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  1. 2761
    “…Promoter methylation of four candidate tumor suppressor genes (adenylate cyclase 8 (ADCY8), cadherin 8, type 2 (CDH8), MGMT, and zinc finger protein 582 (ZNF582)) out of 48 genes screened was quantified by bisulfite-pyrosequencing of genomic DNA. …”
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    Molecular Pap smear: HPV genotype and DNA methylation of ADCY8, CDH8, and ZNF582 as an integrated biomarker for high-grade cervical cytology
  2. 2762
    “…The Phytophthora infestans RXLR-type effector PexRD54 binds potato ATG8 via its ATG8 family-interacting motif (AIM) and perturbs host-selective autophagy. …”
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    Structural Basis of Host Autophagy-related Protein 8 (ATG8) Binding by the Irish Potato Famine Pathogen Effector Protein PexRD54
  3. 2763
    “…In reality, many candidates either destabilize the duplex or do not base pair indiscriminatingly. The novel base 8-aza-7-deazaadenine (pyrazolo[3,4-d]pyrimidin- 4-amine) N(8)-(2′deoxyribonucleoside), a deoxyadenosine analog (UB), pairs with each of the natural DNA bases with little sequence preference. …”
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    Using NMR and molecular dynamics to link structure and dynamics effects of the universal base 8-aza, 7-deaza, N8 linked adenosine analog
  4. 2764
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    De Novo San Luis Valley Syndrome-like der(8) Chromosome With a Concomitant dup(8p22) in a Mexican Girl
  5. 2765
    por Tan, Ka-Liong, Pezzella, Francesco
    Publicado 2016
    “…The ubiquitin ligase activity of the SCF complexes requires the conjugation of neural precursor cell expressed, developmentally down-regulated 8 (NEDD8) to cullin proteins. A tumour suppressor and degrading enzyme named NEDD8 ultimate buster 1 (NUB1) is able to recruit HLA-F-adjacent transcript 10 (FAT10)- and NEDD8-conjugated proteins for proteasomal degradation. …”
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    Inhibition of NEDD8 and FAT10 ligase activities through the degrading enzyme NEDD8 ultimate buster 1: A potential anticancer approach
  6. 2766
    “…To investigate this, we deleted Rac1 or modulated its activity in mice with transgenic expression of Human papilloma virus type-8 (HPV-8) in epidermal keratinocytes. Our data show that inhibition or deletion of Rac1 results in reduced papilloma formation upon UV-irradiation with a single dose, whereas constitutive activation of Rac1 strongly increases papilloma frequency in these mice. …”
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    Deletion of epidermal Rac1 inhibits HPV-8 induced skin papilloma formation and facilitates HPV-8- and UV-light induced skin carcinogenesis
  7. 2767
    “…Milk fat globule-EGF factor 8 (MFG-E8), as a link between apoptotic cells and phagocytes, facilitates clearance of apoptotic cells and attenuates inflammation. …”
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    Cigarette smoke attenuates phagocytic ability of macrophages through down-regulating Milk fat globule-EGF factor 8 (MFG-E8) expressions
  8. 2768
    “…Neutrophil elastase (NE) suppresses IL-8/CXCL8 in human airway smooth muscle cells (hASM) while stimulating its production in respiratory epithelial cells. …”
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    Noncanonical NF-κB mediates the Suppressive Effect of Neutrophil Elastase on IL-8/CXCL8 by Inducing NKRF in Human Airway Smooth Muscle
  9. 2769
    “…Integrin beta8 (ITGB8) is involved in the endometrial receptivity. …”
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    Integrin beta8 (ITGB8) activates VAV-RAC1 signaling via FAK in the acquisition of endometrial epithelial cell receptivity for blastocyst implantation
  10. 2770
    “…Coronary artery bypass grafting (CABG), one of the most common cardiac surgical procedures, is characterized by a burst of oxidative stress. 8-Oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG), produced following DNA repairing, is used as an indicator of oxidative DNA damage in humans. …”
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    Assessing Free-Radical-Mediated DNA Damage during Cardiac Surgery: 8-Oxo-7,8-dihydro-2′-deoxyguanosine as a Putative Biomarker
  11. 2771
