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  1. 3981
    “…We investigated the mechanism by which MET phosphorylates the human epidermal growth factor receptor-3 (HER3 or ERBB3), a catalytically impaired RTK whose phosphorylation by MET has been described as an essential component of drug resistance to inhibitors targeting EGFR and HER2. …”
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    Overexpression-mediated activation of MET in the Golgi promotes HER3/ERBB3 phosphorylation
  2. 3982
    “…RESULTS: Three-dimensional Membrane Morphological Segmentation (3DMMS) makes use of several novel techniques, such as statistical intensity normalization, and region filters, to pre-process the cell images. …”
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    3DMMS: robust 3D Membrane Morphological Segmentation of C. elegans embryo
  3. 3983
    “…The molecular mechanism has not been well understood, however, it seems that PI3K, AKT, GSK3, and their downstream molecules have crucial roles in the pathogenesis. …”
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    Roles of PI3K/AKT/GSK3 Pathway Involved in Psychiatric Illnesses
  4. 3984
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    General, Practical and Selective Oxidation Protocol for CF(3)S into CF(3)S(O) Group
  5. 3985
    “…Here, we analyzed the expression patterns of the Chinese cabbage AN3 gene (BrAN3) before and after leafy head formation, and produced BrAN3 gene silencing plants by using the turnip yellow mosaic virus (TYMV)-derived vector in order to explore its potential function in leafy head formation in Chinese cabbage. …”
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    Transcription Coactivator ANGUSTIFOLIA3 (AN3) Regulates Leafy Head Formation in Chinese Cabbage
  6. 3986
    “…During hemostasis and thrombosis, ultralarge (UL) VWF (ULVWF) multimers initiate platelet adhesion. In vitro, human C3 binds to ULVWF multimeric strings secreted by and anchored to human endothelial cell to promote the assembly and activation of C3 convertase (C3bBb) and C5 convertase (C3bBbC3b) of the alternative complement pathway (AP). …”
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    Complement Component C3 Binds to the A3 Domain of von Willebrand Factor
  7. 3987
    por Wagner, Hanna J., Weber, Wilfried
    Publicado 2019
    “…Here, we describe and compare different design strategies for the generation of a human rhinovirus-14 (HRV14) 3C protease-inducible caspase-3 (CASP3). We exemplify the application potential of the resulting protease by controlling the activity of a synthetic enzyme cascade, which represents an important motif for the design of artificial signal transduction networks. …”
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    Design of a Human Rhinovirus-14 3C Protease-Inducible Caspase-3
  8. 3988
    “…The aim of the present study is to examine the role of 3 fibulin-3 peptides (Fib3-1, Fib3-2, and Fib3-3) and a type II collagen degradation product in a rat osteoarthritis model with systemic metabolic alterations combined with local cartilage damage. …”
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    Fib3-3 as a Biomarker for Osteoarthritis in a Rat Model with Metabolic Dysregulation
  9. 3989
    “…BACKGROUND: SEMA3B is known as an inhibitor of angiogenesis and cell proliferation. …”
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    Expression of Semaphorin 3B (SEMA3B) in Various Grades of Endometrial Cancer
  10. 3990
    “…Cell morphology of methylmercury and theaflavin-3,3′-digallate treated adipocytes was assessed using Lipid (Oil Red O) staining. …”
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    Effects of Methylmercury and Theaflavin Digallate on Adipokines in Mature 3T3-L1 Adipocytes
  11. 3991
    por Kwak, Sang Hee, Kim, Yoon Hee
    Publicado 2019
    “…Differentiated 3T3-L1 cells were subjected to Oil red O solution or used for Western blot analysis. …”
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    Zaluzanin C Inhibits Differentiation of 3T3-L1 Preadipocytes into Mature Adipocytes
  12. 3992
    “…Here we present an example of this by studying a missense variant in a well-known autism spectrum disorder (ASD) causing gene SHANK3. We analyzed Shank3’s in vivo phosphorylation profile and identified S685 as one phosphorylation site where one ASD-linked variant has been reported. …”
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    An autism-linked missense mutation in SHANK3 reveals the modularity of Shank3 function
  13. 3993
    “…In this paper, the systematic investigation of metastable dissolution regularity of Nd(3+) in Na(2)CO(3) solution was carried out. The results showed that Nd(3+) has an instantaneous saturated solubility in Na(2)CO(3) solution. …”
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    Metastable Dissolution Regularity of Nd(3+) in Na(2)CO(3) Solution and Mechanism
  14. 3994
    “…[Image: see text] A two-step one-pot efficient synthesis of pyrido[2,3-b]indoles via reaction between isatin, α-amino acid, and dipolarophile has been developed. …”
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    Dehydrative Transformation of Spirooxindoles to Pyrido[2,3-b]indoles via POCl(3)
  15. 3995
    “…Discovering conserved three-dimensional (3D) patterns among protein structures may provide valuable insights into protein classification, functional annotations or the rational design of multi-target drugs. …”
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    3D-PP: A Tool for Discovering Conserved Three-Dimensional Protein Patterns
  16. 3996
    “…BACKGROUND: Dok-3 has been shown to play an important role in immune system. …”
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    Dok-3 deficient mice display different immune clustering and Tim-3 expression
  17. 3997
    “…TNF-like ligand 1 A (TL1A) and death receptor 3 (DR3) are a ligand-receptor pair involved in the pathogenesis of inflammatory bowel disease. …”
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    Activation of DR3 signaling causes loss of ILC3s and exacerbates intestinal inflammation
  18. 3998
    “…The presence of autoantibodies against 14-3-3ζ in human autoimmune diseases indicates its antigenic function. …”
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    14-3-3ζ-A Novel Immunogen Promotes Inflammatory Cytokine Production
  19. 3999
    “…14-3-3 proteins are a family of conserved regulatory adaptor molecules which are expressed in all eukaryotic cells. …”
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    14-3-3 Proteins Are on the Crossroads of Cancer, Aging, and Age-Related Neurodegenerative Disease
  20. 4000
    “…These phenotypes were recapitulated by genetic deletion of CR3, a microglia-expressed receptor for the C3 activation product iC3b, implicating C3-CR3 signaling as a regulator of microglia–photoreceptor interactions. …”
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    C3- and CR3-dependent microglial clearance protects photoreceptors in retinitis pigmentosa
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