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  1. 926661
    “…One hundred five respondents comprised the final sample: men (39%) and women (61%) aged 23–66. 66.7% of the respondents were employed in a public organization, 28.5% in a private organization, and 4.8% in a national organization. Years of education: less than 12 (14.3%); 12 full years (17.1%); tertiary education (10.5%); bachelor’s degree (40%); and master’s degree and above (18.1%). …”
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    Insights into abusive workplace behavior
  2. 926662
    “…There were no significant differences between the intervention and comparison groups in mean [SD] PPPY all-cause medical care costs ($7,475 [$17,601] vs. $8,577 [$22,972], respectively, P = 0.213) or total all-cause costs ($10,613 [$18,590] vs. $11,431 [$24,060], P = 0.666). …”
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    Evaluation of a Program to Improve Diabetes Care Through Intensified Care Management Activities and Diabetes Medication Copayment Reduction
  3. 926663
    “…Rates of discontinuation were similar between groups (KM: 71.8% vs. 71.7% at 12 months; HR = 0.98, P = 0.600). …”
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    Comparative Treatment Patterns, Resource Utilization, and Costs in Stimulant-Treated Children with ADHD Who Require Subsequent Pharmacotherapy with Atypical Antipsychotics Versus Non-Antipsychotics
  4. 926664
    por Jayasooriya, S., Stolbrink, M., Khoo, E. M., Sunte, I. T., Awuru, J. I., Cohen, M., Lam, D. C., Spanevello, A., Visca, D., Centis, R., Migliori, G. B., Ayuk, A.C., Buendia, J.A., Awokola, B. I., Del-Rio-Navarro, B. E., Muteti-Fana, S., Lao-araya, M., Chiarella, P., Badellino, H, Somwe, S. W., Anand, M. P., Garcí-Corzo, J. R., Bekele, A., Soto-Martinez, M. E., Ngahane, B. H. M., Florin, M., Voyi, K., Tabbah, K., Bakki, B., Alexander, A., Garba, B. L., Salvador, E. M., Fischer, G. B., Falade, A. G., Živković, Zorica, Romero-Tapia, S. J., Erhabor, G. E., Zar, H., Gemicioglu, B., Brandão, H. V., Kurhasani, X., El-Sharif, N., Singh, V., Ranasinghe, J. C., Kudagammana, S. T., Masjedi, M. R., Velásquez, J. N., Jain, A., Cherrez-Ojeda, I., Valdeavellano, L. F. M., Gómez, R. M., Mesonjesi, E., Morfin-Maciel, B. M., Ndikum, A. E., Mukiibi, G. B., Reddy, B. K., Yusuf, O., Taright-Mahi, S., Mérida-Palacio, J. V., Kabra, S. K., Nkhama, E., Filho, N. R., Zhjegi, V. B., Mortimer, K., Rylance, S., Masekela, R. R.
    Publicado 2023
    “…RESULTS: Eighteen clinical standards were defined: Standard 1, Every individual with symptoms and signs compatible with asthma should undergo a clinical assessment; Standard 2, In individuals (>6 years) with a clinical assessment supportive of a diagnosis of asthma, a hand-held spirometry measurement should be used to confirm variable expiratory airflow limitation by demonstrating an acute response to a bronchodilator; Standard 3, Pre- and post-bronchodilator spirometry should be performed in individuals (>6 years) to support diagnosis before treatment is commenced if there is diagnostic uncertainty; Standard 4, Individuals with an acute exacerbation of asthma and clinical signs of hypoxaemia or increased work of breathing should be given supplementary oxygen to maintain saturation at 94–98%; Standard 5, Inhaled short-acting beta-2 agonists (SABAs) should be used as an emergency reliever in individuals with asthma via an appropriate spacer device for metered-dose inhalers; Standard 6, Short-course oral corticosteroids should be administered in appropriate doses to individuals having moderate to severe acute asthma exacerbations (minimum 3–5 days); Standard 7, Individuals having a severe asthma exacerbation should receive emergency care, including oxygen therapy, systemic corticosteroids, inhaled bronchodilators (e.g., salbutamol with or without ipratropium bromide) and a single dose of intravenous magnesium sulphate should be considered; Standard 8, All individuals with asthma should receive education about asthma and a personalised action plan; Standard 9, Inhaled medications (excluding dry-powder devices) should be administered via an appropriate spacer device in both adults and children. …”
