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926261por Malhi, Gin S., Byrow, Yulisha, Cassidy, Frederick, Cipriani, Andrea, Demyttenaere, Koen, Frye, Mark A., Gitlin, Michael, Kennedy, Sidney H., Ketter, Terence A., Lam, Raymond W., McShane, Rupert, Mitchell, Alex J., Ostacher, Michael J., Rizvi, Sakina J., Thase, Michael E., Tohen, Mauricio“…(formerly Schering Plough and Organon), Moksha8, Naurex Inc., Neuronetics Inc., Novartis, Ortho-McNeil Pharmaceuticals (Johnson & Johnson; Janssen), Otsuka, Pamlab, L.L.C. …”
Publicado 2016
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926262por van ’t Hof, Femke N. G., Ruigrok, Ynte M., Lee, Cue Hyunkyu, Ripke, Stephan, Anderson, Graig, de Andrade, Mariza, Baas, Annette F., Blankensteijn, Jan D., Böttinger, Erwin P., Bown, Matthew J., Broderick, Joseph, Bijlenga, Philippe, Carrell, David S., Crawford, Dana C., Crosslin, David R., Ebeling, Christian, Eriksson, Johan G., Fornage, Myriam, Foroud, Tatiana, von und zu Fraunberg, Mikael, Friedrich, Christoph M., Gaál, Emília I., Gottesman, Omri, Guo, Dong‐Chuan, Harrison, Seamus C., Hernesniemi, Juha, Hofman, Albert, Inoue, Ituro, Jääskeläinen, Juha E., Jones, Gregory T., Kiemeney, Lambertus A. L. M., Kivisaari, Riku, Ko, Nerissa, Koskinen, Seppo, Kubo, Michiaki, Kullo, Iftikhar J., Kuivaniemi, Helena, Kurki, Mitja I., Laakso, Aki, Lai, Dongbing, Leal, Suzanne M., Lehto, Hanna, LeMaire, Scott A., Low, Siew‐Kee, Malinowski, Jennifer, McCarty, Catherine A., Milewicz, Dianna M., Mosley, Thomas H., Nakamura, Yusuke, Nakaoka, Hirofumi, Niemelä, Mika, Pacheco, Jennifer, Peissig, Peggy L., Pera, Joanna, Rasmussen‐Torvik, Laura, Ritchie, Marylyn D., Rivadeneira, Fernando, van Rij, Andre M., Santos‐Cortez, Regie Lyn P., Saratzis, Athanasios, Slowik, Agnieszka, Takahashi, Atsushi, Tromp, Gerard, Uitterlinden, André G., Verma, Shefali S., Vermeulen, Sita H., Wang, Gao T., Han, Buhm, Rinkel, Gabriël J. E., de Bakker, Paul I. W., Bown, Matthew J., Harrison, Seamus C., Saratzis, Athanasios, Verissimo, Ana, Wright, Benjamin J., Bumpstead, Suzannah, Baas, Annette F., Gretarsdottir, Solveig, Badger, Stephen A., Child, Anne H., Clough, Rachel E., Cockerill, Gillian, Hafez, Hany, Scott, D. Julian A., Futers, Simon, Sohrabi, Soroush, Smith, Alberto, Thompson, Matthew M., van Bockxmeer, Frank M., Matthiasson, Stefan E., Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Blankensteijn, Jan D., Teijink, Joep A. W., Wijmenga, Cisca, de Graaf, Jacqueline, Kiemeney, Lambertus A., Palmen, Jutta, Smith, Andrew J., Lindholt, Jes S., Bradley, Declan T., Waltham, Matthew, Edkins, Sarah, Gwilliam, Rhian, Hunt, Sarah E., Potter, Simon, Golledge, Jonathan, Eriksson, Per, Norman, Paul E., Powell, Janet T., Stefansson, Kari, Thompson, John R., Humphries, Steve E., Sayers, Robert D., Deloukas, Panos, Samani, Nilesh J., Jones, Gregory T., Phillip, L. Victoria, van Rij, Andre M., Hill, Geraldine B., Williams, Michael J. A., Thomson, Ian A., Krysa, Jo, Wilkins, Gerard T., Merriman, Tony R., Vasudevan, Thodor M., Lewis, David R., Blair, Ross D., Hill, Andrew A.“…Last, we evaluated the evidence for 14 previously published aneurysm risk single‐nucleotide polymorphisms through collaboration in extended aneurysm cohorts, with a total of 6548 cases and 16 843 controls (IA) and 4391 cases and 37 904 controls (AAA), and found nominally significant associations for IA risk locus 18q11 near RBBP8 to AAA (odds ratio [OR]=1.11; P=4.1×10(−5)) and for TAA risk locus 15q21 near FBN1 to AAA (OR=1.07; P=1.1×10(−3)). …”
