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121por Paranjpe, Manish D., Belonwu, Stella, Wang, Jason K., Oskotsky, Tomiko, Gupta, Aarzu, Taubes, Alice, Zalocusky, Kelly A., Paranjpe, Ishan, Glicksberg, Benjamin S., Huang, Yadong, Sirota, Marina“…In spite of evidence of females having a greater lifetime risk of developing Alzheimer’s Disease (AD) and greater apolipoprotein E4-related (APOE ε4) AD risk compared to males, molecular signatures underlying these differences remain elusive. …”
Publicado 2021
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122por DeMichele-Sweet, Mary Ann A., Klei, Lambertus, Creese, Byron, Harwood, Janet C., Weamer, Elise A., McClain, Lora, Sims, Rebecca, Hernandez, Isabel, Moreno-Grau, Sonia, Tárraga, Lluís, Boada, Mercè, Alarcón-Martín, Emilio, Valero, Sergi, Liu, Yushi, Hooli, Basavaraj, Aarsland, Dag, Selbaek, Geir, Bergh, Sverre, Rongve, Arvid, Saltvedt, Ingvild, Skjellegrind, Håvard K., Engdahl, Bo, Stordal, Eystein, Andreassen, Ole A., Djurovic, Srdjan, Athanasiu, Lavinia, Seripa, Davide, Borroni, Barbara, Albani, Diego, Forloni, Gianluigi, Mecocci, Patrizia, Serretti, Alessandro, De Ronchi, Diana, Politis, Antonis, Williams, Julie, Mayeux, Richard, Foroud, Tatiana, Ruiz, Agustín, Ballard, Clive, Holmans, Peter, Lopez, Oscar L., Kamboh, M. Ilyas, Devlin, Bernie, Sweet, Robert A.“…Gene-based analysis identified a significant association with APOE, due to the APOE risk haplotype ε4. AD+P demonstrated negative genetic correlations with cognitive and educational attainment and positive genetic correlation with depressive symptoms. …”
Publicado 2021
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123“…Treatments were as follows: 1) control, 2) adLAB (2.0 × 10(5) CFU LAB/g liquid feed), 3) adLys (0.60% DM supplemented lysine), and 4) adLAB+Lys (combination of adLAB and adLys; n = 8). …”
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124por Koul, Parvaiz A, Saha, Siddhartha, Kaul, Kaisar A, Mir, Hyder, Potdar, Varsha, Chadha, Mandeep, Iuliano, Danielle, Lafond, Kathryn E, Lal, Renu B, Krishnan, Anand“…Among enrolees, 256 (62%) were positive for any virus; RSV was the most commonly detected (n = 118, 29%) followed by HRV/enteroviruses (n = 88, 21%), PIVs (n = 31, 8%), influenza viruses (n = 18, 4%), BoV (n = 15, 4%), coronaviruses (n = 16, 4%), AdV (n = 14, 3%), and hMPV (n = 9, 2%). Fifty-four children had evidence of virus co-detection. …”
Publicado 2022
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125por Abreu, Daciele, Dubeux, José C. B., Queiroz, Luana Dantas, Jaramillo, David, Da Silva Santos, Erick Rodrigo, van Cleef, Flávia, Vela-Garcia, Carlos, DiLorenzo, Nicolas, Ruiz-Moreno, Martin“…Treatments were allocated in a randomized block design, in four treatments: (CTL) access ad libitum to the LH; (SUP2) ad libitum access to LH and supplementation with 0.9 kg d(−1); (SUP4) ad libitum access to LH and supplementation with 1.8 kg d(−1) and; (SUP6) ad libitum access to LH with 2.7 kg d(−1). …”
Publicado 2022
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126por Durand, Geraldine, Dupieux-Chabert, Celine, Gustave, Claude-Alexandre, Bes, Michèle, Fruiquière, Berangere, Fulchiron, Corine, Munoz, Lorette, Rivat, Sarah, Ranc, Anne-gaelle, Vandenesch, Francois, Laurent, Frederic, Tristan, Anne, Martins-Simoes, Patricia“…The small colonies (SL1P, SL2P) were Oxacillin resistant (V2 OXA MIC≥4; AD MIC = 4) and V2 OXSF POSITIVE whereas the regular colonies (SL1G, SL2G) were Oxacillin susceptible (V2 OXA MIC = 2; AD MIC = 0.5) and V2 OXSF NEGATIVE. …”
