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926201por Hankosky, Emily R, Wang, Hui, Lisa, Neff M, Kan, Hongjun, Wang, Fangyu, Ahmad, Nadia N, Stefanski, Adam, Timothy Garvey, W“…At week 72, MMRM-estimated relative change in risk from baseline was -16.4%, -23.5%, -22.4%, and 12.7% for TZP 5/10/15mg and PBO, leading to significantly greater reduction for TZP groups compared to PBO (TZP 5 mg: -25.8%; 10 mg: -32.1%; 15 mg: -31.1%; p≤0.001). Among 272 participants (TZP 5 mg, n=83; 10 mg, n=66; 15 mg, n=55; PBO, n=68) with intermediate-to-high baseline ASCVD risk, median risk scores for TZP 5/10/15 mg and PBO groups were: baseline: 11.3%, 10.5%, 10.9%, 10.1%; week 72: 11.3%, 9.0%, 10.3%, 11.7%, respectively. …”
Publicado 2023
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926202por Horlen, Kyle, Kaminskaya, Kristina, Yamaguchi, Alyson, Fung, Leonard C, Kennedy, Heather, Nguyen, Son, Dasari, Anvesh, Toledo Vo, April, Archana, Battiwala, Patel, Nidhi, Mohan, Deepa, Syed, Baber, Dhalla, Arvinder K, Imran, Mir, Hashim, Mir A“…Teriparatide concentrations in serial blood samples (collected for up to 300 minutes) were quantitated via a validated ELISA.PD Study: OVX Sprague-Dawley rats (n=50) underwent an 8-week bone depletion period followed by 6-weeks of daily treatment with teriparatide at a dose of 2, 5, or 15 µg/kg via IP injection or 5 µg/kg via SC injection (Forteo®) (n = 10 per treatment). …”
Publicado 2023
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926203por Yamaguchi, Alyson, Horlen, Kyle, Patel, Nidhi, Tran, Vinh, Vo, April T, Medida, Ramya Lekha, Myers, Joshua T, Fung, Leonard C, Kaminskaya, Kristina, Mohan, Deepa, Nguyen, Vy, Nguyen, Son, Syed, Baber, Dhalla, Arvinder K, Imran, Mir, Hashim, Mir A“…Nonclinical Proof-of-Concept: Single doses of RT-112 (150 IU (n=7) and 450 IU (n=8)) were orally administered to awake, fasted Beagle dogs (7.0-13.0 kg body weight); a control group (n=3) received a dose of 20 IU/kg (∼180 IU) FSH via SC injection. …”
Publicado 2023
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926204por Kwok, T'ng Choong, Ramage, Lynne E, Suchacki, Karla Jade, Gray, Calum, Alexandra, Kelman, Boyle, Luke David, Semple, Robert Kenneth, Semple, Scott I, MacGillivray, Tom, van Beek, Edwin J R, Wakelin, Sonia, Stimson, Roland H“…BAT (18)F-FDG uptake (standard uptake value 5.1 ± 0.5 vs 4.2 ± 0.6 g/mL) and volume (69 ± 14 vs 72 ± 32 cm(3)) were similar between weight groups, despite greater insulin resistance in obese subjects (fasting glucose 5.5 ± 0.2 vs 4.3 ± 0.1mmol/L, insulin 11.9 ± 1.3 vs 5.8 ± 0.9mU/L, HOMA-IR 2.9 ± 0.3 vs 1.1 ± 0.2, free fatty acids 465 ± 78 vs 240 ± 34µM, all P<0.05), suggesting that (18)F-FDG uptake by BAT is not significantly affected by insulin resistance. …”
Publicado 2023
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926205por Kutrieb, Emily, Baum, Seth J, Dukes, Ellen, Sikora Kessler, Asia, Weycker, Derek, Vera Llonch, Montserrat, Respress, Jonathan, Soffer, Daniel“…Among patients with lower initial TG values (<500: N=453,940; 500-999: N=8,847), TG testing patterns were largely comparable to those among SHTG patients. …”
