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  1. 2781
    “…Background: Characterization of the intracellular biochemical processes that regulate the generation and maintenance of effector and memory CD8(+) T-cells from naïve precursors is essential for our understanding of adaptive immune responses and the development of immunotherapies. …”
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    Naïve CD8(+) T-Cells Engage a Versatile Metabolic Program Upon Activation in Humans and Differ Energetically From Memory CD8(+) T-Cells
  2. 2782
    “…The phylogenetic trees revealed relatedness between the VP7 and VP4 genes of the G3P[8] RVA Italian strain (namely PG2) and those belonging to recent G3P[8] RVAs detected worldwide. …”
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    First detection of a reassortant G3P[8] rotavirus A strain in Italy: a case report in an 8-year-old child
  3. 2783
    “…Bioavailability of 8:2-FTOH ranged from 22 to 41% for both sexes with no dose-dependent trends. 8:2-FTOH metabolites, PFOA and 7:3-FTA were detected in plasma following administration of the parent FTOH. …”
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    Toxicokinetics of 8:2 fluorotelomer alcohol (8:2-FTOH) in male and female Hsd:Sprague Dawley SD rats after intravenous and gavage administration
  4. 2784
    “…BACKGROUND: HuMax-IL8 (now known as BMS-986253) is a novel, fully human monoclonal antibody that inhibits interleukin-8 (IL-8), a chemokine that promotes tumor progression, immune escape, epithelial-mesenchymal transition, and recruitment of myeloid-derived suppressor cells. …”
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    Phase I trial of HuMax-IL8 (BMS-986253), an anti-IL-8 monoclonal antibody, in patients with metastatic or unresectable solid tumors
  5. 2785
    “…CyclinD1 was downregulated by CBX8 knockdown but upregulated by CBX8 overexpression. …”
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    Chromobox homolog 8 (CBX8) Interacts with Y-Box binding protein 1 (YBX1) to promote cellular proliferation in hepatocellular carcinoma cells
  6. 2786
    “…Here, we revealed that the E. coli O8:H8 strains isolated from patients in 2 independent diarrhea outbreaks were negative for any known virulence determinants in routine microbiological tests, were very closely related, and carried a prophage-encoded gene for a novel LT2 variant (LT2d) and the genes for colonization factor antigen III. …”
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    Escherichia coli O8:H8 Carrying a Novel Variant of the Heat-Labile Enterotoxin LT2 Gene Caused Outbreaks of Diarrhea
  7. 2787
    “…SNP-7/8a delivering in silico-designed mock neoantigens also induced CD8 T cells in non-human primates. …”
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    Peptide-TLR-7/8a conjugate vaccines chemically programmed for nanoparticle self-assembly enhance CD8 T cell immunity to tumor antigens
  8. 2788
    “…The high-temperature superplastic deformation behavior of rolled Mg-8Al-2Sn (AT82) and Mg-8Al-1Sn-1Zn (ATZ811) alloys were investigated in this study. …”
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    Superplastic Deformation Behavior of Rolled Mg-8Al-2Sn and Mg-8Al-1Sn-1Zn Alloys at High Temperatures
  9. 2789
    “…Moreover, the association between oxidative DNA damage, measured as urinary 8-oxo-7,8-dihydro-2’deoxyguanosine (8-oxodG) and co-exposure to metals and polycyclic aromatic hydrocarbons (PAHs) was evaluated. …”
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    Biological Monitoring of Occupational Exposure to Metals in Electric Steel Foundry Workers and Its Contribution to 8-Oxo-7,8-Dihydro-2′-Deoxyguanosine Levels
  10. 2790
    “…In this study, we identified Placenta-specific 8 (Plac8) as a gene that is uniquely expressed in Th1 CD4 T cells relative to other CD4 T cell subsets and hypothesized that Plac8 may represent a novel therapeutic target in Th1 CD4 T cells. …”
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    Placenta-specific 8 limits IFNγ production by CD4 T cells in vitro and promotes establishment of influenza-specific CD8 T cells in vivo
  11. 2791
