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8581A Conserved Cysteine Residue in Coxsackievirus B3 Protein 3A with Implication for Elevated Virulencepor Voss, Martin, Pinkert, Sandra, Kespohl, Meike, Gimber, Niclas, Klingel, Karin, Schmoranzer, Jan, Laue, Michael, Gaida, Matthias, Kloetzel, Peter-Michael, Beling, Antje“…We recently reported on the biochemical properties of the highly conserved cysteine residue at position 38 (C38) of enteroviral protein 3A and demonstrated a C38-mediated homodimerization of the Coxsackievirus B3 protein 3A (CVB3-3A) that resulted in its profound stabilization. …”
Publicado 2022
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8582por La Torre, Chiara, Fazio, Alessia, Caputo, Paolino, Tursi, Antonio, Formoso, Patrizia, Cione, Erika“…The highest yield was recorded for the cow kefiran using method III (4.79%). The recoveries of goat and buffalo kefirans with methods II and III were similar (2.75–2.81%). …”
Publicado 2022
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8583por Feng, Lina, Chen, Yanping, Xu, Ke, Li, Yingchao, Riaz, Farooq, Lu, Kaikai, Chen, Qian, Du, Xiaojuan, Wu, Litao, Cao, Dan, Li, Chunyan, Lu, Shemin, Li, Dongmin“…Objectives: Leucine aminopeptidase 3 (LAP3), an M1 member of leucine aminopeptidase, was reported to be significantly upregulated in serum of nonalcoholic fatty liver disease (NAFLD) patients. …”
Publicado 2022
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8584Leveraging omic features with F3UTER enables identification of unannotated 3’UTRs for synaptic genespor Sethi, Siddharth, Zhang, David, Guelfi, Sebastian, Chen, Zhongbo, Garcia-Ruiz, Sonia, Olagbaju, Emmanuel O., Ryten, Mina, Saini, Harpreet, Botia, Juan A.“…There is growing evidence for the importance of 3’ untranslated region (3’UTR) dependent regulatory processes. …”
Publicado 2022
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8585por Dottermusch, Matthias, Uksul, Nesrin, Knappe, Ulrich J., Erdlenbruch, Bernhard, Wefers, Annika K.“…We here describe the first SHH medulloblastoma with H3 K27M mutation. This may have diagnostic implications as H3 K27M mutations are the hallmark of diffuse midline gliomas, H3 K27M mutant, WHO grade IV. …”
Publicado 2021
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8586“…The paper presents the results of a comprehensive study of effects that In(3+) ion impurities have on the optical properties of SrF(2) and SrF(2):Ce(3+) crystals. …”
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8587por Popa, Marcel Mirel, Shova, Sergiu, Hrubaru, Madalina, Barbu, Loredana, Draghici, Constantin, Dumitrascu, Florea, Dumitrescu, Denisa E.“…New 1-arylpyrazoles substituted with halogen atoms (Br, I) were synthesized from the corresponding sydnones by 1,3-dipolar cycloaddition. By introduction of a prochiral group such as isopropyl, in the ortho position of the benzene ring, in the starting phenylglycine 1 the rotamers caused by the hindered rotation between the phenyl and the heterocyclic ring were detected by NMR spectroscopy for 1-arylpyrazoles and for the first time for 3-arylsydnones. …”
Publicado 2020
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8588por Kieu Giang, Lam Thi, Trejgis, Karolina, Marciniak, Łukasz, Opalińska, Agnieszka, Koltsov, Iwona E., Łojkowski, Witold“…In the present work, nanothermometers based on amorphous zirconium metal–organic frameworks co-doped with rare-earth ions (YZ-BDC:Eu(3+),Tb(3+) nanothermometers) with sizes of about 10–30 nm were successfully synthesized via a microwave-assisted hydrothermal method at 120 °C for 15 min. …”
Publicado 2022
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8589por Brito-Santos, Gabriela, Gil-Hernández, Beatriz, Martín, Inocencio R., Guerrero-Lemus, Ricardo, Sanchiz, Joaquín“…Five new complexes namely, [Er(bta)(3)(me-phen)] (1), [Yb(bta)(3)(me-phen)] (2), [Gd(bta)3(me-phen)] (3), [Yb(bta)(3)(pyz-phen)] (4), and [Er(tta)(3)(pyz-phen)] (5) have been prepared with the fluorinated β-diketone ligands Hbta and Htta (Hbta = benzoyltrifluoroacetone and Htta = 2-thenoyltrifluoroacetone) combined with the azacyclo phenanthroline-derivatives, 5-methyl-1,10-phenanthroline (me-phen) and pyrazino[2,3-f][1,10]phenanthroline (pyz-phen). …”
Publicado 2020
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8590“…Catalytic activities of zeolites HY, Hβ and HZSM-5 in the heterogeneous synthesis of 3,3′-dichloro-4,4′-diaminodiphenyl methane (MOCA) from o-chloroaniline and formaldehyde were pre-screened in an autoclave, and HY demonstrated better performance than others. …”