Publicado 2023
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926206por Araujo-Castro, Marta, Paja Fano, Miguel, González Boillos, Marga, Pla Peris, Begoña, Pascual-Corrales, Eider, García Cano, Ana María, Parra, Paola, Martín Rojas-Marcos, Patricia, Ruiz-Sanchez, Jorge Gabriel, Vicente Delgado, Almudena, Gómez Hoyos, Emilia, Ferreira, Rui, García Sanz, Iñigo, Recasens Sala, Mònica, San Millan, Rebeca Barahona, Picón César, María José, Díaz Guardiola, Patricia, García González, Juan Jesús, Perdomo, Carolina M, Manjón Miguélez, Laura, García Centeno, Rogelio, Rebollo Román, Ángel, Gracia Gimeno, Paola, Robles Lázaro, Cristina, Morales-Ruiz, Manuel, Calatayud Gutiérrez, María, Andree Furio Collao, Simone Simone, Meneses, Diego, Sampedro Nuñez, Miguel Antonio, Escudero Quesada, Verónica, Mena Ribas, Elena, Sanmartin Sánchez, Alicia, Gonzalvo Diaz, Cesar, Lamas, Cristina, Hanzu, Felicia“…We identified as risk factors of type 2 diabetes: male sex (OR 2.80 [1.81-4.34], P<0.001), older age (OR 1.05 [1.03-1.07], P<0.001), familiar history of T2DM (OR 4.64 [2.39-8.99]), P<0.001), dyslipidemia (OR 4.05 [2.67-6.14], P<0.001), cardiovascular (OR 1.30 [1.14-1.48], P<0.001) and cerebrovascular disease (OR 1.59 [0.92-2.74], P=0.003), sleep apnea syndrome (SAS) (OR 2.21 [1.34-3.63], P=0.003), higher BMI (OR 1.06 per unit [1.03-1.10], <0.001), hypertension duration (OR 1.04 per year [1.02-1.06], P<0.001) and the number of antihypertensive drugs (OR 1.50 [1.29-1.74], P<0.0001). …”
Publicado 2023
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926207por Jin, Yonglong, Shimizu, Shosei, Li, Yinuo, Yao, Yuan, Liu, Xiguang, Si, Hongzong, Sakurai, Hideyuki, Xiao, WenjingEnlace del recurso
Publicado 2023
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926208por Dyson, Alftan, Aberg, Judith A, Molina, Jean-Michel, Cassetti, Isabel, Kozal, Michael, Treviño-Pérez, Sandra, Latiff, Gulam, Lalezari, Jacob, Pialoux, Gilles, Li, Bo, Prakash, Manyu, Clark, Andrew, Tenorio, Allan R, Pierce, Amy, Lataillade, Max“…Participants with 1 or 2 ARVs entered the RC and received open-label FTR + OBT after an 8-day blinded placebo-controlled period; those with 0 ARVs entered the NRC and received open-label FTR + OBT from Day 0. …”
Publicado 2023
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926209por Francica, Joseph R, Cai, Yingyun, Diallo, Seme, Rosenthal, Kim, Ren, Kuishu, Flores, Daniel J, Dippel, Andrew, Wu, Yuling, Chen, Xiaoru, Cantu, Erin, Choudhary, Rakesh, Sulikowski, Michal, Adissu, Hibret, Chawla, Bhavna, Kar, Swagata, van Dyk, Nydia, Oganesyan, Vaheh, Rajan, Saravanan, Ryan, Patricia C, Loo, Yueh-Ming, Cohen, Taylor, Esser, Mark T, Blair, Wade“…AZD3152 potently neutralizes authentic viral variants (EC(50) range, 8.3 to 110.9 ng/mL) and SARS-CoV-2 pseudoviruses (EC(50) range of 3.2 to 25.0 ng/mL), including XBB.1.5. …”
Publicado 2023
