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926521“…The extraction parameters were as follows: the extraction solvent was 50% (v/v) hexane in dichloromethane, the extraction temperature was 100 ℃, the static time was 8 min, the cell was rinsed with 60% cell volume using the aforementioned extraction solvent, the purging time was 180 s with N(2) gas, and the extraction proceeded through three cycles. …”
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926522por Kotanidis, Christos P, Xie, Cheng, Alexander, Donna, Rodrigues, Jonathan C L, Burnham, Katie, Mentzer, Alexander, O’Connor, Daniel, Knight, Julian, Siddique, Muhammad, Lockstone, Helen, Thomas, Sheena, Kotronias, Rafail, Oikonomou, Evangelos K, Badi, Ileana, Lyasheva, Maria, Shirodaria, Cheerag, Lumley, Sheila F, Constantinides, Bede, Sanderson, Nicholas, Rodger, Gillian, Chau, Kevin K, Lodge, Archie, Tsakok, Maria, Gleeson, Fergus, Adlam, David, Rao, Praveen, Indrajeet, Das, Deshpande, Aparna, Bajaj, Amrita, Hudson, Benjamin J, Srivastava, Vivek, Farid, Shakil, Krasopoulos, George, Sayeed, Rana, Ho, Ling-Pei, Neubauer, Stefan, Newby, David E, Channon, Keith M, Deanfield, John, Antoniades, Charalambos“…The adjusted HR for in-hospital mortality was 8·24 (95% CI 2·16–31·36, p=0·0019) in patients who received no dexamethasone treatment, but 2·27 (0·69–7·55, p=0·18) in those who received dexamethasone after the scan, suggesting that vascular inflammation might have been a therapeutic target of dexamethasone in COVID-19. …”
Publicado 2022
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926523por Grohskopf, Lisa A., Blanton, Lenee H., Ferdinands, Jill M., Chung, Jessie R., Broder, Karen R., Talbot, H. Keipp, Morgan, Rebecca L., Fry, Alicia M.“…CERTAIN CHILDREN AGED 6 MONTHS THROUGH 8 YEARS NEED 2 DOSES; THESE CHILDREN SHOULD RECEIVE THE FIRST DOSE AS SOON AS POSSIBLE AFTER VACCINE IS AVAILABLE, INCLUDING DURING JULY AND AUGUST. …”
Publicado 2022
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926524por Grandt, Caine Lucas, Brackmann, Lara Kim, Poplawski, Alicia, Schwarz, Heike, Hummel-Bartenschlager, Willempje, Hankeln, Thomas, Kraemer, Christiane, Marini, Federico, Zahnreich, Sebastian, Schmitt, Iris, Drees, Philipp, Mirsch, Johanna, Grabow, Desiree, Schmidberger, Heinz, Binder, Harald, Hess, Moritz, Galetzka, Danuta, Marron, Manuela“…Second primary neoplasms occur in 8% of all cancer survivors within 30 years after the first diagnosis in Germany, but the underlying factors for intrinsic susceptibilities have not yet been clarified. …”
Publicado 2022
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926525por Carr, Caitlin, Layne, Tracy, Tomita, Shannon, Wang, Kelly, Saleh, Mona, Zeligs, Kristen, Papatla, Katya, Prasad-Hayes, Monica, Blank, Stephanie“…Similarly, age was an identified modifier related to burnout between W1 and W2 (p=0.04), where those aged ≥ 56 years were 2.7 times more likely to endorse burnout in W1 versus W2 (95% CI: 0.84-8.63). Multivariable analysis of novel COVID-19 stressors (Table 1) demonstrated significantly higher levels of reported stress in W1 versus W2 due to change in work quality/deployment, current/potential PPE shortage, and significantly lower levels of stress regarding finances. …”
Publicado 2022
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926526por Hodkinson, Alexander, Zhou,, Anli, Johnson, Judith, Geraghty, Keith, Riley, Ruth, Zhou, Andrew, Panagopoulou, Efharis, Chew-Graham, Carolyn A, Peters, David, Esmail, Aneez, Panagioti,, Maria“…Low professionalism was twice as likely compared with maintained professionalism (2.33, 1.96 to 2.70, I(2)=96%, k=40, n=32 321), as was patient dissatisfaction compared with patient satisfaction (2.22, 1.38 to 3.57, I(2)=75%, k=8, n=1002). Burnout and poorer job satisfaction was greatest in hospital settings (1.88, 0.91 to 3.86, P=0.09), physicians aged 31-50 years (2.41, 1.02 to 5.64, P=0.04), and working in emergency medicine and intensive care (2.16, 0.98 to 4.76, P=0.06); burnout was lowest in general practitioners (0.16, 0.03 to 0.88, P=0.04). …”