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    Clinical standards for the diagnosis and management of asthma in low- and middle-income countries
  5. 926665
    “…RESULT(S): The risk of HDP (14 studies, odds ratio (OR) 2.17; 95% confidence interval (CI) 1.95-2.41; P<0.00001; I(2) = 43%), gestational hypertension (11 studies, OR 1.38; 95% CI 1.15-1.66; P=0.0006; I(2) = 19%), PE (12 studies, OR 2.09; 95% CI 1.88-2.32; P<0.00001; I(2) = 0%), GDM (20 studies, OR 1.09; 95% CI 1.02-1.17; P=0.02; I(2) = 8%), LGA (18 studies, OR 1.11; 95% CI 1.07-1.15; P<0.00001; I(2) = 46%), macrosomia (12 studies, OR 1.15; 95% CI 1.07-1.24; P=0.0002; I(2) = 31%), PTD (22 studies, OR 1.21; 95% CI 1.15-1.27; P<0.00001; I(2) = 49%), placenta previa (17 studies, OR 1.2; 95% CI 1.02-1.41; P=0.03; I(2) = 11%), PPROM (9 studies, OR 1.19; 95% CI 1.02-1.39; P=0.02; I(2) = 40%), and PPH (12 studies, OR 2.27; 95% CI 2.02-2.55; P <0.00001; I(2) = 55%) were increased in programmed FET cycles versus natural FET cycles with overall embryo transfer. …”
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    The influence of embryo stage on obstetric complications and perinatal outcomes following programmed compared to natural frozen-thawed embryo transfer cycles: a systematic review and meta-analysis
  6. 926666
    por Kadalayil, Latha, Alam, Md. Zahangir, White, Cory Haley, Ghantous, Akram, Walton, Esther, Gruzieva, Olena, Merid, Simon Kebede, Kumar, Ashish, Roy, Ritu P., Solomon, Olivia, Huen, Karen, Eskenazi, Brenda, Rzehak, Peter, Grote, Veit, Langhendries, Jean-Paul, Verduci, Elvira, Ferre, Natalia, Gruszfeld, Darek, Gao, Lu, Guan, Weihua, Zeng, Xuehuo, Schisterman, Enrique F., Dou, John F., Bakulski, Kelly M., Feinberg, Jason I., Soomro, Munawar Hussain, Pesce, Giancarlo, Baiz, Nour, Isaevska, Elena, Plusquin, Michelle, Vafeiadi, Marina, Roumeliotaki, Theano, Langie, Sabine A. S., Standaert, Arnout, Allard, Catherine, Perron, Patrice, Bouchard, Luigi, van Meel, Evelien R., Felix, Janine F., Jaddoe, Vincent W. V., Yousefi, Paul D., Ramlau-Hansen, Cecilia H., Relton, Caroline L., Tobi, Elmar W., Starling, Anne P., Yang, Ivana V., Llambrich, Maria, Santorelli, Gillian, Lepeule, Johanna, Salas, Lucas A., Bustamante, Mariona, Ewart, Susan L., Zhang, Hongmei, Karmaus, Wilfried, Röder, Stefan, Zenclussen, Ana Claudia, Jin, Jianping, Nystad, Wenche, Page, Christian M., Magnus, Maria, Jima, Dereje D., Hoyo, Cathrine, Maguire, Rachel L., Kvist, Tuomas, Czamara, Darina, Räikkönen, Katri, Gong, Tong, Ullemar, Vilhelmina, Rifas-Shiman, Sheryl L., Oken, Emily, Almqvist, Catarina, Karlsson, Robert, Lahti, Jari, Murphy, Susan K., Håberg, Siri E., London, Stephanie, Herberth, Gunda, Arshad, Hasan, Sunyer, Jordi, Grazuleviciene, Regina, Dabelea, Dana, Steegers-Theunissen, Régine P. M., Nohr, Ellen A., Sørensen, Thorkild I. A., Duijts, Liesbeth, Hivert, Marie-France, Nelen, Vera, Popovic, Maja, Kogevinas, Manolis, Nawrot, Tim S., Herceg, Zdenko, Annesi-Maesano, Isabella, Fallin, M. Daniele, Yeung, Edwina, Breton, Carrie V., Koletzko, Berthold, Holland, Nina, Wiemels, Joseph L., Melén, Erik, Sharp, Gemma C., Silver, Matt J., Rezwan, Faisal I., Holloway, John W.
