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  1. 926381
  2. 926382
    “…HIV prevalence was lowest among adolescents than in other age groups in Eswatini (adolescents 11.9%, young 24.2% and older 47.3%), but comparable to young women in Ethiopia (adolescents 1.6%, young 1.6% and older 2.2%) and Mozambique (adolescents 2.5%, young 2.5% and older 5.8%), However, in each of the three countries, lower proportions of adolescents knew their HIV-positive status before ANC enrollment compared to other age groups: in Eswatini (adolescents 51.3%, young 59.9% and older 79.2%), in Ethiopia (adolescents 42.9%, young 63.7% and older 75.2%), and in Mozambique (adolescents 16.4%, young 33.2% and older 45.6%). …”
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  3. 926383
    “…However, the use of CDK4/6 inhibitors in combination with ET was associated with significantly increased risk of grade 3 or 4 adverse events compared with ET alone, including neutropenia (HR, 57.05; 95% CI, 38.26-85.05; P < .001), leukopenia (HR, 36.36; 95% CI, 19.35-68.34; P < .001), and diarrhea (HR, 4.97; 95% CI, 2.84-8.69; P < .001). CONCLUSIONS AND RELEVANCE: This meta-analysis indicated that, compared with ET alone, treatment with CDK4/6 inhibitors plus ET was associated with significantly improved OS, PFS, and objective response rate among patients with HR-positive, ERBB2-negative metastatic breast cancer.…”
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  4. 926384
    “…PD-ENE was defined by measuring from the point where tumor tissue broke the node capsule to the highest point of the tumor cells in the perinodal adipose tissue.K The average PD-ENE was 1.8 mm; therefore, we divided ENE-positive patients into two groups: PD-ENE no greater than 2 mm and PD-ENE greater than 2 mm. …”
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  5. 926385
    “…Aucune association entre l’exposition chronique aux ISRA et la mortalité (HR non ajusté = 1,13, IC95 % [0,8–1,6] ; HR pondéré sur l’IPT = 1,09 [0,86–1,39] ; HR pondéré sur le SMR = 1,08 [0,79–1,47]) n’a été mise en évidence. …”
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  6. 926386
    “…Une analyse spatiale de la COVID-19 a été réalisée à travers ArcGIS 10.8 qui est un logiciel de traitement de l’information géographique. …”
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  7. 926387
    “…Les patients étaient principalement traités par chimiothérapie seule (49 %), chimiothérapie associée à une thérapie ciblée (17 %), thérapie ciblée seule (19 %), ou immunothérapie seule (8 %), les autres recevant une combinaison de traitements ; 272 patients (37 %) ont commencé ce traitement pendant la période de confinement. …”
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  8. 926388
    “…La fraction d’éjection ventriculaire gauche était < 50 % chez 8/83 (10 %) patients post-USI. Deux nouvelles maladies rénales chroniques ont été observées, toutes deux chez des patients post-USI. …”
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  9. 926389
    “…After comparing the LONN models against conventional deep-learning models we observe that our implemented models are less accurate (accuracy loss of about 8%). However, the loss of accuracy is compensated by the fact that LONN models are transparent and safe because the freezing of training parameters makes them less prone to adversarial attacks. …”
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  10. 926390
  11. 926391
    por Huyghe, Jeroen R, Harrison, Tabitha A, Bien, Stephanie A, Hampel, Heather, Figueiredo, Jane C, Schmit, Stephanie L, Conti, David V, Chen, Sai, Qu, Conghui, Lin, Yi, Barfield, Richard, Baron, John A, Cross, Amanda J, Diergaarde, Brenda, Duggan, David, Harlid, Sophia, Imaz, Liher, Kang, Hyun Min, Levine, David M, Perduca, Vittorio, Perez-Cornago, Aurora, Sakoda, Lori C, Schumacher, Fredrick R, Slattery, Martha L, Toland, Amanda E, van Duijnhoven, Fränzel J B, Van Guelpen, Bethany, Agudo, Antonio, Albanes, Demetrius, Alonso, M Henar, Anderson, Kristin, Arnau-Collell, Coral, Arndt, Volker, Banbury, Barbara L, Bassik, Michael C, Berndt, Sonja I, Bézieau, Stéphane, Bishop, D Timothy, Boehm, Juergen, Boeing, Heiner, Boutron-Ruault, Marie-Christine, Brenner, Hermann, Brezina, Stefanie, Buch, Stephan, Buchanan, Daniel D, Burnett-Hartman, Andrea, Caan, Bette J, Campbell, Peter T, Carr, Prudence R, Castells, Antoni, Castellví-Bel, Sergi, Chan, Andrew T, Chang-Claude, Jenny, Chanock, Stephen J, Curtis, Keith R, de la Chapelle, Albert, Easton, Douglas F, English, Dallas R, Feskens, Edith J M, Gala, Manish, Gallinger, Steven