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8841por Pang, Bin, Sun, Lei, Shen, Xuan, Lv, Yang-Yang, Li, Xiao, Wu, Fei-Xiang, Yao, Shu-Hua, Zhou, Jian, Zhang, Shan-Tao, Chen, Y.B.“…The most notable feature is that LFO-YMO multilayers grown on (001)-SrTiO(3) substrate have three types of domains, while those on (111)-SrTiO(3) have only one. …”
Publicado 2017
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8842por Weisberg, Ellen L., Puissant, Alexandre, Stone, Richard, Sattler, Martin, Buhrlage, Sara J., Yang, Jing, Manley, Paul W., Meng, Chengcheng, Buonopane, Michael, Daley, John F., Lazo, Suzan, Wright, Renee, Weinstock, David M., Christie, Amanda L., Stegmaier, Kimberly, Griffin, James D.“…Oncogenic FLT3 kinase is a clinically validated target in acute myeloid leukemia (AML), and both multi-targeted and selective FLT3 inhibitors have been developed. …”
Publicado 2017
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8843“…METHODS: 3T3-L1 adipocytes were cultured with or without β-carotene and treated with G/GO, which produces H(2)O(2). mRNA and protein levels in the medium were determined by a real-time PCR and an ELISA. …”
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8844por Ji, Jie, Yin, Yin, Ju, Huanyu, Xu, Xiaoliang, Liu, Wei, Fu, Qiang, Hu, Jiaojiao, Zhang, Xudong, Sun, Beicheng“…Mechanistically, Lnc-Tim3 specifically binds to Tim-3 and blocks its interaction with Bat3, thus suppressing downstream Lck/ NFAT1/AP-1 signaling, leading to nuclear localization of Bat3, and enhancing p300-dependent p53 and RelA transcriptional activation of anti-apoptosis genes including MDM2 and Bcl-2. …”
Publicado 2018
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8845por Wang, Yong, Fu, Donghe, Chen, Yajing, Su, Jing, Wang, Yiting, Li, Xin, Zhai, Wei, Niu, Yuanjie, Yue, Dan, Geng, Hua“…The chronic inflammatory microenvironment within or surrounding the primary renal cell carcinoma (RCC) site promotes oncogenic transformation as well as contributes to the development of metastasis. G3BP stress granule assembly factor 1 (G3BP1) was found to be involved in the regulation of multiple cellular functions. …”
Publicado 2018
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8846“…In this work, an efficient diastereoselective 1,3-dipolar cycloaddition reaction of azomethine ylides generated in situ from 3-amino oxindoles and aldehydes with maleimides has been described. …”
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8847“…BACKGROUND: Serum and glucocorticoid-regulated kinase 3 (SGK3) has been reported to play an important role in tumour progression, but its role in cancer stem cells (CSCs) remains obscure. …”
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8848por Zhang, Chao, Zhang, Leilei, Wang, Dongdong, Ma, Haoli, Liu, Bailin, Shi, Zheng, Ma, Xiaohui, Chen, Yue, Chen, Qin“…The results showed that GH3 proteins are mainly present in seed plants. Phylogenetic analysis of all GH3 proteins showed three separate clades. …”
Publicado 2018
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8849“…A novel fused system with three or four fused rings—pyridazino[3′,4′:5,6][1,2,4]triazino[4,3-b][1,2,4,5]tetrazine and pyridazino[3′,4′:5,6][1,2,4]triazino[3,4-b]pyrimido[4,5-e][1,3,4]thiadiazine was obtained from the starting materials 4(6H)-amino-3-hydrazino-7-(2-thienyl)pyridazino[3,4-e][1,2,4]-triazine 2 and 9-amino-3-(2-thienyl)-2H,8H-pyridazino[3′,4′:5,6][1,2,4]triazino[3,4-b][1,3,4]thiadiazine-8-carbonitrile 12. …”
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8850“…Deep-UV light detection has important application in surveillance and homeland security regions. CH(3)NH(3)PbX(3) (X = Cl, Br, I) materials have outstanding optical absorption and electronic transport properties suitable for obtaining excellent deep-UV photoresponse. …”