Publicado 2019
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127por Cao, Jiqing, Huang, Min, Guo, Lei, Zhu, Li, Hou, Jianwei, Zhang, Larry, Pero, Adriana, Ng, Sabrina, El Gaamouch, Farida, Elder, Gregory, Sano, Mary, Goate, Alison, TCW, Julia, Haroutunian, Vahram, Zhang, Bin, Cai, Dongming“…In addition, elevating miR-195 rescues AD-related lysosomal defects in inducible pluripotent stem cells (iPSCs)-derived brain cells of ApoE4(+/+) AD subjects while inhibiting miR-195 exacerbates these phenotypes. …”
Publicado 2020
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128por Ferreira, Mariana, Ribeiro, Pedro C., Ribeiro, Laura, Barata, Marisa, Domingues, Valentina F., Sousa, Sara, Soares, Cristina, Marques, Alexandra, Pousão-Ferreira, Pedro, Dias, Jorge, Castro, L. Filipe C., Marques, António, Nunes, Maria L., Valente, Luisa M. P.“…Diets were supplemented with Laminaria digitata (0.4% AD1 and AD2; 0.8% AD3) and selenised yeast (0.02% AD1 and AD2; 0.04% AD3). …”
Publicado 2022
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129por Teo, Pey Sze, Lim, Amanda JiaYing, Goh, Ai Ting, R, Janani, Choy, Jie Ying Michelle, McCrickerd, Keri, Forde, Ciarán G“…METHODS: In this crossover study, 50 healthy-weight participants [n = 50 (24 men); mean ± SD age: 24.4 ± 3.1 y; BMI: 21.3 ± 1.9 kg/m(2)] consumed 4 ad libitum lunch meals consisting of “soft minimally processed,” “hard minimally processed,” “soft ultra-processed,” and “hard ultra-processed” components. …”
Publicado 2022
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130por Schuldt, Nathaniel J, Aldhamen, Yasser A, Godbehere-Roosa, Sarah, Seregin, Sergey S, Kousa, Youssef A, Amalfitano, Andrea“…The research described in this article examines the utility of alternative serotype adenovirus serotype 4 (Ad4) expressing a sporozoite surface protein (circumsporozoite protein (CSP)) (Ad4-CSP) to induce immune responses against CSP. …”
Publicado 2012
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131por Bateman, Daniel Robert, Brady, Erin, Wilkerson, David, Yi, Eun-Hye, Karanam, Yamini, Callahan, Christopher M“…RESULTS: In total, 6 AD caregivers completed the initial online survey and semistructured telephone interview. Of these, 4 AD caregivers agreed to participate in the online Facebook closed group activity portion of the study. …”
Publicado 2017
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132por Tolar, Martin, Abushakra, Susan, Hey, John A., Porsteinsson, Anton, Sabbagh, Marwan“…The most advanced selective anti-oligomer agent is ALZ-801, an optimized oral prodrug of tramiprosate, which demonstrated efficacy in homozygous APOE4/4 AD subjects. ALZ-801 selectively and fully inhibits the formation of Aβ42 oligomers at the clinical dose, without evidence of vasogenic edema, and will be evaluated in a phase 3 trial in homozygous APOE4/4 patients with early AD. …”
Publicado 2020
