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  1. 74281
    “…Individuals with an initial HCV-negative test result followed by 1 additional test between January 1, 2000, and December 31, 2017, and who had no history of substance use at baseline (first HCV-negative test), were included. …”
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    Association Between Prescription Opioid Therapy for Noncancer Pain and Hepatitis C Virus Seroconversion
  2. 74282
    “…Após aprovação do Comitê de Ética e Pesquisa da Universidade Federal do Espírito Santo (UFES) (protocolo 4.374.111), os dados foram gerados através do sistema do hospital, MV2000i e posteriormente planilhados em Excel (Microsoft ® 365). …”
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    PERFIL DE MICRORGANISMOS E DE RESISTÊNCIA AOS ANTIMICROBIANOS EM UM HOSPITAL PÚBLICO DE REFERÊNCIA PARA TRATAMENTO DE COVID-19 NO ESPÍRITO SANTO ANTES E DURANTE O PRIMEIRO ANO DA PANDEMIA
  3. 74283
    por Pizzuti, Laura, Krasniqi, Eriseld, Sperduti, Isabella, Barba, Maddalena, Gamucci, Teresa, Mauri, Maria, Veltri, Enzo Maria, Meattini, Icro, Berardi, Rossana, Di Lisa, Francesca Sofia, Natoli, Clara, Pistelli, Mirco, Iezzi, Laura, Risi, Emanuela, D’Ostilio, Nicola, Tomao, Silverio, Ficorella, Corrado, Cannita, Katia, Riccardi, Ferdinando, Cassano, Alessandra, Bria, Emilio, Fabbri, Maria Agnese, Mazzotta, Marco, Barchiesi, Giacomo, Botticelli, Andrea, D’Auria, Giuliana, Ceribelli, Anna, Michelotti, Andrea, Russo, Antonio, Salimbeni, Beatrice Taurelli, Sarobba, Giuseppina, Giotta, Francesco, Paris, Ida, Saltarelli, Rosa, Marinelli, Daniele, Corsi, Domenico, Capomolla, Elisabetta Maria, Sini, Valentina, Moscetti, Luca, Mentuccia, Lucia, Tonini, Giuseppe, Raffaele, Mimma, Marchetti, Luca, Minelli, Mauro, Ruggeri, Enzo Maria, Scavina, Paola, Bacciu, Olivia, Salesi, Nello, Livi, Lorenzo, Tinari, Nicola, Grassadonia, Antonino, Fedele Scinto, Angelo, Rossi, Rosalinda, Valerio, Maria Rosaria, Landucci, Elisabetta, Stani, Simonetta, Fratini, Beatrice, Maugeri-Saccà, Marcello, De Tursi, Michele, Maione, Angela, Santini, Daniele, Orlandi, Armando, Lorusso, Vito, Cortesi, Enrico, Sanguineti, Giuseppe, Pinnarò, Paola, Cappuzzo, Federico, Landi, Lorenza, Botti, Claudio, Tomao, Federica, Cappelli, Sonia, Bon, Giulia, Pelle, Fabio, Cavicchi, Flavia, Fiorio, Elena, Foglietta, Jennifer, Scagnoli, Simone, Marchetti, Paolo, Ciliberto, Gennaro, Vici, Patrizia
    Publicado 2021
    “…METHODS: The observational PANHER study included 1,328 HER2-positive advanced BC patients treated with HER2 blocking agents since June 2000 throughout July 2020. Endpoints of efficacy were progression-free survival (PFS) and overall survival (OS). …”
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    PANHER study: a 20-year treatment outcome analysis from a multicentre observational study of HER2-positive advanced breast cancer patients from the real-world setting
  4. 74284
    “…The Lyon R96-2 Phase III trial (2004) demonstrated that, when combined with preoperative EBRT, a CXB boost (90 Gy/3 fr) significantly increased the rate of clinical complete response (cCR) and sphincter preservation, with some patients having OP at 10 years. With more than 2000 patients treated in Europe (2010–2020) using the Papillon 50(TM), organ preservation appears possible in close to 80% of cases in selected early T2–T3. …”
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    Targeted Radiotherapy Using Contact X-ray Brachytherapy 50 kV
  5. 74285
    “…METHODS AND RESULTS: We analysed 75 518 patients from the large and nationwide Swedish HF registry between 2000–2018. Multivariable logistic regression models were fitted to identify the independent predictors of planned follow‐up in specialty vs. primary care, and multivariable Cox models to assess the association between follow‐up type and outcomes. …”
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    Patient profile and outcomes associated with follow‐up in specialty vs. primary care in heart failure