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8851por Menčík, Přemysl, Přikryl, Radek, Stehnová, Ivana, Melčová, Veronika, Kontárová, Soňa, Figalla, Silvestr, Alexy, Pavol, Bočkaj, Ján“…PHB/PLA/plasticizer blends in the weight ratio (wt %) of 60/25/15 were then prepared by single screw and corotating meshing twin screw extruders in the form of filament for further three-dimensional (3D) printing. Mechanical, thermal properties, and shape stability (warping effect) of 3D printed products can be improved just by the addition of appropriate plasticizer to polymeric blend. …”
Publicado 2018
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8852por Fan, Ying-Sai, Li, Qin, Hamdan, Nawras, Bian, Yi-Fei, Zhuang, Shen, Fan, Kai, Liu, Zhong-Jie“…To better understand its biological function, we determined TSG’s effect on murine pre-osteoblastic MC3T3-E1 cells by the MTT assay, flow cytometry, FQ-PCR, Western blot, and ELISA. …”
Publicado 2018
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8853“…A new process is described for preparing very pure linear alkanethiols and linear α,ω-alkanedithiols using a sequential alkylation of the title compound, followed by a ring closure to quantitatively give the corresponding 3-methyl[1,3]thiazolo[3,2-a]-[3,1]benzimidazol-9-ium salt and the alkanethiol derivative under mild conditions. …”
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8854“…A mild and efficient two-step synthesis of 3-substituted β-carbolinone derivatives from 3-substituted β-carboline in good yields is described. …”
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8855“…The Winterfeldt oxidation (NaOH, DMF, air, rt) of substituted 1,2,3,4-tetrahydro-γ-carbolines has been developed, which provides a convenient and efficient method for the synthesis of the corresponding dihydropyrrolo[3,2-b]quinolones in moderate to excellent yields (38–94%). …”
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8856“…A series of new 3-[(5-aryl-1,3,4-oxadiazol-2-yl)methy])benzo[d]thiazol-2(3H)-ones were synthesized by reaction of (5-substituted-2-oxobenzothiazolin-3-yl)-acetohydrazide with various aromatic acids in POCl(3) under reflux conditions. …”
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8857“…Low-frequency electron paramagnetic resonance (EPR) is used to extract the EPR parameter A-mid and support the approximate X-band value of g-mid for Ba(Co(y)Zn(1/3−y)Ta(2/3))O(3). Although the cobalt hyperfine structure for the |±1/2〉 state is often unresolved at X-band or S-band, it is resolved in measurements on this compound. …”
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8858por Bhat, Mashooq A., Al-Dhfyan, Abdullah, Naglah, Ahmed M., Ali Khan, Azmat, Al-Omar, Mohamed A.“…Lead derivatives of 2-cyclohexyl-N-[(Z)-(3-methoxyphenyl/3-hydroxyphenyl) methylidene]hydrazinecarbothioamides 1–18 were synthesized, characterized and evaluated in vitro against HER-2 overexpressed breast cancer cell line SKBr-3. …”
Publicado 2015
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8859por Kang, Guo-Qiang, Duan, Wen-Gui, Lin, Gui-Shan, Yu, You-Pei, Wang, Xiao-Yu, Lu, Sun-Zhong“…In order to design more effective antifungal compounds against P. piricola, the analysis of three-dimensional quantitative structure-activity relationship (3D-QSAR) was carried out using the CoMFA method, and a reasonable and effective 3D-QSAR model (r(2) = 0.990, q(2) = 0.569) has been established.…”
Publicado 2019
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8860“…In recent years, copolymers of PHAs, i.e., poly(3-hydroxybutyrate) (PHB) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), have received attention for medical and packaging industrial applications, due to their biodegradable, toxic-free, and biocompatible nature. …”
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