    Publicado 2023
    “…Furthermore, we identified twenty-six differentially methylated regions (DMR) at birth (winter-born: 8, spring-born: 15, summer-born: 3) and thirty-two in childhood (winter-born: 12, spring and summer: 10 each) meta-analyses with few overlapping DMRs between the birth seasons or the two time points. …”
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    Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude
  7. 926667
    “…With the premise that this was a primary pneumothorax, ambulatory management was initiated with an 8FG Rocket® Pleural Vent™. A repeat CXR showed a small right residual pneumothorax, a new small left pneumothorax and a subtle cavitatory lesion. …”
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    OA19 A complex case of bilateral pneumothoraces due to probable certolizumab driven rheumatoid lung nodules
  8. 926668
    “…His skin lesions have gradually resolved 8 weeks after starting treatment and he has had an improvement in his respiratory and musculoskeletal symptoms. …”
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    P15 JAKi of all trades
  9. 926669
    “…Blood tests demonstrated strongly positive rheumatoid factor (116.8 IU/ml) and anti-cyclic citrullinated peptide (>250 units/ml); anti-Ro, anti-La, and anti-Ro52 were also positive. …”
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    P24 TB or not TB? A case of severe multi-organ erosive rheumatoid arthritis in a Ukrainian refugee
  10. 926670
    “…IGF-I level prior to initiating OOC was the only predictor of response in the run-in phase for randomization into the RCT phase; randomized mean (SD) 0.8 × ULN (0.25), not randomized 1.0 × ULN (0.25), adjusted P<.0001. …”
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    THU057 Predictors Of Response To Oral Octreotide Capsules In Patients With Acromegaly In A Large Prospective International Trial
  11. 926671
    “…Each admission involved 2 nights of unfragmented sleep [8-h time-in-bed (TIB)] followed by 3 nights of sleep fragmentation, induced by auditory stimuli distributed across the night, producing 1-hr of cumulative wakefulness while enabling equal sleep opportunity (9-h TIB). …”
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    FRI411 Pharmacologically Induced Hypoestrogenism And Experimentally Induced Menopause-Pattern Sleep Fragmentation Independently Influence Circulating Lipids, Heart Rate, And Blood Pressure In Women
  12. 926672
    “…The intratumoral targeting efficiency of MSC guidance is 93.5%, effectively assisting the homogeneous diffusion of LNPs throughout the tumor tissue at 3.8- and 2.7-fold higher concentrations compared to the intravenous and intratumoral administrations of LNPs, respectively. …”
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    Micro-syringe chip-guided intratumoral administration of lipid nanoparticles for targeted anticancer therapy
  13. 926673
    “…For OS, SoC + PbCT was most likely to rank first in patients with and without BM, with cumulative probabilities of 46.8%, and 37.3%, respectively. CONCLUSION: Osimertinib + bevacizumab is most likely to rank first in PFS in advanced EGFR-mutated NSCLC patients with or without BM, and SoC + PbCT is most likely to rank first in OS.…”
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    Front-line therapy for brain metastases and non-brain metastases in advanced epidermal growth factor receptor-mutated non-small cell lung cancer: a network meta-analysis
  14. 926674
    “…In pregnant patients, rectal administration continued until Week 8 of gestation, and oestradiol and vaginal progesterone treatment continued until Week 10 of gestation. …”
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    Rectal progesterone administration secures a high ongoing pregnancy rate in a personalized Hormone Replacement Therapy Frozen Embryo Transfer (HRT-FET) protocol: a prospective interventional study
  15. 926675
    “…RESULTS: Among 15–49-year-old women in Sierra Leone, the prevalence of underweight was 6.7% (95%CI: 4.5-8.9%); overweight at 19.7% (95%CI: 17.7-21.7%); obesity was 7.4% (95% CI: 5.2-9.6%); and overnutrition, 27.1% (95%CI: 25.2-29.0%). …”
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    Double burden of malnutrition among women in reproductive Age (15–49 years) in Sierra Leone: a secondary data analysis of the demographic health survey 2019 (SLDHS-2019)
  16. 926676
    “…The probability of a better DOOR outcome in a randomly selected patient with CO BSI compared to a patient with HO BSI is 60.6% (95% CI: 56.8-64.3%). Mortality at 30-days was 11.6% higher in HO BSI than CO BSI (95% CI: 5.7, 17.6%, p=0.0003). …”
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    1029. Increased Mortality in Hospital-Onset Carbapenem-Resistant Enterobacterales Bloodstream Infections
  17. 926677
    “…RESULTS: 595 patients with suspected IE were included, of whom 399 (67%) were adjudicated as having IE. 111 patients (19%) had prosthetic valve IE, 48 (8%) had cardiac implantable electronic device IE. …”
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    963. External Validation of the 2023 Duke - International Society for Cardiovascular Infectious Diseases (ISCVID) Diagnostic Criteria for Infective Endocarditis (IE)
  18. 926678
    “…Again, prognostic correlates have been noted, with presence of circulating p53 autoantibodies at diagnosis of breast cancer being associated with reduced overall survival [5,6] and with poor prognostic factors such as high histological grade and the absence of hormone receptors [5,7,8]. Little is known of the potential value of p53 autoantibody in follow up of cancer. …”
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    P53 autoantibodies in 1006 patients followed up for breast cancer
  19. 926679
    “…IL-4 is also known to be a potent anti-inflammatory cytokine that acts by inhibiting the synthesis of proinflammatory cytokines such as IL-1, TNF-α, IL-6, IL-8 and IL-12 by macrophages and monocytes. Moreover, IL-4 stimulates the synthesis of several cytokine inhibitors such as interleukin-1 receptor antagonist (IL-1Ra), soluble IL-1-receptor type II and TNF receptors IL-4 suppresses metalloproteinase production and stimulates tissue inhibitor of metalloproteinase-1 production in human mononuclear phagocytes and cartilage explants, indicating a protective effect of IL-4 towards extracellular matrix degradation. …”
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    Protection against cartilage and bone destruction by systemic interleukin-4 treatment in established murine type II collagen-induced arthritis
  20. 926680
    “…On day 23, however, the percentage of TUNEL-positive cells was significantly increased [15.8±5.1% (mean ± standard error of the mean); P=0.01]. …”
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    Apoptosis and p53 expression in rat adjuvant arthritis
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