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133por Seo, Jieun, Byun, Min Soo, Yi, Dahyun, Lee, Jun Ho, Jeon, So Yeon, Shin, Seong A., Kim, Yu Kyeong, Kang, Koung Mi, Sohn, Chul-Ho, Jung, Gijung, Park, Jong-Chan, Han, Sun-Ho, Byun, Jayoung, Mook-Jung, Inhee, Lee, Dong Young, Choi, Murim“…RESULTS: We called 5391 high-quality single nucleotide variants (SNVs) on AD susceptibility genes and selected significant associations between variants and five in vivo AD pathologies: (1) amyloid β (Aβ) deposition, (2) AD-signature region cerebral glucose metabolism (AD-Cm), (3) posterior cingulate cortex (PCC) cerebral glucose metabolism (PCC-Cm), (4) AD-signature region cortical thickness (AD-Ct), and (5) hippocampal volume (Hv). …”
Publicado 2020
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134por Ruggiero, Rosanna, Balzano, Nunzia, Di Napoli, Raffaella, Mascolo, Annamaria, Berrino, Pasquale Maria, Rafaniello, Concetta, Sportiello, Liberata, Rossi, Francesco, Capuano, Annalisa“…Among the ICSRs reporting CLS with unfavorable outcome, we found also 9 fatal cases (BNT162b2 = 1; ChAdOx1-SARS-COV-2 = 4; Ad26.COV2-S = 4). From disproportionality analysis emerged a lower CLS reporting probability after vaccination with mRNA vaccines compared to viral vector-based ones (ROR 0.5, 95% CI 0.3–0.7; p <0.001).Our findings, even if subject to the limitations of spontaneous reporting systems, suggest a small but statistically significant safety concern for CLS following receipt of COVID-19 viral vector vaccines, in particular with Ad26.COV2-S. …”
Publicado 2022
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135por Walters, Skylar, Contreras, Alex G., Eissman, Jaclyn M., Mukherjee, Shubhabrata, Lee, Michael L., Choi, Seo-Eun, Scollard, Phoebe, Trittschuh, Emily H., Mez, Jesse B., Bush, William S., Kunkle, Brian W., Naj, Adam C., Peterson, Amalia, Gifford, Katherine A., Cuccaro, Michael L., Cruchaga, Carlos, Pericak-Vance, Margaret A., Farrer, Lindsay A., Wang, Li-San, Haines, Jonathan L., Jefferson, Angela L., Kukull, Walter A., Keene, C. Dirk, Saykin, Andrew J., Thompson, Paul M., Martin, Eden R., Bennett, David A., Barnes, Lisa L., Schneider, Julie A., Crane, Paul K., Hohman, Timothy J., Dumitrescu, Logan“…DESIGN, SETTING, AND PARTICIPANTS: This genetic association study included longitudinal cognitive data from 4 AD and cognitive aging cohorts. Participants were older than 60 years and self-identified as non-Hispanic White or non-Hispanic Black (hereafter, White and Black). …”
Publicado 2023
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136por Wang, Xianwei, Liu, Lu, Jiang, Xiaohua, Saredy, Jason, Xi, Hang, Cueto, Ramon, Sigler, Danni, Khan, Mohsin, Wu, Sheng, Ji, Yong, Snyder, Nathaniel W., Hu, Wenhui, Yang, Xiaofeng, Wang, Hong“…By analyzing MG transcriptomes from 4 AD patient and 7 mouse AD datasets, 409 human and 777 mouse AD MG DEGs were identified, of which 37 were found common in both species. …”
Publicado 2023
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137por Chen, Jinghan Jenny, Thiyagarajah, Mathura, Song, Jianmeng, Chen, Clara, Herrmann, Nathan, Gallagher, Damien, Rapoport, Mark J., Black, Sandra E., Ramirez, Joel, Andreazza, Ana C., Oh, Paul, Marzolini, Susan, Graham, Simon J., Lanctôt, Krista L.“…RESULTS: For brain GSH, 4 AD (AD=135, HC=223) and 4 MCI (MCI=213, HC=211) studies were included. …”
Publicado 2022
