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6141por Wu, Qinghua, Zhang, Peikai, O’Leary, Gerard, Zhao, Yimu, Xu, Yinghao, Rafatian, Naimeh, Okhovatian, Sargol, Landau, Shira, Valiante, Taufik A, Travas-Sejdic, Jadranka, Radisic, Milica“…The high aspect ratio microelectrodes were 3D-printed into the device using a conductive polymer, poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS). …”
Publicado 2023
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6142por López-Cervantes, Valeria B., Bara, Dominic, Yañez-Aulestia, Ana, Martínez-Ahumada, Eva, López-Olvera, Alfredo, Amador-Sánchez, Yoarhy A., Solis-Ibarra, Diego, Sánchez-González, Elí, Ibarra, Ilich A., Forgan, Ross S.“…Modulated self-assembly protocols are used to develop facile, HF-free syntheses of the archetypal flexible PCP, MIL-53(Cr), and novel isoreticular analogues MIL-53(Cr)-Br and MIL-53(Cr)-NO(2). All three PCPs show good SO(2) uptake (298 K, 1 bar) and high chemical stabilities against dry and wet SO(2). …”
Publicado 2023
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6143por Amaral, Rebeca A. S., Motta, Fabiana L., Zin, Olivia A., da Palma, Mariana M., Rodrigues, Gabriela D., Sallum, Juliana M. F.“…Pathogenic variants in six genes encoding proteins composing the cone phototransduction cascade (CNGA3, CNGB3, PDE6C, PDE6H, GNAT2) and of the unfolded protein response (ATF6) have been related to ACHM cases, while CNGA3 and CNGB3 alone are responsible for most cases. …”
Publicado 2023
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6144por Liang, Peir-In, Lai, Hong-Yue, Chan, Ti-Chun, Li, Wei-Ming, Hsing, Chung-Hsi, Huang, Steven K., Hsieh, Kun-Lin, Tseng, Wen-Hsin, Chen, Tzu-Ju, Li, Wan-Shan, Chen, Huan-Da, Kuo, Yu-Hsuan, Li, Chien-Feng“…BACKGROUND: Dihydropyrimidinase-like 3 (DPYSL3) is a cytosolic phosphoprotein expressed in the nervous system and is crucial for neurogenesis. …”
Publicado 2023
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6145“…Despite the several advantages that 3D printing offers for the fabrication of microneedles, their poor penetration capability into the skin should be improved. …”
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6146por Tretiakov, Serhii, Lutz, Martin, Titus, Charles James, de Groot, Frank, Nehrkorn, Joscha, Lohmiller, Thomas, Holldack, Karsten, Schnegg, Alexander, Tarrago, Maxime François Xavier, Zhang, Peng, Ye, Shengfa, Aleshin, Dmitry, Pavlov, Alexander, Novikov, Valentin, Moret, Marc-Etienne“…Furthermore, [(TSMP)(2)Fe(III)](−) can be reversibly oxidized to the stable high-valent [(TSMP)(2)Fe(IV)](0) complex. …”
Publicado 2023
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6147“…The Mexican axolotl (Ambystoma mexicanum) is a neotenic species that has lost the ability to undergo metamorphosis; however, it can be artificially induced by exogenous administration of thyroxine (T4) and 3,3′,5-triiodo-L-thyronine (T3). Another TH derivative with demonstrative biological effects in fish and mammals is 3,5-diiodo-L-thyronine (3,5-T2). …”
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6148por Cahyadi, Danang Dwi, Warita, Tomoko, Irie, Nanami, Mizoguchi, Kana, Tashiro, Jiro, Hosaka, Yoshinao Z., Warita, Katsuhiko“…Reverse transcription-quantitative polymerase chain reaction was used to measure the expression of 10 candidate housekeeping genes in non-differentiated (ND) and differentiated (DI) 3T3-L1 cells on days 5 and 10. We used geNorm, NormFinder, BestKeeper, RefFinder, and the ∆Ct method to evaluate expression stability. …”
Publicado 2023
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6149por Ekowati, Juni, Nofianti, Kholis Amalia, Yunita, Maya Nurwartanti, Hamid, Iwan Sahrial, Dwiningrum, Fitria, Ramadhan, Darwin Ryan, Ananda, Ghinalya Chalbi“…OBJECTIVES: The present study aimed to synthesize the (E)-3- (3-methoxyphenyl)propenoic acid (3MPCA), to determine the anti-angiogenic activity and predict its toxicity. …”
Publicado 2023
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6150por Chen, Qiuyan, Schafer, Christopher T., Mukherjee, Somnath, Gustavsson, Martin, Agrawal, Parth, Yao, Xin-Qiu, Kossiakoff, Anthony A., Handel, Tracy M., Tesmer, John J. G.“…Atypical chemokine receptor 3 (ACKR3, also known as CXCR7) is a scavenger receptor that regulates extracellular levels of the chemokine CXCL12 to maintain responsiveness of its partner, the G protein-coupled receptor (GPCR), CXCR4. …”
Publicado 2023
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6151“…Some of the most robust descriptors are derived from geometrical representations of molecules, called 3-dimensional (3D) descriptors. When calculated from molecular dynamics (MD) simulation trajectories, 3D descriptors can also capture the effects of operating conditions such as temperature or pressure. …”
