“…In the title compound, C(25)H(22)N(2)OSe, the fused six-membered cyclo­hexene ring of the 4,5,6,7-tetra­hydro-1,2,3-benzoselenadiazole group adopts a near half-chair conformation and the five-membered 1,2,3-selenadiazole ring is essentially planar (r.m.s. deviation = 0.004 Å). …”
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“…In the title compound, (C(8)H(15)N(2))[Ni(C(4)N(2)S(2))(2)], the Ni(III) atom is coordinated by four S atoms of two maleonitrile­dithiol­ate ligands and exhibits a distorted square-planar geometry. …”
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“…In the crystal, weak S⋯S [3.368 (2) and 3.482 (3) Å], Ni⋯S [3.680 (2) Å] and Cl⋯S [3.491 (2) Å] inter­actions and C—H⋯S hydrogen bonds lead to a three-dimensional supra­molecular network.…”
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“…In the title compound, C(25)H(26)N(4)O(3), the two fused pyrrolo­[3,2-d]pyrimidine rings form a dihedral angle of 3.7 (2)°. …”
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“…In the title compound, C(24)H(20)N(4), obtained through the condensation of naphthalene-2,3-diamine with formaldehyde in methanol, the mol­ecule is located on a special position of site symmetry -4. …”
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“…The complete molecule of the compound, C(6)H(4)N(8)O(3), is generated by a crystallographic twofold rotation axis that runs through the central ring. …”
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“…In the title compound, C(30)H(23)ClN(6)OS, the benzyl, the 3-chloro­anilino, the phenyl and the anilino groups form dihedral angles of 85.95 (6), 29.63 (7), 28.55 (1) and 87.48 (6)°, respectively, with the pyrazolo­[3,4-d]pyrimidine unit [maximum deviation = 0.052 (2) Å]. …”
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“…The mol­ecule of the title compound, C(16)H(21)BO(2), comprises a chiral fused tricyclic system containing five-membered (1,3,2-dioxaborolane), six-membered (cyclo­hexa­ne) and four-membered (cyclo­butane) rings. …”
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“…An amino acid, 3S-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid, was isolated for the first time from the leaves of Cichorium endivia. …”
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“…This combined genetic-gonadal-genitals sex, here referred to as 3G-sex, is internally consistent in ~99% of humans (i.e., one has either the “female” form at all levels, or the “male” form at all levels). …”
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“…However, the role of C3a during sensitization to allergen is poorly understood. …”
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“…In the title mol­ecule, C(20)H(18)N(2)O(3), the pyrazole ring forms a dihedral angle of 2.2 (1)° with its meth­oxy­phenyl substituent and a dihedral angle of 67.2 (1)° with the benzene substituent on the propenal unit. …”
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“…HSP20 proteins in the HuH7 cells were coimmunoprecipitated with the p85 regulatory subunit and p110 catalytic subunit of phosphoinositide 3-kinase (PI3K), an upstream kinase of AKT. Although HSP20 overexpression in HCC cells failed to affect the expression levels of PI3K, the activity of PI3K in the unstimulated cells and even in the transforming growth factor-α stimulated cells were downregulated by HSP20 overexpression. …”
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“…A chemoenzymatic strategy for the synthesis of enantiomerically pure novel alkaloids (1S,3R)-1-benzyl-2,3-dimethyl-1,2,3,4-tetrahydroisoquinolines is presented. …”
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“…C—H⋯π inter­actions involving the phenyl ring and π–π inter­actions [centroid–centroid separation for triazole rings = 3.5660 (18) Å] are also observed.…”
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“…In the title compound, C(27)H(24)Cl(2)N(2)O(3), the indole ring system is essentially planar, with a maximum deviation of 0.082 (2) Å for the carbonyl C atom. …”
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“…The title hydrated complex, [Zn(2)Cl(4)(C(9)H(12)N(4))(2)]·2H(2)O, is a discrete dinuclear zinc complex with 1,3-bis­(1H-imidazol-1-yl)propane as the bridging ligand. …”
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“…In preclinical treatment response studies that featured models of wild-type KRAS or mutant BRAF colorectal cancer treated with either cetuximab or vemurafenib, respectively, we illustrate that [(18)F]-FLT PET, a non-invasive molecular imaging readout of thymidine salvage, closely reflects pro-survival responses to targeted therapy that are mediated by PI3K-mTOR activity. Activation of pro-survival mechanisms forms the basis of numerous modes of resistance. …”
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