Publicado 2022
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926527por Fooladi, Saba, Faramarz, Sanaz, Dabiri, Shahriar, Kajbafzadeh, Abdolmohammad, Nematollahi, Mohammad Hadi, Mehrabani, Mehrnaz“…Although the maximum strain to the rupture was reduced in tissues decellularized using 0.5% SDS and CHAPS compared to that of native ones (116% ± 6.79, 139.1% ± 3.24, and 164% ± 8.54%, respectively), ultimate stress was decreased in all decellularized and recellularized groups. …”
Publicado 2022
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926528por Lam, Jonathan Y, Shimizu, Chisato, Tremoulet, Adriana H, Bainto, Emelia, Roberts, Samantha C, Sivilay, Nipha, Gardiner, Michael A, Kanegaye, John T, Hogan, Alexander H, Salazar, Juan C, Mohandas, Sindhu, Szmuszkovicz, Jacqueline R, Mahanta, Simran, Dionne, Audrey, Newburger, Jane W, Ansusinha, Emily, DeBiasi, Roberta L, Hao, Shiying, Ling, Xuefeng B, Cohen, Harvey J, Nemati, Shamim, Burns, Jane C“…KIDMATCH achieved a median area under the receiver operating characteristic curve during internal validation of 98·8% (IQR 98·0–99·3) in the first stage and 96·0% (95·6–97·2) in the second stage. …”
Publicado 2022
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926529“…On certolizumab he developed progressively more active arthritis with CRP 83, bilateral ankle inflammation and large knee effusions requiring aspiration and steroid injection. After 8 weeks of certolizumab, there was no improvement and the decision was made to switch to upadacitinib 15mg daily. …”
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926530“…DISCUSSION/RESULTS: LEn has been reported in only 0.2-5.8% of SLE cases. It is defined by the British Isles Lupus Assessment Group (BILAG 2004) by either vasculitis or inflammation of the small bowel supported by imaging or histology. …”
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926531“…Case 2: A 12-year-old boy was referred to Paediatric Rheumatology after previously presenting to General Paediatrics at the age of 8 years with a history of a dry mouth, dry eyes and thick nasal secretions. …”
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926532“…Manual muscle testing (MMT)-8 and Childhood Muscle Assessment Scale (CMAS) scores were 54/80 and 42/52 respectively. …”
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926533por Essex, Alyson L., Deosthale, Padmini, Huot, Joshua R., Davis, Hannah M., Momeni, Nicholas, Bonetto, Andrea, Plotkin, Lilian I.“…METHODS: miR21fl/fl mice and 8kbDMP1-Cre mice were mated to obtain miR21-deficient mice primarily in the osteocyte (OtmiR21Δ) and littermate controls (miR21fl/fl). …”
Publicado 2022
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926534por Kirwan, Collette, Hynes, Lisa, Hart, Nigel, Mulligan, Sarah, Leathem, Claire, McQuillan, Laura, Maxwell, Marina, Carr, Emma, Roche, Kevin, Walkin, Scott, McCarthy, Caroline, Bradley, Colin, Byrne, Molly, Smith, Susan M., Hughes, Carmel, Corry, Maura, Kearney, Patricia M., McCarthy, Geraldine, Cupples, Margaret, Gillespie, Paddy, Hobbins, Anna, Newell, John, Glynn, Liam, Roshan, Davood, Sinnott, Carol, Murphy, Andrew W.“…Anonymised patient-related quantitative data, from practice medical records and patient questionnaires were collected at baseline, 4 and 8 months, to inform potential outcome measures for a definitive trial. …”
Publicado 2022
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926535por Wong, Carlos King Ho, Lui, David Tak Wai, Xiong, Xi, Chui, Celine Sze Ling, Lai, Francisco Tsz Tsun, Li, Xue, Wan, Eric Yuk Fai, Cheung, Ching Lung, Lee, Chi Ho, Woo, Yu Cho, Au, Ivan Chi Ho, Chung, Matthew Shing Hin, Cheng, Franco Wing Tak, Tan, Kathryn Choon Beng, Wong, Ian Chi Kei“…RESULTS: A total of 2,288,239 people received at least one dose of COVID-19 vaccination (57.8% BNT162b2 recipients and 42.2% CoronaVac recipients). 94.3% of BNT162b2 recipients and 92.2% of CoronaVac recipients received the second dose. …”
Publicado 2022
