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  1. 2641
    “…BACKGROUND: The aim of this research was to study the levels of 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) in tumour tissue samples of colorectal carcinoma based upon immunohistochemical detection and compare those results with patients’ outcome. …”
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    Immunohistochemical expression of 8-oxo-7,8-dihydro-2′-deoxyguanosine in cytoplasm of tumour and adjacent normal mucosa cells in patients with colorectal cancer
  2. 2642
    “…SLC30A8 encodes a zinc transporter ZnT8 largely restricted to pancreatic islet β- and α-cells, and responsible for zinc accumulation into secretory granules. …”
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    The Zinc Transporter Slc30a8/ZnT8 Is Required in a Subpopulation of Pancreatic α-Cells for Hypoglycemia-induced Glucagon Secretion
  3. 2643
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    Crystal structure of (±)-(7RS,8SR)-7-methyl-1,4-dioxa­spiro­[4.5]decane-7,8-diol
  4. 2644
    “…Chemokine CXCL8/interleukin-8 (IL-8) plays a crucial role in directing neutrophils and oligodendrocytes to combat infection/injury and tumour cells in metastasis development. …”
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    Solution NMR characterization of chemokine CXCL8/IL-8 monomer and dimer binding to glycosaminoglycans: structural plasticity mediates differential binding interactions
  5. 2645
    “…The MUC1-derived SAPDTRPA (MUC1-8-mer) peptide is a potent epitope recognized by CD8(+) T cells in murine models. …”
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    Expansion of quiescent lung adenocarcinoma CD8(+) T cells by MUC1-8-mer peptide-T2 cell-β2 microglobulin complexes
  6. 2646
    “…These memory CD161(int) CD8+ T cells are enriched within the colon and express both CD103 and CD69, markers associated with tissue residence. …”
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    CD161(int) CD8+ T cells: a novel population of highly functional, memory CD8+ T cells enriched within the gut
  7. 2647
    “…The α8 integrin (Itga8) chain contributes to the regulation of cell proliferation and apoptosis in renal glomerular cells. …”
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    Alpha8 Integrin (Itga8) Signalling Attenuates Chronic Renal Interstitial Fibrosis by Reducing Fibroblast Activation, Not by Interfering with Regulation of Cell Turnover
  8. 2648
    “…Less is known about the potential of IL-6 in regulating CD8(+) T cell effector function. Here, we identify IL-6 as a master regulator of IL-21 in effector CD8(+) T cells. …”
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    IL-6 promotes the differentiation of a subset of naive CD8(+) T cells into IL-21–producing B helper CD8(+) T cells
  9. 2649
    “…The rearrangement between isomers 6‐ and 8‐bromo‐apigeninidin (6 and 8) was studied by pH jumps using stopped flow, UV/Vis, NMR, and HPLC analysis. …”
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    Extending the Study of the 6,8 Rearrangement in Flavylium Compounds to Higher pH Values: Interconversion between 6‐Bromo and 8‐Bromo‐apigeninidin
  10. 2650
    “…As one of the most common forms of oxidative DNA damage, 7,8-dihydro-8-oxo-2′-deoxyguanosine (8-oxoG) generally leads to G:C to T:A mutagenesis. …”
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    Error-Free Bypass of 7,8-dihydro-8-oxo-2′-deoxyguanosineby DNA Polymerase of Pseudomonas aeruginosa Phage PaP1
  11. 2651
    “…This work presents a cost-effective, label-free in point-of-care (POC) biosensor for the sensitive detection of 8-hydroxy-2′-deoxyguanosine (8-OHdG), the most abundant oxidative product of DNA, that may allow a premature assessment of cancer disease, thereby improving diagnosis, prognostics and survival rates. …”
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    Paper-Based Sensing Device for Electrochemical Detection of Oxidative Stress Biomarker 8-Hydroxy-2′-deoxyguanosine (8-OHdG) in Point-of-Care
  12. 2652
    “…In C57BL/6 mice, HSV-1 induces a highly skewed CD8(+) T cell repertoire, in which half of CD8(+) T cells (gB-CD8s) recognize a single epitope on glycoprotein B (gB(498-505)), while the remainder (non-gB-CD8s) recognize, in varying proportions, 19 subdominant epitopes on 12 viral proteins. …”
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    Influence of an immunodominant herpes simplex virus type 1 CD8(+) T cell epitope on the target hierarchy and function of subdominant CD8(+) T cells
  13. 2653
    “…The mutant TAF8 protein could not be detected in extracts from the patient’s fibroblasts, indicating a loss of TAF8 function and that the mutation is most likely causative. …”
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    Homozygous TAF8 mutation in a patient with intellectual disability results in undetectable TAF8 protein, but preserved RNA polymerase II transcription
  14. 2654
    “…In the present study, a docking based virtual screening procedure using the crystal structure of histone deacetylase 8 from Schistosoma mansoni (smHDAC8) was designed. …”
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    A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing
  15. 2655
    “…Age-related hearing loss (ARHL) is the most common sensory disorder in the elderly population. SAMP8 mouse model presents accelerated senescence and has been identified as a model of gerontological research. …”
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    N-acetylcysteine Treatment Reduces Age-related Hearing Loss and Memory Impairment in the Senescence-Accelerated Prone 8 (SAMP8) Mouse Model
  16. 2656
    “…To investigate the effects of Lactobacillus paracasei PS23 (LPPS23) on the progression of age-related cognitive decline, male and female senescence-accelerated mouse prone 8 (SAMP8) mice were divided into two groups (n = 6 each): the control and PS23 groups. …”
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    Lactobacillus paracasei PS23 Delays Progression of Age-Related Cognitive Decline in Senescence Accelerated Mouse Prone 8 (SAMP8) Mice
  17. 2657
    por Mao, Lingna, Guo, Cheng, Zheng, Shu
    Publicado 2018
    “…BACKGROUND AND PURPOSE: Oxidative stress is closely related to the pathogenesis of colorectal cancer (CRC). 8-Oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) is a typical bio-marker of oxidative stress. …”
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    Elevated urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine and serum uric acid are associated with progression and are prognostic factors of colorectal cancer
  18. 2658
    “…Human milk fat globule-EGF factor 8 protein (MFG-E8) is similar to MFG-E8-S, a short isoform, of the mouse MFG-E8. …”
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    The Healing Effect of Human Milk Fat Globule-EGF Factor 8 Protein (MFG-E8) in A Rat Model of Parkinson’s Disease
  19. 2659
    “…PURPOSE: To investigate changes in corneal nerves positive to substance P (SP) and transient receptor potential melastatin 8 (TRPM8) and gene expression in the trigeminal ganglia (TG) following corneal surgery to unveil peripheral nerve mechanism of induced dry eye-like pain (DELP). …”
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    Remodeling of Substance P Sensory Nerves and Transient Receptor Potential Melastatin 8 (TRPM8) Cold Receptors After Corneal Experimental Surgery
  20. 2660
    “…Here, we investigated whether alterations in macrophage expression of the transcriptional regulator for myeloid commitment and function, interferon regulatory factor-8 (IRF8), could predict survival of clear cell renal cell carcinoma patients. …”
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    Tumor-associated macrophage expression of interferon regulatory Factor-8 (IRF8) is a predictor of progression and patient survival in renal cell carcinoma
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