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6152“…CONCLUSIONS: 3D-SPACE and 3D-VIBE are more successful in evaluating CSF leakages compared to 3D-MPRAGE. 3D-SPACE has lower artifact scores compared to 3D-VIBE and 3D-MPRAGE sequences.…”
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6153por Burley, Kate, Fitzgibbon, Lucy, van Heel, David, Vuckovic, Dragana, Mumford, Andrew D.“…Functional annotation, mapping to megakaryocyte regulatory regions, and colocalization with blood expression quantitative trait loci identified the likely mediator of the PLT phenotype to be PIK3R3 encoding a regulator of phosphoinositol 3-kinase (PI3K). …”
Publicado 2023
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6154por Cao, Ruijie, Li, Yaning, Chen, Xin, Ge, Xichuan, Li, Meiqi, Guan, Meiling, Hou, Yiwei, Fu, Yunzhe, Xu, Xinzhu, Leterrier, Christophe, Jiang, Shan, Gao, Baoxiang, Xi, Peng“…Open-3DSIM is an open-source reconstruction platform for three-dimensional structured illumination microscopy. …”
Publicado 2023
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6155por Kaneda, Marisa, Oyama, Manami, Yoshimi, Takashi, Michihara, Seiwa, Han, Li-Kun, Fujita, Nina, Takahashi, Ryuji“…Previous studies using human liver microsomes have reported that constituents of NYT either inhibit (schisandra fruit, cinnamon bark, glycyrrhiza, and poria sclerotium) or induce (schisandra fruit and glycyrrhiza) CYP3A4 expression. Herein, we conducted in vitro and in vivo studies targeting human CYP3A and mouse CYP3A to elucidate the effects of NYT coadministration with other drugs on hepatic drug metabolism. …”
Publicado 2023
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6156Engineering Agrobacterium tumefaciens with a Type III Secretion System to Express Type III Effectors“…Some pathogenic bacteria have sophisticated mechanisms to counteract these defense responses by injecting Type III effectors (T3Es) through the Type III secretion system (T3SS). …”
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6157por Rendošová, Michaela, Gyepes, Róbert, Sovová, Simona, Sabolová, Danica, Vilková, Mária, Olejníková, Petra, Kello, Martin, Lakatoš, Boris, Vargová, Zuzana“…A series of novel Ga(III)—pyridine carboxylates ([Ga(Pic)(3)]·H(2)O (GaPic; HPic = picolinic acid), H(3)O[Ga(Dpic)(2)]·H(2)O (GaDpic; H(2)Dpic = dipicolinic acid), [Ga(Chel)(H(2)O)(OH)](2)·4H(2)O (GaChel; H(2)Chel = chelidamic acid) and [Ga(Cldpic)(H(2)O)(OH)](2) (GaCldpic; H(2)Cldpic = 4-chlorodipicolinic acid)) have been synthesized by simple one-step procedure. …”
Publicado 2023
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6158por Yan, Chaojun, Xiong, Jingjing, Zhou, Zirui, Li, Qifang, Gao, Chuan, Zhang, Mengyao, Yu, Liya, Li, Jinpeng, Hu, Ming-Ming, Zhang, Chen-Song, Cai, Cheguo, Zhang, Haojian, Zhang, Jing“…Here, we identify a novel cleaved form METTL3a (residues 239–580 of METTL3). We find that METTL3a is required for the METTL3–WTAP interaction, RNA m(6)A deposition, as well as cancer cell proliferation. …”
Publicado 2023
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6159por Issarapu, Prachand, Arumalla, Manisha, Elliott, Hannah R., Nongmaithem, Suraj S., Sankareswaran, Alagu, Betts, Modupeh, Sajjadi, Sara, Kessler, Noah J., Bayyana, Swati, Mansuri, Sohail R., Derakhshan, Maria, Krishnaveni, G. V., Shrestha, Smeeta, Kumaran, Kalyanaraman, Di Gravio, Chiara, Sahariah, Sirazul A., Sanderson, Eleanor, Relton, Caroline L., Ward, Kate A., Moore, Sophie E., Prentice, Andrew M., Lillycrop, Karen A., Fall, Caroline H. D., Silver, Matt J., Chandak, Giriraj R.“…We investigate links between blood DNA methylation and child height in four LMIC cohorts (n = 1927) and identify a robust association at three CpGs in the suppressor of cytokine signaling 3 (SOCS3) gene which replicates in a high-income country cohort (n = 879). …”
Publicado 2023
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6160por Rathod, Vikas Damu, Paganelli, Stefano, Kočevar, Marijan, Krivec, Marko, Piccolo, Oreste“…The obtained mixture of 1-(3,3-diethoxypropyl)-3-(trifluoromethyl)benzene (III), impure for ethyl 3-(3-trifluoromethylphenyl) propanoate (IV), was finally treated, under mild conditions, with potassium diisobutyl-tert-butoxyaluminum hydride (PDBBA) to obtain after hydrolysis 3-(3-trifluoromethylphenyl)propanal (II), in an excellent overall yield and very high purity. …”
Publicado 2023
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