Publicado 2016
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926263por Crank, Michelle C., Wilson, Eleanor M. P., Novik, Laura, Enama, Mary E., Hendel, Cynthia S., Gu, Wenjuan, Nason, Martha C., Bailer, Robert T., Nabel, Gary J., McDermott, Adrian B., Mascola, John R., Koup, Richard A., Ledgerwood, Julie E., Graham, Barney S.“…A trend toward more robust CD8 T cell responses using rAd5-EnvA prime and rAd35-EnvA boost was observed. …”
Publicado 2016
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926264por Rothwell, Peter M, Algra, Ale, Chen, Zhengming, Diener, Hans-Christoph, Norrving, Bo, Mehta, ZiyahEnlace del recurso
Publicado 2016
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926265por Kalasariya, R. M., Dhami, A. J., Hadiya, K. K., Borkhatariya, D. N., Patel, J. A.“…MATERIAL AND METHODS: A total of 85 advanced pregnant (~8 months) pluriparous buffaloes selected at farmers’ doorstep in three tribal villages of Middle Gujarat were randomly divided into two groups, viz., control (n=45) and nutrients treatment (40). …”
Publicado 2017
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926266por Silver, Lynn D., Ng, Shu Wen, Ryan-Ibarra, Suzanne, Taillie, Lindsey Smith, Induni, Marta, Miles, Donna R., Poti, Jennifer M., Popkin, Barry M.“…Reductions in self-reported mean daily SSB intake in grams (−19.8%, p = 0.49) and in mean per capita SSB caloric intake (−13.3%, p = 0.56) from baseline to post-tax were not statistically significant. …”
Publicado 2017
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926267por McLellan, Julie, Heneghan, Carl J, Perera, Rafael, Clements, Alison M, Glasziou, Paul P, Kearley, Karen E, Pidduck, Nicola, Roberts, Nia W, Tyndel, Sally, Wright, F Lucy, Bankhead, Clare“…The evidence showed uncertainty for quality of life data (MD ‐0.03, 95% CI ‐1.18 to 1.13; patients = 1812; studies = 8; very low quality of evidence). We completed a 'Risk of bias' assessment for all studies. …”
Publicado 2016
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926268“…For death, there were 2/150 (1.3%) in the six‐month group and 4/144 (2.8%) in the nine‐month group. All deaths occurred in the first four months of treatment, so was not linked to the duration of treatment in the included trials. …”
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926269por Witt, S H, Streit, F, Jungkunz, M, Frank, J, Awasthi, S, Reinbold, C S, Treutlein, J, Degenhardt, F, Forstner, A J, Heilmann-Heimbach, S, Dietl, L, Schwarze, C E, Schendel, D, Strohmaier, J, Abdellaoui, A, Adolfsson, R, Air, T M, Akil, H, Alda, M, Alliey-Rodriguez, N, Andreassen, O A, Babadjanova, G, Bass, N J, Bauer, M, Baune, B T, Bellivier, F, Bergen, S, Bethell, A, Biernacka, J M, Blackwood, D H R, Boks, M P, Boomsma, D I, Børglum, A D, Borrmann-Hassenbach, M, Brennan, P, Budde, M, Buttenschøn, H N, Byrne, E