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926210por Snape, Matthew D, Ghamloush, Sabine Schnyder, Chen, Grace L, Dhar, Rakesh, Mithani, Runa, Righi, Vinicius, Morsy, Louie, Kapoor, Archana, Girard, Bethany, Asmar, Laila El, Shaw, Christine A“…One mRNA-1653 injection boosted hMPV and PIV3 nAb titers (GMFR over baseline: hMPV-A=2.9-6.1; hMPV-B=6.2-13.2; PIV3=2.8-3.0) and preF and postF bAb concentrations (GMFR: hMPV preF=5.3-6.1; postF=4.6-6.5 and PIV3 preF=13.9-14.2; postF=11.0-12.1); a second injection did not further increase antibody levels (Fig 1B,C and 2B,C). …”
Publicado 2023
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926211por Wurster, Jenna, Straub, Tim, O’Brien, Edward J, Ennis, Nathaniel J, Mayol, Melissa, Brown, Jessica, Vulić, Marin, Beauchemin, Nicholas, Halvorsen, Elizabeth, Ford, Christopher, Henn, Matthew“…SER-147 candidate strains were additionally assessed in vitro for their capacity to tolerate low pH, grow in hypoxic culture conditions, suppress IL-8 activity, and utilize lactulose as a sole carbon source as it is a commonly prescribed medication in the CLD patient population CONCLUSION: Patients with CLD are at increased risk of mortality from infections seeded from the GI tract due to microbiome disruption and GI barrier compromise. …”
Publicado 2023
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926212por Sahni, Leila C, Amarin, Justin Z, Stopczynski, Tess, Spieker, Andrew J, Stewart, Laura S, Staat, Mary A, Quigley, Christina M, Selvarangan, Rangaraj, Schuster, Jennifer E, Michaels, Marian G, Williams, John V, Szilagyi, Peter G, Weinberg, Geoffrey A, Englund, Janet A, Klein, Eileen J, Clopper, Benjamin R, Moline, Heidi L, Avadhanula, Vasanthi, Munoz, Flor M, Piedra, Pedro A, Halasa, Natasha B, Boom, Julie A“…Median age of enrolled children was 8.9 years (IQR: 6.6, 12.2), 55% were male, 38% were non-Hispanic White, and 76% had ≥ 1 underlying medical condition (Table). …”
Publicado 2023
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926213por Nguyen, Sean T, DeJonge, Boudewijn L, Bryowsky, Jason J, Henriksen, Anne, Longshaw, Christopher M, Maher, Joshua, Mendes, Rodrigo E, Takemura, Miki, Yamano, Yoshinori“…CFDC (MIC(50/90), 0.25/1 mg/L; 95.7 %S) displayed better in vitro potency in CarbNS ABC as compared to SAM (MIC(50/90), 32/ >64 mg/L; 17.4 %S CLSI) and CST (MIC(50/90), 0.5/ >8 mg/L; 78.3%S EUCAST). Among pediatric S. maltophilia, CFDC was the most active agent with MIC(50/90,) 0.06/0.25 and 100 %S per CLSI & EUCAST breakpoints. …”
Publicado 2023
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926214por Halvorsen, Elizabeth, Vulić, Marin, Barrasso, Kelsey, Beauchemin, Nicholas, Brown, Jessica, Ennis, Nathaniel J, Mayol, Melissa, Wurster, Jenna, O’Brien, Edward J, Ford, Christopher, Henn, Matthew“…Individual pathogens were introduced on day 4 of the experiment, followed by a vancomycin pre-treatment from days 5-8. On days 10-16, five unique candidate consortia (DE061, DE456, DE240, DE714, and DE492) were dosed daily as the microbiome intervention. …”
Publicado 2023