J, Gauderman, W James, Giles, Graham G, Goodman, Phyllis J, Grady, William M, Grove, John S, Gsur, Andrea, Gunter, Marc J, Haile, Robert W, Hampe, Jochen, Hoffmeister, Michael, Hopper, John L, Hsu, Wan-Ling, Huang, Wen-Yi, Hudson, Thomas J, Jenab, Mazda, Jenkins, Mark A, Joshi, Amit D, Keku, Temitope O, Kooperberg, Charles, Kühn, Tilman, Küry, Sébastien, Le Marchand, Loic, Lejbkowicz, Flavio, Li, Christopher I, Li, Li, Lieb, Wolfgang, Lindblom, Annika, Lindor, Noralane M, Männistö, Satu, Markowitz, Sanford D, Milne, Roger L, Moreno, Lorena, Murphy, Neil, Nassir, Rami, Offit, Kenneth, Ogino, Shuji, Panico, Salvatore, Parfrey, Patrick S, Pearlman, Rachel, Pharoah, Paul D P, Phipps, Amanda I, Platz, Elizabeth A, Potter, John D, Prentice, Ross L, Qi, Lihong, Raskin, Leon, Rennert, Gad, Rennert, Hedy S, Riboli, Elio, Schafmayer, Clemens, Schoen, Robert E, Seminara, Daniela, Song, Mingyang, Su, Yu-Ru, Tangen, Catherine M, Thibodeau, Stephen N, Thomas, Duncan C, Trichopoulou, Antonia, Ulrich, Cornelia M, Visvanathan, Kala, Vodicka, Pavel, Vodickova, Ludmila, Vymetalkova, Veronika, Weigl, Korbinian, Weinstein, Stephanie J, White, Emily, Wolk, Alicja, Woods, Michael O, Wu, Anna H, Abecasis, Goncalo R, Nickerson, Deborah A, Scacheri, Peter C, Kundaje, Anshul, Casey, Graham, Gruber, Stephen B, Hsu, Li, Moreno, Victor, Hayes, Richard B, Newcomb, Polly A, Peters, Ulrike
    Publicado 2021
    “…RESULTS: We identified 13 loci that reached genome-wide significance (p<5×10(−8)) and that were not reported by previous GWASs for overall CRC risk. …”
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  12. 926392
  13. 926393
    “…This study is registered with ClinicalTrials.gov, NCT04871165. FINDINGS: Between Jan 8 and April 21, 2021, 885 participants with haematological malignancies were included in the study. 857 patients were anti-S1 IgG seronegative at timepoint 0 and constituted the main analysis cohort. …”
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  14. 926394
  15. 926395
    “…FINDINGS: Between April 2, 2020, and Feb 1, 2021, 52 cases were identified; in England, there were 51 cases among 1334 children and adolescents hospitalised with COVID-19, giving an estimated prevalence of 3·8 (95% CI 2·9–5·0) cases per 100 paediatric patients. 22 (42%) patients were female and 30 (58%) were male; the median age was 9 years (range 1–17). 36 (69%) patients were Black or Asian, 16 (31%) were White. 27 (52%) of 52 patients were classified into the COVID-19 neurology group and 25 (48%) were classified into the PIMS-TS neurology group. …”
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  16. 926396
    “…METHODS: These data were prospectively collected as part of a large cross-sectional study of healthy youth athletes aged 8-16 years-old. Self-selected limb dominance was determined by asking the following question: “Which leg would you use to kick a ball as far as you could?”. …”
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  17. 926397
    “…RÉSULTATS: Deux cent quatre-vingt-onze patients ont été inclus entre septembre et novembre 2020, dont 203 (69,8 %) étaient âgés de 75 ans et plus. Dans la population des moins de 75 ans, seuls 3 patients (3,4 %) avaient des symptômes atypiques, contre 51 (25,1 %) chez les 75 ans et plus. …”
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  18. 926398
    “…La qualité de la réponse immunitaire est comparée en fonction de l’état nutritionnel des sujets âgés et des indicateurs d’immunosénescence sur l’immunité adaptative (nombre de lymphocytes T, taux d’anticorps totaux anti-S et d’anticorps neutralisants en fonction des taux basals de cytokines proinflammatoires, du pourcentage et du nombre absolu de lymphocytes CD4+ naïfs, lymphocytes CD8+ de différenciation terminale). RÉSULTATS: Seules les données pour les réponses à 3 mois seront disponibles pour cette communication. …”
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  19. 926399
    “…La moyenne observée est de 5,1 messages par semaine pour la phase 1, de 14,5 pour la phase 2, de 5,2 pour la phase 3 et de 8,7 pour la phase 4. Avec une majorité relative d’entre 27 à 31 % des messages, le thème principal dans chacune des phases était l’organisation des soins, à l’exception de la phase 1 où le thème du diagnostic – prise en charge individuelle était également représenté (29 %). …”
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  20. 926400
    “…L’âge médian des voyageurs suit une pente descendante progressive passant de 38,8 ans en mars 2019 à 25,1 ans en février 2021. …”
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