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  1. 3801
    por Xu, Xinfang, Doyle, Michael P.
    Publicado 2014
    “…[Image: see text] The combination of two or more unsaturated structural units to form cyclic organic compounds is commonly referred to as cycloaddition, and the combination of two unsaturated structural units that forms a six-membered ring is formally either a [5 + 1]-, [4 + 2]-, [2 + 2 + 2]-, or [3 + 3]-cycloaddition. Occurring as concerted or stepwise processes, cycloaddition reactions are among the most useful synthetic constructions in organic chemistry. …”
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    The [3 + 3]-Cycloaddition Alternative for Heterocycle Syntheses: Catalytically Generated Metalloenolcarbenes as Dipolar Adducts
  2. 3802
    “…The four-layered [3.3]MCP has an S-shaped structure in which three [3.3]MCP moieties take syn-(chair-boat), anti-(chair-boat) and syn-(chair-boat) conformations. …”
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    Four-layered [3.3]meta­cyclo­phane with ethene­tetra­carbo­nitrile
  3. 3803
    “…The structure shows a three dimensional domain swapping with a β-strand of one molecule inserted between two strands of the paired molecule, suggesting a possible role in PBP3(57–577) dimerization.…”
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    Crystal Structure of Penicillin-Binding Protein 3 (PBP3) from Escherichia coli
  4. 3804
    “…Depletion of gnrh3 by morpholinos led to a reduction of GFP- and gnrh3-expressing cells, while over-expression of gnrh3 mRNA increased the number of these cells. …”
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    Hedgehog-PKA Signaling and gnrh3 Regulate the Development of Zebrafish gnrh3 Neurons
  5. 3805
    “…In a previous study we analyzed changes in the abundance of free and polysomal, i.e. ribosome bound, RNAs in the first hours of adipogenesis in the murine cell line 3T3-L1. Here we analyze changes of mRNA levels and their potential contribution to the changing protein pool by determination of mRNA levels and ribosome binding to mRNAs in 3T3-L1 cells stimulated for adipogenesis. …”
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    Dynamics of mRNA and polysomal abundance in early 3T3-L1 adipogenesis
  6. 3806
    “…BACKGROUND: Histone variants establish structural and functional diversity of chromatin by affecting nucleosome stability and histone-protein interactions. H3.3 is an H3 histone variant that is incorporated into chromatin outside of S-phase in various eukaryotes. …”
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    Arabidopsis replacement histone variant H3.3 occupies promoters of regulated genes
  7. 3807
    “…In 2007, the Ubiquitously Transcribed Tetratricopeptide Repeat on chromosome X (UTX) was identified as a histone demethylase that specifically targets di- and tri-methyl groups on lysine 27 of histone H3 (H3K27me2/3). Since then, UTX has been proven essential during normal development, as it is critically required for correct reprogramming, embryonic development and tissue-specific differentiation. …”
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    The H3K27me3 demethylase UTX in normal development and disease
  8. 3808
    “…The proteins with the highest Mascot score were validated using western blot analysis in an additional 55 sera samples from the control and CIN III groups. The eight highest score spots that were found to be overexpressed in the CIN III sera group were identified as α-1-B glycoprotein (A1BG), complement component 3 (C3), a pro-apolipoprotein, two apolipoproteins and three haptoglobins. …”
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    A1BG and C3 are overexpressed in patients with cervical intraepithelial neoplasia III
  9. 3809
    “…In this review, we discuss JAK-STAT signalling pathway inhibition by the inducible inhibitor “suppressor of cytokine signaling 3 (SOCS3), its role in diseases such as myeloproliferative disorders, and its function as part of a multi-subunit E3 ubiquitin ligase complex. …”
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    Role of Ubiquitylation in Controlling Suppressor of Cytokine Signalling 3 (SOCS3) Function and Expression
  10. 3810
    “…Here, we investigated the effect of a zinc-chelated vitamin C (ZnC) compound on the adipogenic differentiation of 3T3-L1 preadipocytes. Treatment with ZnC for 8 d significantly promoted adipogenesis, which was characterized by increased glycerol-3-phosphate dehydrogenase activity and intracellular lipid accumulation in 3T3-L1 cells. …”
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    Zinc-chelated Vitamin C Stimulates Adipogenesis of 3T3-L1 Cells
  11. 3811
    “…In the case of the Cullin3 (Cul3), it forms a BTB-Cul3-Rbx1 (BCR) ubiquitin ligase complex where it is believed that a BTB domain-containing protein performs dual functions where it serves as both the substrate adaptor and the substrate recognition protein. …”
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    Novel Cul3 binding proteins function to remodel E3 ligase complexes
  12. 3812
    “…The activation profiles of these TFs at different times following induction of adipogenic differentiation were quantified using 3T3-L1 reporter cell lines constructed to secrete the Gaussia luciferase enzyme upon binding of a TF to its DNA binding element. …”
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    Analysis of Transcription Factor Network Underlying 3T3-L1 Adipocyte Differentiation
  13. 3813
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    3-Bromo-N-(3,5-di-tert-butyl­phen­yl)propanamide
  14. 3814
    “…Phosphorylated tyrosine hydroxylase (TH) can form complexes with 14-3-3 proteins, resulting in enzyme activation and stabilization. …”
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    Phosphorylation Dependence and Stoichiometry of the Complex Formed by Tyrosine Hydroxylase and 14-3-3γ
  15. 3815
    “…Lymphocyte Activation Gene-3 (LAG-3) is a CD4-related, MHC-class II binding molecule expressed on activated T cells and NK cells which maintains lymphocyte homeostatic balance via various inhibitory mechanisms. …”
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    Lymphocyte Activation Gene-3 (LAG-3) Negatively Regulates Environmentally-Induced Autoimmunity
  16. 3816
    “…In particular, the topological surface state, the hallmark of the three-dimensional semimetal, has not been observed in Cd(3)As(2). …”
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    Evidence of Topological Surface State in Three-Dimensional Dirac Semimetal Cd(3)As(2)
  17. 3817
    por Sun, Wan, Liu, Wen-Mo, Li, Sheng-Li
    Publicado 2014
    “…In the crystal, mol­ecules are linked by O—H⋯O hydrogen bonds, forming inversion dimers; π–π stacking between carbazole ring systems of adjacent dimers further links the dimers into supra­molecular chains propagating along the b-axis direction [centroid-to-centroid distances = 3.868 (2) and 3.929 (2) Å].…”
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    (E)-3-(9-Hexyl-9H-carbazol-3-yl)acrylic acid
  18. 3818
    “…The two-component regulatory system (2CRS) SenX3-RegX3 is required for Mtb virulence. We showed recently that the senX3-regX3 intergenic region contains promoter activity, driving senX3-independent regX3 expression. …”
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    senX3-independent contribution of regX3 to Mycobacterium tuberculosis virulence
  19. 3819
    “…Meta-analysis was performed using 2.3 million single-nucleotide polymorphisms (SNPs) tested against each of the three PCs of hearing ability in 4939 individuals. …”
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    Salt-inducible kinase 3, SIK3, is a new gene associated with hearing
  20. 3820
    “…In general, the BALB/c 3T3 cell line is more than 1000 times more sensitive than the in vivo studies. …”
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    Toxicity of silver nanoparticle in rat ear and BALB/c 3T3 cell line
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