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7601por Yanny, Kyrollos, Antipa, Nick, Liberti, William, Dehaeck, Sam, Monakhova, Kristina, Liu, Fanglin Linda, Shen, Konlin, Ng, Ren, Waller, LauraEnlace del recurso
Publicado 2023
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7602por Tsai, Hung-Pei, Lin, Chien-Ju, Lieu, Ann-Shung, Chen, Yi-Ting, Tseng, Tzu-Ting, Kwan, Aij-Lie, Loh, Joon-Khim“…Numerous studies have considered galectin-3 or Glycogen synthase kinase 3 beta (GSK3B) as a potential prognosis marker for various cancers. …”
Publicado 2023
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7603por Zhu, Phillip, Stanisheuski, Stanislau, Franklin, Rachel, Vogel, Amber, Vesely, Cat Hoang, Reardon, Patrick, Sluchanko, Nikolai N., Beckman, Joseph S., Karplus, P. Andrew, Mehl, Ryan A., Cooley, Richard B.“…Using this autonomous “PermaPhos” expression system, we produce three biologically relevant proteins with nhpSer and confirm that nhpSer mimics the effects of phosphoserine for activating GSK3β phosphorylation of the SARS-CoV-2 nucleocapsid protein, promoting 14-3-3/client complexation, and monomerizing 14-3-3 dimers. …”
Publicado 2023
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7604por Anusha, Kumari, Priyanka, Poornesh, P., Chattopadhyay, Saikat, Rao, Ashok, Kulkarni, Suresh D.“…Pristine WO(3) and Zn-doped WO(3) were synthesized using the spray pyrolysis technique to detect ammonia gas. …”
Publicado 2023
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7605por Liang, Xiaoqin, Deng, Shengping, Huang, Yan, Pan, Liwei, Chang, Yanling, Hou, Ping, Ren, Chenyang, Xu, Weifeng, Yang, Ruiyun, Li, Kanyuan, Li, Jun, He, Ruijie“…The effects of the isolates on insulin-stimulated glucose uptake in 3T3-L1 adipocytes were evaluated and three dammarane triterpenoid saponins (6, 7 and 10) were found to enhance insulin-stimulated glucose uptake in 3T3-L1 adipocytes. …”
Publicado 2023
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7606por Hu, Shibin, Song, Aixia, Peng, Linna, Tang, Nan, Qiao, Zhibin, Wang, Zhenning, Lan, Fei, Chen, Fei XavierEnlace del recurso
Publicado 2023
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7607por Chan, Chee-Hong, Lin, Pei, Yang, Tse-Yen, Bao, Bo-Ying, Jhong, Jhen-Yang, Weng, Yui-Ping, Lee, Te-Hsiu, Cheng, Hui-Fen, Lu, Te-Ling“…However, it was not clear whether MST3 was involved in cell polarity. Here, control MDCK cells, HA-MST3 and HA-MST3 kinase-dead (HA-MST3-KD) overexpressing MDCK cells were cultured in collagen or Matrigel. …”
Publicado 2023
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7608por Xiao, Fu-Hui, Wang, Hao-Tian, Chen, Xiao-Qiong, Ge, Ming-Xia, Yan, Dongjing, Yang, Xing-Li, Yang, Li-Qin, Lin, Rong, Guo, Rong-Hui, Zhang, Wen, Tang, Nelson Leung-Sang, He, Yonghan, Zhou, Jumin, Cai, Wang-Wei, Kong, Qing-PengEnlace del recurso
Publicado 2023
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7609“…Here, we investigated the c-Met expression and phosphorylation, knockdown (KD) effects, and pharmacological inhibition of c-Met by JNJ on fat accumulation in murine preadipocyte 3T3-L1 cells. During 3T3-L1 preadipocyte differentiation, strikingly, c-Met expression at the protein and mRNA levels and the protein phosphorylation on Y1234/1235 and Y1349 is crucial for inducing its kinase catalytic activity and activating a docking site for signal transducers were increased in a time-dependent manner. …”
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7610por Huang, Ying, Gao, Changzheng, Song, Wei, Wei, Wanqing, Chen, Xiulai, Gao, Cong, Liu, Jia, Wu, Jing, Liu, Liming“…In this study, a microbial polyphenol oxidase from Bacillus megaterium was screened for the synthesis of theaflavin-3,3′-digallate (TFDG). Based on structural and mechanistic analyses of the enzyme, the O-O bond dissociation was identified as the rate-determining step. …”
Publicado 2023
