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  1. 6661
    por Lundberg, Daniel
    Publicado 2018
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    An overview of eight- and nine-coordinate N-donor solvated lanthanoid(III) and actinoid(III) ions
  2. 6662
    “…To study the physiological role of PIS, we established murine NIH3T3 fibroblasts that stably overexpress PIS, by transfection with PIS cDNA (NIH‐PIS cells). …”
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    Overexpression of Phosphatidylinositol Synthase Enhances Growth and G1 Progression in NIH3T3 cells
  3. 6663
    “…Given the importance of pattern recognition processes for multiple biological tasks, including CNS development and immune recognition, we examined the home cage behavioral phenotype of mice lacking galectin-3 (Lgals3) function. Using a sophisticated monitoring apparatus capable of examining feeding, drinking, and movement at millisecond temporal and 0.5 cm spatial resolutions, we observed daily behavioral patterns from 10 wildtype male C57BL/6J and 10 Lgals3 constitutive knockout (Lgals3(−/−); both cohorts aged 2–3 months) mice over 17 consecutive days. …”
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    Mice lacking galectin-3 (Lgals3) function have decreased home cage movement
  4. 6664
    “…More recently, TGF‐β ligands, TGFB2 and TGFB3, as well as intracellular downstream effectors of the TGF‐β pathway, SMAD2 and SMAD3, were shown to be involved in LDS. …”
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    A mutation update on the LDS‐associated genes TGFB2/3 and SMAD2/3
  5. 6665
    “…This editorial introduces the NC3Rs gateway, which publishes articles and reviews on new models and technologies emerging from NC3Rs-funded research. …”
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    The NC3Rs gateway: Accelerating scientific discoveries with new 3Rs models and technologies
  6. 6666
    “…Tumorigenesis was rescued by the enforced expression of wild-type STAT3 in cells lacking STAT3. In contrast, GICs were highly addicted to STAT3 and upon STAT3 deletion GICs were non-viable. …”
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    The critical role that STAT3 plays in glioma-initiating cells: STAT3 addiction in glioma
  7. 6667
    “…Recently, the rapid development of microfabrication techniques, such as 3-D printing, microfluidics, and photochemistry, has offered great advantages in reconstructing 3-D controllable cancer cell microenvironments in vitro. …”
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    Microfabrication-Based Three-Dimensional (3-D) Extracellular Matrix Microenvironments for Cancer and Other Diseases
  8. 6668
    “…To address such a challenge, we developed a predictor called “iRNA-3typeA,” by which we can simultaneously identify the occurrence sites of the following three most frequently observed modifications in RNA: (1) N(1)-methyladenosine (m(1)A), (2) N(6)-methyladenosine (m(6)A), and (3) adenosine to inosine (A-to-I). …”
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    iRNA-3typeA: Identifying Three Types of Modification at RNA’s Adenosine Sites
  9. 6669
    “…In this reaction mechanism, LiP catalyzes the C–C cleavage of a propenyl side chain, being able to produce veratraldehyde (VAD) from 1-(3′,4′-dimethoxyphenyl) propene (DMPP). One of the few and complete proposed mechanisms includes several non-enzymatic reactions. …”
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    On the Reaction Mechanism of the 3,4-Dimethoxybenzaldehyde Formation from 1-(3′,4′-Dimethoxyphenyl)Propene
  10. 6670
    “…Treg cells from asthmatic patients expressed more FOXP3 as well as GATA3; the expression level of GATA3 negatively correlated with FEV1%pred. …”
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    The Imbalance of FOXP3/GATA3 in Regulatory T Cells from the Peripheral Blood of Asthmatic Patients
  11. 6671
    “…Here we show that one mechanism whereby sex differences in OGT confer variation in vulnerability to prenatal insults is by establishing sex-specific trophoblast gene expression patterns and via regulation of the canonically repressive epigenetic modification, H3K27me3. We demonstrate that high levels of H3K27me3 in the female placenta create resilience to the altered hypothalamic programming associated with prenatal stress exposure.…”
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    Placental H3K27me3 establishes female resilience to prenatal insults
  12. 6672
    “…In the present study, the results demonstrated that there was bidirectional regulation of insulin action in 3T3-L1 adipocytes treated with ROS. Transient and acute ROS exposure improved insulin-induced metabolic effects in 3T3-L1 adipocytes. …”
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    Bidirectional modulation of insulin action by reactive oxygen species in 3T3-L1 adipocytes
  13. 6673
    “…The Stat3 function was manifested by palatal fusion defects in culture following Stat3 inhibitor treatment with significant downregulation of Tgfb3. …”
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    Runx1-Stat3-Tgfb3 signaling network regulating the anterior palatal development
  14. 6674
    “…Three additional patients had a FGFR3-TACC3 rearrangement. …”
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    Fibroblast growth factor receptor 3 (FGFR3) aberrations in muscle-invasive urothelial carcinoma
  15. 6675
    “…RIP3 triggered NLRP3 inflammasome activation independent of necroptosis induction has recently been documented. …”
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    RIP3 dependent NLRP3 inflammasome activation is implicated in acute lung injury in mice
  16. 6676
    “…Our objective was to estimate and externally validate several mapping algorithms to predict Health Utilities Index Mark 3 (HUI3) and EQ-5D-3L utility values from the MOS-HIV. …”
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    Mapping MOS-HIV to HUI3 and EQ-5D-3L in Patients With HIV
  17. 6677
    “…BACKGROUND: This study demonstrates a three-dimensional (3D) free-breathing native myocardial T(1) mapping sequence at 3 T. …”
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    Three-dimensional free breathing whole heart cardiovascular magnetic resonance T(1) mapping at 3 T
  18. 6678
    “…Described herein is an environmentally benign method for the synthesis of multisubstituted 3-alkoxylated-2-oxindoles 3 via direct alkoxylation of 3-halooxindoles 1. …”
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    Alcohols as Substrates and Solvents for the Construction of 3-Alkoxylated-2-Oxindoles by Direct Alkoxylation of 3-Halooxindoles
  19. 6679
    “…MDR Mtb poses a significant global health problem, calling for urgent development of novel drugs to combat TB. Here, we report the 3.3 Å resolution structure of the ~2 MDa type-I fatty acid synthase (FAS-I) from Mtb, determined by single particle cryo-EM. …”
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    Structure of Type-I Mycobacterium tuberculosis fatty acid synthase at 3.3 Å resolution
  20. 6680
    “…In addition, The rs441467651 T allele was significantly related with increased GC risk regardless of lymph node metastasis (LNM), T classification, and tumor stage compared to that of controls (adjusted OR = 2.00, 95% CI = 1.12-3.55, P = 0.019 in LNM-negative subjects; adjusted OR = 2.10, 95% CI = 1.05-4.22, P = 0.0379 in LNM-positive subjects; adjusted OR = 1.82, 95% CI = 1.02-3.24, P = 0.042 in T1/T2 subjects; adjusted OR = 2.60, 95% CI = 1.29-5.24, P = 0.007 in T3/T4 subjects; adjusted OR = 1.91, 95% CI = 1.09-3.34, P = 0.025 in tumor stage I (A+B)/II (A+B+C) subjects; adjusted OR = 2.36, 95% CI = 1.12-5.13, P = 0.025 in tumor stage III (A+B+C) subjects) compared to that of controls. …”
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    Mitochondrial NADH Dehydrogenase Subunit 3 (MTND3) Polymorphisms are Associated with Gastric Cancer Susceptibility
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