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  1. 461
    “…For Ca(2+) signals initiated by inositol trisphosphate (IP(3)) this requires local interactions between IP(3) receptors (IP(3)R)3,4 mediated by their rapid stimulation and slower inhibition4 by cytosolic Ca(2+). …”
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    Clustering of IP(3) receptors by IP(3) retunes their regulation by IP(3) and Ca(2+)
  2. 462
    por Lee, Hon Man, Lu, Chi-Ying
    Publicado 2008
    “…Non­classical inter­molecular C—H⋯Br hydrogen bonds link the imidazolium cations and the bromide anions into a three-dimensional network.…”
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    3,3′-Bis(3-methoxy­benz­yl)-1,1′-ethyl­enediimidazolium dibromide
  3. 463
    “…The title compound, C(16)H(17)NO(5)S, was one of two condensation products from the reaction of 1-(1,3-benzothia­zol-2-yl)propan-2-one with methyl chloro­acetate. …”
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    Dimethyl 3-acetyl-3-(1,3-benzothia­zol-2-yl)penta­nedioate
  4. 464
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    3-[(3-Oxo-1,3-dihydro­isobenzofuran-1-yl)amino]benzoic acid
  5. 465
    “…The dimers are further linked into a three-dimensional network by C—H⋯O inter­actions.…”
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    3-Benzyl-3-hy­droxy-2-phenyl-3H-indole 1-oxide
  6. 466
    “…In the title compound, C(13)H(14)N(2)O(3), the fused ring system is almost planar (r.m.s. deviation = 0.015 Å). …”
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    Ethyl 3-(3-oxo-3,4-dihydro­quinoxalin-2-yl)propano­ate
  7. 467
    por Qiu, Yu-E
    Publicado 2011
    “…Neighboring chains are further packed via weak π–π inter­actions between inter­chain parallel 1,10-phen rings [centroid–centroid distance = 3.5197 (9) Å] into a three-dimensional supra­molecular architecture.…”
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    Poly[(μ(3)-biphenyl-3,3′-dicarboxyl­ato)(1,10-phenanthroline)cadmium]
  8. 468
    “…Reactions of linear allyl ethers are consistent with the [3,3]-sigmatropic rearrangement mechanism, while those of branched allyl ethers provided [3,3]- and [1,3]-rearrangement products through the formation of a tight ion–dipole pair.…”
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    Gold-catalyzed intermolecular coupling of sulfonylacetylene with allyl ethers: [3,3]- and [1,3]-rearrangements
  9. 469
    “…Actively transcribed regions of the genome have been found enriched for the histone H3 variant H3.3. This variant is incorporated into nucleosomes throughout the cell cycle whereas the canonical isoforms are predominately deposited in association with replication. …”
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    Distinct chromatin signature of histone H3 variant H3.3 in human cells
  10. 470
    “…Although the anticonvulsant activity of 3-hydroxy-3-ethyl-3-phenylproionamide (HEPP) is well-known, its use is limited by the pharmacotoxicological profile. …”
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    Anticonvulsant and Toxicological Evaluation of Parafluorinated/Chlorinated Derivatives of 3-Hydroxy-3-ethyl-3-phenylpropionamide
  11. 471
    “…Moreover, expression of chemokine CCL2, MCP-1 and its receptor CCR2, which play an important role in macrophage chemotaxis, were reduced in WAT of PDE3B(−/−)mice. In addition, atherosclerotic plaque formation was significantly reduced in the aorta of apoE(−/−)/PDE3B(−/−)and LDL-R(−/−)/PDE3B(−/−)mice compared to apoE(−/−)and LDL-R(−/−)mice, respectively. …”
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    Phosphodiesterase 3B (PDE3B) regulates NLRP3 inflammasome in adipose tissue
  12. 472
    “…The reaction of N-(2,3- and 3,5-dimethylphenyl)-α-methyl-β-alanines with ethyl acetoacetate gave 1-(2,3- or 3,5-dimethylphenyl)-2,5-dimethyl-1,4,5,6-tetrahydro-4(1H)pyridones. …”
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    Synthesis and Cyclizations of N-(2,3-, 3,4- and 3,5-Dimethylphenyl)-β-alanines
  13. 473
    “…Although they are based on the nominally simple cubic perovskite structure, these compounds are in fact very complex. For example, in (CH(3)NH(3))PbI(3) the dynamics and ensuing structural fluctuations associated with the (CH(3)NH(3))(+) ions and the interplay with the electronic properties are still not fully understood, despite extensive study. …”
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    Multi Band Gap Electronic Structure in CH(3)NH(3)PbI(3)
  14. 474
    “…Autophagy is a conserved eukaryotic pathway critical for cellular adaptation to changes in nutrition levels and stress. The class III phosphatidylinositol (PI)3-kinase complexes I and II (PI3KC3-C1 and -C2) are essential for autophagosome initiation and maturation, respectively, from highly curved vesicles. …”
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    Regulation of LC3 lipidation by the autophagy-specific class III phosphatidylinositol-3 kinase complex
  15. 475
    “…Excellent conversion efficiencies of over 20 % and facile cell production have placed hybrid perovskites at the forefront of novel solar cell materials, with CH(3)NH(3)PbI(3) being an archetypal compound. The question why CH(3)NH(3)PbI(3) has such extraordinary characteristics, particularly a very efficient power conversion from absorbed light to electrical power, is hotly debated, with ferroelectricity being a promising candidate. …”
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    Role of the Iodide–Methylammonium Interaction in the Ferroelectricity of CH(3)NH(3)PbI(3)
  16. 476
    “…Toll-like receptor 3 (TLR3)-mediated signaling is important for host defense against RNA virus. …”
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    ZCCHC3 modulates TLR3-mediated signaling by promoting recruitment of TRIF to TLR3
  17. 477
    por Weil, Matthias
    Publicado 2020
    “…A qu­anti­tative structural comparison with isotypic RbPO(3) and CsPO(3) reveals that the usually pronounced stereoactivity of the 6s (2) lone pair at the Tl(I) atom is not apparent in the case of TlPO(3).…”
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    TlPO(3) and its comparison with isotypic RbPO(3) and CsPO(3)
  18. 478
    “…In the present work, arylethynes were studied as new C-nucleophiles in the asymmetric Mannich addition reactions with (S)-N-tert-butylsulfinyl-3,3,3-trifluoroacetaldimine. The reactions were conducted under operationally convenient conditions affording the corresponding Mannich adducts with up to 87% yield and 70:30 diastereoselectivity. …”
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    Asymmetric Mannich reactions of (S)-N-tert-butylsulfinyl-3,3,3-trifluoroacetaldimines with yne nucleophiles
  19. 479
    “…Driven by the intrinsic structural differences of pathogens, IQ–Cm with a cationic isoquinolinium moiety and a membrane-active coumarin unit as the targeting and interacting groups selectively locates in different sites of three pathogens and gives three naked-eye discernible emission colors. …”
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    One stone, three birds: one AIEgen with three colors for fast differentiation of three pathogens
  20. 480
    por Williams, David E.
    Publicado 2021
    “…Hydrolysis of glucobrassicin by plant or bacterial myrosinase produces multiple indoles predominantly indole-3-carbinol (I3C). I3C and its major in vivo product, 3,3'-diindolylmethane (DIM), are effective cancer chemopreventive agents in pre-clinical models and show promise in clinical trials. …”
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    Indoles Derived From Glucobrassicin: Cancer Chemoprevention by Indole-3-Carbinol and 3,3'-Diindolylmethane
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