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138por Pettigrew, Corinne, Nazarovs, Jurijs, Soldan, Anja, Singh, Vikas, Wang, Jiangxia, Hohman, Timothy, Dumitrescu, Logan, Libby, Julia, Kunkle, Brian, Gross, Alden L., Johnson, Sterling, Lu, Qiongshi, Engelman, Corinne, Masters, Colin L., Maruff, Paul, Laws, Simon M., Morris, John C., Hassenstab, Jason, Cruchaga, Carlos, Resnick, Susan M., Kitner-Triolo, Melissa H., An, Yang, Albert, Marilyn“…CONCLUSIONS: These results suggest that APOE-ε4 and non-APOE-ε4 AD polygenic risk are independently associated with global cognitive and executive function declines among individuals with normal cognition at baseline, but only APOE-ε4 is associated with declines in episodic memory. …”
Publicado 2023
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139por Qiao, Lei, Hu, Jiayi, Qiu, Xiaohan, Wang, Chunlin, Peng, Jieqiong, Zhang, Cheng, Zhang, Meng, Lu, Huixia, Chen, Wenqiang“…Abbreviation: ACSL4: acyl-CoA synthetase long-chain family member 4; AD: Alzheimer disease; Ag: antigens; APP: amyloid beta precursor protein; ATG14: autophagy related 14; AVSF: autophagic vacuoles with unique sarcolemmal features; BBC3/PUMA: BCL2 binding component 3; CCD: C-terminal coiled coil domain; CMA: chaperone-mediated autophagy; CVDs: cardiovascular diseases; DDIT4/REDD1: DNA damage inducible transcript 4; ECs: endothelial cells; ER: endoplasmic reticulum; ESCs: embryonic stem cells; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GBA/β-glucocerebrosidase: glucosylceramidase beta; GSCs: glioblastoma stem cells; HCC: hepatocellular carcinoma; HD: Huntington disease; HSCs: hematopoietic stem cells; HSPA8/HSC70: heat shock protein family A (Hsp70) member 8; IL3: interleukin 3; IR: ischemia-reperfusion; LAMP2: lysosomal associated membrane protein 2; LDs: lipid droplets; LRRK2: leucine rich repeat kinase 2; MA: macroautophagy; MHC: major histocompatibility complex; MST1: macrophage stimulating 1; NAFLD: nonalcoholic fatty liver disease; NFE2L2/NRF2: NFE2 like bZIP transcription factor 2; NLRP3: NLR family pyrin domain containing 3; PARK7: Parkinsonism associated deglycase; PD: Parkinson disease; PEA15/PED: proliferation and apoptosis adaptor protein 15; PKM/PKM2: pyruvate kinase M1/2; RA: rheumatoid arthritis; RARA: retinoic acid receptor alpha; RCAN1: regulator of calcineurin 1; RCC: renal cell carcinoma; RDA: RNautophagy and DNautophagy; RNAi: RNA interference; RND3: Rho Family GTPase 3; SG-NOS3/eNOS: deleterious glutathionylated NOS3; SLE: systemic lupus erythematosus; TAMs: tumor-associated macrophages; TME: tumor microenvironment; UCHL1: ubiquitin C-terminal hydrolase L1; VAMP8: vesicle associated membrane protein 8…”
Publicado 2023
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140por Probst, Varvara, Stopczynski, Tess, Amarin, Justin Z, Spieker, Andrew J, Rahman, Herdi Kurnia, Stewart, Laura S, Selvarangan, Rangaraj, Schuster, Jennifer E, Michaels, Marian G, Williams, John, Boom, Julie A, Sahni, Leila C, Avadhanula, Vasanthi, Staat, Mary A, Schlaudecker, Elizabeth P, McNeal, Monica, Harrison, Christopher J, Moffatt, Mary E, Weinberg, Geoffrey A, Szilagyi, Peter G, Englund, Janet A, Klein, Eileen J, Curns, Aaron T, Perez, Ariana, Clopper, Benjamin R, Rha, Brian, Gerber, Susan I, Chappell, James, Halasa, Natasha B“…The distribution of types among the 1,330 (63.2%) successfully typed specimens were as follows: 31.7% AdV-2, 28.9% AdV-1, 15.3% AdV-3, 7.9% AdV-5, 5.9% AdV-7, 1.4% AdV-4, 1.2% AdV-6, 0.5% AdV-14, 0.2% AdV-21, 0.1% AdV-11, and 7.0% ≥1 AdV type. …”
Publicado 2022
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