M, Cervantes, P, Clarke, T-K, Craddock, N, Cruceanu, C, Curtis, D, Czerski, P M, Dannlowski, U, Davis, T, de Geus, E J C, Di Florio, A, Djurovic, S, Domenici, E, Edenberg, H J, Etain, B, Fischer, S B, Forty, L, Fraser, C, Frye, M A, Fullerton, J M, Gade, K, Gershon, E S, Giegling, I, Gordon, S D, Gordon-Smith, K, Grabe, H J, Green, E K, Greenwood, T A, Grigoroiu-Serbanescu, M, Guzman-Parra, J, Hall, L S, Hamshere, M, Hauser, J, Hautzinger, M, Heilbronner, U, Herms, S, Hitturlingappa, S, Hoffmann, P, Holmans, P, Hottenga, J-J, Jamain, S, Jones, I, Jones, L A, Juréus, A, Kahn, R S, Kammerer-Ciernioch, J, Kirov, G, Kittel-Schneider, S, Kloiber, S, Knott, S V, Kogevinas, M, Landén, M, Leber, M, Leboyer, M, Li, Q S, Lissowska, J, Lucae, S, Martin, N G, Mayoral-Cleries, F, McElroy, S L, McIntosh, A M, McKay, J D, McQuillin, A, Medland, S E, Middeldorp, C M, Milaneschi, Y, Mitchell, P B, Montgomery, G W, Morken, G, Mors, O, Mühleisen, T W, Müller-Myhsok, B, Myers, R M, Nievergelt, C M, Nurnberger, J I, O'Donovan, M C, Loohuis, L M O, Ophoff, R, Oruc, L, Owen, M J, Paciga, S A, Penninx, B W J H, Perry, A, Pfennig, A, Potash, J B, Preisig, M, Reif, A, Rivas, F, Rouleau, G A, Schofield, P R, Schulze, T G, Schwarz, M, Scott, L, Sinnamon, G C B, Stahl, E A, Strauss, J, Turecki, G, Van der Auwera, S, Vedder, H, Vincent, J B, Willemsen, G, Witt, C C, Wray, N R, Xi, H S, Tadic, A, Dahmen, N, Schott, B H, Cichon, S, Nöthen, M M, Ripke, S, Mobascher, A, Rujescu, D, Lieb, K, Roepke, S, Schmahl, C, Bohus, M, Rietschel, M“…Gene-based analysis yielded two significant genes: DPYD (P=4.42 × 10(−7)) and PKP4 (P=8.67 × 10(−7)); and gene-set analysis yielded a significant finding for exocytosis (GO:0006887, P(FDR)=0.019; FDR, false discovery rate). …”
Publicado 2017
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926270“…RESULTS: The content of ErbB3 protein was 18.9±26.4 pg/mL in renal cell carcinoma group, 17.8±26.6 pg/mL in clear cell renal carcinoma group, 3.1±37.4 pg/mL in urinary calculus group, 335.3±702.4 pg/mL in urothelium carcinoma group, 13.7±15.6 pg/mL in prostate cancer group, 40.4±52.4 pg/mL in BPH group and 59.0±54.7 pg/mL in normal group, respectively. …”
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926271por Perl, Alexander E., Altman, Jessica K., Cortes, Jorge, Smith, Catherine, Litzow, Mark, Baer, Maria R., Claxton, David, Erba, Harry P., Gill, Stan, Goldberg, Stuart, Jurcic, Joseph G., Larson, Richard A., Liu, Chaofeng, Ritchie, Ellen, Schiller, Gary, Spira, Alexander I., Strickland, Stephen A., Tibes, Raoul, Ustun, Celalettin, Wang, Eunice S., Stuart, Robert, Röllig, Christoph, Neubauer, Andreas, Martinelli, Giovanni, Bahceci, Erkut, Levis, Mark“…Serious adverse events in ≥5% of patients were febrile neutropenia (31%; n=78/252), progressive disease (17%; n=43/252), sepsis (14%; n=36/252), pneumonia (11%; n=27/252), and acute renal failure (10%; n=25/252), pyrexia (8%; n=21/252), bacteremia (6%; n=14/252), and respiratory failure (6%; n=14/252). …”
Publicado 2017