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7611por Joosse, I. R., Wirtz, V. J., van Mourik, A. T., Wagner, B. A., Mantel-Teeuwisse, A. K., Suleman, F., van den Ham, H. A.“…BACKGROUND: Sustainable Development Goal (SDG) indicator 3.b.3 monitors progress in medicines’ accessibility for adults and has significant limitations when applying to medicines for children. …”
Publicado 2023
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7612por Zhang, Zimei, Wang, Gang, Li, Rui, Ni, Lin, Zhang, RunZe, Cheng, Kaiyang, Ren, Qun, Kong, Xiangtai, Ni, Shengkun, Tong, Xiaochu, Luo, Li, Wang, Dingyan, Lu, Xiaojie, Zheng, Mingyue, Li, Xutong“…Three-dimensional (3D) conformations of a small molecule profoundly affect its binding to the target of interest, the resulting biological effects, and its disposition in living organisms, but it is challenging to accurately characterize the conformational ensemble experimentally. …”
Publicado 2023
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7613“…Therefore, it is necessary to systematically study the formation process of cholesterol in egg yolk and reduce the content of cholesterol in egg yolk. After using 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) inhibitors to inhibit the synthesis of cholesterol in the liver of laying hens, this study investigated the changes in the cholesterol content in egg yolk and the surrounding tissues and utilised RNA sequencing (RNA-seq) technology to explore the biological mechanism that is involved when HMGCR inhibitors reduce egg yolk cholesterol. …”
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7614por Niu, Jianfang, Yan, Taiqiang, Guo, Wei, Wang, Wei, Ren, Tingting, Huang, Yi, Zhao, Zhiqing, Yu, Yiyang, Chen, Chenglong, Huang, Qingshan, Lou, Jingbing, Guo, Lei“…We previously demonstrated that COPS3/CSN3 (COP9 signalosome subunit 3) functions as an oncogene to promote OS cells lung metastasis, which is closely related to chemoresistance. …”
Publicado 2022
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7615por Soumboundou, Sankoung, Ndiaye, Mamadou Lamine, Marcellin Nouaman, N'zebo, Farhat, Ons, Abdou Lecor, Papa“…MATERIAL AND METHODS: A total of 104 3D facial photographs taken with the Bellus 3D application were studied. …”
Publicado 2023
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7616“…As an important bridge between the environment and tumors, SETD2-H3K36me3 plays an important role in the occurrence and development of tumors. …”
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7617por Rudin, Charles M., Reck, Martin, Johnson, Melissa L., Blackhall, Fiona, Hann, Christine L., Yang, James Chih-Hsin, Bailis, Julie M., Bebb, Gwyn, Goldrick, Amanda, Umejiego, John, Paz-Ares, Luis“…Current treatment options are limited, with no therapies specifically approved as third-line or beyond. Delta-like ligand 3 (DLL3), a Notch inhibitory ligand, is an attractive therapeutic target because it is overexpressed on the surface of SCLC cells with minimal to no expression on normal cells. …”
Publicado 2023
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7618por Baruch, Yifat, Golberg, Karina, Sun, Qun, Yew-Hoong Gin, Karina, Marks, Robert S., Kushmaro, Ariel“…In this study, we test the effect of a natural bis-indole, 3,3′-Diindolylmethane (DIM), in mitigating the pathogenicity of the oral biofilm inhabiting bacterium Streptococcus mutans, a bacterium that is considered to be a principal etiological agent in dental caries. …”
Publicado 2023
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7619por Kropla, Fabian, Winkler, Dirk, Lindner, Dirk, Knorr, Patrick, Scholz, Sebastian, Grunert, Ronny“…A new approach uses 3D surface scans, which accurately replicate the curvature of the removed bone flap. …”
Publicado 2023
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7620por Dillingham, Caleb, Cormaty, Harshini, Morgan, Ellen, Esgdaille, Dakarai, Boutz, Paul, Sridharan, Rupa“…We find through immunoaffinity purification of the KDM3A or KDM3B interactome and proximity ligation assays that KDM3A and KDM3B interact with RNA processing factors such as EFTUD2 and PRMT5. …”
Publicado 2023
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