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926215por Musa, Samar, Zhang, Xueyan, Balasubramani, G K, Halasa, Natasha B, Stewart, Laura S, Schuster, Jennifer E, Selvarangan, Rangaraj, Weinberg, Geoffrey A, Szilagyi, Peter G, Klein, Eileen J, Englund, Janet A, Avadhanula, Vasanthi, Piedra, Pedro A, Quigley, Christina M, Staat, Mary A, Perez, Ariana, Moline, Heidi L, Williams, John V, Michaels, Marian G“…HCoV-229E was the most common HCoV detected among inpatients (57.0%), followed by HCoV-HKU1-(45.2%); HCoV-OC43- (40.8%); and HCoV-NL63 (38.9%). Among those positive for a HCoV age, race, and insurance status were significantly associated with hospitalization. …”
Publicado 2023
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926216por Balachandran, Neha, Wikswo, Mary, Boom, Julie A, Sahni, Leila C, Selvarangan, Rangaraj, Harrison, Christopher J, Halasa, Natasha B, Stewart, Laura S, Weinberg, Geoffrey A, Szilagyi, Peter G, Englund, Janet A, Klein, Eileen J, Staat, Mary A, Burrell, Allison, Williams, John V, Michaels, Marian G, Parashar, Umesh D, Mirza, Sara“…Among tested antibiotic recipients, the predominant pathogens detected were norovirus [IP=58/422 (14%), ED=40/304 (13%)] and rotavirus [IP=89/886 (10%), ED=40/531 (8%)] without bacterial codetection, and Enteropathogenic E. coli [IP=10/93 (11%), ED=4/39 (10%)]. …”
Publicado 2023
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926217por Wang, Ke, Jiang, Xunliang, Jiang, Yu, Liu, Jun, Du, Yongtao, Zhang, Zecheng, Li, Yunlong, Zhao, Xinhui, Li, Jipeng, Zhang, Rui“…MicroRNA (miRNA) inhibitor and mimics, siRNA, PLKO-shRNA, and plenti6.3-miR-139 were used to upregulate or downregulate the expression of target genes. CCK8, EdU, clone formation, and senescence-associated β-galactosidase (SA-β-gal) staining assays were performed to assess cell proliferation and cellular senescence phenotypes. …”
Publicado 2023
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926218por Chatzikonstantinou, Thomas, Scarfò, Lydia, Karakatsoulis, Georgios, Minga, Eva, Chamou, Dimitra, Iacoboni, Gloria, Kotaskova, Jana, Demosthenous, Christos, Smolej, Lukas, Mulligan, Stephen, Alcoceba, Miguel, Al-Shemari, Salem, Aurran-Schleinitz, Thérèse, Bacchiarri, Francesca, Bellido, Mar, Bijou, Fontanet, Calleja, Anne, Medina, Angeles, Khan, Mehreen Ali, Cassin, Ramona, Chatzileontiadou, Sofia, Collado, Rosa, Christian, Amy, Davis, Zadie, Dimou, Maria, Donaldson, David, Santos, Gimena Dos, Dreta, Barbara, Efstathopoulou, Maria, El-Ashwah, Shaimaa, Enrico, Alicia, Fresa, Alberto, Galimberti, Sara, Galitzia, Andrea, García-Serra, Rocío, Gimeno, Eva, González-Gascón-y-Marín, Isabel, Gozzetti, Alessandro, Guarente, Valerio, Guieze, Romain, Gogia, Ajay, Gupta, Ritu, Harrop, Sean, Hatzimichael, Eleftheria, Herishanu, Yair, Hernández-Rivas, José-Ángel, Inchiappa, Luca, Jaksic, Ozren, Janssen, Susanne, Kalicińska, Elżbieta, Kamel, Laribi, Karakus, Volkan, Kater, Arnon P., Kho, Bonnie, Kislova, Maria, Konstantinou, Eliana, Koren-Michowitz, Maya, Kotsianidis, Ioannis, Kreitman, Robert