  6. 74286
    “…BACKGROUND: Between 2000 and 2019, more than 1.8 billion long-lasting insecticidal nets (LLINs) were distributed in Africa. …”
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    “In starvation, a bone can also be meat”: a mixed methods evaluation of factors associated with discarding of long-lasting insecticidal nets in Bagamoyo, Tanzania
  7. 74287
    “…METHODS: Adult patients who underwent transplantation between 2000 and 2018 for HCC in 47 centres were included. …”
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    R3-AFP score is a new composite tool to refine prediction of hepatocellular carcinoma recurrence after liver transplantation
  8. 74288
    “…METHODS: We conducted an observational cohort study among HIV-positive adults treated for TB between 2000 and 2018 and after enrollment into the Caribbean, Central, and South America network for HIV epidemiology (CCASAnet; Brazil, Chile, Haiti, Honduras, Mexico and Peru). …”
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    Tuberculosis treatment intermittency in the continuation phase and mortality in HIV-positive persons receiving antiretroviral therapy
  9. 74289
    “…METHODS AND FINDINGS: MEDLINE, PsycINFO, and CINAHL were searched for English-language cross-sectional/longitudinal studies reporting prevalence and/or severity of symptoms and/or HRQOL in CKD, published between January 2000 and September 2021, including adult patients with CKD, and measuring symptom prevalence/severity and/or HRQOL using a patient-reported outcome measure (PROM). …”
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    Symptom burden and health-related quality of life in chronic kidney disease: A global systematic review and meta-analysis
  10. 74290
    “…The participants having psychiatric illness in the family showed significantly higher mean values for DASS-42 (DASS-D: 20.00 ±26.870 vs. 3.50 ±6.264, p=0.001; DASS-A: 18.50 ±20.506 vs. 3.88 ±6.215, p=0.002; DASS-S: 18.00 ±21.213 vs. 3.64 ±6.346, p=0.003) as compared to those without any psychiatric illness in the family. …”
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    The Impact of the COVID-19 Pandemic on the Psychological Well-being of Healthcare Workers in Obstetrics and Gynaecology: An Observational Study at an Apex Institute
  11. 74291
    “…However, spending more than 2000 Yuan a month on basic needs (AOR = 2.55, 95% CI:2.07–3.14), residing in urban areas (AOR = 1.35, 95% CI:1.15–1.59) and being knowledgeable of the national AIDS policy (AOR = 1.40,95% CI:1.18–1.66) increased the chance of exhibiting RD. …”
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    Discordance between perceived risk and actual risky sexual behaviors among undergraduate university students in mainland China: a cross-sectional study
  12. 74292
    “…METHODS: The 2015–2016 (Ethicus-2) vs. 1999–2000 (Ethicus-1) comparison study was a two-period, prospective observational study assessing the frequency of limitation decisions in 4952 patients from 22 European ICUs. …”
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    Derivation and performance of an end-of-life practice score aimed at interpreting worldwide treatment-limiting decisions in the critically ill
  13. 74293
    “…METHODOLOGY: After registration of the present systematic review and meta-analysis in the PROSPERO, a search was done according to the Cochrane guidelines for evaluation of clinical trials to find eligible clinical trials that investigated the effect of SCT on T1DM (based on ADA® diagnostic criteria) from PubMed, Web of science, Scopus, etc, as well as registries of clinical trials from January 1, 2000, to September 31, 2019. A search strategy was designed using MeSH and EM-tree terms. …”
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    Investigating the safety and efficacy of hematopoietic and mesenchymal stem cell transplantation for treatment of T1DM: a systematic review and meta-analysis
  14. 74294