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8591Addition of 1,3-dicarbonyl compounds to terminal alkynes catalyzed by a cationic cobalt(iii) complex“…The Nakamura reaction using a cationic cobalt(iii) complex, [Cp*Co(CH(3)CN)(3)][SbF(6)](2) as the catalyst under neutral and aerobic conditions at 110 °C has been described. …”
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8592“…First principles calculations in the framework of density functional theory (DFT) were performed to tune the electronic structures of wide gap KNbO(3) through 3d transition metal substitution, using PBE and HSE06 functionals for the exchange correlation potentials. …”
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8593por Zhou, Yuqi, Zhao, Mingming, Guo, Haiyang, Li, Yuhao, Liu, Qingsheng, Deng, Bingyao“…Poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/polyhedral oligomeric silsesquioxane (PHBV/POSS) hybrids with different POSS contents of 5, 10, 15, 20, 25 and 30 wt% were prepared by solution casting. …”
Publicado 2019
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8594por Solone, Xzaviar K. V., Caldara, Amber L., Wells, Brady, Qiao, Hao, Wade, Lydia R., Salerno, John C., Helms, Katy A., Smith, Katherine E. R., McMurry, Jonathan L., Chrestensen, Carol A.“…Nitric oxide synthase 3 (NOS3) is a major vasoprotective enzyme that catalyzes the conversion of l‐arginine to nitric oxide (NO) in response to a significant number of signaling pathways. …”
Publicado 2022
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8595“…To ensure the survival and the dispersion of the nanocrystals in the glasses with x = 0 and 10, three doping temperatures (T(doping)) (525, 550 and 575 °C) at which the nanocrystals were added in the glass melt after melting and 2 dwell times (3 and 5 minutes) before quenching the glasses were tested. …”
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8596“…The three-component reaction of 1,2,3,4-tetrahydroisoquinoline, isatins and 3-phenacylideneoxindoles in refluxing ethanol afforded dispiro[indoline-3,1′-pyrrolo[2,1-a]isoquinoline-3′,3′-indolines] (4a–4x) in good yields via 1,3-dipolar cycloaddition of in situ generated azomethine ylide with the exocyclic double bond of 3-phenacylideneoxindoles. (1)H NMR spectra and single crystal structures indicated the reaction has high regioselectivity and diastereoselectivity. …”
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8597“…Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph Disease, is a progressive neurodegenerative disorder characterized by loss of neuronal matter due to the expansion of the CAG repeat in the ATXN3/MJD1 gene and subsequent ataxin-3 protein. …”
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8598por Kang, Ju Young, Kim, Suho, Moon, Junghyea, Chung, Eunjae, Kim, Jaeyoung, Kyung, So Young, Kim, Hyung Sik, Mishra, Neeraj Kumar, Kim, In Su“…We herein disclose the rhodium(III)-catalyzed 1,4-addition reaction of maleimides with N-aryl indazol-3-ols, which provides the succinimide-bearing indazol-3-ol scaffolds with complete regioselectivity and a good functional group tolerance. …”
Publicado 2022
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8599por Mugabo, Yves, Zhao, Cheng, Tan, Ju Jing, Ghosh, Anindya, Campbell, Scott A., Fadzeyeva, Evgenia, Paré, Frédéric, Pan, Siew Siew, Galipeau, Maria, Ast, Julia, Broichhagen, Johannes, Hodson, David J., Mulvihill, Erin E., Petropoulos, Sophie, Lim, Gareth E.“…While critical for neurotransmitter synthesis, 14-3-3 proteins are often assumed to have redundant functions due to their ubiquitous expression, but despite this assumption, various 14-3-3 isoforms have been implicated in regulating metabolism. …”
Publicado 2022
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8600In Situ Synthesis of Fe(3)O(4) Nanoparticles and Wood Composite Properties of Three Tropical Species“…This work reports on the synthesis of Fe(3)O(4) nanoparticles (NPs) in wood from three tropical species (Pinus oocarpa, Vochysia ferruginea and Vochysia guatemalensis) using a solution of iron (III) hexahydrate and iron (II) chloride tetrahydrate with a molar ratio of 1.6:1 at a concentration of 1.2 mol/L ferric chlorate under 700 kPa pressure for 2 h. …”
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