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2741por Vujanovic, Lazar, Ballard, Wenners, Thorne, Stephen H., Vujanovic, Nikola L., Butterfield, Lisa H.“…The importance of CXCL8/IL-8 was further demonstrated in vivo. Pretreatment of mice with the neutralizing anti-CXCL8/IL-8 antibody led to significant inhibition of Ad.DC-induced migration of NK cells in vivo. …”
Publicado 2012
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2742por Mikuła-Pietrasik, Justyna, Kuczmarska, Angelika, Kucińska, Małgorzata, Murias, Marek, Wierzchowski, Marcin, Winckiewicz, Marek, Staniszewski, Ryszard, Bręborowicz, Andrzej, Książek, Krzysztof“…This effect was associated with decreased secretion of VEGF and IL-8/CXCL8 by HPMCs treated with RVT, which confirmed the experiments with recombinant forms of these angiogenic agents. …”
Publicado 2012
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2743
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2744por Talhaoui, Ibtissam, Couvé, Sophie, Ishchenko, Alexander A., Kunz, Christophe, Schär, Primo, Saparbaev, Murat“…Hydroxyl radicals predominantly react with the C(8) of purines forming 7,8-dihydro-8-oxoguanine (8oxoG) and 7,8-dihydro-8-oxoadenine (8oxoA) adducts, which are highly mutagenic in mammalian cells. …”
Publicado 2013
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2745“…The Ag(I) ion displays a distorted tetrahedral coordination geometry defined by two N and two O atoms from a neutral quinolin-8-ol ligand (HQ) and a deprotonated quinolin-8-olate anion (Q(−)). …”
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2746“…We investigated the effect of memantine combined with EE on spatial learning and memory and AD-like pathology in a widely used AD model, the senescence-accelerated prone mice (SAMP8). The SAMP8 mice were randomly assigned to enriched housing (EH) or standard housing (SH), where either memantine (20 mg/kg) or saline was given by gastric lavage once daily continuously for eight weeks. …”
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2747por Kim, Ki Cheon, Lee, In Kyung, Kang, Kyoung Ah, Cha, Ji Won, Cho, Suk Ju, Na, Soo Young, Chae, Sungwook, Kim, Hye Sun, Kim, Suhkmann, Hyun, Jin Won“…The modified guanine base 8-oxoguanine (8-oxoG) is abundantly produced by oxidative stress, can contribute to carcinogenesis, and can be removed from DNA by 8-oxoguanine DNA glycosylase-1 (OGG1), which acts as an 8-oxoG glycosylase and endonuclease. …”
Publicado 2013
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2748por Hansen, Ashleigh, Alston, Laurie, Tulk, Sarah E., Schenck, L. Patrick, Grassie, Michael E., Alhassan, Basmah F., Veermalla, Arun Teja, Al-Bashir, Samir, Gendron, Fernand-Pierre, Altier, Christophe, MacDonald, Justin A., Beck, Paul L., Hirota, Simon A.“…TcdA and TcdB alter cytoskeletal signaling and trigger the release of CXCL8/IL-8, a potent neutrophil chemoattractant, from intestinal epithelial cells; however, little is known about the surface receptor(s) that mediate these events. …”
Publicado 2013
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2749“…Molecular dynamics (MD) simulations coupled with solvated interaction energy method (SIE) were carried out to study the binding modes of three inhibitors 8CA, F8A and I4A to A-FABP. The rank of our predicted binding affinities is in accordance with experimental data. …”
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2750“…RESULTS: After applying the template-based 8-state secondary structure prediction method, the 7-fold cross-validated Q8 accuracy is 78.85%. …”
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2751por Hamouda, Mohamed-Amine, Belhacene, Nathalie, Puissant, Alexandre, Colosetti, Pascal, Robert, Guillaume, Jacquel, Arnaud, Mari, Bernard, Auberger, Patrick, Luciano, Frederic“…In addition, pangenomic profiling of velcade-sensitive and resistant cells showed that the small heat shock protein HSPB8 was overexpressed in resistant cells. Finally, gain and loss of function experiment demonstrated that HSPB8 is a key factor for velcade resistance. …”
Publicado 2014
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2752por Halbach, Melanie Vanessa, Stehning, Tanja, Damrath, Ewa, Jendrach, Marina, Şen, Nesli Ece, Başak, A. Nazlı, Auburger, Georg“…Jointly, all available data suggest that the degradation of wildtype and mutant ATXN2 is dependent on FBXW8, and that ATXN2 accumulation selectively modulates FBXW8 levels, while PARK2 might act indirectly through FBXW8. …”
Publicado 2015
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2753
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2754por Lee, Laura L., Izquierdo, Javier A., Blumer-Schuette, Sara E., Zurawski, Jeffrey V., Conway, Jonathan M., Cottingham, Robert W., Huntemann, Marcel, Copeland, Alex, Chen, I-Min A., Kyrpides, Nikos, Markowitz, Victor, Palaniappan, Krishnaveni, Ivanova, Natalia, Mikhailova, Natalia, Ovchinnikova, Galina, Andersen, Evan, Pati, Amrita, Stamatis, Dimitrios, Reddy, T.B.K., Shapiro, Nicole, Nordberg, Henrik P., Cantor, Michael N., Hua, Susan X., Woyke, Tanja, Kelly, Robert M.“…Here, we report genome sequences for three additional Caldicellulosiruptor species: Rt8.B8 DSM 8990 (New Zealand), Wai35.B1 DSM 8977 (New Zealand), and “Thermoanaerobacter cellulolyticus” strain NA10 DSM 8991 (Japan).…”
Publicado 2015
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2755por Radtke, Andrea J., Kastenmüller, Wolfgang, Espinosa, Diego A., Gerner, Michael Y., Tse, Sze-Wah, Sinnis, Photini, Germain, Ronald N., Zavala, Fidel P., Cockburn, Ian A.“…A few hours after sporozoite arrival to the DLNs, CD8(+) T cells are primed by resident CD8α(+) DCs with no apparent role for skin-derived DCs. …”
Publicado 2015
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2756por Nebel, Rebecca A., Kirschen, Jill, Cai, Jinlu, Woo, Young Jae, Cherian, Koshi, Abrahams, Brett S.“…Data support A kinase anchor protein 8 and 8-like (AKAP8 and AKAP8L) as candidate genes involved in regulation of head growth, an interesting finding given previous work implicating the AKAP gene family in autism. …”
Publicado 2015
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2757
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2758por Ma, Bin, Jing, Meng, Villalta, Peter W., Kapphahn, Rebecca J., Montezuma, Sandra R., Ferrington, Deborah A., Stepanov, Irina“…Measurement of oxidative DNA lesions such as 8-oxo-2’-deoxyguanosine (8-oxo-dG) and 8-oxo-2’-deoxyadenosine (8-oxo-dA) in diseased RPE could provide important insights into the mechanism of AMD development. …”
Publicado 2016
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2759por Garagiola, Isabella, Seregni, Sabrina, Mortarino, Mimosa, Mancuso, Maria Elisa, Fasulo, Maria Rosaria, Notarangelo, Lucia Dora, Peyvandi, Flora“…This F8 variant was the second most frequent mutation in our cohort, after the intron 22 inversion. …”
Publicado 2015
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2760“…We report a new type of sustained and reversible unipolar resistive switching in a nanowire device made from a single strand of Cu:7,7,8,8-tetracyanoquinodimethane (Cu:TCNQ) nanowire (diameter <100 nm) that shows high ON/OFF ratio (~10(3)), low threshold voltage of switching (~3.5 V) and large cycling endurance (>10(3)). …”
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