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4081por Sims, Natalie A.“…Specifically, this review describes defects in JAK1, STAT3, and SOCS3 signaling in mouse models and in humans, including mutations designed to modify these pathways downstream of the gp130 coreceptor. …”
Publicado 2020
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4082“…The aim of this case presentation is to emphasise the typical electrocardiographic findings that are detected with massive pulmonary embolism along with the electrocardiographic S1Q3 and S1Q3T3 accompanied by T negativity at the D3 derivation based on prevalent T negativity. …”
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4083por Trofimova, Olesya Y., Maleeva, Arina V., Ershova, Irina V., Cherkasov, Anton V., Fukin, Georgy K., Aysin, Rinat R., Kovalenko, Konstantin A., Piskunov, Alexandr V.“…Three new 3D metal–organic frameworks of lanthanum based on mixed anionic ligands, [(La(2)(pQ)(2)(BDC)(4))·4DMF](n), [(La(2)(pQ)(2)(DHBDC)(4))·4DMF](n), [(La(2)(CA)(2)(BDC)(4))·4DMF](n) (pQ—dianion of 2,5-dihydroxy-3,6-di-tert-butyl-para-quinone, CA—dianion of chloranilic acid, BDC-1,4-benzenedicarboxylate, DHBDC-2,5-dihydroxy-1,4-benzenedicarboxylate and DMF-N,N′-dimethylformamide), were synthesized using solvothermal methodology. …”
Publicado 2021
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4084por López-Pérez, Arancha, Freischem, Stefan, Grimm, Immanuel, Weiergräber, Oliver, Dingley, Andrew J., López-Alberca, María Pascual, Waldmann, Herbert, Vollmer, Waldemar, Kumar, Kamal, Vuong, Cuong“…To discover novel, non-β-lactam inhibitors against PBP3 of Pseudomonas aeruginosa, we optimised a fluorescence assay based on a well-known thioester artificial substrate and performed a target screening using a focused protease-targeted library of 2455 compounds, which led to the identification of pyrrolidine-2,3-dione as a potential scaffold to inhibit the PBP3 target. …”
Publicado 2021
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4085por Mahfouz, Mohamed R., Abdel Fatah, Emam E., Johnson, J. Michael, Komistek, Richard D.“…AIMS: The objective of this study is to assess the use of ultrasound (US) as a radiation-free imaging modality to reconstruct 3D anatomy of the knee for use in preoperative templating in knee arthroplasty. …”
Publicado 2021
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4086“…In this work, we systematically study the so-called three-loop braiding statistics for 3D interacting fermion systems. …”
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4087“…The loading capacity was found to be 179.3 g L(−1) and 141.5 g L(−1), respectively, for Ce (III) and Pr (III) ions at pH 5 with a contact time of 30 min and dose being 0.1 g L(−1). …”
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4088“…Cullin3-based ubiquitin E3 ligases induce ubiquitination of substrates leading to their proteasomal or lysosomal degradation. …”
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4089“…(2-Chloroquinolin-3-yl)-1,3,4-thiadiazole-2-carboxamides were synthesized from hydrazones obtained via the reaction of 3-formyl-2-chloroquinoline with oxamic acid thiohydrazides.…”
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4090por Li, Chuanyin, Lu, Wenli, Yang, Liguang, Li, Zhengwei, Zhou, Xiaoyi, Guo, Rong, Wang, Junqi, Wu, Zhebao, Dong, Zhiya, Ning, Guang, Shi, Yujiang, Gu, Yinmin, Chen, Peng, Hao, Zijian, Han, Tianting, Yang, Meiqiang, Wang, Wei, Huang, Xuehui, Li, Yixue, Gao, Shan, Hu, Ronggui“…Previously, loss-of-function mutations in human MKRN3, encoding a putative E3 ubiquitin ligase, were found to contribute to about 30% of cases of familial CPP. …”
Publicado 2020
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4091“…The multiferroic materials BiFeO(3) and RMnO(3) exhibit coexisting magnetic order and ferroelectricity, and provide exciting platforms for new physics and potentially novel devices, where intriguing interplay between phonons and magnons exists. …”
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4092“…The aim of the current study was to explore whether the combination of genistein and atorvastatin at low concentrations significantly suppresses adipogenesis in a murine preadipocyte cell line (3T3-L1) compared to treatment with genistein or atorvastatin alone. …”
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4093“…We successfully implemented the 3 × 3 MIMO LED-to-LED communication system using RGB colors at a data rate of 30.62 kbps over a 10 cm transmission distance along with direct current biased optical orthogonal frequency division multiplexing (DCO-OFDM) modulation and zero-forcing (ZF) equalizer.…”
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4094“…MTT assay was used to measure the cell viability and Oil Red O staining was used to evaluate the adipogenesis of 3T3-L1 cells. The total level of triglyceride and released glycerol were detected to evaluate the lipolysis during 3T3-L1 adipogenesis. …”
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4095por Dayarathne, Lakshi A., Ranaweera, Sachithra S., Natraj, Premkumar, Rajan, Priyanka, Lee, Young Jae, Han, Chang-Hoon“…Differential gene expressions in 3T3-L1 adipocytes were evaluated via RNA sequencing analysis. …”
Publicado 2021
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4096por Iessa, Noha, Macolic Sarinic, Viola, Ghazaryan, Lilit, Romanova, Naira, Alemu, Asnakech, Rungapiromnan, Watcharee, Jiamsuchon, Porntip, Pokhagul, Pattreya, Castro, Jose Luis, Macias Saint-Gerons, Diego, Ghukasyan, Gayane, Teferi, Mengistab, Gupta, Madhur, Pal, Shanthi Narayan“…METHOD: The 3S principles were applied to Armenia, Brazil, Ethiopia, India, Peru and Thailand using three priority products: bedaquiline, rotavirus vaccine and tafenoquine. …”
Publicado 2021
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4097“…In response to diverse pathogenic and danger signals, the cytosolic activation of the NLRP3 (NOD-, LRR-, and pyrin domain-containing (3)) inflammasome complex is a critical event in the maturation and release of some inflammatory cytokines in the state of an inflammatory response. …”
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4098“…Teneligliptin, a dipeptidyl peptidase-4 inhibitor, is used to treat type 2 diabetes mellitus. FMO3 and CYP3A4 metabolize teneligliptin into teneligliptin sulfoxide. …”
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4099por Jakkawanpitak, Chanawee, Inafuku, Masashi, Oku, Hirosuke, Hutadilok-Towatana, Nongporn, Bunkrongcheap, Ruthaiwan, Sermwittayawong, Natthawan, Aiemchareon, Piyapat, Sermwittayawong, DechaEnlace del recurso
Publicado 2021
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4100por Soini, Lorenzo, Redhead, Martin, Westwood, Marta, Leysen, Seppe, Davis, Jeremy, Ottmann, Christian“…At the same time identifying molecular glues has received recent sustained interest, especially in the fields of targeted protein degradation and 14-3-3 PPIs. The hub-protein 14-3-3 has a broad interactome with more than 500 known protein partners which presents a great opportunity for therapeutic intervention. …”
Publicado 2021
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