“…The asymmetric unit of the title compound, C(13)H(12)N(2)O(2), obtained in a search for analogs of the fungicide fludioxonil [systematic name: 4-(2,2-difluoro-1,3-benzodioxol-4-yl)-1H-pyrrole-3-carbonitrile], contains two independent mol­ecules, A and B. …”
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“…Pharmaceutical activation of the canonical Wnt pathways in Wnt3/Wnt3a compound morphant embryos is able to restore the lack of the MDO. …”
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“…Independent qPCR analysis confirmed the up-regulation of amygdala 14-3-3ζ during the escalation of alcohol intake. Subsequently, we found that local knockdown of 14-3-3ζ in the amygdala, using RNA interference, dramatically augmented alcohol intake. …”
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“…Fibronectin could be easily immobilized by tresyl chloride-activation technique. MC3T3-E1 cells were seeded on the different titanium surfaces. …”
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“…The three-dimensional framework is made up from four Mn(2+)/Mn(3+) cations surrounded octa­hedrally by O atoms. …”
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“…Wuji Huaxue Xuebao, 7, 351–353], all H atoms could be located, accompanied with higher accuracy and precision. The Gd(III) atom shows a ten-coordination with three nitrate ligands behaving in a bidentate manner and the other positions being occupied by four water mol­ecules, forming a distorted bicapped square anti­prism. …”
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“…In the title compound, the coordination environment of the Pr(III) atom can best be described as a distorted bicapped square anti­prism defined by three bidentate nitrate anions and four water mol­ecules. …”
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“…How the linker interacts with the ring during the ATP hydrolysis cycle is not known. Here we present a 3.3Å crystal structure of the motor domain of Saccharomyces cerevisiae cytoplasmic dynein, crystallized in the absence of nucleotides. …”
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“…This letter describes the use of vertically aligned carbon nanotubes (CNT)-based arrays with estimated 2-nm thick cobalt (Co) nanoparticles deposited inside individual tubes to unravel the possibility of using the unique templates for ultra-high-density low-energy 3-D nano-magneto-electronic devices. The presence of oriented 2-nm thick Co layers within individual nanotubes in the CNT-based 3-D matrix is confirmed through VSM measurements as well as an energy-dispersive X-ray spectroscopy (EDS).…”
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“…One of the clones we identified was 14-3-3θ, which belongs to a family of small acidic protein abundantly expressed in the brain. …”
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“…To examine the precise expression of the Dkk3 protein, we generated BAC-Dkk3-EGFP transgenic mice that express EGFP integrated into the Dkk3 gene in a BAC plasmid. …”
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“…In the title compound, C(15)H(10)F(2)O(3)S, the 3-fluoro­phenyl ring makes a dihedral angle of 79.51 (6)° with the mean plane [r.m.s. deviation = 0.006 (2) Å] of the benzofuran fragment. …”
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“…In the crystal, mol­ecules are linked by weak C—H⋯O hydrogen bonds and a Br⋯O contact [3.200 (3) Å]. The crystal structure also exhibits slipped π–π inter­actions between the benzene and furan rings of neighbouring mol­ecules [centroid–centroid distance = 3.619 (4) Å and slippage of 1.389 (4) Å]. …”
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“…BACKGROUND: Development of small-molecule inhibitors targeting phosphoinositide 3-kinase (PI3K) has been an appealing strategy for the treatment of various types of cancers. …”
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“…To address the relevance of Smad3 binding to the CNS1 enhancer in vivo, we generated mice that exclusively lack the Smad binding site (foxp3(CNS1mut)). …”
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“…Long-chain n-3-polyunsaturated fatty acids (n-3 LCPUFAs), referring particularly to marine-derived eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been shown to be effective in treating arrhythmias in some clinical trials and animal studies. …”
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“…Analyses of nucleosome assembly indicate that mutant D123N H3.3 interferes with H3.3 nucleosomal incorporation by forming aberrant H3 homodimers. …”
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“…In this study, we tested whether plasma concentrations of human pentraxin 3 (PTX3), a local inflammatory marker, would be a useful biomarker for detecting PAH. …”
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