J., Labrador, Jorge, Lad, Deepesh, Levin, Mark-David, Levy, Ilana, Longval, Thomas, Lopez-Garcia, Alberto, Marquet, Juan, Martin-Rodríguez, Lucia, Maynadié, Marc, Maslejova, Stanislava, Mayor-Bastida, Carlota, Mihaljevic, Biljana, Milosevic, Ivana, Miras, Fatima, Moia, Riccardo, Morawska, Marta, Murru, Roberta, Nath, Uttam Kumar, Navarro-Bailón, Almudena, Oliveira, Ana C., Olivieri, Jacopo, Oscier, David, Panovska-Stavridis, Irina, Papaioannou, Maria, Papajík, Tomas, Kubova, Zuzana, Phumphukhieo, Punyarat, Pierie, Cheyenne, Puiggros, Anna, Rani, Lata, Reda, Gianluigi, Rigolin, Gian Matteo, Ruchlemer, Rosa, Daniel de Deus Santos, Marcos, Schipani, Mattia, Schiwitza, Annett, Shen, Yandong, Simkovic, Martin, Smirnova, Svetlana, Abdelrahman Soliman, Dina Sameh, Spacek, Martin, Tadmor, Tamar, Tomic, Kristina, Tse, Eric, Vassilakopoulos, Theodoros, Visentin, Andrea, Vitale, Candida, von Tresckow, Julia, Vrachiolias, George, Vukovic, Vojin, Walewska, Renata, Wasik-Szczepanek, Ewa, Xu, Zhenshu, Yagci, Munci, Yañez, Lucrecia, Yassin, Mohamed, Zuchnicka, Jana, Angelopoulou, Maria, Antic, Darko, Biderman, Bella, Catherwood, Mark, Claus, Rainer, Coscia, Marta, Cuneo, Antonio, Demirkan, Fatih, Espinet, Blanca, Gaidano, Gianluca, Kalashnikova, Olga B., Laurenti, Luca, Nikitin, Eugene, Pangalis, Gerassimos A., Panagiotidis, Panagiotis, Popov, Viola Maria, Pospisilova, Sarka, Sportoletti, Paolo, Stavroyianni, Niki, Tam, Constantine, Trentin, Livio, Chatzidimitriou, Anastasia, Bosch, Francesc, Doubek, Michael, Ghia, Paolo, Stamatopoulos, Kostas“…CLL-directed treatment was associated with non-melanoma skin and prostate cancers (OR = 1.8; 95% CI = 1.36–2.41; p < 0.001/OR = 2.11; 95% CI = 1.12–3.97; p = 0.021). …”
Publicado 2023
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926219por Harrison, China, Greves, Gethin, Barnard, Emma, Davies, Angharad, McEleny, Kevin, Gordon, Uma, Lucky, Marc, Woodward, Bryan, Pacey, Allan, Heatley, Marc, Boivin, Jacky“…Eligible participants were boys and girls in the UK school years 8 and 9 (age 13–14 years). Participants completed a Time 1 (T1) survey (fertility knowledge, demographics) prior to watching the animations and a Time 2 (T2) survey (fertility knowledge, perceptions of the animations) immediately after the animations. …”
Publicado 2023
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926220por Godfrey, Keith M., Titcombe, Philip, El-Heis, Sarah, Albert, Benjamin B., Tham, Elizabeth Huiwen, Barton, Sheila J., Kenealy, Timothy, Chong, Mary Foong-Fong, Nield, Heidi, Chong, Yap Seng, Chan, Shiao-Yng, Cutfield, Wayne S.“…Markers of vitamin insufficiency/deficiency were reduced in the intervention group, and the proportion of participants with vitamin D insufficiency (<50 nmol/L) during late pregnancy was lower in the intervention group (35.1% versus 8.5%; p < 0.0001). Plasma vitamin B12 remained higher in the intervention group than in the control group 6 months postdelivery (by 0.30 SDS (0.14, 0.46), p = 0.0003). …”
Publicado 2023
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