    “…PROCEDURES: [(64)Cu]NOTA-CD8a was produced by enzymatic digestion of rat-anti-mouse CD8a antibody (clone YTS169.4), purified yielding isolated CD8a-F(ab)′2 fragments and randomly conjugated with the 2-S-(isothiocyanatbenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid (p-SCN-Bn-NOTA) chelator. …”
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    Monitoring CD8a(+) T Cell Responses to Radiotherapy and CTLA-4 Blockade Using [(64)Cu]NOTA-CD8a PET Imaging
  12. 2792
    “…Bmets CD8 expression was associated with primary tumor CD8 expression and primary tumor type. …”
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    Brain metastasis PD-L1 and CD8 expression is dependent on primary tumor type and its PD-L1 and CD8 status
  13. 2793
    “…RESULTS: In pretreatment tumors, the percentages of infiltrating CD8(+), PD1(+), PD1(+)CD8(+), and the ratio of PD1(+)CD8(+)/CD8(+) cells, were higher in pCR than non‐pCR patients in either the stromal or intratumoral area, but PD1(+)CD4(+), TIM3(+)CD4(+), TIM3(+)CD8(+) cells and CD4(+)/CD8(+) ratio was not. …”
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    Quantitative multiplex immunofluorescence analysis identifies infiltrating PD1(+)CD8(+) and CD8(+) T cells as predictive of response to neoadjuvant chemotherapy in breast cancer
  14. 2794
    “…Differentially expressed genes in normal brain tissues and glioma tissues, low‐grade and high‐grade gliomas were screened out with GEO database analysis. We found that KLHDC8A (Kelch domain‐containing 8A) expression level was significantly increased in high‐grade glioma tissues and that high KLHDC8A expression was closely related with poor prognosis. …”
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    Lactate induced up‐regulation of KLHDC8A (Kelch domain‐containing 8A) contributes to the proliferation, migration and apoptosis of human glioma cells
  15. 2795
    “…This study aimed to validate and expand the clinical performance of a multiparametric biomarker panel, referred to as the “Molecular Pap smear” based, on HPV genotype and ADCY8, CDH8 and ZNF582 CpG-methylation as a predictive classifier of cervical cytology. …”
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    Molecular Pap Smear: Validation of HPV Genotype and Host Methylation Profiles of ADCY8, CDH8, and ZNF582 as a Predictor of Cervical Cytopathology
  16. 2796
    “…Protease serine S1 family member 8 (PRSS8), a membrane-anchored serine protease, has been reported to be involved in the development of several human cancers. …”
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    Protease Serine S1 Family Member 8 (PRSS8) Inhibits Tumor Growth In Vitro and In Vivo in Human Non-Small Cell Lung Cancer
  17. 2797
    “…8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG), a major product of DNA oxidation, is a pre-mutagenic lesion which is prone to mispair, if left unrepaired, with 2′-deoxyadenosine during DNA replication. …”
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    Towards a comprehensive view of 8-oxo-7,8-dihydro-2’-deoxyguanosine: Highlighting the intertwined roles of DNA damage and epigenetics in genomic instability
  18. 2798
    “…The homeobox gene, LIM‐homeobox 8 (Lhx8), has previously been identified as an essential transcription factor for dental mesenchymal development. …”
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    FGF8 and BMP2 mediated dynamic regulation of dental mesenchyme proliferation and differentiation via Lhx8/Suv39h1 complex
  19. 2799
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    Correction to: High IRF8 expression correlates with CD8 T cell infiltration and is a predictive biomarker of therapy response in ER-negative breast cancer
  20. 2800
    “…Of note, the depletion of CD8 T cells resulted in the reduction of CD8(+) T cells or CD8(+)CD11c(+) DCs and the loss of anti‐tumor efficacy induced by CS‐pL‐Myc/pCAIX vaccine, suggesting the therapeutic efficacy of the vaccine was required for CD8(+) DCs and CD103(+) DCs mediated CD8(+) T cells responses. …”
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    Co‐immunization with L‐Myc enhances CD8(+) or CD103(+) DCs mediated tumor‐specific multi‐functional CD8(+) T cell responses
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