“…Furthermore, we utilized mass spectrometry-based immunopeptidome analyses in an extensive dataset of primary malignant and benign tissue samples for the identification of naturally presented uORF-derived HLA-presented peptides screening for more than 2000 uORFs. RESULTS: We provide experimental evidence for similarly effective translational regulation of cancer-associated transcripts through uORFs initiated by either canonical AUG codons or by alternative translation initiation sites (aTISs). …”
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“…METHODS: We conducted a scoping review to identify, collate and critically appraise the state-of-art in the use of individual-specific networks for prediction modelling in medicine and applied health research, published during 2000–2020 in the electronic databases PubMed, Scopus and Embase. …”
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“…Furthermore, subacute oral toxicity was evaluated in rats for 28 days at daily doses as high as 2000 mg/kg without toxicity or abnormal clinical chemistry or hematological effects. …”
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“…A case–control study will be conducted in the SHs and we aim to enrol a total of 1000 suspected pertussis cases (ie, all hospital admissions and the first 1–3 outpatient visits each week each hospital) and 2000 frequency matched healthy controls in community. …”
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“…METHODS: The Canadian Community Health Survey (CCHS) (2003–2007) and the United States National Health Interview Survey (NHIS) (2000, 2005) linked to individual-level mortality outcomes with follow up to December 31, 2011 were used. …”
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“…Data was collected in a period between 2000 and 2012. Setting: Lesser Poland, Central Europe. …”
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“…Forty clusters spread over four sites will be studied to understand the importance of context, involving more than 40 healthcare service providers and 2000 households to be surveyed. We will collect primary data through questionnaires, in-depth and semi-structured interviews, focus groups and participatory filming. …”
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“…Ten min later, 0.9% saline solution [SAL group], XYL (0.05 mg/kg) [XYL group] or a combination of XYL (0.05 mg/kg) and AD (2000 µg) [XYL-AD group] was injected intrathecally. …”
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“…The 1–10-year aMRR decreased from 2.06 (95% CI: 2.01–2.11) in 1979–1989 to 1.29 (95% CI: 1.26–1.32) in 2000–2009. We found effect modification by age: age 18 to <30 years: aMRR=2.44 (95% CI: 2.24–2.66) vs age ≥70 years: 1.35 (95% CI: 1.33–1.37); comorbidities: baseline comorbidities: aMRR=1.13 (95% CI: 1.10–1.15) vs no comorbidities: aMRR=1.83 (95% CI: 1.80–1.85); and educational level: high educational level: aMRR=1.81 (95% CI: 1.74–1.88) vs low educational level: aMRR=1.70 (95% CI: 1.67–1.72). …”
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“…METHODS: A retrospective longitudinal cohort study was conducted using the Taiwan Longitudinal Health Insurance Database between January 2000 and December 2011. A total of 35,306 patients were initially enrolled, and 14,795 patients with mild TBI and 14,795 patients with moderate/severe TBI were matched using the National Health Insurance Research Database in Taiwan. …”
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“…Papers published in English language between 2000 and 2019, and papers that included patients receiving systemic anti-cancer therapy as the denominator during the study period were included. …”
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“…RESULTS: For HSP, 23 reports were found spanning the years 2000–2019 of which 19 related to North Africans, with high consanguinity, and six included sub-Saharan Africans. …”
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“…METHODS: Electronic search for randomised controlled clinical trials with minimum 6 months follow-up for SPT and implant maintenance programme was conducted for data published from 01 January 2000 to 30 April 2020 using multiple databases and hand searching. …”
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“…A positive trend in age across the years was found with an increase in mean age (“before 1989” = 40.33 ± 10.07 years; “1990–1999” = 44.16 ± 10.37 years; “2000–2009” = 45.99 ± 10.33 years; “2010–2020” = 45.62 ± 10.80 years). …”
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“…METHODS: Thirty volunteered breast cancer survivors (48 ± 8 years) were randomly allocated to a high dose (4000 IU) of vitamin D supplementation (HD) group (n = 10), yoga with a high dose of vitamin D (YHD) group (n = 10), and yoga with a low dose (2000 IU) of vitamin D (YLD) group (n = 10). Participants performed the Hatha yoga style for 12 weeks, twice a week. …”
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“…French- or English-language primary empirical studies, knowledge syntheses, and grey literature published between 2000 and 2021 were included. Data were extracted by two independent reviewers and subjected to a thematic analysis. …”
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“…MATERIALS METHODS: We systematically searched Ovid Medline for population-based longitudinal studies of first-ever spontaneous ICH published from January 2000 to December 2020. We performed meta-analyses on the incidence and survival rate in countries of 4 different income groups with random-effects models (severe inconsistency). …”
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“…In Japan, disease profiles of fewer than 2000 rare diseases, called Nanbyo, have been investigated. …”
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“…METHODS: We retrospectively collected data on the clinicopathologic characteristics, treatments, toxicities, and survival of 27 patients from a single center between 2000 and 2018. Patients were divided into two groups according to whether they received operation. …”
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“…RESULTS: After 24 weeks of treatment, the intracranial pressure was significantly lower in the VPS group than in the non-VPS group (mmH(2)O; 155.0 [120.0–190.0] vs. 200.0 [142.5–290.0]; P = 0.025), and the rate of neuroimaging improvement was significantly higher in the VPS group (16/17 [94.1%] vs. 2/10 [20%]; P < 0.001). …”
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