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1por Zheng, Wu, Zhou, Jianhong, Luan, Yanan, Yang, Jianglan, Ge, Yuanyuan, Wang, Muran, Wu, Beibei, Wu, Zhongnan, Chen, Xingjun, Li, Fei, Li, Zhihui, Vakal, Sergii, Guo, Wei, Chen, Jiang-Fan“…We showed that optogenetic activation of ChR2/opto-GPR37 elicited specific GPR37 signaling, as evidenced by reduced cAMP level, enhanced ERK phosphorylation and increased motor activity, confirming the specificity of opto-GPR37 signaling. …”
Publicado 2018
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2por Qian, Zhengjiang, Li, Hongchao, Yang, Haiyang, Yang, Qin, Lu, Zhonghua, Wang, Liping, Chen, Ying, Li, Xiang“…Overall, these findings suggest that OCN orchestrates the transition between OPCs and myelinating OLs via GPR37 signaling, and hence, the OCN/GPR37 pathway regulates myelin homeostasis in the CNS.…”
Publicado 2021
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3“…Together, these results identify a new role for GPR37 signaling during development – modulating cell migration.…”
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6“…These observations demonstrate that LL-37 signals through CsrRS to induce a virulence phenotype in GAS characterized by heightened resistance to ingestion and killing by both epithelial cells and phagocytes. …”
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7por Zhang, Shu, Zeng, Jianxiong, Zhou, Yuzheng, Gao, Ruoyun, Rice, Stephanie, Guo, Xinying, Liu, Yongzhen, Feng, Pinghui, Zhao, Zhen“…As a result, both LAT and UL37 signals were detectable in neurons in the hippocampus and trigeminal ganglia (TG). …”
Publicado 2022
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8por Sánchez-Fernández, Alba, Zandee, Stephanie, Amo-Aparicio, Jesús, Charabati, Marc, Prat, Alexandre, Garlanda, Cecilia, Eisenmesser, Elan Z., Dinarello, Charles A., López-Vales, Rubèn“…Background: Interleukin 37 (IL-37), a member of IL-1 family, broadly suppresses inflammation in many pathological conditions by acting as a dual-function cytokine in that IL-37 signals via the extracellular receptor complex IL1-R5/IL-1R8, but it can also translocate to the nucleus. …”
Publicado 2021
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9por Trejo-Castro, Alejandro I., Caballero-Luna, Ricardo A., Garnica-López, José A., Vega-Lara, Fernando, Martinez-Torteya, Antonio“…From these maps, the mean value and absolute difference of 37 signal and texture imaging features for 40 contralateral pairs of regions were measured. …”
Publicado 2021
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10por Zhang, Zinan Z., Zhang, Yu, He, Tingyan, Sweeney, Colin L., Baris, Safa, Karakoc-Aydiner, Elif, Yao, Yikun, Ertem, Deniz, Matthews, Helen F., Gonzaga-Jauregui, Claudia, Malech, Harry L., Su, Helen C., Ozen, Ahmet, Smith, Kenneth G. C., Lenardo, Michael J.“…Interleukin (IL)-37, an antiinflammatory IL-1 family cytokine, is a key suppressor of innate immunity. IL-37 signaling requires the heterodimeric IL-18R1 and IL-1R8 receptor, which is abundantly expressed in the gastrointestinal tract. …”
Publicado 2021
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11por Wawrocki, Sebastian, Seweryn, Michal, Kielnierowski, Grzegorz, Rudnicka, Wieslawa, Wlodarczyk, Marcin, Druszczynska, Magdalena“…Therefore, direct analysis of the serum components of the IL-18/IL-37 signalling complex and IP-10 may be applicable in designing novel diagnostic tests for ATB.…”
Publicado 2019
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12por Li, Yun-Dong, Si, Meng-Ru, Jiang, Shi-Gui, Yang, Qi-Bin, Jiang, Song, Yang, Li-Shi, Huang, Jian-Hua, Chen, Xu, Zhou, Fa-Lin, Li, ErChao“…HC group, 583 DEGs significantly mapped to 37 signaling pathways, such as the NOD-like receptor signaling pathway, Toll-like receptor signaling pathway, and PI3K-Akt signaling pathway; in the MC vs. …”
Publicado 2023
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13“…Replacement of a cluster of three acidic amino acids with uncharged residues in the extracellular domain of CsrS abrogated LL-37 signaling and conferred a hyporesponsive phenotype consistent with tonic activation of CsrS autokinase activity, an effect that could be overridden by mutation of the CsrS active site histidine. …”
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14por Li, Guo, Qiu, Yuanzheng, Su, Zhongwu, Ren, Shuling, Liu, Chao, Tian, Yongquan, Liu, Yong“…Subsequent KEGG analyses demonstrated that the 53 mRNAs were enriched in 37 signaling pathways. Further qRT-PCR assays confirmed 3 down-regulated miRNAs (miR-324-3p, miR-93-3p and miR-4501), 3 up-regulated miRNAs (miR-371a-5p, miR-34c-5p and miR-1323) and 2 novel miRNAs. …”
Publicado 2013
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15Publicado 2017“…Amongst these, the most frequent mutations was associated with epigenetics (50%), followed by spliceosome (37%), signal transduction (34%), transcription factors (24%) and cell cycle/apoptosis (17%). 439 subjects (86%) had at least one gene mutation. …”
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16“…RESULTS: A comprehensive pathway network containing 37 signalling pathways as nodes and 263 pathway interactions were obtained. …”
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17“…We found that signaling induced by LL-37 was dependent on the recruitment of β-arrestin to the fully functional IGF-1R and by using mutant receptors we demonstrated that LL-37 signaling is dependent on β-arrestin-1 binding to the C-terminus of IGF-1R. …”
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