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  1. 73741
    “…Since its enactment in 2000, the European Orphan Medicinal Products Regulation has allowed the review and approval of approaching 70 treatments for some 55 different conditions in Europe. …”
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    Paying for the Orphan Drug System: break or bend? Is it time for a new evaluation system for payers in Europe to take account of new rare disease treatments?
  2. 73742
    “…A total of 1,212 cases reported from 138 counties in Texas from Jan 2000 to Dec 2010 were analyzed. We used temperature and precipitation raster grids to generate humidity maps for Texas region. …”
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    Geographical Information Systems: A Tool to Map and Analyze Disease Spread
  3. 73743
    “…In the United Kingdom (UK), statistical surveillance methods have been in routine use at the Health Protection Agency (HPA) since the early 1990s and at Health Protection Scotland (HPS) since the early 2000s (1,2). These are based on a simple yet robust quasi-Poisson regression method (1). …”
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    An Improved Algorithm for Outbreak Detection in Multiple Surveillance Systems
  4. 73744
    “…To identify small non-coding RNAs (sncRNAs) upon rickettsial infection, RNAs from pulverized mouse lung tissues and HUVECs were subjected to library preparation and deep sequencing analysis using an Illumina 2000 instrument. Identified sncRNAs were confirmed by Northern hybridization, and their target mRNAs were predicted in silico using BLAST and RNA hybrid programs. …”
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    Compartmentalized, functional role of angiogenin during spotted fever group rickettsia-induced endothelial barrier dysfunction: evidence of possible mediation by host tRNA-derived small noncoding RNAs
  5. 73745
    “…The search was done in two batches, the first covering January 2000–March 2010 and the second March 2009–February 2011. …”
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    Vitamin D – a systematic literature review for the 5th edition of the Nordic Nutrition Recommendations
  6. 73746
    “…METHODS: Eight databases (Scopus, CINAHL, Medline, ProQuest, EMBASE, PsycINFO, Cochrane, Web of Science and Communication & Mass Media Complete) were searched from 2000 to present using a comprehensive search strategy. …”
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    Are Health Behavior Change Interventions That Use Online Social Networks Effective? A Systematic Review
  7. 73747
    “…We collated and analysed data from hospital records regarding the cause of death of 18,385 patients with diabetes who died in 282 medical institutions throughout Japan over the 10‐year period between 1991 and 2000. Autopsy was carried out in 1750 cases. The most frequent cause of death in all 18,385 cases was malignant neoplasia, accounting for 34.1% of cases, followed by vascular diseases (including diabetic nephropathy, ischemic heart diseases and cerebrovascular diseases) in 26.8%, infections in 14.3%, and then diabetic coma in 1.2%. …”
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    Causes of death in Japanese diabetics: A questionnaire survey of 18,385 diabetics over a 10‐year period
  8. 73748
    por Aleksandrova, Krasimira, Pischon, Tobias, Jenab, Mazda, Bueno-de-Mesquita, H Bas, Fedirko, Veronika, Norat, Teresa, Romaguera, Dora, Knüppel, Sven, Boutron-Ruault, Marie-Christine, Dossus, Laure, Dartois, Laureen, Kaaks, Rudolf, Li, Kuanrong, Tjønneland, Anne, Overvad, Kim, Quirós, José Ramón, Buckland, Genevieve, Sánchez, María José, Dorronsoro, Miren, Chirlaque, Maria-Dolores, Barricarte, Aurelio, Khaw, Kay-Tee, Wareham, Nicholas J, Bradbury, Kathryn E, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Palli, Domenico, Krogh, Vittorio, Tumino, Rosario, Naccarati, Alessio, Panico, Salvatore, Siersema, Peter D, Peeters, Petra HM, Ljuslinder, Ingrid, Johansson, Ingegerd, Ericson, Ulrika, Ohlsson, Bodil, Weiderpass, Elisabete, Skeie, Guri, Borch, Kristin Benjaminsen, Rinaldi, Sabina, Romieu, Isabelle, Kong, Joyce, Gunter, Marc J, Ward, Heather A, Riboli, Elio, Boeing, Heiner
    Publicado 2014
    “…METHODS: In the EPIC cohort, a total of 347,237 men and women, 25- to 70-years old, provided dietary and lifestyle information at study baseline (1992 to 2000). Over a median follow-up time of 12 years, 3,759 incident CRC cases were identified. …”
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    Combined impact of healthy lifestyle factors on colorectal cancer: a large European cohort study
  9. 73749
    “…Two cross-sectional surveys on HBV surface antigen (HBsAg) seroprevalence were conducted in 1996–2000 and 2008–2012. The participation rates of the two surveys were 57.5% (21,770) and 50.7% (17,204) in the vaccination group and 36.3% (12,184) and 58.6% (17,395) in the control group, respectively. …”
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    Efficacy of Neonatal HBV Vaccination on Liver Cancer and Other Liver Diseases over 30-Year Follow-up of the Qidong Hepatitis B Intervention Study: A Cluster Randomized Controlled Trial
  10. 73750
    “…Nous rapportons une étude rétrospective entre 2000 et 2013 portant sur 135 patients opérés dans notre formation et remplissant les critères inclusions. …”
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    Les myélopathies cervicarthrosiques: résultat clinique et radiologique de la chirurgie sur une série de 135 patients opérés au service de neurochirurgie CHU Avicenne
  11. 73751