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926272por Wasan, Harpreet S, Gibbs, Peter, Sharma, Navesh K, Taieb, Julien, Heinemann, Volker, Ricke, Jens, Peeters, Marc, Findlay, Michael, Weaver, Andrew, Mills, Jamie, Wilson, Charles, Adams, Richard, Francis, Anne, Moschandreas, Joanna, Virdee, Pradeep S, Dutton, Peter, Love, Sharon, Gebski, Val, Gray, Alastair, van Hazel, Guy, Sharma, Ricky A“…The median survival time in the FOLFOX plus SIRT group was 22·6 months (95% CI 21·0–24·5) compared with 23·3 months (21·8–24·7) in the FOLFOX alone group. In the safety population containing patients who received at least one dose of study treatment, as treated, the most common grade 3–4 adverse event was neutropenia (137 [24%] of 571 patients receiving FOLFOX alone vs 186 (37%) of 507 patients receiving FOLFOX plus SIRT). …”
Publicado 2017
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926273por Scott, Robert A., Scott, Laura J., Mägi, Reedik, Marullo, Letizia, Gaulton, Kyle J., Kaakinen, Marika, Pervjakova, Natalia, Pers, Tune H., Johnson, Andrew D., Eicher, John D., Jackson, Anne U., Ferreira, Teresa, Lee, Yeji, Ma, Clement, Steinthorsdottir, Valgerdur, Thorleifsson, Gudmar, Qi, Lu, Van Zuydam, Natalie R., Mahajan, Anubha, Chen, Han, Almgren, Peter, Voight, Ben F., Grallert, Harald, Müller-Nurasyid, Martina, Ried, Janina S., Rayner, Nigel W., Robertson, Neil, Karssen, Lennart C., van Leeuwen, Elisabeth M., Willems, Sara M., Fuchsberger, Christian, Kwan, Phoenix, Teslovich, Tanya M., Chanda, Pritam, Li, Man, Lu, Yingchang, Dina, Christian, Thuillier, Dorothee, Yengo, Loic, Jiang, Longda, Sparso, Thomas, Kestler, Hans A., Chheda, Himanshu, Eisele, Lewin, Gustafsson, Stefan, Frånberg, Mattias, Strawbridge, Rona J., Benediktsson, Rafn, Hreidarsson, Astradur B., Kong, Augustine, Sigurðsson, Gunnar, Kerrison, Nicola D., Luan, Jian'an, Liang, Liming, Meitinger, Thomas, Roden, Michael, Thorand, Barbara, Esko, Tõnu, Mihailov, Evelin, Fox, Caroline, Liu, Ching-Ti, Rybin, Denis, Isomaa, Bo, Lyssenko, Valeriya, Tuomi, Tiinamaija, Couper, David J., Pankow, James S., Grarup, Niels, Have, Christian T., Jørgensen, Marit E., Jørgensen, Torben, Linneberg, Allan, Cornelis, Marilyn C., van Dam, Rob M., Hunter, David J., Kraft, Peter, Sun, Qi, Edkins, Sarah, Owen, Katharine R., Perry, John R.B., Wood, Andrew R., Zeggini, Eleftheria, Tajes-Fernandes, Juan, Abecasis, Goncalo R., Bonnycastle, Lori L., Chines, Peter S., Stringham, Heather M., Koistinen, Heikki A., Kinnunen, Leena, Sennblad, Bengt, Mühleisen, Thomas W., Nöthen, Markus M., Pechlivanis, Sonali, Baldassarre, Damiano, Gertow, Karl, Humphries, Steve E., Tremoli, Elena, Klopp, Norman, Meyer, Julia, Steinbach, Gerald, Wennauer, Roman, Eriksson, Johan G., Mӓnnistö, Satu, Peltonen, Leena, Tikkanen, Emmi, Charpentier, Guillaume, Eury, Elodie, Lobbens, Stéphane, Gigante, Bruna, Leander, Karin, McLeod, Olga, Bottinger, Erwin P., Gottesman, Omri, Ruderfer, Douglas, Blüher, Matthias, Kovacs, Peter, Tonjes, Anke, Maruthur, Nisa M., Scapoli, Chiara, Erbel, Raimund, Jöckel, Karl-Heinz, Moebus, Susanne, de Faire, Ulf, Hamsten, Anders, Stumvoll, Michael, Deloukas, Panagiotis, Donnelly, Peter J., Frayling, Timothy M., Hattersley, Andrew T., Ripatti, Samuli, Salomaa, Veikko, Pedersen, Nancy L., Boehm, Bernhard O., Bergman, Richard N., Collins, Francis S., Mohlke, Karen