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  1. 7681
    “…We stimulated serum-starved Swiss 3T3 fibroblasts with LPA and compared the effects of C3 exoenzyme, a Rho inhibitor, with those of Y-27632, a ROCK inhibitor. …”
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    ROCK and mDia1 antagonize in Rho-dependent Rac activation in Swiss 3T3 fibroblasts
  2. 7682
    “…We now report that downregulation of 14-3-3σ, which is specifically expressed in human stratified epithelia, prevents keratinocyte clonal evolution, thereby forcing keratinocytes into the stem cell compartment. …”
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    Downregulation of 14-3-3σ Prevents Clonal Evolution and Leads to Immortalization of Primary Human Keratinocytes
  3. 7683
    Publicado 1990
    “…These A-type-specific CTL clones (HLA B8 restricted) were used to screen peptides derived from the EBV nuclear antigens (EBNAs) 2, 3, 4, and 6 as potential CTL epitopes. Of the 76 peptides screened, one sequence from EBNA 3 (residues 329-353) was recognized by A-type-specific CTL clones after absorption onto target cells (either autologous B-type transformants or PHA blasts). …”
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    An Epstein-Barr virus-specific cytotoxic T cell epitope in EBV nuclear antigen 3 (EBNA 3)
  4. 7684
    Publicado 1990
    “…We recently described a mAb 3.2.3 (IgG1), that recognizes a 60-kD dimeric molecule expressed exclusively on fresh and rIL-2-activated NK cells and polymorphonuclear cells. mAb 3.2.3 enhances cytolytic activity of NK cells against selected FcR+ tumor target cells by reverse antibody-dependent cellular cytotoxicity (ADCC), indicating that it recognizes an important triggering site on NK cells. …”
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    In vivo treatment with monoclonal antibody 3.2.3 selectively eliminates natural killer cells in rats
  5. 7685
    “…We show that three different GSK-3 antagonists (LiCl, SB-216763, and SB-415286) can inhibit the growth cone collapse response induced by Sema 3A. …”
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    An inactive pool of GSK-3 at the leading edge of growth cones is implicated in Semaphorin 3A signaling
  6. 7686
    Publicado 1988
    “…We conclude that in the nominal absence of HCO3-, three transport systems contribute to acid extrusion by S3 cells: (a) a Na+-independent mechanism, possibly an H+ pump; (b) a Na-H exchanger, confined primarily to the luminal membrane; and (c) an Ac- and luminal Na+- dependent mechanism. …”
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    Intracellular pH regulation in the S3 segment of the rabbit proximal tubule in HCO3- -free solutions
  7. 7687
    “…Mammalian mitochondrial initiation factor 3 (IF3(mt)) has a central region with homology to bacterial IF3. …”
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    The interaction of mammalian mitochondrial translational initiation factor 3 with ribosomes: evolution of terminal extensions in IF3(mt)
  8. 7688
    por Woll, P. J., Rozengurt, E.
    Publicado 1988
    “…Bombesins are potent growth factors for murine Swiss 3T3 cells. Using these cells in chemically defined conditions we have been able to characterise the bombesin receptor and the early signals preceding DNA synthesis. …”
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    Bombesin and bombesin antagonists: studies in Swiss 3T3 cells and human small cell lung cancer.
  9. 7689
    “…In this study, we examine three steps critical in the mechanism of the transcriptional regulation by Glis3: its translocation to the nucleus, DNA binding and transcriptional activity. …”
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    Functional analysis of the zinc finger and activation domains of Glis3 and mutant Glis3(NDH1)
  10. 7690
    Publicado 1992
    “…A rat cDNA encoding a 51-kD protein tyrosine phosphatase (PTP1) was cloned into a mammalian expression vector and transfected into normal and v-src-transformed mouse NIH 3T3 fibroblasts. In the stable subclones isolated, PTP1 expression at the mRNA level was elevated twofold to 25-fold. …”
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    Expression of a protein tyrosine phosphatase in normal and v-src- transformed mouse 3T3 fibroblasts
  11. 7691
    “…To pursue a borderline increased risk of breast cancer for carriers of two integrin beta(3) (ITGB3) 33Pro alleles found in a recent prospective study, we conducted a case–control study of 1088 women with breast cancer and 4815 female controls. …”
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    No association of breast cancer risk with integrin beta(3) (ITGB3) Leu33Pro genotype
  12. 7692
    “…The premalignant as well as the grade I tumours were consistently negative for collagenase-1 and -3 and TIMP-1 and -3. The collagenases were predominantly expressed in the cancer cells of Clark grade III and IV tumours. …”
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    Expression of collagenases-1 and -3 and their inhibitors TIMP-1 and -3 correlates with the level of invasion in malignant melanomas
  13. 7693
    “…The MR spectra indicated that phosphocholine (PC) levels increased significantly from 3 ± 2 fmol cell(−1)in NIH 3T3 cells to 13 ± 4  fmol cell(−1)in the transfected cells. …”
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    Magnetic resonance detects changes in phosphocholine associated with Ras activation and inhibition in NIH 3T3 cells
  14. 7694
    “…We recently reported the SART3 tumour-rejection antigen as possessing tumour epitopes capable of inducing HLA-class I-restricted cytotoxic T lymphocytes (CTLs). …”
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    Expression of SART3 antigen and induction of CTLs by SART3-derived peptides in breast cancer patients
  15. 7695
    “…Dkk-3 is a newly characterised mortalisation-related gene and an antagonist of the Wnt oncogenic signalling pathway whose expression is decreased in a variety of cancer cell lines, suggesting that the Dkk-3 gene, located at chromosome 11p15.1, functions as a tumour suppressor gene. …”
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    Transcriptional silencing of the Dickkopfs-3 (Dkk-3) gene by CpG hypermethylation in acute lymphoblastic leukaemia
  16. 7696
    “…Degradation of cytoplasmic components by autophagy requires the class III phosphatidylinositol 3 (PI(3))–kinase Vps34, but the mechanisms by which this kinase and its lipid product PI(3) phosphate (PI(3)P) promote autophagy are unclear. …”
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    The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila
  17. 7697
    “…Recent evidence implicated the scaffold protein, 14-3-3, in Vpr cell cycle blockade. RESULTS: We found that in human T cells, 14-3-3 plays an active role in mediating Vpr-induced cell cycle arrest and reveal a dramatic increase in the amount of Cdk1, Cdc25C, and CyclinB1 bound to 14-3-3 θ during Vpr(v)-induced G(2),M arrest. …”
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    14-3-3 theta binding to cell cycle regulatory factors is enhanced by HIV-1 Vpr
  18. 7698
    “…APOBEC3G (A3G)/APOBEC3F (A3F) are two members of APOBEC3 cytidine deaminase subfamily. …”
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    APOBEC3G and APOBEC3F Require an Endogenous Cofactor to Block HIV-1 Replication
  19. 7699
    “…Non-structural protein 3 (NS3) is a multifunctional enzyme possessing serine protease, NTPase, and RNA unwinding activities that are required for hepatitis C viral (HCV) replication. …”
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    Hepatitis C Viral NS3-4A Protease Activity Is Enhanced by the NS3 Helicase
  20. 7700
    “…The zinc finger protein Mig1 is the main effector in glucose repression, but yeast also has two related proteins: Mig2 and Mig3. We have used microarrays to study global gene expression in all possible combinations of mig1, mig2 and mig3 deletion mutants. …”
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    Combinatorial control of gene expression by the three yeast repressors Mig1, Mig2 and Mig3
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