverage of the genome. …”
Publicado 2016
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31“…Nuclear receptor 2f1 (Nr2f1) and nuclear receptor 2f2 (Nr2f2) in addition to Meis homeobox 1 (Meis1) and Meis homeobox 2 (Meis2) gene family members were identified by our approach, and double knockouts of each family demonstrated previously unknown requirements for body axis and/or limb formation. …”
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32por Katsumoto, Takuo, Ogawara, Yoko, Yamagata, Kazutsune, Aikawa, Yukiko, Goitsuka, Ryo, Nakamura, Takuro, Kitabayashi, Issay“…AML development induced by MOZ-TIF2 was rescued by introducing Meis1 into Moz-deficient cells carrying MOZ-TIF2. Meis1 deletion impaired MOZ-TIF2–mediated AML development. …”
Publicado 2022
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34por Regal, Joshua, Guerra-Garcia, Maria, Jain, Vaibhav, Chandramohan, Vidyalakshmi, Ashley, David, Gregory, Simon, Thompson, Eric, Lopez, Giselle, Reitman, Zachary“…Gene regulatory network inference of CD34+ ganglioglioma cells indicated TCF7L2/MEIS1-PAX6 and SOX2-mediated transcriptional programming, similar to that found during neuroectodermal/neural development in utero. …”
Publicado 2023
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35por Wu, Meei-Maan, Chen, Chi-Wei, Chen, Chiu-Yi, Lee, Chih-Hung, Chou, Mark, Hsu, Ling-I, Lee, Te-Chang, Chen, Chien-Jen“…We validated that the C allele of rs9619311 attenuated the binding affinity of BACH2, MEIS2, NFE2L2, and PBX2 to the TIMP3 promoter, and that the G allele of rs2234921 reduced the affinity of E2F8 and RUNX1 to bind to the promoter. …”
Publicado 2022
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36“…Moreover, most markers for stem cells such as CD133, CD44, AXIN2, MEIS2 and NANOG were increased in cells with SATB2 knockdown and decreased in cells with SATB2 overexpression. …”
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37Identification of a Prognostic Signature Associated With the Homeobox Gene Family for Bladder Cancerpor Dong, Bingqi, Liang, Jiaming, Li, Ding, Song, Wenping, Song, Jinbo, Zhu, Mingkai, Zhao, Shiming, Ma, Yongkang, Yang, Tiejun“…Results: Six genes were selected to construct this prognostic model: TSHZ3, ZFHX4, ZEB2, MEIS1, ISL1, and HOXC4. We divided the BLCA cohort into high- and low-risk groups based on the median risk score calculated with the novel signature. …”
Publicado 2021
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38“…Three neuronal-related genes (JAK2, MEIS1, and LRRTM4) were revealed as candidates for predation behavior. …”
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39por Paylakhi, Seyed Hassan, Fan, Jian-Bing, Mehrabian, Mohadeseh, Sadeghizadeh, Majid, Yazdani, Shahin, Katanforoush, Ali, Kanavi, Mozhgan Rezaei, Ronaghi, Mostafa, Elahi, Elahe“…The five genes were DIRAS3 (DIRAS family, GTP-binding RAS-like 3), CXCL6 (chemokine (C-X-C motif) ligand 6), SAMD5 (sterile alpha motif domain containing 5), CBFB (core-binding factor, beta subunit), and MEIS2 (meis homeobox 2). Real time PCR experiments verified results on a subset of genes tested. …”
Publicado 2011
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