L., Tuomilehto, Jaakko, Hansen, Torben, Pedersen, Oluf, Barroso, Inês, Lannfelt, Lars, Ingelsson, Erik, Lind, Lars, Lindgren, Cecilia M., Cauchi, Stephane, Froguel, Philippe, Loos, Ruth J.F., Balkau, Beverley, Boeing, Heiner, Franks, Paul W., Barricarte Gurrea, Aurelio, Palli, Domenico, van der Schouw, Yvonne T., Altshuler, David, Groop, Leif C., Langenberg, Claudia, Wareham, Nicholas J., Sijbrands, Eric, van Duijn, Cornelia M., Florez, Jose C., Meigs, James B., Boerwinkle, Eric, Gieger, Christian, Strauch, Konstantin, Metspalu, Andres, Morris, Andrew D., Palmer, Colin N.A., Hu, Frank B., Thorsteinsdottir, Unnur, Stefansson, Kari, Dupuis, Josée, Morris, Andrew P., Boehnke, Michael, McCarthy, Mark I., Prokopenko, Inga“…We identified 13 novel T2D-associated loci (P < 5 × 10(−8)), including variants near the GLP2R, GIP, and HLA-DQA1 genes. …”
Publicado 2017
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926274por Peters, Sanne A. E., Yang, Ling, Guo, Yu, Chen, Yiping, Bian, Zheng, Du, Jianwei, Yang, Jie, Li, Shanpeng, Li, Liming, Woodward, Mark, Chen, Zhengming, Chen, Junshi, Collins, Rory, Peto, Richard, Bennett, Derrick, Chang, Yumei, Clarke, Robert, Du, Huaidong, Fan, Xuejuan, Gilbert, Simon, Hacker, Alex, Holmes, Michael, Iona, Andri, Kartsonaki, Christiana, Kerosi, Rene, Kong, Ling, Kurmi, Om, Lancaster, Garry, Lewington, Sarah, McDonnell, John, Millwood, Iona, Nie, Qunhua, Radhakrishnan, Jayakrishnan, Rafiq, Sajjad, Ryder, Paul, Sansome, Sam, Schmidt, Dan, Sherliker, Paul, Sohoni, Rajani, Turnbull, Iain, Walters, Robin, Wang, Jenny, Wang, Lin, Yang, Xiaoming, Chen, Ge, Han, Bingyang, Hou, Can, Lv, Jun, Pei, Pei, Qu, Shuzhen, Tan, Yunlong, Yu, Canqing, Zhou, Huiyan, Pang, Zengchang, Gao, Ruqin, Wang, Shaojie, Liu, Yongmei, Du, Ranran, Zang, Yajing, Cheng, Liang, Tian, Xiaocao, Zhang, Hua, Lv, Silu, Wang, Junzheng, Hou, Wei, Yin, Jiyuan, Jiang, Ge, Liu, Shumei, Pang, Zhigang, Zhou, Xue, Yang, Liqiu, He, Hui, Yu, Bo, Li, Yanjie, Mu, Huaiyi, Xu, Qinai, Dou, Meiling, Ren, Jiaojiao, Wang, Shanqing, Hu, Ximin, Wang, Hongmei, Chen, Jinyan, Fu, Yan, Fu, Zhenwang, Wang, Xiaohuan, Dong, Hua, Weng, Min, Zheng, Xiangyang, Li, Yijun, Li, Huimei, Li, Chenglong, Wu, Ming, Zhou, Jinyi, Tao, Ran, Shen, Jie, Hu, Yihe, Lu, Yan, Gao, Yan, Ma, Liangcai, Zhou, Renxian, Tang, Aiyu, Zhang, Shuo, Jin, Jianrong, Tang, Zhenzhu, Chen, Naying, Huang, Ying, Li, Mingqiang, Meng, Jinhuai, Pan, Rong, Jiang, Qilian, Qing, Jingxin, Zhang, Weiyuan, Liu, Yun, Wei, Liuping, Zhou, Liyuan, Chen, Ningyu, Yang, Jun, Guan, Hairong, Wu, Xianping, Zhang, Ningmei, Chen, Xiaofang, Tang, Xuefeng, Luo, Guojin, Li, Jianguo, Chen, Xiaofang, Wang, Jian, Liu, Jiaqiu, Sun, Qiang, Ge, Pengfei, Ren, Xiaolan, Dong, Caixia, Zhang, Hui, Mao, Enke, Wang, Xiaoping, Wang, Tao, Liu, Guohua, Zhu, Baoyu, Zhou, Gang, Feng, Shixian, Chang, Liang, Fan, Lei, Gao, Yulian, He, Tianyou, Jiang, Li, Sun, Huarong, He, Pan, Hu, Chen, Lv, Qiannan, Zhang, Xukui, Yu, Min, Hu, Ruying, Fang, Le, Wang, Hao, Qian, Yijian, Wang, Chunmei, Xie, Kaixue, Chen, Lingli, Pan, Yaxing, Pan, Dongxia, Huang, Yuelong, Chen, Biyun, Jin, Donghui, Liu, Huilin, Fu, Zhongxi, Xu, Qiaohua, Xu, Xin, g, Youping, Jia, Weifang, Li, Xianzhi, Zhang, Libo, Qiu, Zhe“…METHODS AND RESULTS: In 2004–2008, the nationwide China Kadoorie Biobank recruited 0.5 million individuals aged 30 to 79 years from 10 diverse regions across China. During 8 years of follow‐up, 16 671 incident cases of coronary heart disease and 23 983 cases of stroke were recorded among 289 573 women without prior CVD at baseline. …”