    “…METHODS: ART-naïve PWH ≥18 years old, enrolled in Brazil, Honduras, Mexico, Peru, and Haiti (sites within CCASAnet) and the US (NA-ACCORD) starting ART between 2000 and 2017, with at least one weight measured after ART initiation were included. …”
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    Weight gain post-ART in HIV+ Latinos/as differs in the USA, Haiti, and Latin America
  15. 74295
    por Speich, Benjamin, Gryaznov, Dmitry, Busse, Jason W., Gloy, Viktoria L., Lohner, Szimonetta, Klatte, Katharina, Taji Heravi, Ala, Ghosh, Nilabh, Lee, Hopin, Mansouri, Anita, Marian, Ioana R., Saccilotto, Ramon, Nury, Edris, Kasenda, Benjamin, Ojeda–Ruiz, Elena, Schandelmaier, Stefan, Tomonaga, Yuki, Amstutz, Alain, Pauli–Magnus, Christiane, Bischoff, Karin, Wollmann, Katharina, Rehner, Laura, Meerpohl, Joerg J., Nordmann, Alain, Wong, Jacqueline, Chow, Ngai, Hong, Patrick Jiho, Mc Cord – De Iaco, Kimberly, Sricharoenchai, Sirintip, Agarwal, Arnav, Schwenkglenks, Matthias, Hemkens, Lars G., von Elm, Erik, Copsey, Bethan, Griessbach, Alexandra N., Schönenberger, Christof, Mertz, Dominik, Blümle, Anette, von Niederhäusern, Belinda, Hopewell, Sally, Odutayo, Ayodele, Briel, Matthias
    Publicado 2022
    “…BACKGROUND: We previously found that 25% of 1,017 randomized clinical trials (RCTs) approved between 2000 and 2003 were discontinued prematurely, and 44% remained unpublished at a median of 12 years follow-up. …”
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    Nonregistration, discontinuation, and nonpublication of randomized trials: A repeated metaresearch analysis
  16. 74296
    “…Designer crossbreeds had a significantly higher purchase price, with 25.7% of designer crossbreed puppies costing £2000-£2999 compared to 15.1% of purebred puppies (X(2) = 207.31, p <  0.001). …”
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    How much is that doodle in the window? Exploring motivations and behaviours of UK owners acquiring designer crossbreed dogs (2019-2020)
  17. 74297
    “…Radix Bupleuri has been used in China for over 2000 years to regulate liver-qi. Extracted from Radix Bupleuri, Saikosaponin D (SSD) is a pharmacologically active substance that has antidepressant effects. …”
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    Saikosaponin D exerts antidepressant effect by regulating Homer1-mGluR5 and mTOR signaling in a rat model of chronic unpredictable mild stress
  18. 74298
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    The Racial Divide: A Follow Up Study on Racial Disparity Amongst COVID-19 Survivors in an Urban Community
  19. 74299
    “…METHODS: Using a hybrid-type II effectiveness-implementation cluster randomized controlled trial (cRCT), we will randomize 36 schools (18 urban and 18 rural) with 540 teachers and nearly 2000 families to one of three conditions: PD + Teacher-Wellness (PDT), PD alone (PD), and Control. …”
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    Advancing scalability and impacts of a teacher training program for promoting child mental health in Ugandan primary schools: protocol for a hybrid-type II effectiveness-implementation cluster randomized trial
  20. 74300
    por Duan, Taimei
    Publicado 2022
    “…A total of 444 strains of pathogenic bacteria were detected, including 328 strains of Gram-negative bacteria (73.87%, mainly Klebsiella pneumoniae, Pseudomonas aeruginosa, Stenotrophomonas maltophilia, and Serratia marcescens), 28 strains of Gram-positive bacteria (6.30%, mainly Staphylococcus aureus), and 88 strains of fungi (20.00%, mainly Candida albicans). Regarding Klebsiella pneumoniae in elderly patients with pulmonary infection, the drug resistance rates were 59.72% for amoxicillin-clavulanate potassium, 52.78% for ampicillin sodium-sulbactam sodium, and 51.39% for cefazolin sodium. …”
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    Analysis of Microbiological and Clinical Characteristics of Bacterial Infection in Patients with Pulmonary Infection
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