    “…Whether inflation of CD8(+) memory T (mT) cells, which is often derived from repeated prime-boost vaccinations or chronic viral infections in the elderly, would affect late CD8(+) T-cell immunity is a long-standing paradox. …”
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    CD8(+) memory T-cell inflation renders compromised CD4(+) T-cell-dependent CD8(+) T-cell immunity via naïve T-cell anergy
  12. 2772
    “…CD4(+) T cell help to CD8(+) T cell responses requires that CD4(+) and CD8(+) T cells interact with the same antigen presenting dendritic cell (Ag(+)DC), but it remains controversial whether helper signals are delivered indirectly through a licensed DC and/or involve direct CD4(+)/CD8(+) T cell contacts and/or the formation of ternary complexes. …”
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    CD4/CD8/Dendritic cell complexes in the spleen: CD8(+) T cells can directly bind CD4(+) T cells and modulate their response
  13. 2773
    “…T-cell death-associated gene 8 (TDAG8) is a proton-sensing G protein-coupled receptor found on cardiac macrophages that recognise increases in extracellular protons. …”
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    The proton-sensing G protein-coupled receptor T-cell death-associated gene 8 (TDAG8) shows cardioprotective effects against myocardial infarction
  14. 2774
    “…OBJECTIVE: The aim of this study was to compare the endometrial expression of milk fat globule-EGF factor 8 (MFG-E8), its receptor integrin αvβ3, and leukemia inhibitory factor (LIF) in patients with endometriosis and infertility and in healthy fertile patients during the window of implantation. …”
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    Alterations in expression of endometrial milk fat globule-EGF factor 8 (MFG-E8) and leukemia inhibitory factor (LIF) in patients with infertility and endometriosis
  15. 2775
    “…In this work, we targeted an antigen to the CD8α(+) or the CD8α(−) DC subsets in the presence of CpG oligodeoxinucleotides (ODN) or bacterial flagellin, using hybrid αDEC205 or αDCIR2 mAbs, respectively. …”
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    CpG Oligodeoxinucleotides and Flagellin Modulate the Immune Response to Antigens Targeted to CD8α(+) and CD8α(−) Conventional Dendritic Cell Subsets
  16. 2776
    “…Bloodstream infections induce considerable morbidity, high mortality, and represent a significant burden of cost in health care; however, our understanding of the immune response to bacteremia is incomplete. Langerin(+) CD8α(+) dendritic cells (DCs), residing in the marginal zone of the murine spleen, have the capacity to cross-prime CD8(+) T cells and produce IL-12, both of which are important components of antimicrobial immunity. …”
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    Langerin(+) CD8α(+) Dendritic Cells Drive Early CD8(+) T Cell Activation and IL-12 Production During Systemic Bacterial Infection
  17. 2777
    “…BACKGROUND: Widespread scepticism persists on the use of the Under-Privileged Area (UPA8) score of Jarman in distributing supplementary resources to so-attributed 'deprived' UK general practices. …”
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    Does Council Tax Valuation Band (CTVB) correlate with Under-Privileged Area 8 (UPA8) score and could it be a better 'Jarman Index'?
  18. 2778
    “…Carbonic anhydrase-8 (Car8; murine gene symbol) is an allosteric inhibitor of inositol trisphosphate receptor-1 (ITPR1), which regulates neuronal intracellular calcium release. …”
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    Human Carbonic Anhydrase-8 AAV8 Gene Therapy Inhibits Nerve Growth Factor Signaling Producing Prolonged Analgesia and Anti-Hyperalgesia in Mice
  19. 2779
    “…In this paper, the c-C(4)F(8) and c-C(4)F(8)/N(2) gas mixture models were built to study its decomposition process by the combination of reactive molecular dynamics method and density functional theory. …”
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    Insights on decomposition process of c-C(4)F(8) and c-C(4)F(8)/N(2) mixture as substitutes for SF(6)
  20. 2780
    “…Human MAIT cells predominantly express the CD8α coreceptor (CD8(+)), with a smaller subset lacking both CD4 and CD8 (double-negative, DN). …”
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    The CD4(−)CD8(−) MAIT cell subpopulation is a functionally distinct subset developmentally related to the main CD8(+) MAIT cell pool
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