Publicado 2017
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926275por Alloway, Rita R., Vinks, Alexander A., Fukuda, Tsuyoshi, Mizuno, Tomoyuki, King, Eileen C., Zou, Yuanshu, Jiang, Wenlei, Woodle, E. Steve, Tremblay, Simon, Klawitter, Jelena, Klawitter, Jost, Christians, Uwe“…Abbreviated New Drug Applications (ANDA) data that included manufacturing and healthy individual pharmacokinetic data for all generics were evaluated to select the 2 most disparate generics from innovator, and these were named Generic Hi and Generic Lo. During the 8-week study period, pharmacokinetic studies assessed the bioequivalence of Generic Hi and Generic Lo with the Innovator tacrolimus and with each other. …”
Publicado 2017
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926276por Metwaly, Mohamed, Awaad, Awaad Mousa, El‐Sayed, El‐Sayed Mahmoud, Sallam, Abdel Sattar Mohamed“…These same doses in BW‐DAT were lower than those in IMRT by 8.7%, 10.6%, and 6.2% respectively, but they were quite lower than those in 2A‐DAT, because the average variation was 41.6% (with a maximum of 44.0%). …”
Publicado 2008
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926277por Güngör, Görkem, Demir, Melek, Aydın, Gökhan, Yapıcı, Bülent, Atalar, Banu, Özyar, Enis“…D(2 cm) ranged between 35.7% and 67.0% (Mean: 53.2%); 42.1%–79.2% (Mean: 57.8%) for DCA‐DMD‐6FFF, VMAT‐6FFF respectively. DCA‐DMD‐6FFF have significantly better and sharp falloff gradient 2 cm away from PTV compared to VMAT‐6FFF (P = 0.009). …”
Publicado 2017
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926278“…Among U.S. residents for whom information on chemoprophylaxis use and travel region was known, 7.8% reported that they initiated and adhered to a chemoprophylaxis drug regimen recommended by CDC for the regions to which they had traveled. …”
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926279por Guillory, Jamie, Wiant, Kristine F, Farrelly, Matthew, Fiacco, Leah, Alam, Ishrat, Hoffman, Leah, Crankshaw, Erik, Delahanty, Janine, Alexander, Tesfa N“…Social media recruitment was faster (incidence rate ratio, IRR=3.31, 95% CI 3.11-3.52, P<.001) and less expensive (2.2% of combined social media and intercept recruitment cost) but had greater data quality issues—a larger percentage of social media respondents were lost because of duplicate and low-quality responses (374/4446, 8.41%) compared with intercept respondents lost to interviewer misrepresentation (15/4446, 0.34%; P<.001). …”
Publicado 2018
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926280“…METHODS: Between May 2017 and March 2018, 48 male mice were divided into six groups (n = 8 in each group). Various doses of genistein (25 and 50 mg/kg) and morphine plus genistein (25 and 50 mg/kg) were administered intraperitoneally to 48 male mice for 20 consequent days. …”
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