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926536por Hansen, Christian Holm, Friis, Nikolaj Ulrik, Bager, Peter, Stegger, Marc, Fonager, Jannik, Fomsgaard, Anders, Gram, Mie Agermose, Christiansen, Lasse Engbo, Ethelberg, Steen, Legarth, Rebecca, Krause, Tyra Grove, Ullum, Henrik, Valentiner-Branth, Palle“…Vaccine coverage (three mRNA doses vs none) was 9307 (94·2%) of 9878 among BA.5 cases and 30 581 (94·8%) of 32 272 among BA.2 cases, although in the adjusted analysis, there was a trend towards slightly higher vaccination coverage among BA.5 cases than BA.2 cases (OR 1·18 [95% CI 0·99–1·42]; p=0·064), possibly suggesting marginally poorer vaccine protection against BA.5. …”
Publicado 2023
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926537por Htoo, Phyo T., Tesfaye, Helen, Schneeweiss, Sebastian, Wexler, Deborah J., Everett, Brendan M., Glynn, Robert J., Kim, Seoyoung C., Najafzadeh, Mehdi, Koeneman, Lisette, Farsani, Soulmaz Fazeli, Déruaz-Luyet, Anouk, Paik, Julie M., Patorno, Elisabetta“…Absolute benefits of empagliflozin vs sitagliptin were larger in patients with a history of ASCVD (modified MACE: RD, −17.6 [95% CI, −24.9 to −10.4]; HHF: RD, −16.7 [95% CI, −21.7 to −11.9]), HF (modified MACE: RD, −41.1 [95% CI, −59.9 to −22.6]; HHF: RD, −50.4 [95% CI, −67.5 to −33.9]), or CKD (modified MACE: RD, −26.7 [95% CI, −41.3 to −12.3]; HHF: RD, −31.9 [95% CI, −43.5 to −20.8]). CONCLUSIONS AND RELEVANCE: In this comparative effectiveness study of older adults, empagliflozin was associated with a lower risk of HHF (relative to both liraglutide and sitagliptin) and the modified MACE outcome (relative to sitagliptin), with larger absolute benefits in patients with established cardiorenal diseases. …”
Publicado 2022
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926538por Taneja, Sunita, Chowdhury, Ranadip, Dhabhai, Neeta, Upadhyay, Ravi Prakash, Mazumder, Sarmila, Sharma, Sitanshi, Bhatia, Kiran, Chellani, Harish, Dewan, Rupali, Mittal, Pratima, Bhan, MK, Bahl, Rajiv, Bhandari, Nita, Rafiqui, Farhana, Kaur, Jasmine, Shekhar, Medha, Kate, Anita, Aggarwal, Gunjan, Ghosh, Runa, Shekhawat, Ratan, Kishore, Kunal, Mehra, Navneet, Arya, Nikita, Chaudhary, Ritu, Tamaria, Anuradha, Sapra, Savita, Kumar, Tivendra, Prakash, Sowmya, Modi, Poornima, Kaur, Neelam, Tyagi, Neha, Mehto, Geeta, Khatun, Afifa, Ahmed, Sayeed, Singh, Aparna, Ansari, Gulafshan, Kaur, Ramanjeet, Gupta, Manisha, Pant, Girish Chand, Dutta, Ankita, More, Deepak, Kumar, Mukesh, Siraj, Sabreen, Abbasi, Farah, Chaudhary, Heena, Sharma, Karishma, Kuruvilla, Sonia, Chandra, Anjali, Arya, Sugandha, Debata, Pradeep, Yadav, Anita, Aggarwal, KC, Das, Sujata, Jain, Abhinav, Sachdev, Rahul, Bansal, Omprakash, Aggarwal, Raghav“…The proportion stunted at 24 months of age was substantially lower in the pregnancy and early childhood intervention groups (79/746) compared with the groups that did not receive these interventions (136/710; 0.51, 0.38 to 0.70; −8.32%, −12.31% to −4.32%), and in the group that received preconception, pregnancy, and early childhood interventions (47/453) compared with the control group (51/271; 0.49, 0.32 to 0.75; −7.98%, −14.24% to −1.71%). …”
Publicado 2022
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926539por De Rycke, Martine, Capalbo, Antonio, Coonen, Edith, Coticchio, Giovanni, Fiorentino, Francesco, Goossens, Veerle, Mcheik, Saria, Rubio, Carmen, Sermon, Karen, Sfontouris, Ioannis, Spits, Claudia, Vermeesch, Joris Robert, Vermeulen, Nathalie, Wells, Dagan, Zambelli, Filippo, Kakourou, Georgia“…MAIN RESULTS AND THE ROLE OF CHANCE: Eighty percent of centres that biopsy three or more cells report mosaicism, even though only 66.9% of all centres have validated their technology and only 61.8% of these have validated specifically for the calling of chromosomal mosaicism. …”
Publicado 2022
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926540“…RESULTS: Among the 234 subjects who were screened in the 13-month period, 44 subjects (18.8%) tested positive for moth-toxin IgE, of which 28 were males and 16 were females. …”
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