    por Bhoo-Pathy, Nirmala, Peeters, Petra HM, Uiterwaal, Cuno SPM, Bueno-de-Mesquita, H Bas, Bulgiba, Awang M, Bech, Bodil Hammer, Overvad, Kim, Tjønneland, Anne, Olsen, Anja, Clavel-Chapelon, Françoise, Fagherazzi, Guy, Perquier, Florence, Teucher, Birgit, Kaaks, Rudolf, Schütze, Madlen, Boeing, Heiner, Lagiou, Pagona, Orfanos, Philippos, Trichopoulou, Antonia, Agnoli, Claudia, Mattiello, Amalia, Palli, Domenico, Tumino, Rosario, Sacerdote, Carlotta, van Duijnhoven, Franzel JB, Braaten, Tonje, Lund, Eiliv, Skeie, Guri, Redondo, María-Luisa, Buckland, Genevieve, Pérez, Maria José Sánchez, Chirlaque, Maria-Dolores, Ardanaz, Eva, Amiano, Pilar, Wirfält, Elisabet, Wallström, Peter, Johansson, Ingegerd, Nilsson, Lena Maria, Khaw, Kay-Tee, Wareham, Nick, Allen, Naomi E, Key, Timothy J, Rinaldi, Sabina, Romieu, Isabelle, Gallo, Valentina, Riboli, Elio, van Gils, Carla H
    Publicado 2015
    “…METHODS: A total of 335,060 women participating in the European Prospective Investigation into Nutrition and Cancer (EPIC) Study, completed a dietary questionnaire from 1992 to 2000, and were followed-up until 2010 for incidence of breast cancer. …”
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    Coffee and tea consumption and risk of pre- and postmenopausal breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study
  12. 73752
    “…Participants 238 963 patients aged 20 to 64 years with a first diagnosis of depression between 1 January 2000 and 31 July 2011, followed up until 1 August 2012. …”
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    Antidepressant use and risk of suicide and attempted suicide or self harm in people aged 20 to 64: cohort study using a primary care database
  13. 73753
    “…Although 43.3% contributed <$500 on procedure and test costs, 20.0% spent >$2000 in the past year. Families with household income between $50,000 and $100,000 had a statistically significant probability (80.6%) of higher annual OOP costs than families with lower income <$50,000 (20.0%; P < 0.0001) or higher income >$100,000 (64.6%; P < 0.05). …”
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    Out-of-pocket Cost Burden in Pediatric Inflammatory Bowel Disease: A Cross-sectional Cohort Analysis
  14. 73754
    “…METHODS: A systematic review was conducted by searching various databases between January 1, 2000, and June 30, 2014. Studies reporting up to a maximum follow-up period of 24 months were retrieved and screened using the EPPI-Reviewer 4 gateway. …”
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    iStent as a Solo Procedure for Glaucoma Patients: A Systematic Review and Meta-Analysis
  15. 73755
    “…METHODS: The National Health Insurance Research Database (NHIRD) was used to identify female medical professionals, aged 18 to 45 years, who obtained their licenses during January 1, 2000 to December 31, 2012. Personnel from six different medical professions were examined and they included (1) medical technologists and therapists, (2) registered nurses, (3) physicians, (4) doctors of Chinese medicine, (5) dentists, and (6) pharmacists. …”
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    Ambulatory medical services utilization for menstrual disorders among female personnel of different medical professions in Taiwan: a nationwide retrospective cohort study
  16. 73756
    “…There was a statistically significant difference between groups 1 and 2 for the ossified lateral femoral condylar width where femoral tunnel location would be expected (20.00 ± 4.20 vs 26.27 ± 4.12 mm, respectively; P = .0035) and for total lateral femoral condylar width (25.57 ± 3.47 vs 29.43 ± 4.04 mm, respectively; P = .0339). …”
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    A Study of Epiphyses in the Young Prepubescent Knee Using Magnetic Resonance Imaging: Evaluation of Parameters for Anterior Cruciate Ligament Reconstruction
  17. 73757
    “…METHODS AND FINDINGS: This study was a pragmatic, single-centre randomised controlled clinical trial in community-dwelling individuals aged 65 y or older registered with one of 19 primary care physician (PCP) practices in a mixed rural and urban area in Switzerland. From November 2000 to January 2002, 874 participants were randomly allocated to the intervention and 1,410 to usual care. …”
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    Effect of Health Risk Assessment and Counselling on Health Behaviour and Survival in Older People: A Pragmatic Randomised Trial
  18. 73758
    “…RNA-seq of both mRNA and miRNA libraries were performed on an Illumina® HiSeq(™) 2000. Paired reads were aligned to the bovine genome with Bowtie2 and differentially expressed genes were identified using EdgeR. …”
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    Integrated analysis of the local and systemic changes preceding the development of post-partum cytological endometritis
  19. 73759
    “…Fermenters were fed 72 g of dry matter/d equally divided in two meals/d, at 0800 and 2000 h. Solid and liquid dilution rates were adjusted daily to 5.5 and 11%/h, respectively. …”
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    Effects of Partial Replacement of Corn with Glycerin on Ruminal Fermentation in a Dual-Flow Continuous Culture System
  20. 73760
    “…The results of pedometers also indicated that men walk significantly more than women (p < 0.001), with a difference of approximately 2000 steps/day. CONCLUSIONS: The data collection process itself also gave us some clues on the involvement of local communities, exploring the potential of social capital of these settings and the role of the woman in family and society in Cape Verde. …”
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    Urban Planning and Health Inequities: Looking in a Small-Scale in a City of Cape Verde
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